acidic amino acids

Summary

Summary: Amino acids with side chains that are negatively charged at physiological pH.

Top Publications

  1. doi Arg143 and Lys192 of the human mast cell chymase mediate the preference for acidic amino acids in position P2' of substrates
    Mattias K Andersson
    Department of Cell and Molecular Biology, Uppsala University, The Biomedical Center, Uppsala, Sweden
    FEBS J 277:2255-67. 2010
  2. ncbi Utilization of acidic amino acids and their amides by pseudomonads: role of periplasmic glutaminase-asparaginase
    Avinash Sonawane
    Institute of Physiological Chemistry, Philipps University, Marburg Lahn, Germany
    Arch Microbiol 179:151-9. 2003
  3. pmc Acidic amino acids impart enhanced Ca2+ permeability and flux in two members of the ATP-gated P2X receptor family
    Damien S K Samways
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Gen Physiol 129:245-56. 2007
  4. pmc CDC7 kinase phosphorylates serine residues adjacent to acidic amino acids in the minichromosome maintenance 2 protein
    Won Ho Cho
    Department of Biology Education, Seoul National University, Seoul 151 742, Korea
    Proc Natl Acad Sci U S A 103:11521-6. 2006
  5. pmc Covalent cross-linking of proteins without chemical reagents
    Brigitte L Simons
    Centre for Biologics Research, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa, Canada K1A 0L2
    Protein Sci 11:1558-64. 2002
  6. ncbi Possible association of non-binding of HSP70 to HLA-DRB1 peptide sequences and protection from rheumatoid arthritis
    Jan T Maier
    Department of Hematology and Oncology, Children s Hospital, University of Tubingen, Hoppe Seyler Strasse 1, 72076 Tubingen, Germany
    Immunogenetics 54:67-73. 2002
  7. ncbi Are acidic and basic groups in buried proteins predicted to be ionized?
    Jinrang Kim
    Physics Department J 419, City College of New York, 138th Street and Convent Avenue, New York, NY 10031, USA
    J Mol Biol 348:1283-98. 2005
  8. ncbi Calcium regulation of inositol 1,4,5-trisphosphate receptors
    Suresh K Joseph
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Rm 230A JAH, 1020 Locust Street, Philadelphia, PA 19107, USA
    Cell Calcium 38:539-46. 2005
  9. ncbi Structure of calmodulin complexed with an olfactory CNG channel fragment and role of the central linker: residual dipolar couplings to evaluate calmodulin binding modes outside the kinase family
    Gian Marco Contessa
    Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133, Rome, Italy
    J Biomol NMR 31:185-99. 2005
  10. ncbi Characterization and location of post-translational modifications on chromogranin B from bovine adrenal medullary chromaffin granules
    Claire Gasnier
    INSERM Unité 575, Physiopathologie du Système Nerveux, Strasbourg, France
    Proteomics 4:1789-801. 2004

Research Grants

  1. Development of Chemical Receptors for Proteins
    Sanku Mallik; Fiscal Year: 2005
  2. Tyrosine Sulfation and Chemokine Receptor Function
    Kevin Moore; Fiscal Year: 2006
  3. FUNCTIONAL SIGNIFICANCE OF THE ACTIN N-TERMINAL REGION
    PETER RUBENSTEIN; Fiscal Year: 1993
  4. Factor Va regulation of prothrombinase activity
    JAMILA HIRBAWI; Fiscal Year: 2006
  5. GLUTAMATE TRANSPORTERS IN THE CNS
    Michael Robinson; Fiscal Year: 2009
  6. MECHANISM OF INOSITOL TRISPHOSPHATE ACTION
    Suresh Joseph; Fiscal Year: 2004
  7. GLUTAMATE TRANSPORTERS IN THE CNS
    MICHAEL BYRNE ROBINSON; Fiscal Year: 2011
  8. REACTIVE INTERMEDIATES OF ENZYMATIC REACTIONS
    John Richard; Fiscal Year: 2000
  9. BRAIN ENDOPEPTIDASES AND NEUROPEPTIDE METABOLISM
    Sherwin Wilk; Fiscal Year: 2001
  10. REGULATION OF EXTRACELLULAR EXCITOTOXINS
    Michael Robinson; Fiscal Year: 2006

Detail Information

Publications193 found, 100 shown here

  1. doi Arg143 and Lys192 of the human mast cell chymase mediate the preference for acidic amino acids in position P2' of substrates
    Mattias K Andersson
    Department of Cell and Molecular Biology, Uppsala University, The Biomedical Center, Uppsala, Sweden
    FEBS J 277:2255-67. 2010
    ..of eight such chymases have been determined, and four of these were shown to have a strong preference for acidic amino acids at position P2'. These enzymes have basic amino acids in positions 143 and 192 (Arg and Lys, respectively)...
  2. ncbi Utilization of acidic amino acids and their amides by pseudomonads: role of periplasmic glutaminase-asparaginase
    Avinash Sonawane
    Institute of Physiological Chemistry, Philipps University, Marburg Lahn, Germany
    Arch Microbiol 179:151-9. 2003
    The acidic amino acids (Asp, Glu) and their amides (Asn, Gln) support rapid growth of a variety of Pseudomonas strains when provided as the sole source of carbon and nitrogen. All key enzymes of glutamate metabolism were detected in P...
  3. pmc Acidic amino acids impart enhanced Ca2+ permeability and flux in two members of the ATP-gated P2X receptor family
    Damien S K Samways
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Gen Physiol 129:245-56. 2007
    ..2001). Here, we test the hypothesis that the formal charge of acidic amino acids underlies the higher fractional Ca2+ currents (Pf%) of the rat and human P2X1 and P2X4 subtypes...
  4. pmc CDC7 kinase phosphorylates serine residues adjacent to acidic amino acids in the minichromosome maintenance 2 protein
    Won Ho Cho
    Department of Biology Education, Seoul National University, Seoul 151 742, Korea
    Proc Natl Acad Sci U S A 103:11521-6. 2006
    ..This finding may explain why the sequential action of cyclin-dependent and Cdc7 kinases is essential for the initiation of DNA replication...
  5. pmc Covalent cross-linking of proteins without chemical reagents
    Brigitte L Simons
    Centre for Biologics Research, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa, Canada K1A 0L2
    Protein Sci 11:1558-64. 2002
    ....
