Genomes and Genes
acidic amino acids
Summary: Amino acids with side chains that are negatively charged at physiological pH.
Publications233 found, 100 shown here
- Functional analysis of acidic amino acids in the cytosolic tail of the Na+/H+ exchangerXiuju Li
Department of Biochemistry, 347 Medical Science Building, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
Biochemistry 43:16477-86. 2004..Our results demonstrate that the acidic sequence is critical in maintaining proper conformation of the cytosolic domain, calmodulin binding, and in maintenance of Na(+)/H(+) exchanger activity...
- Utilization of acidic amino acids and their amides by pseudomonads: role of periplasmic glutaminase-asparaginaseAvinash Sonawane
Institute of Physiological Chemistry, Philipps University, Marburg Lahn, Germany
Arch Microbiol 179:151-9. 2003The acidic amino acids (Asp, Glu) and their amides (Asn, Gln) support rapid growth of a variety of Pseudomonas strains when provided as the sole source of carbon and nitrogen. All key enzymes of glutamate metabolism were detected in P...
- CDC7 kinase phosphorylates serine residues adjacent to acidic amino acids in the minichromosome maintenance 2 proteinWon Ho Cho
Department of Biology Education, Seoul National University, Seoul 151 742, Korea
Proc Natl Acad Sci U S A 103:11521-6. 2006..This finding may explain why the sequential action of cyclin-dependent and Cdc7 kinases is essential for the initiation of DNA replication...
- Acidic amino acids impart enhanced Ca2+ permeability and flux in two members of the ATP-gated P2X receptor familyDamien S K Samways
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
J Gen Physiol 129:245-56. 2007..2001). Here, we test the hypothesis that the formal charge of acidic amino acids underlies the higher fractional Ca2+ currents (Pf%) of the rat and human P2X1 and P2X4 subtypes...
- Arg143 and Lys192 of the human mast cell chymase mediate the preference for acidic amino acids in position P2' of substratesMattias K Andersson
Department of Cell and Molecular Biology, Uppsala University, The Biomedical Center, Uppsala, Sweden
FEBS J 277:2255-67. 2010..of eight such chymases have been determined, and four of these were shown to have a strong preference for acidic amino acids at position P2'. These enzymes have basic amino acids in positions 143 and 192 (Arg and Lys, respectively)...
- Towards control of aggregational behaviour of alpha-lactalbumin at acidic pHJane B Pedersen
Institute of Physics and Nanotechnology, Aalborg University, Aalborg, Denmark
J Fluoresc 16:611-21. 2006..The results presented in this paper provide detailed knowledge on the external parameters leading to aggregation of alpha-La at acidic pH, thus permitting rational design of the aggregation process...
- Hydrophobic and acidic moments of a nucleoplasmin NP-core chaperoneB David Silverman
IBM Thomas J Watson Research Center, Yorktown Heights, NY 10598, USA
J Biomol Struct Dyn 24:49-56. 2006..It is also pointed out that the prevalence of basic residues on the short helices of the histone cores also provides regions of charge that would complement histone binding to the chaperone...
- Structural basis for budding by the ESCRT-III factor CHMP3Tadeusz Muzioł
European Molecular Biology Laboratory, 6 rue Jules Horowitz, 38042 Grenoble, France
Dev Cell 10:821-30. 2006..Thus, the final steps in the budding process may include CHMP protein polymerization and lattice formation on membranes by employing different bilayer-recognizing surfaces, a function shared by all CHMP family members...
- The alpha-helix of the second chromodomain of the 43 kDa subunit of the chloroplast signal recognition particle facilitates binding to the 54 kDa subunitRebecca Hermkes
Lehrstuhl für Allgemeine und Molekulare Botanik, Ruhr Universitat Bochum, 44780 Bochum, Germany
FEBS Lett 580:3107-11. 2006..Further analysis of the binding interface of cpSRP by mutagenesis studies and a pepscan approach demonstrates that the C-terminal alpha-helix of CD2 facilitates binding to cpSRP54...
- Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse developmentShihui Liu
Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Cell Biol 26:3835-41. 2006..These results attest to the physiological importance of Dph3 in development. The biological roles of Dph3 are also discussed...
