leucine

Summary

Summary: An essential branched-chain amino acid important for hemoglobin formation.

Top Publications

  1. ncbi Hypothalamic mTOR signaling regulates food intake
    Daniela Cota
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Science 312:927-30. 2006
  2. ncbi Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    J P Hugot
    Fondation Jean Dausset CEPH, 27 rue J Dodu 75010 Paris, France
    Nature 411:599-603. 2001
  3. ncbi Analysis and prediction of leucine-rich nuclear export signals
    Tanja la Cour
    Center for Biological Sequence Analysis, BioCentrum DTU, Technical University of Denmark, Building 208, DK 2800 Lyngby, Denmark
    Protein Eng Des Sel 17:527-36. 2004
  4. ncbi A putative leucine-rich repeat receptor kinase involved in brassinosteroid signal transduction
    J Li
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Cell 90:929-38. 1997
  5. doi Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
    Jung Min Han
    Medicinal Bioconvergence Research Center, Seoul National University, Seoul 151 742, Republic of Korea
    Cell 149:410-24. 2012
  6. ncbi Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
    Daniel Cuthbertson
    Division of Molecular Physiology, School of Life Sciences, University of Dundee, Dundee, Scotland
    FASEB J 19:422-4. 2005
  7. pmc Leucine-rich repeat protein complex activates mosquito complement in defense against Plasmodium parasites
    Michael Povelones
    Division of Cell and Molecular Biology, Department of Life Sciences, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Science 324:258-61. 2009
  8. pmc The root knot nematode resistance gene Mi from tomato is a member of the leucine zipper, nucleotide binding, leucine-rich repeat family of plant genes
    S B Milligan
    Center for Engineering Plants for Resistance Against Pathogens, University of California, Davis, California 95616, USA
    Plant Cell 10:1307-19. 1998
  9. ncbi A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly
    Christos S Katsanos
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77550, USA
    Am J Physiol Endocrinol Metab 291:E381-7. 2006
  10. ncbi CRM1 is an export receptor for leucine-rich nuclear export signals
    M Fornerod
    European Molecular Biology Laboratory, Heidelberg, Germany
    Cell 90:1051-60. 1997

Detail Information

Publications337 found, 100 shown here

  1. ncbi Hypothalamic mTOR signaling regulates food intake
    Daniela Cota
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Science 312:927-30. 2006
    ..Central administration of leucine increases hypothalamic mTOR signaling and decreases food intake and body weight...
  2. ncbi Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    J P Hugot
    Fondation Jean Dausset CEPH, 27 rue J Dodu 75010 Paris, France
    Nature 411:599-603. 2001
    ..These NOD2 variants alter the structure of either the leucine-rich repeat domain of the protein or the adjacent region...
  3. ncbi Analysis and prediction of leucine-rich nuclear export signals
    Tanja la Cour
    Center for Biological Sequence Analysis, BioCentrum DTU, Technical University of Denmark, Building 208, DK 2800 Lyngby, Denmark
    Protein Eng Des Sel 17:527-36. 2004
    ..We employ both neural networks and hidden Markov models in the prediction algorithm and verify the method on the most recently discovered NESs. The NES predictor (NetNES) is made available for general use at http://www.cbs.dtu.dk/...
  4. ncbi A putative leucine-rich repeat receptor kinase involved in brassinosteroid signal transduction
    J Li
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Cell 90:929-38. 1997
    ..It encodes a ubiquitously expressed putative receptor kinase. The extracellular domain contains 25 tandem leucine-rich repeats that resemble repeats found in animal hormone receptors, plant disease resistance genes, and genes ..
  5. doi Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
    Jung Min Han
    Medicinal Bioconvergence Research Center, Seoul National University, Seoul 151 742, Republic of Korea
    Cell 149:410-24. 2012
    ..synthetase (LRS) plays a critical role in amino acid-induced mTORC1 activation by sensing intracellular leucine concentration and initiating molecular events leading to mTORC1 activation...
  6. ncbi Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
    Daniel Cuthbertson
    Division of Molecular Physiology, School of Life Sciences, University of Dundee, Dundee, Scotland
    FASEB J 19:422-4. 2005
    ..Countermeasures to maximize muscle maintenance should target these deficits...
  7. pmc Leucine-rich repeat protein complex activates mosquito complement in defense against Plasmodium parasites
    Michael Povelones
    Division of Cell and Molecular Biology, Department of Life Sciences, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Science 324:258-61. 2009
    b>Leucine-rich repeat-containing proteins are central to host defense in plants and animals...
  8. pmc The root knot nematode resistance gene Mi from tomato is a member of the leucine zipper, nucleotide binding, leucine-rich repeat family of plant genes
    S B Milligan
    Center for Engineering Plants for Resistance Against Pathogens, University of California, Davis, California 95616, USA
    Plant Cell 10:1307-19. 1998
    ..Prf and Mi-1.2 share several structural motifs, including a nucleotide binding site and a leucine-rich repeat region, that are characteristic of a family of plant proteins, including several that are required ..
  9. ncbi A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly
    Christos S Katsanos
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77550, USA
    Am J Physiol Endocrinol Metab 291:E381-7. 2006
    This study was designed to evaluate the effects of enriching an essential amino acid (EAA) mixture with leucine on muscle protein metabolism in elderly and young individuals...
  10. ncbi CRM1 is an export receptor for leucine-rich nuclear export signals
    M Fornerod
    European Molecular Biology Laboratory, Heidelberg, Germany
    Cell 90:1051-60. 1997
    ..We conclude that CRM1 is an export receptor for leucine-rich nuclear export signals and discuss a model for the role of RanGTP in CRM1 function and in nuclear export in ..
  11. ncbi Oral leucine administration stimulates protein synthesis in rat skeletal muscle
    Stephen J Crozier
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Nutr 135:376-82. 2005
    Oral administration of a single bolus of leucine in an amount equivalent to the daily intake (1.35 g/kg body wt) enhances skeletal muscle protein synthesis in food-deprived rats...