  6. ncbi Possible association of non-binding of HSP70 to HLA-DRB1 peptide sequences and protection from rheumatoid arthritis
    Jan T Maier
    Department of Hematology and Oncology, Children s Hospital, University of Tubingen, Hoppe Seyler Strasse 1, 72076 Tubingen, Germany
    Immunogenetics 54:67-73. 2002
    ..Thus, our results suggest a possible association of non-binding of HSP70 to HLA-DR molecules or its 70-74 fragments and protection from RA...
  7. ncbi Are acidic and basic groups in buried proteins predicted to be ionized?
    Jinrang Kim
    Physics Department J 419, City College of New York, 138th Street and Convent Avenue, New York, NY 10031, USA
    J Mol Biol 348:1283-98. 2005
    ..Thus, hydroxyls are better hydrogen bond donors than acceptors. Buried ionized residues are more likely to be conserved than those on the surface. There are 3.95 residues buried per 100 residues in an average protein...
  8. ncbi Calcium regulation of inositol 1,4,5-trisphosphate receptors
    Suresh K Joseph
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Rm 230A JAH, 1020 Locust Street, Philadelphia, PA 19107, USA
    Cell Calcium 38:539-46. 2005
    ..The data support the view that all IP3R isoforms may display a range of Ca2+ sensitivities that are determined by multiple sites within the protein and markedly influenced by the affinity of the receptor for IP3...
  9. ncbi Structure of calmodulin complexed with an olfactory CNG channel fragment and role of the central linker: residual dipolar couplings to evaluate calmodulin binding modes outside the kinase family
    Gian Marco Contessa
    Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133, Rome, Italy
    J Biomol NMR 31:185-99. 2005
    ..Excluded regions comprise calcium binding loops and loops connecting the EF-hand motifs...
  10. ncbi Characterization and location of post-translational modifications on chromogranin B from bovine adrenal medullary chromaffin granules
    Claire Gasnier
    INSERM Unité 575, Physiopathologie du Système Nerveux, Strasbourg, France
    Proteomics 4:1789-801. 2004
    ..Furthermore, we have identified at the molecular level the presence of a mutation M/V on position 577 of natural CGB. All together these data reflect the complex structure of this protein marker of the neuroendocrine system...
  11. ncbi Both acidic and basic amino acids in an amphitropic enzyme, CTP:phosphocholine cytidylyltransferase, dictate its selectivity for anionic membranes
    Joanne E Johnson
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
    J Biol Chem 278:514-22. 2003
    ..Thus anionic lipids, working via surface-localized pH effects, can promote membrane binding by modifying protein charge and hydrophobicity, and this novel mechanism contributes to the membrane selectivity of CT in vivo...
  12. ncbi Chemiluminescent studies on the antioxidant activity of amino acids
    T M Triantis
    Institute of Physical Chemistry, NCSR Demokritos, 15310 Ag Paraskevi, Athens, Greece
    Anal Chim Acta 591:106-11. 2007
    ..Amino acids with phenolic groups present higher inhibition than basic, acidic or neutral amino acids. The calculated antioxidant activities by the CL method are compared with those of the N,N-diphenyl-picryl hydrazyl (DPPH) method...
  13. ncbi Ammonium assimilation and amino acid metabolism in conifers
    Francisco M Canovas
    Departamento de Biologia Molecular y Bioquimica, Instituto Andaluz de Biotecnología, Unidad Asociada UMA CSIC, Universidad de Malaga, E 29071 Malaga, Spain
    J Exp Bot 58:2307-18. 2007
    ..In this paper, details of recent progress in our understanding of the metabolism of arginine and the other major amino acids glutamine, glutamate, aspartate, and asparagine in pine, a conifer model tree, are presented and discussed...
  14. ncbi Insights into the structure and molecular basis of ligand docking to the G protein-coupled secretin receptor using charge-modified amino-terminal agonist probes
    Maoqing Dong
    M D Director, Cancer Center Mayo Clinic in Scottsdale, 13400 East Shea Boulevard, Johnson Research Building, Scottsdale AZ 85259, USA
    Mol Endocrinol 19:1821-36. 2005
    ..This supports the possibility that there is a charge-charge interaction between this residue and the amino terminus of secretin that is critical to its normal docking...
  15. ncbi A novel theory on the origin of the genetic code: a GNC-SNS hypothesis
    Kenji Ikehara
    Department of Chemistry, Faculty of Science, Nara Women s University, Kita Uoya Nishi machi, Nara 630 8506, Japan
    J Mol Evol 54:530-8. 2002
    ..Thus, we concluded that the universal genetic code originated not from a three-amino acid system but from a four-amino acid system, the GNC code encoding [GADV]-proteins, as the most primitive genetic code...
  16. pmc Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development
    Shihui Liu
    Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 26:3835-41. 2006
    ..These results attest to the physiological importance of Dph3 in development. The biological roles of Dph3 are also discussed...
  17. ncbi The alpha-helix of the second chromodomain of the 43 kDa subunit of the chloroplast signal recognition particle facilitates binding to the 54 kDa subunit
    Rebecca Hermkes
    Lehrstuhl für Allgemeine und Molekulare Botanik, Ruhr Universitat Bochum, 44780 Bochum, Germany
    FEBS Lett 580:3107-11. 2006
    ..Further analysis of the binding interface of cpSRP by mutagenesis studies and a pepscan approach demonstrates that the C-terminal alpha-helix of CD2 facilitates binding to cpSRP54...
  18. ncbi Structural basis for budding by the ESCRT-III factor CHMP3
    Tadeusz Muzioł
    European Molecular Biology Laboratory, 6 rue Jules Horowitz, 38042 Grenoble, France
    Dev Cell 10:821-30. 2006
    ..Thus, the final steps in the budding process may include CHMP protein polymerization and lattice formation on membranes by employing different bilayer-recognizing surfaces, a function shared by all CHMP family members...
  19. ncbi Hydrophobic and acidic moments of a nucleoplasmin NP-core chaperone
    B David Silverman
    IBM Thomas J Watson Research Center, Yorktown Heights, NY 10598, USA
    J Biomol Struct Dyn 24:49-56. 2006
    ..It is also pointed out that the prevalence of basic residues on the short helices of the histone cores also provides regions of charge that would complement histone binding to the chaperone...