- DNA binding provides a molecular strap activating the adenovirus proteinaseSayan Gupta
Center for Synchrotron Biosciences, Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Mol Cell Proteomics 3:950-9. 2004..In addition, both pVIc and DNA may independently alter the active site conformation as well as drive it cooperatively to fully activate AVP...
- A novel theory on the origin of the genetic code: a GNC-SNS hypothesisKenji Ikehara
Department of Chemistry, Faculty of Science, Nara Women s University, Kita Uoya Nishi machi, Nara 630 8506, Japan
J Mol Evol 54:530-8. 2002..Thus, we concluded that the universal genetic code originated not from a three-amino acid system but from a four-amino acid system, the GNC code encoding [GADV]-proteins, as the most primitive genetic code...
- Geometry of nonbonded interactions involving planar groups in proteinsPinak Chakrabarti
Department of Biochemistry and Bioinformatics Centre, Bose Institute, P 1 12 CIT Scheme VIIM, Kolkata 700054, India
Prog Biophys Mol Biol 95:83-137. 2007..The geometrical relationship between interacting residues provides valuable insights into the process of protein folding and would be useful for the design of protein molecules and modulation of their binding properties...
- Redox potential difference between Desulfovibrio vulgaris and Clostridium beijerinckii flavodoxinsHiroshi Ishikita
Department of Chemistry, University of Southern California, Los Angeles, California 90089, USA
Biochemistry 47:4394-402. 2008..The E sq/hq difference can be best explained by the lower compensation of the side chain influence by the backbone influence in the D. vulgaris flavodoxin than in the C. beijerinckii flavodoxin...
- Increasing the potency of a cytotoxin with an arginine graftStephen M Fuchs
Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706 1544, USA
Protein Eng Des Sel 20:505-9. 2007..These findings correlate the potency of a ribonuclease with its deliverance of ribonucleolytic activity to the cytosol, and indicate a rational means to enhance the efficacy of ribonucleases and other cytotoxic proteins...
- Cooperative interactions between R531 and acidic residues in the voltage sensing module of hERG1 channelsDavid R Piper
Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84113, USA
Cell Physiol Biochem 21:37-46. 2008..We propose that hERG1 activation involves a cooperative conformational change involving the entire voltage sensing module, while inactivation may involve a more limited interaction between R531 and D456, D460 and D509...
- The acidic repetitive domain of the Magnetospirillum gryphiswaldense MamJ protein displays hypervariability but is not required for magnetosome chain assemblyAndré Scheffel
Max Planck Institute for Marine Microbiology, Bremen, Germany
J Bacteriol 189:6437-46. 2007....
- Interactions between neuronal fusion proteins explored by molecular dynamicsMarie Pierre Durrieu
Institut de Biologie Physico Chimique, Laboratoire de Biochimie Theorique, Centre National de la Recherche Scientifique, UPR 9080, Paris, France
Biophys J 94:3436-46. 2008..The interaction patterns we observe provide a new tool for interpreting the impact of mutations on the complex...
- Non-covalent interactions between unsolvated peptides: helical complexes based on acid-base interactionsRajagopalan Sudha
Chemistry Department, Indiana University, Bloomington, Indiana 47405 7102, USA
J Phys Chem B 109:6442-7. 2005..The enthalpy change indicates that the interaction between the E and K residues in the middle of the helices is a weak neutral hydrogen bond. The EKK interaction is significantly stronger...
- A di-acidic sequence motif enhances the surface expression of the potassium channel TASK-3Marylou Zuzarte
Institute of Physiology, Marburg University, Deutschhausstr 2, 35037 Marburg, Germany
Traffic 8:1093-100. 2007..Our data suggest that the di-acidic motif, EDE, in human TASK-3 is a major determinant of the rate of ER export and is required for efficient surface expression of the channel...
- Ammonium assimilation and amino acid metabolism in conifersFrancisco M Canovas
Departamento de Biologia Molecular y Bioquimica, Instituto Andaluz de Biotecnología, Unidad Asociada UMA CSIC, Universidad de Malaga, E 29071 Malaga, Spain
J Exp Bot 58:2307-18. 2007..In this paper, details of recent progress in our understanding of the metabolism of arginine and the other major amino acids glutamine, glutamate, aspartate, and asparagine in pine, a conifer model tree, are presented and discussed...