  12. pmc A competitive inhibitor traps LeuT in an open-to-out conformation
    Satinder K Singh
    Vollum Institute, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
    Science 322:1655-61. 2008
    ..We used crystallographic and functional studies on the leucine transporter (LeuT), a model for neurotransmitter sodium symporters, to show that various amino acid substrates ..
  13. pmc LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake
    Zheng Zhou
    Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Science 317:1390-3. 2007
    ..We determined the crystal structure at 2.9 angstroms of the bacterial leucine transporter (LeuT), a homolog of SERT, NET, and DAT, in complex with leucine and the antidepressant desipramine...
  14. pmc The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site
    Lei Shi
    Department of Physiology and Biophysics, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Mol Cell 30:667-77. 2008
    ..The crystal structure of LeuT(Aa), a prokaryotic NSS homolog, revealed an occluded state in which one leucine and two Na(+) ions are bound, but provided limited clues to the molecular mechanism of transport...
  15. ncbi Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms
    Yiying Zhang
    Department of Pediatrics, Division of Molecular Genetics, Columbia University, New York, NY 10032, USA
    Diabetes 56:1647-54. 2007
    b>Leucine, as an essential amino acid and activator of mTOR (mammalian target of rapamycin), promotes protein synthesis and suppresses protein catabolism...
  16. pmc Mutagenesis of tyrosine and di-leucine motifs in the HIV-1 envelope cytoplasmic domain results in a loss of Env-mediated fusion and infectivity
    Sushma J Bhakta
    Emory Vaccine Center at the Yerkes National Primate Research Center and Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30329, USA
    Retrovirology 8:37. 2011
    ..Additional mutants targeting individual motifs were then constructed...
  17. ncbi Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis
    Scot R Kimball
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA, USA
    J Nutr 136:227S-31S. 2006
    ..Of the three BCAAs, leucine is the one primarily responsible for the stimulation of protein synthesis under these circumstances...
  18. doi Leucine or carbohydrate supplementation reduces AMPK and eEF2 phosphorylation and extends postprandial muscle protein synthesis in rats
    Gabriel J Wilson
    Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Am J Physiol Endocrinol Metab 301:E1236-42. 2011
    ..This study evaluated the potential for supplemental leucine (Leu), carbohydrates (CHO), or both to prolong elevated MPS after a meal...
  19. pmc Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women
    Erin L Glynn
    Departments of Physical Therapy, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Nutr 140:1970-6. 2010
    Essential amino acids (EAA) stimulate skeletal muscle protein synthesis (MPS) in humans. Leucine may have a greater stimulatory effect on MPS than other EAA and/or decrease muscle protein breakdown (MPB)...
  20. pmc Structural basis for leucine-rich nuclear export signal recognition by CRM1
    Xiuhua Dong
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park, Dallas, Texas 75390 9041, USA
    Nature 458:1136-41. 2009
    ..known as XPO1 and exportin 1) mediates nuclear export of hundreds of proteins through the recognition of the leucine-rich nuclear export signal (LR-NES). Here we present the 2.9 A structure of CRM1 bound to snurportin 1 (SNUPN)...
  21. pmc Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle
    Hans C Dreyer
    Department of Physical Therapy, Division of Rehabilitation Sciences, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1144, USA
    Am J Physiol Endocrinol Metab 294:E392-400. 2008
    ..we hypothesized that enhanced mTOR signaling might be responsible for the greater muscle protein synthesis when leucine-enriched EAA+CHOs are ingested during postexercise recovery...
  22. ncbi Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains
    Jonathan A Harton
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 169:4088-93. 2002
    Large mammalian proteins containing a nucleotide-binding domain (NBD) and C-terminal leucine-rich repeats (LRR) similar in structure to plant disease resistance proteins have been suggested as critical in innate immunity...
  23. pmc Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production
    Tobias Moehlmann
    Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s Disease Research, Ludwig Maximilians University, 80336 Munich, Germany
    Proc Natl Acad Sci U S A 99:8025-30. 2002
    ..Finally, we show that PS1 L166 mutants affect the generation of NICD and AICD in a similar manner, supporting the concept that S3 protease and S3-like gamma-secretase cleavages are mediated by identical proteolytic activities...
  24. ncbi Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers
    T W Hai
    Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138
    Genes Dev 3:2083-90. 1989
    ..All ATF cDNA clones examined contain a leucine zipper motif and are significantly similar to one another only within this region...
  25. doi The role of small leucine-rich proteoglycans in collagen fibrillogenesis
    Sebastian Kalamajski
    Lund University, Department of Experimental Medical Science, BMC B12, Lund, Sweden
    Matrix Biol 29:248-53. 2010
    Small leucine-rich proteoglycans/proteins (SLRPs) are associated with collagen fibril formation, and therefore important for the proper formation of extracellular matrices...
  26. doi Effect of Leucine and Lysine substitution on the antimicrobial activity and evaluation of the mechanism of the HPA3NT3 analog peptide
    Ramamourthy Gopal
    Research Center for Proteineous Materials RCPM, Chosun University, Gwangju, Korea
    J Pept Sci 15:589-94. 2009
    ..These results suggest that the substitutions of Arg and Asn with Lys and two Trp with Leu resulted in small changes in HPA3NT3-analog activity and significant decreases in hemolytic activity...
  27. doi Paxillin associates with the microtubule cytoskeleton and the immunological synapse of CTL through its leucine-aspartic acid domains and contributes to microtubule organizing center reorientation
    Leslie K Robertson
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton T6G 2S2, Alberta, Canada
    J Immunol 187:5824-33. 2011
    ..We mapped the region of paxillin that associates with both the MTOC and SMAC to the leucine-aspartic acid (LD) domains and showed that a protein segment containing LD2-4 was sufficient for MTOC and SMAC ..
  28. ncbi Leucine-rich nuclear-export signals: born to be weak
    Ulrike Kutay
    Swiss Federal Institute of Technology ETH Zurich, Institute of Biochemistry, Schafmattstrasse 18, HPM F11 1, 8093 Zurich, Switzerland
    Trends Cell Biol 15:121-4. 2005
    CRM1 mediates the nuclear export of proteins exposing leucine-rich nuclear-export signals (NESs). Most NESs bind to CRM1 with relatively low affinity. Recently, higher-affinity NESs were selected from a 15-mer random peptide library...