  20. ncbi Role of acidic amino acid residues in chitooligosaccharide-binding to Streptomyces sp. N174 chitosanase
    Tomomi Katsumi
    Department of Advanced Bioscience, Kinki University, 3327 204 Nakamachi, Nara 631 8505, Japan
    Biochem Biophys Res Commun 338:1839-44. 2005
    ..The fluorescence quenching was very weak in D57A, suggesting a strong contribution of this residue to the oligosaccharide binding...
  21. ncbi Towards control of aggregational behaviour of alpha-lactalbumin at acidic pH
    Jane B Pedersen
    Institute of Physics and Nanotechnology, Aalborg University, Aalborg, Denmark
    J Fluoresc 16:611-21. 2006
    ..The results presented in this paper provide detailed knowledge on the external parameters leading to aggregation of alpha-La at acidic pH, thus permitting rational design of the aggregation process...
  22. pmc pH sensing in the two-pore domain K+ channel, TASK2
    Michael J Morton
    School of Biomedical Sciences, Medical and Dental Building, University of Leeds, Leeds LS2 9NQ, United Kingdom
    Proc Natl Acad Sci U S A 102:16102-6. 2005
    ..Thus, pH sensing in TASK2 channels is conferred by the combined action of several charged residues in the large extracellular M1-P1 loop...
  23. ncbi Non-covalent interactions between unsolvated peptides: helical complexes based on acid-base interactions
    Rajagopalan Sudha
    Chemistry Department, Indiana University, Bloomington, Indiana 47405 7102, USA
    J Phys Chem B 109:6442-7. 2005
    ..The enthalpy change indicates that the interaction between the E and K residues in the middle of the helices is a weak neutral hydrogen bond. The EKK interaction is significantly stronger...
  24. ncbi Tools for building a comprehensive modeling system for virtual screening under real biological conditions: The Computational Titration algorithm
    Glen E Kellogg
    Department of Medicinal Chemistry and Institute for Structural Biology and Drug Discovery, School of Pharmacy, Virginia Commonwealth University, Box 980540, Richmond, VA 23298 0540, USA
    J Mol Graph Model 24:434-9. 2006
    ..As an example, three complexes of dihydrofolate reductase (DHFR) are analyzed with our system and these results are compared with the experimental free energies of binding...
  25. ncbi Ion-ion and ion-molecule reactions at the surface of proteins produced by nanospray. Information on the number of acidic residues and control of the number of ionized acidic and basic residues
    Udo H Verkerk
    Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada
    J Am Soc Mass Spectrom 16:1325-41. 2005
    ....
  26. ncbi Effects of hydrogen-bonding and stacking interactions with amino acids on the acidity of uracil
    Ken C Hunter
    Department of Chemistry, Mount Allison University, 63C York Street, Sackville, New Brunswick E4L 1G8, Canada
    J Phys Chem B 111:1858-71. 2007
    ..The present study has general implications for understanding the nature of active site amino acids in enzymes, such as DNA repair enzymes, that catalyze reactions involving anionic nucleobase intermediates...
  27. pmc Piv site-specific invertase requires a DEDD motif analogous to the catalytic center of the RuvC Holliday junction resolvases
    John M Buchner
    Department of Microbiology, University of Georgia, Athens, GA 30602 2605, USA
    J Bacteriol 187:3431-7. 2005
    ..On the basis of these results, a working model for Piv-mediated inversion that includes resolution of a Holliday junction is presented...
  28. ncbi A di-acidic sequence motif enhances the surface expression of the potassium channel TASK-3
    Marylou Zuzarte
    Institute of Physiology, Marburg University, Deutschhausstr 2, 35037 Marburg, Germany
    Traffic 8:1093-100. 2007
    ..Our data suggest that the di-acidic motif, EDE, in human TASK-3 is a major determinant of the rate of ER export and is required for efficient surface expression of the channel...
  29. ncbi Charged amino acids of the N-terminal domain are involved in coupling binding and gating in alpha7 nicotinic receptors
    Francisco Sala
    Instituto de Neurociencias, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, Apartado 18, 03550 Sant Joan d Alacant, Alicante, Spain
    J Biol Chem 280:6642-7. 2005
    ..Rather, a network of interactions formed by residues Lys-46, Asp-128, Asp-135, Asp-266, and possibly others appears to link agonist binding to channel gating...
  30. pmc The acidic repetitive domain of the Magnetospirillum gryphiswaldense MamJ protein displays hypervariability but is not required for magnetosome chain assembly
    André Scheffel
    Max Planck Institute for Marine Microbiology, Bremen, Germany
    J Bacteriol 189:6437-46. 2007
    ....
  31. ncbi Sequence context strongly modulates association of polar residues in transmembrane helices
    Jessica P Dawson
    Department of Molecular Biophysics and Biochemistry, Yale University, Bass Centre Room 420A, 266 Whitney Avenue, New Haven, CT 06520 8114, USA
    J Mol Biol 331:255-62. 2003
    ..Overall, these results suggest that an innate structural mechanism may operate to control non-specific association of membrane-embedded polar residues...
  32. pmc The cytoplasmic domain of the Plasmodium falciparum ligand EBA-175 is essential for invasion but not protein trafficking
    Tim Wolf Gilberger
    The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    J Cell Biol 162:317-27. 2003
    ..These results show that the parasite uses the same components of its cellular machinery for invasion regardless of the host cell type and invasive form...
  33. ncbi Structural basis for a non-phosphorus-containing cyclic peptide binding to Grb2-SH2 domain with high affinity
    Peng Li
    Laboratory of Medicinal Chemistry, National Cancer Institute, National Institutes of Health, 376 Boyles Street, Frederick, MD 21702 1201, USA
    Biochem Biophys Res Commun 307:1038-44. 2003
    ..Whole cell assays indicate that peptide 20 can penetrate the cell membranes and inhibit the association of Grb2 with p185(erbB2) in erbB2-overexpressing MDA-MA-453 cancer cells at low micromolar concentrations...
  34. ncbi Identification and mutational analysis of Mg2+ binding site in EcoP15I DNA methyltransferase: involvement in target base eversion
    Pradeep Bist
    Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India
    J Biol Chem 278:41837-48. 2003
    ..This is the first example of metal-dependent function of a DNA methyltransferase. These findings provide impetus for exploring the role(s) of metal ions in the structure and function of DNA methyltransferases...
