glutamic acid

Summary

Summary: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.

Top Publications

  1. ncbi Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways
    R D Almeida
    Center for Neuroscience and Cell Biology and Department of Zoology, University of Coimbra, 3004 517 Coimbra, Portugal
    Cell Death Differ 12:1329-43. 2005
  2. ncbi Structural basis of long-term potentiation in single dendritic spines
    Masanori Matsuzaki
    Department of Cell Physiology, National Institute for Physiological Sciences and The Graduate University of Advanced Studies Sokendai, Myodaiji, Okazaki 444 8787, Japan
    Nature 429:761-6. 2004
  3. ncbi The molecular logic of endocannabinoid signalling
    Daniele Piomelli
    Department of Pharmacology, University of California, Irvine 92697 4625, USA
    Nat Rev Neurosci 4:873-84. 2003
  4. ncbi Glutamate exocytosis from astrocytes controls synaptic strength
    Pascal Jourdain
    Department of Cell Biology and Morphology, University of Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland
    Nat Neurosci 10:331-9. 2007
  5. doi Glutamate receptors, neurotoxicity and neurodegeneration
    Anthony Lau
    Division of Applied and Interventional Research, Toronto Western Research Institute, 399 Bathurst Street, Toronto, ON, Canada, M5T 2S8
    Pflugers Arch 460:525-42. 2010
  6. ncbi Properties of synaptically evoked astrocyte calcium signal reveal synaptic information processing by astrocytes
    Gertrudis Perea
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    J Neurosci 25:2192-203. 2005
  7. ncbi The tripartite synapse: roles for gliotransmission in health and disease
    Michael M Halassa
    Silvio Conte Center for Integration at the Tripartite Synapse, Department of Neuroscience, University of Pennsylvania, School of Medicine Philadelphia, PA 19104, USA
    Trends Mol Med 13:54-63. 2007
  8. ncbi Astrocytes and brain injury
    Yongmei Chen
    Department of Neurology, University of California at San Francisco, California 94121, USA
    J Cereb Blood Flow Metab 23:137-49. 2003
  9. ncbi Astrocytes potentiate transmitter release at single hippocampal synapses
    Gertrudis Perea
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Science 317:1083-6. 2007
  10. ncbi Subunit arrangement and function in NMDA receptors
    Hiroyasu Furukawa
    Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, New York 10032, USA
    Nature 438:185-92. 2005

Research Grants

Detail Information

Publications320 found, 100 shown here

  1. ncbi Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways
    R D Almeida
    Center for Neuroscience and Cell Biology and Department of Zoology, University of Coimbra, 3004 517 Coimbra, Portugal
    Cell Death Differ 12:1329-43. 2005
    ..The results indicate that the protective effect of BDNF in hippocampal neurons against glutamate toxicity is mediated by the PI3-K and the Ras/MAPK signaling pathways, and involves a long-term change in protein synthesis...
  2. ncbi Structural basis of long-term potentiation in single dendritic spines
    Masanori Matsuzaki
    Department of Cell Physiology, National Institute for Physiological Sciences and The Graduate University of Advanced Studies Sokendai, Myodaiji, Okazaki 444 8787, Japan
    Nature 429:761-6. 2004
    ..They further suggest that small spines are preferential sites for long-term potentiation induction, whereas large spines might represent physical traces of long-term memory...
  3. ncbi The molecular logic of endocannabinoid signalling
    Daniele Piomelli
    Department of Pharmacology, University of California, Irvine 92697 4625, USA
    Nat Rev Neurosci 4:873-84. 2003
  4. ncbi Glutamate exocytosis from astrocytes controls synaptic strength
    Pascal Jourdain
    Department of Cell Biology and Morphology, University of Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland
    Nat Neurosci 10:331-9. 2007
    ..Thus, we provide the first combined functional and ultrastructural evidence for a physiological control of synaptic activity via exocytosis of glutamate from astrocytes...
  5. doi Glutamate receptors, neurotoxicity and neurodegeneration
    Anthony Lau
    Division of Applied and Interventional Research, Toronto Western Research Institute, 399 Bathurst Street, Toronto, ON, Canada, M5T 2S8
    Pflugers Arch 460:525-42. 2010
    ....
  6. ncbi Properties of synaptically evoked astrocyte calcium signal reveal synaptic information processing by astrocytes
    Gertrudis Perea
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    J Neurosci 25:2192-203. 2005
    ..Therefore, because astrocytes discriminate and integrate synaptic information, we propose that they can be considered as cellular elements involved in the information processing by the nervous system...
  7. ncbi The tripartite synapse: roles for gliotransmission in health and disease
    Michael M Halassa
    Silvio Conte Center for Integration at the Tripartite Synapse, Department of Neuroscience, University of Pennsylvania, School of Medicine Philadelphia, PA 19104, USA
    Trends Mol Med 13:54-63. 2007
    ..The results of future experimental tests of the astrocyte activation spectrum, which relates gliotransmission to neurological and psychiatric disorders, might point to a new therapeutic target in the brain...
  8. ncbi Astrocytes and brain injury
    Yongmei Chen
    Department of Neurology, University of California at San Francisco, California 94121, USA
    J Cereb Blood Flow Metab 23:137-49. 2003
    ..In addition, the death or survival of astrocytes themselves may affect the ultimate clinical outcome and rehabilitation through effects on neurogenesis and synaptic reorganization...