  29. doi An overview of the therapeutic effects of leucine supplementation on skeletal muscle under atrophic conditions
    Humberto Nicastro
    Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of Sao Paulo, Sao Paulo, Brazil
    Amino Acids 40:287-300. 2011
    ..Among anti-atrophic therapies, amino acid supplementation, particularly with leucine, has received a lot of attention...
  30. pmc Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters
    Derek P Claxton
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Nat Struct Mol Biol 17:822-9. 2010
    ..the dynamics of LeuT in the region of the extracellular vestibule associated with the binding of Na(+) and leucine. The results outline the Na(+)-dependent formation of a dynamic outward-facing intermediate that exposes the ..
  31. pmc Activation of an Arabidopsis resistance protein is specified by the in planta association of its leucine-rich repeat domain with the cognate oomycete effector
    Ksenia V Krasileva
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
    Plant Cell 22:2444-58. 2010
    ..The leucine-rich repeat (LRR) domain of RPP1 mediates the interaction with ATR1, while the Toll/Interleukin1 Receptor (TIR) ..
  32. pmc Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo
    Joon Ho Sheen
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cancer Cell 19:613-28. 2011
    Autophagy is of increasing interest as a target for cancer therapy. We find that leucine deprivation causes the caspase-dependent apoptotic death of melanoma cells because it fails to appropriately activate autophagy...
  33. pmc Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism
    Yazmin Macotela
    Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e21187. 2011
    ..In the present study we demonstrate how a single, simple dietary factor--leucine--can modify insulin resistance by acting on multiple tissues and at multiple levels of metabolism...
  34. pmc Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans
    Renato V Iozzo
    Department of Pathology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    FEBS J 277:3864-75. 2010
    The small leucine-rich proteoglycans (SLRPs) are involved in many aspects of mammalian biology, both in health and disease...
  35. doi Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in colorectal cancer
    Hiroshi Uchida
    Department of Pathology, School of Medicine, Keio University, Tokyo, Japan
    Cancer Sci 101:1731-7. 2010
    b>Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) is a 7-transmembrane receptor reportedly expressed in stem cells of the intestinal crypts and hair follicles of mice...
  36. pmc Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit
    Clemence Blouet
    Department of Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
    J Neurosci 29:8302-11. 2009
    ..While central leucine reduces food intake and body weight, the specific neuroanatomical sites of leucine sensing, downstream neural ..
  37. doi The leucine content of a complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of rapamycin signaling in rats
    Layne E Norton
    Division of Nutritional Sciences, Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Nutr 139:1103-9. 2009
    This study examined the impact of leucine (Leu) derived from complete meals on stimulation of skeletal muscle protein synthesis (MPS). Expt. 1 examined time course changes in translation initiation and MPS after a meal...
  38. ncbi Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters
    Atsuko Yamashita
    Department of Biochemistry and Molecular Biophysics and
    Nature 437:215-23. 2005
    ..structure of a bacterial homologue of these transporters from Aquifex aeolicus, in complex with its substrate, leucine, and two sodium ions...
  39. ncbi RP105, a novel B cell surface molecule implicated in B cell activation, is a member of the leucine-rich repeat protein family
    K Miyake
    Department of Immunology, Saga Medical School, Japan
    J Immunol 154:3333-40. 1995
    ..The RP105 molecule possesses 22 tandem repeats of a leucine-rich motif...
  40. ncbi Leucine and protein synthesis: mTOR and beyond
    Martha H Stipanuk
    Division of Nutritional Sciences, 227 Savage Hall, Cornell University, Ithaca, NY 14853, USA
    Nutr Rev 65:122-9. 2007
    ..acid intake on protein synthesis in the intact rat appear to be mediated almost entirely by a single amino acid: leucine. The effect of leucine on protein synthesis appears to be closely associated with eIF4G phosphorylation and its ..
  41. pmc Brassinosteroid-insensitive-1 is a ubiquitously expressed leucine-rich repeat receptor serine/threonine kinase
    D M Friedrichsen
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Plant Physiol 123:1247-56. 2000
    ..Screens for BR signaling mutants identified one locus, BRI1, which encodes a protein with homology to leucine-rich repeat receptor serine (Ser)/threonine (Thr) kinases...
  42. pmc Both the extracellular leucine-rich repeat domain and the kinase activity of FSL2 are required for flagellin binding and signaling in Arabidopsis
    L Gomez-Gomez
    Friedrich Miescher Institut, P O Box 2543, CH 4002 Basel, Switzerland
    Plant Cell 13:1155-63. 2001
    ..domain of flagellin, represented by the peptide flg22, in a process involving the FLS2 gene, which encodes a leucine-rich repeat serine/threonine protein kinase...
  43. pmc The thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction
    Yumiko Mizutori
    Autoimmune Disease Unit, Cedars Sinai Research Institute, University of California, Los Angeles, California 90048, USA
    Mol Endocrinol 22:1171-82. 2008
    The glycoprotein hormone receptor hinge region connects the leucine-rich and transmembrane domains. The prevalent concept is that the hinge does not play a significant role in ligand binding and signal transduction...
  44. ncbi Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region
    J Wu
    Laboratory of Cell Biology, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    J Biol Chem 270:14209-13. 1995
    ..Nup358 contains a leucine-rich region, four potential Ran binding sites (i.e...
  45. pmc Phosphorylation regulates the subcellular location and activity of the snail transcriptional repressor
    David Dominguez
    Unitat de Biologia Cel lular i Molecular, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    Mol Cell Biol 23:5078-89. 2003
    ..These findings show the existence in tumor cells of an effective and fine-tuning nontranscriptional mechanism of regulation of Snail activity dependent on the extracellular environment...
  46. pmc Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia
    Isabelle Rieu
    Unite de Nutrition Humaine, UMR1019, Institut National de la Recherche Agronomique, Centre de Recherche, en Nutrition Humaine d Auvergne, F 63122 Saint Genes Champanelle, France
    J Physiol 575:305-15. 2006
    The present study was designed to assess the effects of dietary leucine supplementation on muscle protein synthesis and whole body protein kinetics in elderly individuals...