- Chemiluminescent studies on the antioxidant activity of amino acidsT M Triantis
Institute of Physical Chemistry, NCSR Demokritos, 15310 Ag Paraskevi, Athens, Greece
Anal Chim Acta 591:106-11. 2007..Amino acids with phenolic groups present higher inhibition than basic, acidic or neutral amino acids. The calculated antioxidant activities by the CL method are compared with those of the N,N-diphenyl-picryl hydrazyl (DPPH) method...
- Effects of hydrogen-bonding and stacking interactions with amino acids on the acidity of uracilKen C Hunter
Department of Chemistry, Mount Allison University, 63C York Street, Sackville, New Brunswick E4L 1G8, Canada
J Phys Chem B 111:1858-71. 2007..The present study has general implications for understanding the nature of active site amino acids in enzymes, such as DNA repair enzymes, that catalyze reactions involving anionic nucleobase intermediates...
- A class of novel nitronyl nitroxide labeling basic and acidic amino acids: synthesis, application for preparing ESR optionally labeling peptides, and bioactivity investigationsJianwei Zhang
College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China
Bioorg Med Chem 16:4019-28. 2008..Their incorporation led to 12 novel ESR optionally labeling PAK, RGDS, RGDV, and ECG. A series of NO related chemical tests, the in vitro and in vivo assays of these peptides confirmed that this strategy was practical...
- Covalent cross-linking of proteins without chemical reagentsBrigitte L Simons
Centre for Biologics Research, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa, Canada K1A 0L2
Protein Sci 11:1558-64. 2002....
- pH sensing in the two-pore domain K+ channel, TASK2Michael J Morton
School of Biomedical Sciences, Medical and Dental Building, University of Leeds, Leeds LS2 9NQ, United Kingdom
Proc Natl Acad Sci U S A 102:16102-6. 2005..Thus, pH sensing in TASK2 channels is conferred by the combined action of several charged residues in the large extracellular M1-P1 loop...
- An acidic peptide sequence of nucleolin-related protein can mediate the attachment of calcium oxalate to renal tubule cellsElena A Sorokina
Nephrology Division, Medical College of Wisconsin, Milwaukee, WI, USA
J Am Soc Nephrol 15:2057-65. 2004..These results support the notion that surface-associated NRP could mediate attachment of CaOx to the renal tubule epithelium, thereby causing retention of crystals that might eventually become kidney stones...
- Structural basis for a non-phosphorus-containing cyclic peptide binding to Grb2-SH2 domain with high affinityPeng Li
Laboratory of Medicinal Chemistry, National Cancer Institute, National Institutes of Health, 376 Boyles Street, Frederick, MD 21702 1201, USA
Biochem Biophys Res Commun 307:1038-44. 2003..Whole cell assays indicate that peptide 20 can penetrate the cell membranes and inhibit the association of Grb2 with p185(erbB2) in erbB2-overexpressing MDA-MA-453 cancer cells at low micromolar concentrations...
- Identification and mutational analysis of Mg2+ binding site in EcoP15I DNA methyltransferase: involvement in target base eversionPradeep Bist
Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India
J Biol Chem 278:41837-48. 2003..This is the first example of metal-dependent function of a DNA methyltransferase. These findings provide impetus for exploring the role(s) of metal ions in the structure and function of DNA methyltransferases...
- The parsley plastocyanin-turnip cytochrome f complex: a structurally distorted but kinetically functional acidic patchPeter B Crowley
Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Av da Republica, Apartado 127, 2781 901 Oeiras, Portugal
Biochem J 378:45-51. 2004..The results of NMR studies and protein-docking simulations indicate that parsley PCu and its spinach analogue adopt different orientations in their complexes with cyt f...
- NMR solution structure of the archaebacterial chromosomal protein MC1 reveals a new protein foldFrançoise Paquet
Centre de Biophysique Moleculaire, CNRS, rue Charles Sadron, 45071 Orleans Cedex 2, France
Biochemistry 43:14971-8. 2004..Its structure suggests a different DNA-binding mode than those of the histone-like proteins HU or HMGB. Thus, MC1 may be classified as a member of a new family...