  9. ncbi Astrocytes potentiate transmitter release at single hippocampal synapses
    Gertrudis Perea
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Science 317:1083-6. 2007
    ..This persistent plasticity was mGluR-mediated but N-methyl-d-aspartate receptor-independent. These results indicate that astrocytes are actively involved in the transfer and storage of synaptic information...
  10. ncbi Subunit arrangement and function in NMDA receptors
    Hiroyasu Furukawa
    Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, New York 10032, USA
    Nature 438:185-92. 2005
    ....
  11. ncbi Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors
    Tommaso Fellin
    Istituto CNR di Neuroscienze, Universita di Padova, Viale G Colombo 3, 35121, Italy
    Neuron 43:729-43. 2004
    ..Our results reveal a distinct mechanism for neuronal excitation and synchrony and highlight a functional link between astrocytic glutamate and extrasynaptic NMDA receptors...
  12. ncbi Glutamate uptake
    N C Danbolt
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1105, Blindern, N-0317, Oslo, Norway
    Prog Neurobiol 65:1-105. 2001
    ..g. osteoporosis) can be properly understood unless more is learned about these transporter proteins. Like glutamate itself, glutamate transporters are somehow involved in almost all aspects of normal and abnormal brain activity...
  13. doi Tuned responses of astrocytes and their influence on hemodynamic signals in the visual cortex
    James Schummers
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 320:1638-43. 2008
    ..Furthermore, blocking astrocyte glutamate transporters influenced the magnitude and duration of adjacent visually driven neuronal responses...
  14. doi Do astrocytes really exocytose neurotransmitters?
    Nicola B Hamilton
    Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK
    Nat Rev Neurosci 11:227-38. 2010
    ..However, there is intense controversy about whether astrocytes can exocytose transmitters in vivo. Resolving this issue would considerably advance our understanding of brain function...
  15. doi Endocannabinoids mediate neuron-astrocyte communication
    Marta Navarrete
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    Neuron 57:883-93. 2008
    ..They also reveal the existence of an endocannabinoid-glutamate signaling pathway where astrocytes serve as a bridge for nonsynaptic interneuronal communication...
  16. pmc NMDA receptors are expressed in oligodendrocytes and activated in ischaemia
    Ragnhildur Karadottir
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Nature 438:1162-6. 2005
    ..These results point to NMDA receptors of unusual subunit composition as a potential therapeutic target for preventing white matter damage in a variety of diseases...
  17. ncbi Distribution of glutamate transporters in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy
    E A Proper
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht, The Netherlands
    Brain 125:32-43. 2002
    ..The functional consequences (glutamate transport capacity) of the reported changes in EAAT2 and EAAT3 remain to be determined...
  18. ncbi Structure of a glutamate transporter homologue from Pyrococcus horikoshii
    Dinesh Yernool
    Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, New York 10032, USA
    Nature 431:811-8. 2004
    ..We propose that transport of glutamate is achieved by movements of the hairpins that allow alternating access to either side of the membrane...
  19. pmc Role of excitatory amino acid transporter-2 (EAAT2) and glutamate in neurodegeneration: opportunities for developing novel therapeutics
    Keetae Kim
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298, USA
    J Cell Physiol 226:2484-93. 2011
    ....
  20. pmc From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatment
    Bita Moghaddam
    Department of Neuroscience and Psychiatry, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuropsychopharmacology 37:4-15. 2012
    ..To date, most studies have been done with orthosteric agonists and/or antagonists at specific sites. However, allosteric modulators, both positive and negative, may offer superior efficacy with less danger of downregulation...
  21. doi EAAT expression by macrophages and microglia: still more questions than answers
    Gabriel Gras
    Division of Immuno Virology, Institute of Emerging Diseases and Innovative Therapies, UMR E1 CEA DSV IMETI SIV and University Paris South Paris 11, 18, Route du Panorama, 92265, Fontenay aux Roses, France
    Amino Acids 42:221-9. 2012
    ....
  22. ncbi NMDA spikes in basal dendrites of cortical pyramidal neurons
    J Schiller
    Department of Physiology and Biophysics, Technion Medical School, Bat Galim, Haifa, Israel
    Nature 404:285-9. 2000
    ..In addition, NMDA spikes may serve as a powerful mechanism for modification of the cortical network by inducing long-term strengthening of co-activated neighbouring inputs...
  23. ncbi Glutamate transporters: confining runaway excitation by shaping synaptic transmission
    Anastassios V Tzingounis
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94107, USA
    Nat Rev Neurosci 8:935-47. 2007
    ..We highlight how the diversity of glutamate-transporter function relates to transporter location, density and affinity...
  24. ncbi Interaction of A2A adenosine and D2 dopamine receptors modulates corticostriatal glutamatergic transmission
    Alessandro Tozzi
    Clinica Neurologia, Universita di Perugia, Ospedale S Maria della Misericordia, 06156 Perugia, Italy
    Neuropharmacology 53:783-9. 2007
    ..These results suggest that A2A and D2 receptors converge in the control of corticostriatal glutamatergic transmission by exerting an opposite function...
  25. ncbi Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Penn State Retina Research Group
    E Lieth
    Department of Neuroscience and Anatomy, Pennsylvania State University College of Medicine, Hershey Medical Center, 17033, USA
    Diabetes 47:815-20. 1998
    ..These findings suggest a novel understanding of the mechanism of neural degeneration in the retina during diabetes, involving early and possibly persistent glutamate excitotoxicity...