  47. pmc Leucine-rich repeat transmembrane proteins instruct discrete dendrite targeting in an olfactory map
    Weizhe Hong
    Howard Hughes Medical Institute and Department of Biology, Stanford University, Stanford, California, USA
    Nat Neurosci 12:1542-50. 2009
    ..We found that the leucine-rich repeat (LRR) transmembrane protein Capricious (Caps) was differentially expressed in different classes of ..
  48. pmc Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle
    Asish K Saha
    Diabetes Research Unit, Division of Endocrinology, Department of Medicine, Boston University Medical Center, Boston, Massachusetts, USA
    Diabetes 59:2426-34. 2010
    Branched-chain amino acids, such as leucine and glucose, stimulate protein synthesis and increase the phosphorylation and activity of the mammalian target of rapamycin (mTOR) and its downstream target p70S6 kinase (p70S6K)...
  49. pmc Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism
    Pengxiang She
    Dept of Cellular and Molecular Physiology, MC H166, Penn State Univ College of Medicine, 500 University Dr, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 293:E1552-63. 2007
    ..Our results are consistent with the idea that tissue-specific alterations in BCAA metabolism, in liver and adipose tissue but not in muscle, may contribute to the rise in plasma BCAAs in obesity...
  50. pmc Deletion of v7-3 (SLC6A15) transporter allows assessment of its roles in synaptosomal proline uptake, leucine uptake and behaviors
    Jana Drgonova
    Molecular Neurobiology Branch, NIDA, NIH, 333 Cassell Drive, Baltimore, MD 21224, USA
    Brain Res 1183:10-20. 2007
    ..into cortical synaptosomes of v7-3 knockouts identified 15% and 40% reductions in sodium-dependent proline and leucine transport, respectively, compared to wild type controls...
  51. pmc L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway
    Latif Rachdi
    INSERM U845, Research Center Growth and Signaling, Paris Descartes University, Sorbonne Paris Cité, Necker Hospital, Paris, France
    Diabetes 61:409-17. 2012
    b>Leucine (Leu) is an essential branched-chain amino acid, which activates the mammalian target of rapamycin (mTOR) signaling pathway. The effect of Leu on cell differentiation during embryonic development is unknown...
  52. doi Leucine as a pharmaconutrient to prevent and treat sarcopenia and type 2 diabetes
    Marika Leenders
    Top Institute Food and Nutrition TIFN, Wageningen, The Netherlands
    Nutr Rev 69:675-89. 2011
    ..These findings have been particularly pronounced for the amino acid leucine. Furthermore, leucine has the ability to act as a strong insulin secretagogue...
  53. pmc Leucine supplementation chronically improves muscle protein synthesis in older adults consuming the RDA for protein
    Shanon L Casperson
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA
    Clin Nutr 31:512-9. 2012
    ..Protein-energy supplementation is routinely employed to combat muscle loss. However, success is often compromised by increased satiety, poor palatability, high costs and low compliance...
  54. pmc Amino acid availability and age affect the leucine stimulation of protein synthesis and eIF4F formation in muscle
    Jeffery Escobar
    USDA ARS Children s Nutrition Research Center, Dept of Pediatrics, Baylor College of Medicine, 1100 Bates St, Houston, TX 77030, USA
    Am J Physiol Endocrinol Metab 293:E1615-21. 2007
    We have previously shown that a physiological increase in plasma leucine for 60 and 120 min increases translation initiation factor activation in muscle of neonatal pigs...
  55. ncbi NtLRP1, a tobacco leucine-rich repeat gene with a possible role as a modulator of the hypersensitive response
    Alban Jacques
    Institut de Biologie Moleculaire des Plantes du CNRS, Universite Louis Pasteur, Strasbourg, France
    Mol Plant Microbe Interact 19:747-57. 2006
    ..Translation of the open reading frame of DD9-3 revealed a leucine-rich repeat (LRR) domain highly homologous with the receptor domain of a receptor kinase, suggesting a potential ..
  56. ncbi Ultrasonic imaging of tumor angiogenesis using contrast microbubbles targeted via the tumor-binding peptide arginine-arginine-leucine
    Gregory E R Weller
    Department of Bioengineering and McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Cancer Res 65:533-9. 2005
    ..been identified that specifically bind tumor angiogenic endothelium, including the tripeptide arginine-arginine-leucine (RRL)...
  57. doi Leucine and mTORC1: a complex relationship
    Kayleigh M Dodd
    Institute of Medical Genetics, Cardiff University, Heath Park, Cardiff, Wales, UK
    Am J Physiol Endocrinol Metab 302:E1329-42. 2012
    ..The branched-chain amino acid leucine is critical for muscle growth and acts in part through activation of mTORC1...
  58. ncbi JLP associates with kinesin light chain 1 through a novel leucine zipper-like domain
    Quang Nguyen
    Fels Institute for Cancer Research and Molecular Biology, School of Medicine, Temple University, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 280:30185-91. 2005
    ..JLP is a novel leucine zipper protein belonging to a family of scaffolding proteins that assemble JNK signaling modules...
  59. pmc Hypothalamic leucine metabolism regulates liver glucose production
    Ya Su
    Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 61:85-93. 2012
    ..Specifically, we tested the novel hypothesis that the metabolism of leucine within the MBH couples the central sensing of leucine with the control of glucose production by the liver...
  60. ncbi Cerebral leucine uptake and protein synthesis in the near-term ovine fetus: relation to fetal behavioral state
    Marie J Czikk
    Canadian Institute of Health Research Group in Fetal and Neonatal Health and Development, Department of Obstetrics and Gynaecology, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada N6A 4V2
    Am J Physiol Regul Integr Comp Physiol 284:R200-7. 2003
    ..We have therefore determined the cerebral uptake of leucine and [(14)C]leucine during continuous tracer infusion as measures of leucine metabolism in relation to behavioral ..