  35. pmc The parsley plastocyanin-turnip cytochrome f complex: a structurally distorted but kinetically functional acidic patch
    Peter B Crowley
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Av da Republica, Apartado 127, 2781 901 Oeiras, Portugal
    Biochem J 378:45-51. 2004
    ..The results of NMR studies and protein-docking simulations indicate that parsley PCu and its spinach analogue adopt different orientations in their complexes with cyt f...
  36. ncbi Solution structure of coactosin reveals structural homology to ADF/cofilin family proteins
    Maarit Hellman
    Program in Structural Biology and Biophysics, Institute of Biotechnology, University of Helsinki, Finland
    FEBS Lett 576:91-6. 2004
    ..Our analysis also identifies key structural differences between these proteins that may account for the differences in biochemical activities and cellular roles of these proteins...
  37. ncbi Distance dependence of interactions between charged centres in proteins with common structural features
    Ricardo O Louro
    Instituto de Tecnologia Química e Biológica da Universidade Nova de Lisboa, Rua da Quinta Grande 6, Apt 127, 2780 156 Oeiras, Portugal
    FEBS Lett 576:77-80. 2004
    ..However, there is considerable scatter in the data despite the structural similarities among the proteins, which is discussed in the framework of using such simple models in predicting properties of novel proteins...
  38. ncbi Immunoglobulin kappa light chain and its amyloidogenic mutants: a molecular dynamics study
    Mateusz Nowak
    Department of Biostatistics and Medical Informatics, Collegium Medicum, and Faculty of Biotechnology, Jagiellonian University, Krakow, Poland
    Proteins 55:11-21. 2004
    ..This suggests that mild and slow destabilization is the reason of the conversion of V(L) to partially folded amyloidogenic intermediate structure...
  39. ncbi MAP2 prevents protein aggregation and facilitates reactivation of unfolded enzymes
    Taradas Sarkar
    Department of Biochemistry, Centenary Campus, PI 12, Bose Institute, CIT Scheme VIIM, Calcutta 700 054, India
    Eur J Biochem 271:1488-96. 2004
    ..Tau, which shares a homologous C-terminal domain with MAP2, possesses no such activity...
  40. ncbi Cell surface adhesion of pregnancy-associated plasma protein-A is mediated by four clusters of basic residues located in its third and fourth CCP module
    Kathrin Weyer
    Department of Molecular Biology, Science Park, University of Aarhus, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
    Eur J Biochem 271:1525-35. 2004
    ..This explains, at least in part, why PAPP-A2 lacks the ability of cell surface adhesion, and further emphasizes the role of the basic clusters defined in PAPP-A...
  41. ncbi An acidic peptide sequence of nucleolin-related protein can mediate the attachment of calcium oxalate to renal tubule cells
    Elena A Sorokina
    Nephrology Division, Medical College of Wisconsin, Milwaukee, WI, USA
    J Am Soc Nephrol 15:2057-65. 2004
    ..These results support the notion that surface-associated NRP could mediate attachment of CaOx to the renal tubule epithelium, thereby causing retention of crystals that might eventually become kidney stones...
  42. ncbi The luteinizing hormone receptor: influence of buffer composition on ligand binding and signaling of wild type and mutant receptors
    Krassimira Angelova
    Department of Biochemistry and Molecular Biology, University of Georgia, Life Sciences Building, Green Street, Athens, GA 30602 7229, USA
    Mol Cell Endocrinol 204:1-9. 2003
    ....
  43. pmc A ring of eight conserved negatively charged amino acids doubles the conductance of BK channels and prevents inward rectification
    Tinatin I Brelidze
    Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 N W 10th Avenue, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 100:9017-22. 2003
    ..Removing the ring of charge converts BK channels to inwardly rectifying channels. Thus, a simple electrostatic mechanism contributes to the large conductance of BK channels...
  44. doi Redox potential difference between Desulfovibrio vulgaris and Clostridium beijerinckii flavodoxins
    Hiroshi Ishikita
    Department of Chemistry, University of Southern California, Los Angeles, California 90089, USA
    Biochemistry 47:4394-402. 2008
    ..The E sq/hq difference can be best explained by the lower compensation of the side chain influence by the backbone influence in the D. vulgaris flavodoxin than in the C. beijerinckii flavodoxin...
  45. ncbi Geometry of nonbonded interactions involving planar groups in proteins
    Pinak Chakrabarti
    Department of Biochemistry and Bioinformatics Centre, Bose Institute, P 1 12 CIT Scheme VIIM, Kolkata 700054, India
    Prog Biophys Mol Biol 95:83-137. 2007
    ..The geometrical relationship between interacting residues provides valuable insights into the process of protein folding and would be useful for the design of protein molecules and modulation of their binding properties...
  46. ncbi Mutation of charged residues in the TR3 death domain does not perturb interaction with TRADD
    Elisabeth Tunbridge
    Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline, Third Avenue, Harlow, EssexCM19 5AW, UK
    Protein Eng 15:811-5. 2002
    ..These data suggest that despite some similarity between the death domains of TR3 and TNFR1 the nature of the interaction with TRADD differs from that reported for TNFR1...
  47. ncbi Functional analysis of acidic amino acids in the cytosolic tail of the Na+/H+ exchanger
    Xiuju Li
    Department of Biochemistry, 347 Medical Science Building, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Biochemistry 43:16477-86. 2004
    ..Our results demonstrate that the acidic sequence is critical in maintaining proper conformation of the cytosolic domain, calmodulin binding, and in maintenance of Na(+)/H(+) exchanger activity...
  48. ncbi Increasing the potency of a cytotoxin with an arginine graft
    Stephen M Fuchs
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706 1544, USA
    Protein Eng Des Sel 20:505-9. 2007
    ..These findings correlate the potency of a ribonuclease with its deliverance of ribonucleolytic activity to the cytosol, and indicate a rational means to enhance the efficacy of ribonucleases and other cytotoxic proteins...
  49. doi Cooperative interactions between R531 and acidic residues in the voltage sensing module of hERG1 channels
    David R Piper
    Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84113, USA
    Cell Physiol Biochem 21:37-46. 2008
    ..We propose that hERG1 activation involves a cooperative conformational change involving the entire voltage sensing module, while inactivation may involve a more limited interaction between R531 and D456, D460 and D509...