  26. ncbi Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity
    Mark Arundine
    Toronto Western Hospital Research Institute, 399 Bathurst Street, Ont M5T 2S8, Toronto, Canada
    Cell Calcium 34:325-37. 2003
    ..Thus, we summarize the importance of Ca(2+) regulation in mammalian neurons and the excitotoxicity hypothesis, and focus on the molecular determinants of glutamate receptor-mediated excitotoxic mechanisms...
  27. ncbi Functional hemichannels in astrocytes: a novel mechanism of glutamate release
    Zu Cheng Ye
    Department of Neurology, University of Washington School of Medicine, Seattle, Washington 98195 6465, USA
    J Neurosci 23:3588-96. 2003
    ..Our results indicated that astrocyte hemichannels could influence CNS levels of extracellular glutamate with implications for normal and pathological brain function...
  28. ncbi The expression of vesicular glutamate transporters defines two classes of excitatory synapse
    R T Fremeau
    Department of Neurology, Graduate Program in Neuroscience, UCSF School of Medicine, San Francisco, CA 94143, USA
    Neuron 31:247-60. 2001
    ..Like VGLUT1, this protein localizes to synaptic vesicles and functions as a vesicular glutamate transporter (VGLUT2). The complementary expression of VGLUT1 and 2 defines two distinct classes of excitatory synapse...
  29. ncbi Fusion-related release of glutamate from astrocytes
    Qi Zhang
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Biol Chem 279:12724-33. 2004
    ....
  30. ncbi Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas
    Huibert D Mansvelder
    Department of Anesthesia, University of Chicago, Chicago, IL 60637, USA
    Neuron 33:905-19. 2002
    ..These results suggest that spatial and temporal differences in nicotinic receptor activity on both excitatory and inhibitory neurons in reward areas coordinate to reinforce nicotine self-administration...
  31. ncbi Glutamate release promotes growth of malignant gliomas
    T Takano
    Department of Cell Biology, Anatomy and Pathology, New York Medical College, Valhalla, New York, USA
    Nat Med 7:1010-5. 2001
    ..These findings support a new approach for therapy of brain tumors, based upon antagonizing glutamate secretion or its target receptors...
  32. pmc The optimal height of the synaptic cleft
    Leonid P Savtchenko
    Institute of Neurology, University College London, Queen Square, London, United Kingdom
    Proc Natl Acad Sci U S A 104:1823-8. 2007
    ..Therefore, our results suggest that a simple fundamental principle may underlie the synaptic cleft architecture: to maximize synaptic strength...
  33. ncbi Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?
    Chrysanthy Ikonomidou
    Department of Pediatric Neurology, Children s Hospital, Charité Virchow Campus, Humboldt University, Berlin, Germany
    Lancet Neurol 1:383-6. 2002
    ..We propose that NMDA receptor antagonists failed stroke and traumatic brain injury trials in human beings because blockade of synaptic transmission mediated by NMDA receptors hinders neuronal survival...
  34. ncbi Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
    G E Hardingham
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Neurosci 5:405-14. 2002
    ..Specific blockade of extrasynaptic NMDA receptors may effectively prevent neuron loss following stroke and other neuropathological conditions associated with glutamate toxicity...
  35. ncbi Heteromeric NMDA receptors: molecular and functional distinction of subtypes
    H Monyer
    Center for Molecular Biology, University of Heidelberg, Germany
    Science 256:1217-21. 1992
    ..Such heteromeric NMDA receptor subtypes may exist in neurons, since NR1 messenger RNA is synthesized throughout the mature rat brain, while NR2 messenger RNA show a differential distribution...
  36. ncbi Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice
    K Watase
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, Kodaira, Tokyo, Japan
    Eur J Neurosci 10:976-88. 1998
    ..These results indicate that GLAST plays active roles both in the cerebellar climbing fibre synapse formation and in preventing excitotoxic cerebellar damage after acute brain injury...
  37. ncbi Astrocytic control of glutamatergic activity: astrocytes as stars of the show
    Leif Hertz
    College of Basic Medical Sciences, China Medical University, Shenyang, P R China
    Trends Neurosci 27:735-43. 2004
    ....
  38. pmc Autocrine glutamate signaling promotes glioma cell invasion
    Susan A Lyons
    Department of Neurobiology, Center for Glial Biology in Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Cancer Res 67:9463-71. 2007
    ..These data suggest that glioma invasion is effectively disrupted by inhibiting an autocrine glutamate signaling loop with a clinically approved candidate drug, sulfasalazine, already in hand...
  39. doi Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors
    Jochen Schwenk
    Institute of Physiology II, University of Freiburg, Engesserstrasse 4, 79108 Freiburg, Germany
    Science 323:1313-9. 2009
    ..These results demonstrate that cornichons are intrinsic auxiliary subunits of native AMPARs and provide previously unknown molecular determinants for glutamatergic neurotransmission in the central nervous system...
  40. pmc Mechanism of the distance-dependent scaling of Schaffer collateral synapses in rat CA1 pyramidal neurons
    Mark A Smith
    Neuroscience Center, LSUHSC, 2020 Gravier Street, New Orleans, LA 70112, USA
    J Physiol 548:245-58. 2003
    ..We conclude, therefore, that the main synaptic mechanism involved in the production of distance-dependent scaling of Schaffer collateral synapses is an elevated postsynaptic AMPA receptor density...