  61. pmc A single conserved leucine residue on the first intracellular loop regulates ER export of G protein-coupled receptors
    Matthew T Duvernay
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, 1901 Perdido St, New Orleans, LA 70112, USA
    Traffic 10:552-66. 2009
    ..These data indicate a crucial role for a single Leu residue within the ICL1 in ER export of GPCRs...
  62. pmc MD-2 residues tyrosine 42, arginine 69, aspartic acid 122, and leucine 125 provide species specificity for lipid IVA
    Jianmin Meng
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 285:27935-43. 2010
    ..Thus, surface charge differences at the two MD-2/TLR4 interfaces determine the species-specific activation of lipid IV(A)...
  63. doi Select nutrients in the ovine uterine lumen. VII. Effects of arginine, leucine, glutamine, and glucose on trophectoderm cell signaling, proliferation, and migration
    Jin Young Kim
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 84:62-9. 2011
    ..Results from our laboratory indicate that arginine (Arg), leucine (Leu), glutamine (Gln), and glucose increase in the uterine lumen between Days 10 and 15 of pregnancy, coincident ..
  64. ncbi Leucine in food mediates some of the postprandial rise in plasma leptin concentrations
    Christopher J Lynch
    Dept of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 291:E621-30. 2006
    ..at the level of mRNA translation by the rapamycin-sensitive mammalian target of rapamycin (mTOR) and its agonist leucine (Leu)...
  65. ncbi Antagonistic effects of leucine and glutamine on the mTOR pathway in myogenic C2C12 cells
    L Deldicque
    Département d Education Physique et de Réadaptation, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Amino Acids 35:147-55. 2008
    This study compared the effects of leucine and glutamine on the mTOR pathway, on protein synthesis and on muscle-specific gene expression in myogenic C(2)C(12) cells...
  66. doi N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinar
    Kevin S Thorneloe
    Cardiovascular and Urogenital Centre of Excellence in Drug Discovery, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, PA 19406, USA
    J Pharmacol Exp Ther 326:432-42. 2008
    ..Overall TRPV4 plays an important role in urinary bladder function that includes an ability to contract the bladder as a result of the expression of TRPV4 in the UBSM...
  67. pmc Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site
    Chayne L Piscitelli
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Nature 468:1129-32. 2010
    ..We conclude that LeuT harbours a single, centrally located, high-affinity substrate-binding site and that transport is well described by a simple, single-substrate kinetic mechanism...
  68. ncbi The central leucine-rich repeat region of chicken TLR16 dictates unique ligand specificity and species-specific interaction with TLR2
    A Marijke Keestra
    Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands
    J Immunol 178:7110-9. 2007
    ..in which the defined domains of chTLR16 and hTLR1 or hTLR6 had been exchanged revealed that the transfer of leucine-rich repeats (LRR) 6-16 of chTLR16 into hTLR6 was sufficient to confer dual ligand specificity to the human ..
  69. ncbi Identification and functional characterization of a Na+-independent neutral amino acid transporter with broad substrate selectivity
    H Segawa
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    J Biol Chem 274:19745-51. 1999
    ....
  70. ncbi Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region
    S Y Hsu
    Department of Gynecology and Obstetrics, Stanford University Medical School, California 94305 5317, USA
    Mol Endocrinol 12:1830-45. 1998
    ..TM) protein family and are unique in having a large N-terminal extracellular (ecto-) domain containing leucine-rich repeats important for interaction with the glycoprotein ligands...
  71. ncbi A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss
    Eduardo R Ropelle
    Department of Internal Medicine, State University of Campinas UNICAMP, 13083 970, Campinas, Sao Paulo, Brazil
    Diabetes 57:594-605. 2008
    ..Here, we sought to determine whether the response of the AMPK and mTOR pathways could contribute to the molecular effects of an HPD...
  72. ncbi Pro-apoptotic activity of HIV-1 auxiliary regulatory protein Vpr is subtype-dependent and potently enhanced by nonconservative changes of the leucine residue at position 64
    Heng Jian
    Institute for Molecular Virology, St Louis University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 278:44326-30. 2003
    ..It is hypothesized that Vpr molecules from different HIV-1 subtypes as well as Vpr variants that emerge during HIV-1 infection may have different pro-apoptotic potentials and contribute to the diversity of AIDS pathogenesis...
  73. ncbi The leucine-rich repeat as a protein recognition motif
    B Kobe
    Department of Biochemistry and Molecular Biology Institute for Molecular Bioscience, University of Queensland, Brisbane, 4072, Queensland, Australia
    Curr Opin Struct Biol 11:725-32. 2001
    b>Leucine-rich repeats (LRRs) are 20-29-residue sequence motifs present in a number of proteins with diverse functions...
  74. pmc A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein
    Rahel Byland
    Cell Biology Unit, MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, University College London, London WC1E 6BT, United Kingdom
    Mol Biol Cell 18:414-25. 2007
    ....
  75. pmc Identification of the leucine-to-2-methylbutyric acid catabolic pathway of Lactococcus lactis
    Balasubramanian Ganesan
    Western Dairy Center, Utah State University, Logan, UT 84322 4700, USA
    Appl Environ Microbiol 72:4264-73. 2006
    ..and in silico pathway analysis coupled with nuclear magnetic resonance spectroscopy were used to delineate the leucine catabolic pathway. Lactococci produced acetic and propionic acid during logarithmic growth and starvation...
  76. ncbi The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid
    Feifan Guo
    Department of Biology, Pennsylvania State University, University Park, PA 16802, USA
    Cell Metab 5:103-14. 2007
    ..synthase (FAS) in the liver are repressed and lipid stores in adipose tissue are mobilized in wild-type mice upon leucine deprivation. In contrast, GCN2-deficient mice developed liver steatosis and exhibited reduced lipid mobilization...
  77. ncbi Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation
    Joshua C Anthony
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Diabetes 51:928-36. 2002
    ..18 h) control rats and rats with alloxan-induced diabetes were orally administered saline or the amino acid leucine to assess whether it regulates protein synthesis independently of a change in serum insulin concentrations...