  50. pmc Interactions between neuronal fusion proteins explored by molecular dynamics
    Marie Pierre Durrieu
    Institut de Biologie Physico Chimique, Laboratoire de Biochimie Theorique, Centre National de la Recherche Scientifique, UPR 9080, Paris, France
    Biophys J 94:3436-46. 2008
    ..The interaction patterns we observe provide a new tool for interpreting the impact of mutations on the complex...
  51. ncbi Characterization of calcium binding properties of lithostathine
    Byung In Lee
    Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA
    J Biol Inorg Chem 8:341-7. 2003
    ....
  52. ncbi NMR solution structure of the archaebacterial chromosomal protein MC1 reveals a new protein fold
    Françoise Paquet
    Centre de Biophysique Moleculaire, CNRS, rue Charles Sadron, 45071 Orleans Cedex 2, France
    Biochemistry 43:14971-8. 2004
    ..Its structure suggests a different DNA-binding mode than those of the histone-like proteins HU or HMGB. Thus, MC1 may be classified as a member of a new family...
  53. pmc The mouse and human Ah receptor differ in recognition of LXXLL motifs
    Colin Flaveny
    Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, 309A Life Sciences Building, University Park, PA 16802, USA
    Arch Biochem Biophys 471:215-23. 2008
    ..These findings suggest that the human and mouse AhR may display differential recruitment of coactivators and hence may exhibit divergent regulation of target genes...
  54. doi A class of novel nitronyl nitroxide labeling basic and acidic amino acids: synthesis, application for preparing ESR optionally labeling peptides, and bioactivity investigations
    Jianwei Zhang
    College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China
    Bioorg Med Chem 16:4019-28. 2008
    ..Their incorporation led to 12 novel ESR optionally labeling PAK, RGDS, RGDV, and ECG. A series of NO related chemical tests, the in vitro and in vivo assays of these peptides confirmed that this strategy was practical...
  55. ncbi DNA binding provides a molecular strap activating the adenovirus proteinase
    Sayan Gupta
    Center for Synchrotron Biosciences, Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Cell Proteomics 3:950-9. 2004
    ..In addition, both pVIc and DNA may independently alter the active site conformation as well as drive it cooperatively to fully activate AVP...
  56. ncbi Low and high affinity amino acid H+-cotransporters for cellular import of neutral and charged amino acids
    Wolf N Fischer
    Plant Physiology, Zentrum für Molekularbiologie der Pflanzen, Tubingen, Germany
    Plant J 29:717-31. 2002
    Amides and acidic amino acids represent the major long distance transport forms of organic nitrogen. Six amino acid permeases (AAPs) from Arabidopsis mediating transport of a wide spectrum of amino acids were isolated...
  57. ncbi Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)
    Y Kanai
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181, Japan
    J Biol Chem 273:23629-32. 1998
    ..neutral amino acids with branched or aromatic side chains and did not accept basic amino acids or acidic amino acids. The transport via LAT1 was Na+-independent and sensitive to a system L-specific inhibitor 2-aminobicyclo-(2,..
  58. ncbi Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase II
    J A Girault
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York 10021
    J Biol Chem 264:21748-59. 1989
    ..2-fold increase in the Vmax and a 1.4-fold increase in the apparent Km. Phosphorylation of DARPP-32 by casein kinase II in intact cells may therefore modulate its phosphorylation in response to increased levels of cAMP...
  59. ncbi Rat kidney carboxylesterase. Cloning, sequencing, cellular localization, and relationship to rat liver hydrolase
    B Yan
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City 66160 7417
    J Biol Chem 269:29688-96. 1994
    ....
  60. ncbi A two-alpha-helix extra domain mediates the halophilic character of a plant-type ferredoxin from halophilic archaea
    Bianca Lucia Marg
    Max Planck Institut fur Biochemie, Abteilung Membranbiochemie, Am Klopferspitz 18a, 82152 Martinsried, Germany
    Biochemistry 44:29-39. 2005
    ..ferredoxins except for an insertion of 30 amino acids near its N-terminus which is extremely rich in acidic amino acids. Unfolding studies reveal that HsFdx has an unfolding temperature of approximately 85 degrees C in 4...
  61. ncbi LSA: a new liver-specific antigen in the rat. I. Purification and characterization
    A A Mihas
    Division of Digestive Diseases, University of Mississippi School of Medicine, Jackson
    Int Arch Allergy Immunol 98:35-49. 1992
    ..The amino acid composition of the LSA revealed that the acidic amino acids out-number the basic amino acids, with glutamic acid being the most abundant of them...
  62. ncbi A-type ATP binding consensus sequences are critical for the catalytic activity of the calmodulin-sensitive adenylyl cyclase from Bacillus anthracis
    Z G Xia
    Department of Pharmacology, School of Medicine, University of Washington, Seattle 98195
    J Biol Chem 265:6517-20. 1990
    ..It is concluded that Lys-346 and Lys-353 in B. anthracis adenylyl cyclase may interact directly with ATP and contribute to the binding of the nucleotide to the enzyme...
  63. pmc Unique dicistronic operon (ptsI-crr) in Mycoplasma capricolum encoding enzyme I and the glucose-specific enzyme IIA of the phosphoenolpyruvate:sugar phosphotransferase system: cloning, sequencing, promoter analysis, and protein characterization
    P P Zhu
    Laboratory of Biochemical Genetics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    Protein Sci 3:2115-28. 1994
    ..amino acid sequence of the Mycoplasma Enzyme I shows that it differs from other Enzymes I by having fewer acidic amino acids and more basic, amidated, and aromatic amino acids...
  64. doi Electron transfer in Paracoccus denitrificans with the modified fbc operon
    V Dadak
    Institute of Biochemistry, Faculty of Science, Masaryk University, Brno, Czechia
    Folia Microbiol (Praha) 54:475-82. 2009
    ..The mutant strain M 71 expressing the truncated copy of cytochrome c(1) (devoid of a stretch of 150 mainly acidic amino acids) was less sensitive to increasing concentration of cytochrome c and changes in ionic strength of the medium, ..