  41. pmc The endocannabinoid system controls key epileptogenic circuits in the hippocampus
    Krisztina Monory
    Department of Physiological Chemistry, Johannes Gutenberg University, Duesbergweg 6, 55099 Mainz, Germany
    Neuron 51:455-66. 2006
    ..The direct endocannabinoid-mediated control of hippocampal glutamatergic neurotransmission may constitute a promising therapeutic target for the treatment of disorders associated with excessive excitatory neuronal activity...
  42. pmc In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate-glutamine cycling
    N R Sibson
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520 8043, USA
    Proc Natl Acad Sci U S A 94:2699-704. 1997
    ....
  43. pmc What is the role of astrocyte calcium in neurophysiology?
    Cendra Agulhon
    Department of Pharmacology, 1004 Mary Ellen Jones Building CB 7365, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7365, USA
    Neuron 59:932-46. 2008
    ....
  44. ncbi Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1
    K Tanaka
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, Kodaira, Tokyo 187, Japan
    Science 276:1699-702. 1997
    ..These effects can be attributed to elevated levels of residual glutamate in the brains of these mice...
  45. doi Morphological evidence for vesicular glutamate release from astrocytes
    L H Bergersen
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, POB 1105 Blindern, 0317 Oslo, Norway
    Neuroscience 158:260-5. 2009
    ..We describe the presence of small synaptic-like microvesicles, SNARE proteins and vesicular glutamate transporters in astrocytes, as well as NMDA receptors situated in vicinity of the astrocytic vesicles...
  46. doi Macrophage-induced neurotoxicity is mediated by glutamate and attenuated by glutaminase inhibitors and gap junction inhibitors
    Izumi Yawata
    Department of Neuroimmunology, Institute of Environmental Medicine, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    Life Sci 82:1111-6. 2008
    ..Thus, these drugs may be effective therapeutic reagents for inflammatory, demyelinating, and ischemic brain diseases...
  47. pmc A specific role for Ca2+-dependent adenylyl cyclases in recovery from adaptive presynaptic silencing
    Krista L Moulder
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 28:5159-68. 2008
    ....
  48. ncbi Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system
    D D Schoepp
    Neuroscience Research Division, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Pharmacol Exp Ther 299:12-20. 2001
    ..Recent progress on the molecular and pharmacological aspects of these presynaptic mGlu receptors is unveiling their functions and the therapeutic directions of agents designed for these novel glutamate receptor targets...
  49. ncbi Expression of the vesicular glutamate transporters during development indicates the widespread corelease of multiple neurotransmitters
    Jean Luc Boulland
    Institute of Basic Medical Sciences and the Centre for Molecular Biology and Neuroscience, University of Oslo, N 0317 Oslo, Norway
    J Comp Neurol 480:264-80. 2004
    ..In skeletal muscle, VGLUT3 localizes to granular organelles in the axon terminal as well as in the muscle sarcoplasm. The results suggest novel mechanisms and roles for regulated transmitter release...
  50. ncbi Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals
    Nigel S Bamford
    Department of Neurology, University of Washington, Children s Hospital and Regional Medical Center, Seattle, WA 98105 USA
    Neuron 42:653-63. 2004
    ..Thus, dopamine, by filtering less active inputs, appears to reinforce specific sets of corticostriatal synaptic connections...
  51. ncbi Compromised glutamate transport in human glioma cells: reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange
    Z C Ye
    Department of Neurobiology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 19:10767-77. 1999
    ..The resulting glutamate release from glioma cells may contribute to tumor-associated necrosis and possibly to seizures in peritumoral brain tissue...
  52. ncbi Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites
    Robert T Fremeau
    Department of Neurology, Graduate Programs in Neuroscience and Cell Biology, University of California San Francisco School of Medicine, CA 94143, USA
    Science 304:1815-9. 2004
    ..The loss of VGLUT1 also reduced the reserve pool of synaptic vesicles. Thus, VGLUT1 plays an unanticipated role in membrane trafficking at the nerve terminal...
  53. ncbi Changes in synaptic structure underlie the developmental speeding of AMPA receptor-mediated EPSCs
    Laurence Cathala
    1 Department of Pharmacology, University College London, UK
    Nat Neurosci 8:1310-8. 2005
    ..Our findings raise the possibility that structural alterations could be a general mechanism underlying the change in the time course of AMPAR-mediated synaptic transmission...
  54. doi Metabolite concentrations in supraventricular white matter from teenage to early old age: A short echo time 1H magnetic resonance spectroscopy (MRS) study
    Raili Raininko
    Departments of Radiology, Uppsala University, Uppsala, Sweden
    Acta Radiol 51:309-15. 2010
    ..A long repetition time and short echo time technique reduces quantification errors due to T(1) and T(2) relaxation effects and makes it possible to measure metabolites with short T(2) relaxation times...
  55. pmc 1H-MRS at 4 tesla in minimally treated early schizophrenia
    J R Bustillo
    Department of Psychiatry, University of New Mexico, Albuquerque, NM 87131 0001, USA
    Mol Psychiatry 15:629-36. 2010
    ..We conclude that early in the illness, schizophrenia patients already show abnormalities in glutamatergic metabolism and reductions in NAA consistent with glutamate-related excitotoxicity...