  78. pmc Substrate binding and formation of an occluded state in the leucine transporter
    Leyla Celik
    Department of Biochemistry, Center for Biophysics and Computational Biology, and Beckman Institute, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    Biophys J 94:1600-12. 2008
    Translocation through the extracellular vestibule and binding of leucine in the leucine transporter (LeuT) have been studied with molecular dynamics simulations. More than 0...
  79. pmc Leucine supplementation of a low-protein meal increases skeletal muscle and visceral tissue protein synthesis in neonatal pigs by stimulating mTOR-dependent translation initiation
    Roberto Murgas Torrazza
    USDA Agricultural Research Service Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    J Nutr 140:2145-52. 2010
    ..b>Leucine appears to be the most effective single amino acid to trigger these effects...
  80. doi Identification of 13 novel NLRP7 mutations in 20 families with recurrent hydatidiform mole; missense mutations cluster in the leucine-rich region
    C M Wang
    Institute of Reproductive and Developmental Biology, Imperial College London, London W12 0NN, UK
    J Med Genet 46:569-75. 2009
    ..Our objectives were to investigate the diversity of mutations and their localisation to one or both isoforms of NLRP7, by screening a large series of women with FRHM and to examine the normal expression of NLRP7 in ovarian tissue...
  81. pmc Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways
    Fei Xiao
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, The Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 60:746-56. 2011
    ..shown that serum insulin levels decrease threefold and blood glucose levels remain normal in mice fed a leucine-deficient diet, suggesting increased insulin sensitivity...
  82. pmc The stem rust resistance gene Rpg5 encodes a protein with nucleotide-binding-site, leucine-rich, and protein kinase domains
    R Brueggeman
    Department of Crop and Soil Science, Washington State University, Pullman, WA 99164, USA
    Proc Natl Acad Sci U S A 105:14970-5. 2008
    ..of an unusual structure encoding three typical plant disease resistance protein domains: nucleotide-binding site, leucine-rich repeat, and serine threonine protein kinase...
  83. doi Leucine supplementation favors liver protein status but does not reduce body fat in rats during 1 week of food restriction
    Rogerio G Pedrosa
    Department of Zootechny, CCA, Federal University of Espirito Santo, Alegre, ES, Brazil
    Appl Physiol Nutr Metab 35:180-3. 2010
    An important role in protein-energy metabolism has been attributed to leucine because of its long-term effects on body fat reduction and on the improvement of some indicators of protein status in rodents...
  84. doi PLAP-1/asporin inhibits activation of BMP receptor via its leucine-rich repeat motif
    M Tomoeda
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 371:191-6. 2008
    ..The induction of mutation to the leucine-rich repeat (LRR) motif, especially LRR5, within PLAP-1/asporin rescued the inhibitory effect of PLAP-1/asporin ..
  85. doi Control of ion selectivity in LeuT: two Na+ binding sites with two different mechanisms
    Sergei Y Noskov
    Institute for Biocomplexity and Informatics, Department for Biological Sciences, University of Calgary, 2500 University Drive, Calgary, AB, Canada
    J Mol Biol 377:804-18. 2008
    ..predominantly from the strong electrostatic field arising from the negatively charged carboxylate group of the leucine substrate coordinating the ion directly...
  86. ncbi Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain
    C Aiken
    Infectious Disease Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037 1099
    Cell 76:853-64. 1994
    ..Within this region, a dileucine motif, reminiscent of an endocytosis and lysosomal targeting signal found in the CD3 gamma and delta chains, is crucial for CD4 response to Nef...
  87. doi Long-term effects of leucine supplementation on body composition
    Michele Balage
    INRA, UMR 1019 Nutrition Humaine, Saint Genes Champanelle, France
    Curr Opin Clin Nutr Metab Care 13:265-70. 2010
    b>Leucine does not only serve as a substrate for protein synthesis but is also recognized as a potent signal nutrient that regulates protein metabolism...
  88. pmc The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter]
    S Wyss
    Institute of Microbiology, University of Lausanne, CH 1011 Lausanne, Switzerland
    J Virol 75:2982-92. 2001
    ..Mutational analysis revealed that the C-terminal leucine-based motif in Env was crucial for the recruitment of AP-1 in vitro and in Env-expressing cells...
  89. pmc DGA1 (diacylglycerol acyltransferase gene) overexpression and leucine biosynthesis significantly increase lipid accumulation in the Deltasnf2 disruptant of Saccharomyces cerevisiae
    Yasushi Kamisaka
    Lipid Engineering Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki 305 8566, Japan
    Biochem J 408:61-8. 2007
    ..beta-isopropylmalate dehydrogenase), which was used to select transformed strains by complementation of the leucine axotroph, unexpectedly increased both growth and lipid accumulation, especially in the Deltasnf2 disruptant...
  90. doi Whey and casein labeled with L-[1-13C]leucine and muscle protein synthesis: effect of resistance exercise and protein ingestion
    Søren Reitelseder
    Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, University of Copenhagen, Copenhagen NV, Denmark
    Am J Physiol Endocrinol Metab 300:E231-42. 2011
    ..Infusion of l-[1-(13)C]leucine was carried out, and either whey, casein (0...
  91. pmc Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside prevents leucine-stimulated protein synthesis in rat skeletal muscle
    Anne M Pruznak
    Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, PA 17033, USA
    J Nutr 138:1887-94. 2008
    ..conditions are characterized by activation of 5'-AMP-activated protein kinase (AMPK) and the development of leucine resistance in skeletal muscle...
  92. ncbi A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains
    F Letourneur
    Cell Biology and Metabolism Branch, National Institute of Child Health, Human Development, National Institutes of Health, Bethesda, Maryland 20892
    Cell 69:1143-57. 1992
    ..Truncation of these retention motifs revealed lysosomal targeting of both Tac-gamma and delta chimeras. A di-leucine- and a tyrosine-based motif are individually sufficient to induce both endocytosis and delivery to lysosomes of ..