  65. ncbi Replacements of single basic amino acids in the pleckstrin homology domain of phospholipase C-delta1 alter the ligand binding, phospholipase activity, and interaction with the plasma membrane
    H Yagisawa
    Department of Life Science, Faculty of Science, Himeji Institute of Technology, Harima Science Garden City, Hyogo 678 12, Japan
    J Biol Chem 273:417-24. 1998
    ..All residues (with the exception of the K43E substitution) found to be critical for the analyzed PLC-delta1 functions are present at the surface of the PH domain shown to contain the Ins(1,4,5)P3 binding pocket...
  66. ncbi Phosphorylation of the angiotensin II (AT1A) receptor carboxyl terminus: a role in receptor endocytosis
    W G Thomas
    Baker Medical Research Institute, Melbourne, Australia
    Mol Endocrinol 12:1513-24. 1998
    ..sites (Thr332, Ser335, Thr336, and Ser338) were substituted with either neutral [alanine (A)] or acidic amino acids [glutamic acid (E) and aspartic acid (D)], the former to prevent phosphorylation and the latter to reproduce ..
  67. ncbi Electrostatic attraction between cytochrome bc1 and cytochrome c affects kinetics of cytochrome c reduction
    V Dadak
    Institute of Biochemistry, Faculty of Science, Masaryk University, Brno, Czech Republic
    Biochemistry (Mosc) 73:870-80. 2008
    ..The cytochrome c(1) of the WT samples possessed an additional stretch of acidic amino acids, which was lacking in the mutant...
  68. ncbi Involvement of phylogenetically conserved acidic amino acid residues in catalysis by an oxidative DNA damage enzyme formamidopyrimidine glycosylase
    O V Lavrukhin
    Sealy Center for Molecular Science, Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555 1071, USA
    Biochemistry 39:15266-71. 2000
    ..However, in contrast to other enzymes in this class, in which acidic amino acids have been shown to be essential for glycosyl and phosphodiester bond scission, the catalytically essential ..
  69. ncbi Molecular cloning of a histidine-rich Ca2+-binding protein of sarcoplasmic reticulum that contains highly conserved repeated elements
    S L Hofmann
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    J Biol Chem 264:18083-90. 1989
    ..tandem repeats of 29 residues, each consisting of a histidine-rich sequence HRHRGH, a stretch of 10-11 acidic amino acids, and a sequence containing 2 serines and a threonine in a negatively charged context; 3) a 13-residue ..
  70. ncbi Homology models of the Yersinia pseudotuberculosis and Yersinia pestis general porins and comparative analysis of their functional and antigenic regions
    G N Likhatskaya
    Pacific Institute of Bioorganic Chemistry of Far East Branch of Russian Academy of Sciences, Vladivostok, Pr 100 Let Vladivostoku 159, 690022 Russia
    J Biomol Struct Dyn 23:163-74. 2005
    ..located in the loop L3 tip that disturbs the functionally important cluster of the acidic amino acids in the constriction site. Comparative analysis of structural organization of YPS and E...
  71. pmc Contribution of amino acid region 659-663 of Factor Va heavy chain to the activity of factor Xa within prothrombinase
    JAMILA HIRBAWI
    Department of Chemistry, Cleveland State University, Cleveland, Ohio 44115, USA
    Biochemistry 49:8520-34. 2010
    ....
  72. ncbi Identification of a novel Na+-independent acidic amino acid transporter with structural similarity to the member of a heterodimeric amino acid transporter family associated with unknown heavy chains
    Hirotaka Matsuo
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    J Biol Chem 277:21017-26. 2002
    ..proteins were sorted to the plasma membrane and expressed the Na(+)-independent transport activity for acidic amino acids. Distinct from the Na(+)-independent cystine/glutamate transporter xCT structurally related to AGT1, AGT1 ..
  73. ncbi Evaluation of the RBE4 cell line to explore carrier-mediated drug delivery to the CNS via the L-system amino acid transporter at the blood-brain barrier
    Andreas Reichel
    Blood Brain Barrier Research Group, Centre for Neuroscience Research, GKT School of Biomedical Sciences, King s College London, UK
    J Drug Target 10:277-83. 2002
    ..such as L-phenylalanine and 2-aminobicyclo-heptanecarboxylic acid (BCH), whereas small neutral, basic and acidic amino acids had no significant effect...
  74. ncbi cDNA cloning of a novel protein containing two zinc-finger domains that may function as a transcription factor for the human heme-oxygenase-1 gene
    Y Muraosa
    Department of Applied Physiology and Molecular Biology, Tohoku University School of Medicine, Sendai, Japan
    Eur J Biochem 235:471-9. 1996
    ..possesses other structural features characteristic of transcription factors, including a long stretch of acidic amino acids (amino acids 67 - 95), a proline-rich region (positions 733-849), a region rich in basic amino acids (..
  75. ncbi The computer modelling of human TRH receptor, TRH and TRH-like peptides
    R Bilek
    Institute of Endocrinology, First Faculty of Medicine, Charles University, Narodni 8, 11694 Prague 1, Cech Republic
    Physiol Res 54:141-50. 2005
    ..Desamido-TRH or glutamyl metabolites will be repelled by the negative potential of ASP195 (E: D93) and GLU298 (G: E137)...
  76. ncbi The c-erbA alpha-encoded thyroid hormone receptor is phosphorylated in its amino terminal domain by casein kinase II
    C Glineur
    INSERM U186 CNRS UA 1160, Institut Pasteur, Lille, France
    Oncogene 4:1247-54. 1989
    ....
  77. ncbi Aspartic acid 405 contributes to the substrate specificity of aminopeptidase B
    Kayoko M Fukasawa
    Department of Hard Tissue Research, Graduate School of Oral Medicine, Matsumoto Dental University, School of Dentistry, Shiojiri, Nagano 399 0781, Japan
    Biochemistry 45:11425-31. 2006
    ..These data strongly suggest that the Asp 405 residue is involved in substrate binding via an interaction with the P1 amino group of the substrate's side chain...
  78. ncbi Herniated lumbar disc material as a source of free glutamate available to affect pain signals through the dorsal root ganglion
    J F Harrington
    Brown University School of Medicine and the Rhode Island Hospital, Providence, Rhode Island, USA
    Spine (Phila Pa 1976) 25:929-36. 2000
    ..Combined prospective human cohort and prospective controlled animal model...