  56. ncbi Synaptically released acetylcholine evokes Ca2+ elevations in astrocytes in hippocampal slices
    Alfonso Araque
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    J Neurosci 22:2443-50. 2002
    ..Therefore, our results show the existence of cholinergic neuron-astrocyte signaling and suggest that astrocytes are a target of axonal inputs from different brain areas...
  57. doi Impaired mitochondrial bioenergetics determines glutamate-induced delayed calcium deregulation in neurons
    Andrey Y Abramov
    Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3 BG, UK
    Biochim Biophys Acta 1800:297-304. 2010
    ..Exposure of neurons to toxic glutamate concentrations causes an initial transient increase in [Ca(2+)](c) followed by a delayed increase commonly termed delayed [Ca(2+)](c) deregulation (DCD)...
  58. doi Abnormal cingulate and prefrontal cortical neurochemistry in major depression after electroconvulsive therapy
    Angela Merkl
    Department of Psychiatry Charité Universitätsmedizin, Campus Benjamin Franklin, Berlin, Germany
    Biol Psychiatry 69:772-9. 2011
    ....
  59. pmc Local modulation of striatal glutamate efflux by serotonin 1A receptor stimulation in dyskinetic, hemiparkinsonian rats
    Kristin B Dupre
    Behavioral Neuroscience Program, Department of Psychology, Binghamton University State University of New York at Binghamton, Binghamton, NY 13902 6000, USA
    Exp Neurol 229:288-99. 2011
    ..These findings indicate a novel anti-dyskinetic mechanism of action for 5-HT(1A)R agonists with implications for the improved treatment of Parkinson's disease...
  60. doi Glutamate promotes cell growth by EGFR signaling on U-87MG human glioblastoma cell line
    Daniel Pretto Schunemann
    Laboratório de Marcadores de Estresse Celular, Centro de Pesquisas em Ciências Médicas, Universidade Luterana do Brasil, Canoas, RS, Brazil
    Pathol Oncol Res 16:285-93. 2010
    ..Together, our data suggest that glutamate signaling mediated by AMPA receptor induces U-87MG human GBM cell line proliferation via EGFR-phospho-Akt pathway...
  61. pmc Normal glutamate but elevated myo-inositol in anterior cingulate cortex in recovered depressed patients
    Matthew J Taylor
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    J Affect Disord 119:186-9. 2009
    ..Frontal Glx levels appear to be normalised after recovery from depression, but it is not known if this composite measure masks ongoing differences in glutamate or glutamine alone...
  62. doi Glial glutamate transport modulates dendritic spine head protrusions in the hippocampus
    David Verbich
    Department of Neurology and Neurosurgery, McGill University, Montreal, QC H3G 0B1, Canada
    Glia 60:1067-77. 2012
    ..Hence, the dynamic changes of both spines and astrocytes can rapidly modify synaptic connectivity...
  63. doi Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity
    Andrey Y Abramov
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Biochim Biophys Acta 1777:953-64. 2008
    ..Thus, mitochondrial depolarisation represents two consecutive but distinct processes driving cell death, the first of which is reversible while the second is not...
  64. doi Cancer cells release glutamate via the cystine/glutamate antiporter
    Mohit K Sharma
    Department of Pathology and Molecular Medicine, McMaster University, Ont, Canada
    Biochem Biophys Res Commun 391:91-5. 2010
    ..Pharmacological interference with cancer cell glutamate release may be a viable option for limiting host bone response to invading tumor cells in bone metastasis...
  65. pmc Synapse geometry and receptor dynamics modulate synaptic strength
    Dominik Freche
    Department of Mathematics and Department of Neuroscience, Weizmann Institute of Science, Rehovot, Israel
    PLoS ONE 6:e25122. 2011
    ..We conclude that geometrical modifications, reorganization of the PSD or perisynaptic microdomains modulate synaptic strength, as the mechanisms underlying long-term plasticity...
  66. doi The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death
    Junko Sasaki
    Department of Medical Biology, Akita University Graduate School of Medicine, Akita 010 8543, Japan
    Nature 465:497-501. 2010
    ..The discovery of a direct link between PtdIns(3,4)P(2) metabolism and the regulation of neurodegeneration and involuntary movements may aid the development of new approaches for the treatment of neurodegenerative disorders...
  67. doi Astrocytes impose postburst depression of release probability at hippocampal glutamate synapses
    My Andersson
    Institute of Neuroscience and Physiology, Gothenburg University, 405 30 Goteborg, Sweden
    J Neurosci 30:5776-80. 2010
    ..Our results suggest that astrocytes are actively involved in short-term synaptic depression, shaping synaptic activity during behaviorally relevant neural activity...
  68. ncbi Neuritic beading induced by activated microglia is an early feature of neuronal dysfunction toward neuronal death by inhibition of mitochondrial respiration and axonal transport
    Hideyuki Takeuchi
    Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    J Biol Chem 280:10444-54. 2005
    ..Blockage of NMDA receptors may be an effective therapeutic approach for neurodegenerative diseases...
  69. doi Zinc at glutamatergic synapses
    P Paoletti
    Laboratoire de Neurobiologie, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Neuroscience 158:126-36. 2009
    ..Finally, we present and compare two widely used zinc chelators, CaEDTA and tricine, and show why tricine should be preferred to CaEDTA when studying fast transient zinc elevations as may occur during synaptic activity...