  93. ncbi Constitutive display of cryptic translation products by MHC class I molecules
    Susan R Schwab
    Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Science 301:1367-71. 2003
    ..Furthermore, translation of this cryptic peptide occurs by a previously unknown mechanism that decodes the CUG initiation codon as leucine rather than the canonical methionine.
  94. pmc Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain
    A Begitt
    Nachwuchsgruppe Zelluläre Signalverarbeitung, Forschungsinstitut fur Molekulare Pharmakologie, and Freie Universität, Institut fur Kristallographie, D 10315 Berlin, Germany
    Proc Natl Acad Sci U S A 97:10418-23. 2000
    ..We identify a conserved leucine-rich helical segment in the coiled-coil domain of Stat1, which is responsible for the efficient nuclear export of ..
  95. pmc Essential amino acid and carbohydrate ingestion before resistance exercise does not enhance postexercise muscle protein synthesis
    Satoshi Fujita
    Univ of Texas Medical Branch, Dept of Physical Therapy, Div of Rehabilitation Sciences, Sealy Center on Aging, 301 Univ Blvd, Galveston, TX 77555 1144, USA
    J Appl Physiol (1985) 106:1730-9. 2009
    ..05). We conclude that EAA + CHO ingestion before resistance exercise does not enhance postexercise FSR compared with exercise without nutrients...
  96. doi Systemic activation of the transient receptor potential vanilloid subtype 4 channel causes endothelial failure and circulatory collapse: Part 2
    Robert N Willette
    Investigative and Cardiac Biology, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, UW2510, King of Prussia, PA 19406, USA
    J Pharmacol Exp Ther 326:443-52. 2008
    ..It will be important to determine the role of TRPV4 in disorders associated with edema and microvascular congestion...
  97. ncbi The small leucine-rich proteoglycan biglycan modulates BMP-4-induced osteoblast differentiation
    Xiao Dong Chen
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 18:948-58. 2004
    Biglycan (bgn) is a small leucine-rich proteoglycan enriched in extracellular matrices of skeletal tissues. Bgn-deficient mice develop age-related osteopenia with a phenotype that resembles osteoporosis and premature arthritis...
  98. doi Body weight and energy homeostasis was not affected in C57BL/6 mice fed high whey protein or leucine-supplemented low-fat diets
    Anne Noatsch
    German Institute of Human Nutrition in Potsdam Rehbruecke DIfE, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Eur J Nutr 50:479-88. 2011
    b>Leucine is suggested to act as nutrient signal of high-protein diets regulating pathways associated with an alleviation of metabolic syndrome parameters. However, the subject remains controversial.
  99. doi A leucine-rich repeat assembly approach for homology modeling of the human TLR5-10 and mouse TLR11-13 ectodomains
    Tiandi Wei
    Center for Nanoscience, Ludwig Maximilians Universitat Munchen, 80799 Munich, Germany
    J Mol Model 17:27-36. 2011
    ..The TLR ectodomains are composed of varying numbers and types of leucine-rich repeats (LRRs)...
  100. pmc Inhibition of beta(2) integrin-mediated leukocyte cell adhesion by leucine-leucine-glycine motif-containing peptides
    E Koivunen
    Department of Biosciences, Division of Biochemistry, University of Helsinki, Viikinkaari 5, FIN-00014 Helsinki, Finland
    J Cell Biol 153:905-16. 2001
    ..to the extracellular matrix by recognizing short tripeptide sequences such as arginine-glycine-aspartic acid and leucine-aspartate-valine...
  101. ncbi Substitution of leucine 8 in the simian immunodeficiency virus matrix protein impairs particle formation without affecting N-myristylation of the Gag precursor
    S A Gonzalez
    Centro de Virologia Animal CEVAN CONICET, Buenos Aires, Argentina
    Virology 240:27-35. 1998
    ..the assembly phenotype of an SIV Gag mutant (L8Q) carrying the single amino acid substitution of glutamine for leucine at position 8 in the MA domain...

Research Grants92

  1. SMOOTH MUSCLE MYOSIN PHOSPHATASE SUBUNIT ISOFORMS
    Steven A Fisher; Fiscal Year: 2010
    ..E23 skipping codes for a MYPT1 C-terminus leucine zipper (LZ) motif required for cGMP-dependent protein kinase (cGK1) dimerization and activation of MP, resulting ..
  2. SMOOTH MUSCLE MYOSIN PHOSPHATASE SUBUNIT ISOFORMS
    Steven Fisher; Fiscal Year: 2007
    ..We and others have proposed a model in which leucine zipper (LZ) mediated hetero-dimerization of the cGMP-dependent protein kinase (PKG1) and the MP targeting subunit ..
  3. Nutrition and Anabolic Interventions in Cancer Cachexia
    Melinda Sheffield Moore; Fiscal Year: 2010
    ..affected because catabolic factors diminish the plasma concentrations of key branched-chain amino acids such as leucine, thereby suppressing the stimulus for nutrition-derived anabolism...
  4. ENTERAL PRECURSORS FOR UREA SYNTHESIS IN HUMANS
    Brendan Lee; Fiscal Year: 2006
    ..We argue therefore that because of the importance of leucine to protein metabolic regulation, treatment with phenyl butyrate not only diverts N away from urea synthesis, but ..
  5. ENTERAL PRECURSORS FOR UREA SYNTHESIS IN HUMANS
    H Gaskins; Fiscal Year: 2002
    ..We argue therefore that because of the importance of leucine to protein metabolic regulation, treatment with phenyl butyrate not only diverts N away from urea synthesis, but ..
  6. PERIPLASMIC RECEPTORS OF ACTIVE TRANSPORT AND CHEMOTAXIS
    Florante Quiocho; Fiscal Year: 1993
    ..three-dimensional structures of six binding proteins specific for L-arabinose, D-galactose, D-maltose, sulfate, leucine/isoleucine/valine and leucine has recently been achieved...
  7. DNA METHYLATION AND PILI GENE REGULATION
    David Low; Fiscal Year: 2006
    The goal of this proposal is to understand the mechanisms by which DNA adenine methylase (DAM), leucine-responsive regulatory protein (Lrp), and PapI orchestrate the reversible switch between OFF and ON Pap pili expression states in ..