  79. ncbi Mutation effects of a conserved alanine (Ala510) in type I polyhydroxyalkanoate synthase from Ralstonia eutropha on polyester biosynthesis
    Takeharu Tsuge
    Department of Innovative and Engineered Materials, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama, Kanagawa 226 8502, Japan
    Macromol Biosci 4:963-70. 2004
    ..In particular, substitution by acidic amino acids, A510D(E), led to remarkable increases in molecular weights...
  80. ncbi Modulators of the activation of the proteasome by PA28 (11S reg)
    S Wilk
    Department of Pharmacology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Biol Rep 26:39-44. 1999
    ..PA28- proteasome modulators by modifying the profile of peptides produced by the activated proteasome, may either enhance or suppress the immune response...
  81. pmc Molecular cloning and characterization of a cellular protein that interacts with the human immunodeficiency virus type 1 Tat transactivator and encodes a strong transcriptional activation domain
    L Yu
    Institute for Molecular Virology, Saint Louis University School of Medicine, Missouri 63110, USA
    J Virol 69:3007-16. 1995
    ..By deletion analysis, we have identified a TAP C-terminal region rich in acidic amino acids and leucine residues which acts as a strong transcriptional activator when bound through GAL4 sites upstream ..
  82. pmc Caspase-dependent N-terminal cleavage of influenza virus nucleocapsid protein in infected cells
    O P Zhirnov
    D I Ivanovsky Institute of Virology, 123098 Moscow, Russia
    J Virol 73:10158-63. 1999
    ..With D at position -1, acidic amino acids at position -3, and aliphatic ones at positions -2 and +1, the NP cleavage sites show a recognition motif ..
  83. doi Select nutrients and their associated transporters are increased in the ovine uterus following early progesterone administration
    M Carey Satterfield
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 82:224-31. 2010
    ..Thus, select nutrients are increased in the uterine lumen by P4 concomitant with the upregulation of epithelial transporters for glucose and basic amino acids, suggesting that these nutrients stimulate blastocyst growth and development...
  84. pmc Comparative inhibition by hard and soft metal ions of steroid-binding capacity of renal mineralocorticoid receptor cross-linked to the 90-kDa heat-shock protein heterocomplex
    M D Galigniana
    Departamento de Qu approximately ímica Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, and PHROM CONICET, 1428 Buenos Aires, Argentina
    Biochem J 341:585-92. 1999
    ..chemical modification of cysteines with dithionitrobenzoic acid, histidines with diethyl pyrocarbonate and acidic amino acids with Woodward's reagent (N-ethyl-5-phenylisoxazolium-3'-sulphonate)...
  85. ncbi Genes for a second terminal oxidase in Bradyrhizobium japonicum
    M Bott
    Mikrobiologisches Institut, Eidgenossische Technische Hochschule, ETH Zentrum, Zurich, Switzerland
    Arch Microbiol 158:335-43. 1992
    ..This shows that the coxMNOP genes are not essential for respiration in the N2 fixing bacteroid...
  86. ncbi Normal expression and the effects of ectopic expression of the Drosophila muscle segment homeobox (msh) gene suggest a role in differentiation and patterning of embryonic muscles
    P C Lord
    Department of Biochemistry M C 536, University of Illinois, College of Medicine, Chicago 60612, USA
    Dev Biol 171:627-40. 1995
    ..spiracles gene and encodes several stretches of amino acids rich in serine, alanine, proline, glutamine, and acidic amino acids, indicating potential domains of regulatory activity...
  87. ncbi Characterization of a rat Na+-dicarboxylate cotransporter
    X Z Chen
    Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 273:20972-81. 1998
    ..Of note, the acidic amino acids L- and D-glutamate and aspartate were also transported, although with lower affinity (Km = 2-18 mM)...
  88. pmc Aspartate-444 is essential for productive substrate interactions in a neuronal glutamate transporter
    Shlomit Teichman
    Department of Biochemistry, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    J Gen Physiol 129:527-39. 2007
    ..In contrast to acidic amino acids, dicarboxylic acids are not recognized by glutamate transporters, but the related bacterial DctA ..
  89. pmc Identification of acidic and aromatic residues in the Zta activation domain essential for Epstein-Barr virus reactivation
    Z Deng
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Virol 75:10334-47. 2001
    ....
  90. ncbi Influence of an anion-binding site in the stabilization of halophilic malate dehydrogenase from Haloarcula marismortui
    Dominique Madern
    Institut de Biologie Structurale Jean Pierre Ebel, UMR 5075, CEA, CNRS, Universite Joseph Fourier, 41 rue Jules Horowitz, F 38027 Grenoble, France
    Biochimie 89:981-7. 2007
    ..Crystallographic studies have shown that surface enrichment by acidic amino acids is a common structural feature of halophilic proteins...
  91. ncbi Systematic Analysis of proteoglycan modification sites in Caenorhabditis elegans by scanning mutagenesis
    Huan Wang
    Department of Biochemistry and Biophysics, Center for Oral Biology, Aab Institute of Biomedical Sciences, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Biol Chem 282:14586-97. 2007
    ..either one proximal acidic N-terminal amino acid (positions -4, -3, and -2) or a pair of distal N-terminal acidic amino acids (positions -6 and -5)...
  92. ncbi Purification and biochemical characterization of a putative [6Fe-6S] prismane-cluster-containing protein from Desulfovibrio vulgaris (Hildenborough)
    A J Pierik
    Department of Biochemistry, Agricultural University, Wageningen, The Netherlands
    Eur J Biochem 206:697-704. 1992
    ..vulgaris (Monticello) and Desulfovibrio desulfuricans (ATCC 27774). We have not yet identified a physiological function for the prismane protein despite trials for some relevant enzyme activities...
  93. ncbi Acidic amino acids flanking phosphorylation sites in the M2 muscarinic receptor regulate receptor phosphorylation, internalization, and interaction with arrestins
    K B Lee
    Department of Molecular Pharmacology and Biological Chemistry, The Institute for Neuroscience, Northwestern University Medical School, Evanston, Illinois 60208, USA
    J Biol Chem 275:35767-77. 2000
    ..L., and Hosey, M. M. (1997) J. Biol. Chem. 272, 23682-26389). The present study investigated the role of acidic amino acids between P1 and P2 in regulating receptor phosphorylation, internalization, and receptor/arrestin ..