  70. pmc Adult generation of glutamatergic olfactory bulb interneurons
    Monika S Brill
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    Nat Neurosci 12:1524-33. 2009
    ..Taken together, our data indicate that SEZ progenitors not only produce a population of adult-born glutamatergic juxtaglomerular neurons, but may also provide a previously unknown source of progenitors for endogenous repair...
  71. ncbi Neurobiology of hypoxic-ischemic injury in the developing brain
    M V Johnston
    Division of Neurology and Developmental Medicine and Neuroscience Laboratory, Kennedy Krieger Institute and Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Pediatr Res 49:735-41. 2001
    ..The cascade of biochemical and histopathologic events triggered by hypoxic ischemia can extend for days to weeks after the insult is triggered, creating the potential for therapeutic interventions...
  72. pmc Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in mice
    Krisztina Monory
    Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Mainz, Germany
    PLoS Biol 5:e269. 2007
    ....
  73. ncbi Cytochrome c is released from mitochondria in a reactive oxygen species (ROS)-dependent fashion and can operate as a ROS scavenger and as a respiratory substrate in cerebellar neurons undergoing excitotoxic death
    A Atlante
    Centro di Studio sui Mitocondri e Metabolismo Energetico, Consiglio Nazionale delle Ricerche CNR, Via G Amendola, 165 A 70126 Bari, Istituto di Neurobiologia, CNR, Viale K Marx, 15 00137 Roma, Italy
    J Biol Chem 275:37159-66. 2000
    ..In the light of these findings, we propose that in the early phase of neurotoxicity, cytochrome c release can be part of a cellular and mitochondrial defense mechanism against oxidative stress...
  74. ncbi Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures
    J C Jen
    Department of Neurology, School of Medicine, University of California, Los Angeles, CA 90095, USA
    Neurology 65:529-34. 2005
    ..Mutant gene products of both CACNA1A and ATP1A2 may affect neurotransmission of glutamate, the most abundant excitatory amino acid neurotransmitter...
  75. ncbi NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development
    John H Krystal
    Schizophrenia Biological Research Center 116 A, VA Connecticut Healthcare System, 950 Campbell Ave, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 169:215-33. 2003
    ..The purpose of this review is to consider the possibility that agents that attenuate these two components of NMDA receptor antagonist response may play complementary roles in the treatment of schizophrenia...
  76. ncbi Increase in muscle nociceptive substances and anaerobic metabolism in patients with trapezius myalgia: microdialysis in rest and during exercise
    Lars Rosendal
    National Institute of Occupational Health, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    Pain 112:324-34. 2004
    ..In addition, TM was associated with increased anaerobic metabolism, whereas a normal rise in blood flow was seen with exercise. These findings indicate that peripheral nociceptive processes are active in work-related TM...
  77. ncbi Dopamine: a potential substrate for synaptic plasticity and memory mechanisms
    Therese M Jay
    Neurobiologie de l Apprentissage, de la Memoire et de la Communication, CNRS UMR 8620, Universite Paris Sud, Bat 446, 91405 Orsay, France
    Prog Neurobiol 69:375-90. 2003
    ....
  78. pmc The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate
    Robert T Fremeau
    Department of Neurology, University of California School of Medicine, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 99:14488-93. 2002
    ..The dendritic expression of VGLUT3 by particular neurons also indicates the potential for retrograde synaptic signaling. The distribution and subcellular location of VGLUT3 thus suggest novel modes of signaling by glutamate...
  79. ncbi The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration
    Eugene Park
    Division of Neurosurgery and Institute of Medical Science, University of Toronto, and Division of Cell and Molecular Biology, Toronto Western Research Institute, Toronto Western Hospital, University Health Network, Ontario, Canada
    J Neurotrauma 21:754-74. 2004
    ..The latter mechanism appears key to glutamatergic white matter degeneration after SCI and may represent an attractive therapeutic target...
  80. doi Glutamate induces directed chemotaxis of microglia
    Guo Jun Liu
    The Neurobiology Laboratory, Brain and Mind Research Institute, University of Sydney, NSW, Australia
    Eur J Neurosci 29:1108-18. 2009
    ..Thus glutamate, which is released at synapses as well as from damaged cells, can mediate rapid chemotaxic responses from microglial cells...
  81. pmc Immunocytochemical analysis of photoreceptors in the tiger salamander retina
    Jian Zhang
    Cullen Eye Institute, Baylor College of Medicine, One Baylor Plaza, NC 205, Houston, TX 77030, USA
    Vision Res 49:64-73. 2009
    ..The different photoreceptors selectively contacting bipolar and horizontal cells support the idea that visual signals may be conveyed to the inner retina by different functional pathways in the outer retina...
  82. pmc VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch
    Yang Liu
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Neuron 68:543-56. 2010
    ..Our studies suggest that synaptic glutamate release from a group of peripheral nociceptors is required to sense pain and suppress itch. Elimination of VGLUT2 in these nociceptors creates a mouse model of chronic neurogenic itch...
  83. ncbi SNAP-25 modulation of calcium dynamics underlies differences in GABAergic and glutamatergic responsiveness to depolarization
    Claudia Verderio
    Department of Medical Pharmacology, CNR Institute of Neuroscience, Center of Excellence for Neurodegenerative Diseases, University of Milano, Via Vanvitelli 32, Milano 20129, Italy
    Neuron 41:599-610. 2004
    ..SNAP-25 is therefore a multifunctional protein that participates in exocytotic function both at the mechanistic and at the regulatory level...