  8. 18F-FACBC PET-CT for the Detection and Staging of Recurrent Prostate Carcinoma
    David Schuster; Fiscal Year: 2007
    ..The long term goal of this research is to determine if PET imaging with the synthetic L-leucine analog positron emission tomography (PET) radiotracer antf-[18F]FACBC will lead to improved patient care in the ..
  9. NLR Family Proteins: Mechanisms and Regulation
    John C Reed; Fiscal Year: 2010
    ..During the previous funding period, we reported that the leucine-rich repeats (LRRs) of NLRP1 are required for responses to microbial ligands derived from peptidoglycan, ..
  10. NLR Family Proteins: Mechanisms and Regulation
    John Reed; Fiscal Year: 2009
    ..During the previous funding period, we reported that the leucine-rich repeats (LRRs) of NLRP1 are required for responses to microbial ligands derived from peptidoglycan, ..
  11. Neural Progenitor Genes and Brain Tumors
    Harley Kornblum; Fiscal Year: 2009
    ..We have previously found that maternal embryonic leucine zipper kinase (MELK), a serine-threonine kinase, is a marker for and regulates the proliferation of self- ..
  12. Neural Progenitor Genes and Brain Tumors
    Harley Kornblum; Fiscal Year: 2007
    ..We have previously found that maternal embryonic leucine zipper kinase (MELK), a serine-threonine kinase, is a marker for and regulates the proliferation of self- ..
  13. Mechanism of Apoptosis and Inhibition of Tumor Progression and Metastasis by Par-
    Vivek Rangnekar; Fiscal Year: 2009
    Prostate apoptosis response-4 protein (Par-4; also known as PAWR) is a leucine zipper domain protein that is conserved in vertebrates...
  14. Mechanism of Apoptosis and Inhibition of Tumor Progression and Metastasis by Par-
    Vivek Rangnekar; Fiscal Year: 2009
    Prostate apoptosis response-4 protein (Par-4; also known as PAWR) is a leucine zipper domain protein that is conserved in vertebrates...
  15. Mechanism of Apoptosis and Inhibition of Tumor Progression and Metastasis by Par-
    Vivek M Rangnekar; Fiscal Year: 2010
    Prostate apoptosis response-4 protein (Par-4;also known as PAWR) is a leucine zipper domain protein that is conserved in vertebrates...
  16. Ion channel regulation by macromolecular complexes
    Steven Marx; Fiscal Year: 2004
    ..targeting of these signaling molecules is through the specific binding of adaptor proteins to the channel via leucine/isoleucine zipper domains...
  17. CRCNS: Computational and experimental study of dopamine and serotonin transporter
    Jeffry D Madura; Fiscal Year: 2010
    ..and inhibitor binding sites received an unexpected boost with the crystallization of the homologous LeuTAa leucine transporter...
  18. GENETICS OF DISEASE RESISTANCE IN ARABIDOPSIS THALIANA
    Roger W Innes; Fiscal Year: 2010
    ..These intracellular receptors share a common structure consisting of a nucleotide binding (NB) domain and leucine rich repeats (LRR)...
  19. GENETICS OF DISEASE RESISTANCE IN ARABIDOPSIS THALIANA
    Roger W Innes; Fiscal Year: 2010
    ..These intracellular receptors share a common structure consisting of a nucleotide binding (NB) domain and leucine rich repeats (LRR)...
  20. Poly (amino acid) as an Integrin Targeted Drug Carrier
    Xiaoling Li; Fiscal Year: 2005
    ..It is reported that the recognition of the tripeptide sequence, leucine-aspartic acid-valine, (LDV) is limited only to the a4a1 integrin...
  21. Immune Recovery Following LLME Treated Cell Therapy
    Joanne Filicko; Fiscal Year: 2006
    ..GVHD appears to be mediated by T cells bearing cytotoxic effector granules. L-Leucyl-L-Leucine Methyl Ester (LLME) is polymerized by one of the enzymes within cytotoxic granules, resulting in the destruction ..
  22. SMOOTH MUSCLE MYOSIN PHOSPHATASE SUBUNIT ISOFORMS
    Steven Fisher; Fiscal Year: 2004
    ..smooth muscle enhance SMMP activity via the dimerization of the cGMP-dependent protein kinase with the C-terminal leucine zipper of MYPT1...
  23. FETAL BRANCHED CHAIN AMINO ACID AND KETO-ACID METABOLISM
    EDWARD LIECHTY; Fiscal Year: 1991
    ..Specifically, leucine will be studied, because fasting, as well as insulin and glucose concentrations are known to influence its ..
  24. Biological role of modifications to C/EBPbeta-1 and -2
    Linda Sealy; Fiscal Year: 2007
    The basic leucine zipper transcription factor, C/EBPbeta, is critical for growth and differentiation of the mammary gland...
  25. DEVELOP AND EVALUATE NEW LEPROSY AND TB VACCINES
    Thomas Gillis; Fiscal Year: 2003
    ..The TB vaccines are: 1) leucine auxotroph of BCG, 2) leucine auxotroph of MT, 3) MT culture filtrate in adjuvant prepared from the nontoxic ..
  26. CRCNS: Computational and experimental study of dopamine and serotonin transporter
    JEFFRY MADURA; Fiscal Year: 2009
    ..and inhibitor binding sites received an unexpected boost with the crystallization of the homologous LeuTAa leucine transporter...
  27. Transcriptional Repression of PPARgamma-2 by Glucocorticoid-Induced Leucine Zippe
    Xing Ming Shi; Fiscal Year: 2010
    ..of this research is to address the question of how PPAR(2 expression can be repressed by glucocorticoid-induced leucine zipper (GILZ), a recently identified leucine zipper protein...
  28. Transcriptional Repression of PPARgamma-2 by Glucocorticoid-Induced Leucine Zippe
    Xingming Shi; Fiscal Year: 2009
    ..of this research is to address the question of how PPAR(2 expression can be repressed by glucocorticoid-induced leucine zipper (GILZ), a recently identified leucine zipper protein...