  94. ncbi Nucleotide sequence and evolutionary relationships of cucumber mosaic virus (CMV) strains: CMV RNA 1
    T M Rizzo
    Department of Plant Pathology, Cornell University, Ithaca, New York 14853
    J Gen Virol 70:1-11. 1989
    ..While the C-terminal 141 amino acids contain more basic than acidic amino acids, the region of greatest amino acid sequence heterogeneity, amino acids 503 to 600, contained a preponderance ..
  95. pmc Role of the HCF-1 basic region in sustaining cell proliferation
    Marco Mangone
    Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
    PLoS ONE 5:e9020. 2010
    ..b>acidic amino acids) that is required for cell proliferation and has been shown to associate with the Sin3 histone deacetylase (..
  96. doi Influence of the magnesium aspartate hydrochloride administration to the maternal circuit on the aspartate concentration of the fetal circuit under in vitro perfusion of human placenta
    A Malek
    Department of Obstetrics and Gynecology, University of Berne, Inselspital, Switzerland
    Eur J Obstet Gynecol Reprod Biol 142:12-7. 2009
    ..Animal experiments have demonstrated that highly increased fetal levels of acidic amino acids such as Asp could be associated with neurotoxic damage in the fetal brain...
  97. doi Amino acid adsorption on mesoporous materials: influence of types of amino acids, modification of mesoporous materials, and solution conditions
    Qiang Gao
    State Key Laboratory of Coal Conversion, Institute of Coal Chemistry, Chinese Academy of Sciences, Taiyuan 030001, P R China
    J Phys Chem B 112:2261-7. 2008
    ..Thus, all the adsorption of amino acids on mesoporous silica materials can be decided by the combined influence of two fundamental interactions: electrostatic attraction and hydrophobic effect...
  98. pmc Cooperation of the conserved aspartate 439 and bound amino acid substrate is important for high-affinity Na+ binding to the glutamate transporter EAAC1
    Zhen Tao
    University of Miami School of Medicine, Miami, FL 33136, USA
    J Gen Physiol 129:331-44. 2007
    The neuronal glutamate transporter EAAC1 contains several conserved acidic amino acids in its transmembrane domain, which are possibly important in catalyzing transport and/or binding of co/countertransported cations...
  99. ncbi Two clusters of acidic amino acids near the NH2 terminus of complement component C4 alpha'-chain are important for C2 binding
    Q Pan
    Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
    J Immunol 165:2518-27. 2000
    ..Taken together, these results strongly suggest that the NH2-terminal acidic residue-rich segment of C4 alpha'-chain contributes importantly to the interaction of C4b with C2...
  100. pmc NRC-interacting factor 1 is a novel cotransducer that interacts with and regulates the activity of the nuclear hormone receptor coactivator NRC
    Muktar A Mahajan
    Department of Pharmacology and Medicine, New York University School of Medicine, New York 10016, USA
    Mol Cell Biol 22:6883-94. 2002
    ..containing a number of conserved domains, including six Cys-2/His-2 zinc fingers, an N-terminal stretch of acidic amino acids, and a C-terminal leucine zipper-like motif...
  101. ncbi Mutation at a single acidic amino acid enhances the halophilic behaviour of malate dehydrogenase from Haloarcula marismortui in physiological salts
    D Madern
    Institut de Biologie Structurale, Grenoble, France
    Eur J Biochem 230:1088-95. 1995
    In a statistical analysis of the amino acid compositions of 26 halophilic proteins, 24 showed an increase in acidic amino acids and a decrease in basic ones when compared to their non-halophilic homologues...

Research Grants67

  1. Development of Chemical Receptors for Proteins
    Sanku Mallik; Fiscal Year: 2005
    ..Testing of the synthetic receptors for possible applications in detection of metastatic cancer, imaging and delivery of anti- cancer drugs. ..
  2. Tyrosine Sulfation and Chemokine Receptor Function
    Kevin Moore; Fiscal Year: 2006
    ..domains of all known chemokine receptors (CCRs) contain tyrosine residues in the context of several flanking acidic amino acids, features shared by all known tyrosine sulfated proteins...
  3. FUNCTIONAL SIGNIFICANCE OF THE ACTIN N-TERMINAL REGION
    PETER RUBENSTEIN; Fiscal Year: 1993
    ..grant addresses the importance of three conserved elements of the 18 amino acid actin N-terminal region: the acidic amino acids at the N-terminus of mature processed actin; the conserved Ala-Leu-Val beginning at residue 6; and the ..
  4. Factor Va regulation of prothrombinase activity
    JAMILA HIRBAWI; Fiscal Year: 2006
    ..Proteins will be screened for clotting activity in one-and two-stage clotting assays. Kinetic analyses will be done by measuring thrombin formation. ..
  5. GLUTAMATE TRANSPORTERS IN THE CNS
    Michael Robinson; Fiscal Year: 2009
    ..The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page i_ Description, ..
  6. MECHANISM OF INOSITOL TRISPHOSPHATE ACTION
    Suresh Joseph; Fiscal Year: 2004
    ..Ca2+ is the principal regulator of IP3R and exerts a biphasic effect on channel function. Acidic amino acids in 2 known calcium-binding regions of the IP3R will be mutated...
  7. GLUTAMATE TRANSPORTERS IN THE CNS
    MICHAEL BYRNE ROBINSON; Fiscal Year: 2011
    ..The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page i_ Description, ..
  8. REACTIVE INTERMEDIATES OF ENZYMATIC REACTIONS
    John Richard; Fiscal Year: 2000
    ....
  9. BRAIN ENDOPEPTIDASES AND NEUROPEPTIDE METABOLISM
    Sherwin Wilk; Fiscal Year: 2001
    ....
  10. REGULATION OF EXTRACELLULAR EXCITOTOXINS
    Michael Robinson; Fiscal Year: 2006
    The acidic amino acids, glutamate and aspartate, are the predominant excitatory neurotransmitters in the mammalian CNS. An extracellular accumulation of these excitatory amino acids (EAAs) causes neuronal cell death...
  11. GLUTAMATE TRANSPORTERS IN THE CNS
    Michael Robinson; Fiscal Year: 2001
    DESCRIPTION: The acidic amino acids are the predominant excitatory neurotransmitters in the mammalian central nervous system (CNS)...