  84. pmc Cocaine and amphetamine-like psychostimulants: neurocircuitry and glutamate neuroplasticity
    Peter W Kalivas
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Dialogues Clin Neurosci 9:389-97. 2007
    ....
  85. pmc Metabolic control of vesicular glutamate transport and release
    Narinobu Juge
    Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Neuron 68:99-112. 2010
    ..The results indicate an unsuspected link between metabolic state and excitatory neurotransmission through anion-dependent regulation of VGLUT activity...
  86. ncbi Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter
    E E Bellocchio
    Department of Neurology, University of California at San Francisco School of Medicine, 513 Parnassus Avenue, San Francisco, CA 94143 0435, USA
    Science 289:957-60. 2000
    ..In addition, we show that this vesicular glutamate transporter, VGLUT1, exhibits a conductance for chloride that is blocked by glutamate...
  87. pmc Glutamatergic signaling by mesolimbic dopamine neurons in the nucleus accumbens
    Fatuel Tecuapetla
    Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey 07102, USA
    J Neurosci 30:7105-10. 2010
    ..These observations indicate that, in addition to DAergic mechanisms, mesolimbic reward signaling may involve glutamatergic transmission...
  88. pmc GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo
    Neng Wei Hu
    Department of Pharmacology and Therapeutics, Trinity College Institute of Neuroscience, Dublin 2, Ireland
    Proc Natl Acad Sci U S A 106:20504-9. 2009
    ..These findings suggest that preferentially targeting GluN2B subunit-containing NMDARs may provide an effective means of preventing cognitive deficits in early Alzheimer's disease...
  89. pmc Elevated insular glutamate in fibromyalgia is associated with experimental pain
    Richard E Harris
    University of Michigan, Chronic Pain and Fatigue Research Center, Ann Arbor, MI 48106, USA
    Arthritis Rheum 60:3146-52. 2009
    ....
  90. doi TNF-alpha-mediates neuroprotection against glutamate-induced excitotoxicity via NF-kappaB-dependent up-regulation of K2.2 channels
    Amalia M Dolga
    Department of Molecular Neurobiology, University of Groningen, Haren, The Netherlands
    J Neurochem 107:1158-67. 2008
    ..We conclude that treatment of primary cortical neurons with TNF-alpha leads to increased K(Ca)2.2 channel expression which renders neurons more resistant to excitotoxic cell death...
  91. ncbi Free glutamine and glutamic acid increase in human milk through a three-month lactation period
    C Agostoni
    Department of Pediatrics, San Paolo Hospital, Milan, Italy
    J Pediatr Gastroenterol Nutr 31:508-12. 2000
    Previous short observational studies on the free amino acid (FAA) content of human milk have shown that glutamine and glutamic acid increase in the first 4 to 6 weeks of life.
  92. pmc The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma
    Takayuki Harada
    Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Clin Invest 117:1763-70. 2007
    ..We believe these mice are the first animal models of NTG that offer a powerful system for investigating mechanisms of neurodegeneration in NTG and developing therapies directed at IOP-independent mechanisms of RGC loss...
  93. doi Association of an EAAT2 polymorphism with higher glutamate concentration in relapsing multiple sclerosis
    Olatz Pampliega
    Neurotek UPV EHU, Parque Tecnologico de Bizkaia, Zamudio Bizkaia, Spain
    J Neuroimmunol 195:194-8. 2008
    ..These findings suggest that glutamate homeostasis is compromised in MS and that carrying this mutation may contribute to this alteration in relapsing MS...
  94. pmc How do tonic glutamatergic synapses evade receptor desensitization?
    Ji Jie Pang
    Cullen Eye Institute, Baylor College of Medicine, One Baylor Plaza, NC 205, Houston, TX 77030, USA
    J Physiol 586:2889-902. 2008
    ..Our study illustrates for the first time how a tonic glutamatergic synapse avoids postsynaptic receptor desensitization, a strategy that may be shared by many other synapses in the nervous system that need extended operation capacity...
  95. pmc Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3
    Rebecca P Seal
    Department of Physiology, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 57:263-75. 2008
    ..The glutamate release conferred by expression of VGLUT3 thus has an essential role in both function and development of the auditory pathway, as well as in the control of cortical excitability...
  96. pmc In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death
    M A Martel
    Centre for Neuroscience Research, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, UK
    Neuroscience 158:334-43. 2009
    ..In this instance, subunit differences cannot account for the dichotomous nature of NMDA receptor signaling...
  97. doi The vesicular glutamate transporter VGLUT3 synergizes striatal acetylcholine tone
    Christelle Gras
    Institut National de la Sante et de la Recherche Medicale, U513, Universite Pierre et Marie Curie, 9 quai Saint Bernard, 75005 Paris, France
    Nat Neurosci 11:292-300. 2008
    ..Our study reveals a previously unknown effect of glutamate on cholinergic synapses with potential functional and pharmacological implications...
  98. ncbi Potentiation of TRPC5 by protons
    Marcus Semtner
    Institut fur Pharmakologie und Toxikologie, Fachbereich Medizin, Philipps Universitat Marburg, 35032 Marburg, Germany
    J Biol Chem 282:33868-78. 2007
    ....
  99. ncbi Hypoxia suppresses glutamate transport in astrocytes
    Mark Dallas
    School of Medicine, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Neurosci 27:3946-55. 2007
    ..Suppression of glutamate uptake via this mechanism may be an important contributory factor in hypoxic/ischemic triggered glutamate excitotoxicity...
  100. pmc Quantal variability at glutamatergic synapses in area CA1 of the rat neonatal hippocampus
    E Hanse
    Institute of Physiology and Pharmacology, Goteborg University, Sweden
    J Physiol 531:467-80. 2001
    ..The results are compatible with a quantal variability based, to a large extent, on non-saturated AMPA and NMDA responses fluctuating as a function of the amount of transmitter released from each vesicle...
  101. ncbi Distinct mechanisms underlie distinct polyphenol-induced neuroprotection
    Keiko Yazawa
    Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    FEBS Lett 580:6623-8. 2006
    ..Although Ca(2+) influx was not attenuated by CA, caspase-3 was reduced by direct inhibition of the enzyme. All polyphenols reduced glutamate-induced generation of ROS...

Research Grants76

  1. Pacific-Southwest Ctr for Biodefense & Emerg Infect Dis*
    Alan Barbour; Fiscal Year: 2007
    ..The bacteremic phase is made possible by the presence of a capsular polypeptide of poly-gamma-D-glutamic acid (PGA) that prevents phagocytosis of the bacterium...
  2. Treatment of SLE with N-acetylcysteine
    Andras Perl; Fiscal Year: 2010
    ..form of L-cysteine, a rate-limiting factor in synthesis of glutathione (GSH), tripeptide made up of cysteine, glutamic acid, and glycine, which plays key roles in maintenance of a reducing intracellular environment, regulation of the ..
  3. VIRULENCE GENE EXPRESSION BY BACILLUS ANTHRACIS
    THERESA KOEHLER; Fiscal Year: 2007
    ..Well-established virulence factors unique to this organism are the anthrax toxin proteins and a poly-D-glutamic acid capsule...
  4. ISLET CELL MEMBRANE ANTIBODIES IN DIABETES
    Ake Lernmark; Fiscal Year: 1992
    ..autoantigen detected by immunoprecipitation is a Mr 64,000 protein, identified as a hydrophobic isoform of glutamic acid decarboxylase (GAD)...
  5. Prevention of Type I Diabetes Mellitus using a Cell Vac*
    Nick Giannoukakis; Fiscal Year: 2002
    ..on the induction of tolerance to either soluble islet antigens or putative autoantigens like insulin and glutamic acid decarboxylase...
  6. A tri-antigen nasal anthrax vaccine against toxins and vegetative bacilli
    Zhengrong Cui; Fiscal Year: 2007
    ..such as the lethal factor (LF), a protein that binds to PA to form anthrax lethal toxin, and the poly-gamma-D-glutamic acid (PGA) capsule surrounding the vegetative anthrax bacilli, should also be included in an anthrax vaccine for ..
  7. CELLULAR AND NEUROCHEMICAL MECHANISMS OF REM SLEEP
    Subimal Datta; Fiscal Year: 2002
    ..abstract_text> ..
  8. Defining the Beryllium Antigen Complex in Berylliosis
    Lee Newman; Fiscal Year: 2007
    ..gene expression and protein production, especially when beryllium-specific TCRs ligate HLA-DPB1 with a glutamic acid in amino acid position 69...
  9. L-amino and acid taste in mice.
    Eugene Delay; Fiscal Year: 2005
    ..g., diabetics, cardiovascular disease, aged). ..
  10. Structure and Function of NMDA Receptors
    Hiroyasu Furukawa; Fiscal Year: 2010
    ..Defining the molecular structure of the extracellular region of NMDA receptors is expected to help in the design of new therapeutics. ..
  11. N-carbamylglutamate in the treatment of hyperammonemia
    Mendel Tuchman; Fiscal Year: 2009
    ..If the results confirm our hypothesis, these patients can be treated with Carbaglu to keep their ammonia level at normal or close to normal levels, protecting them from brain damage. ..
  12. NHLBI MINORITY INSTITUTION RESEARCH SCIENTIST DEVELOPMEN
    MARIA DEL PILAR AGUINAGA; Fiscal Year: 2004
    ..Sickle cell disease is caused by the substitution of glutamic acid with valine at the position of amino acid six in the Beta- globin chain...
  13. PGA antigenemia for early diagnosis of anthrax
    Thomas Kozel; Fiscal Year: 2007
    ..Bacillus anthracis is surrounded by an anti-phagocytic capsule that is composed of poly-y-D-glutamic acid (PGA), raising the possibility than immunoassay for PGA could be a means for early, specific, rapid and ..
  14. REGULATION OF GABA BIOSYNTHESIS IN THE BRAIN
    Jang Yen Wu; Fiscal Year: 2003
    ..The success of a large scale purification of recombinant human brain GAD65 and GAD67 and the availability of subtype specific antibodies for GAD65 and GAD67, ensure the high feasibility of this proposal. ..
  15. Bacillus anthracis cell surface carbohydrates
    Russell Carlson; Fiscal Year: 2004
    ..anthracis cell wall carbohydrates. B. anthracis produces a capsule consisting of poly-g-glutamic acid, rather than a polysaccharide...
  16. Immune Tolerance Against Type I Diabetes in Mice
    Habib Zaghouani; Fiscal Year: 2007
    ..type 1 (Th1) lymphocytes specific for p cell-associated antigens such as insulin beta (INSbeta) chain or glutamic acid decarboxylase (GAD) can confer disease into healthy animals suggesting that the immune system plays a ..