- Solution structure of coactosin reveals structural homology to ADF/cofilin family proteinsMaarit Hellman
Program in Structural Biology and Biophysics, Institute of Biotechnology, University of Helsinki, Finland
FEBS Lett 576:91-6. 2004..Our analysis also identifies key structural differences between these proteins that may account for the differences in biochemical activities and cellular roles of these proteins...
- Immunoglobulin kappa light chain and its amyloidogenic mutants: a molecular dynamics studyMateusz Nowak
Department of Biostatistics and Medical Informatics, Collegium Medicum, and Faculty of Biotechnology, Jagiellonian University, Krakow, Poland
Proteins 55:11-21. 2004..This suggests that mild and slow destabilization is the reason of the conversion of V(L) to partially folded amyloidogenic intermediate structure...
- MAP2 prevents protein aggregation and facilitates reactivation of unfolded enzymesTaradas Sarkar
Department of Biochemistry, Centenary Campus, PI 12, Bose Institute, CIT Scheme VIIM, Calcutta 700 054, India
Eur J Biochem 271:1488-96. 2004..Tau, which shares a homologous C-terminal domain with MAP2, possesses no such activity...
- Cell surface adhesion of pregnancy-associated plasma protein-A is mediated by four clusters of basic residues located in its third and fourth CCP moduleKathrin Weyer
Department of Molecular Biology, Science Park, University of Aarhus, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
Eur J Biochem 271:1525-35. 2004..This explains, at least in part, why PAPP-A2 lacks the ability of cell surface adhesion, and further emphasizes the role of the basic clusters defined in PAPP-A...
- Characterization and location of post-translational modifications on chromogranin B from bovine adrenal medullary chromaffin granulesClaire Gasnier
INSERM Unité 575, Physiopathologie du Système Nerveux, Strasbourg, France
Proteomics 4:1789-801. 2004..Furthermore, we have identified at the molecular level the presence of a mutation M/V on position 577 of natural CGB. All together these data reflect the complex structure of this protein marker of the neuroendocrine system...
- The cytoplasmic domain of the Plasmodium falciparum ligand EBA-175 is essential for invasion but not protein traffickingTim Wolf Gilberger
The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
J Cell Biol 162:317-27. 2003..These results show that the parasite uses the same components of its cellular machinery for invasion regardless of the host cell type and invasive form...
- Sequence context strongly modulates association of polar residues in transmembrane helicesJessica P Dawson
Department of Molecular Biophysics and Biochemistry, Yale University, Bass Centre Room 420A, 266 Whitney Avenue, New Haven, CT 06520 8114, USA
J Mol Biol 331:255-62. 2003..Overall, these results suggest that an innate structural mechanism may operate to control non-specific association of membrane-embedded polar residues...
- A ring of eight conserved negatively charged amino acids doubles the conductance of BK channels and prevents inward rectificationTinatin I Brelidze
Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 N W 10th Avenue, Miami, FL 33136, USA
Proc Natl Acad Sci U S A 100:9017-22. 2003..Removing the ring of charge converts BK channels to inwardly rectifying channels. Thus, a simple electrostatic mechanism contributes to the large conductance of BK channels...
- Both acidic and basic amino acids in an amphitropic enzyme, CTP:phosphocholine cytidylyltransferase, dictate its selectivity for anionic membranesJoanne E Johnson
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
J Biol Chem 278:514-22. 2003..Thus anionic lipids, working via surface-localized pH effects, can promote membrane binding by modifying protein charge and hydrophobicity, and this novel mechanism contributes to the membrane selectivity of CT in vivo...
- Tools for building a comprehensive modeling system for virtual screening under real biological conditions: The Computational Titration algorithmGlen E Kellogg
Department of Medicinal Chemistry and Institute for Structural Biology and Drug Discovery, School of Pharmacy, Virginia Commonwealth University, Box 980540, Richmond, VA 23298 0540, USA
J Mol Graph Model 24:434-9. 2006..As an example, three complexes of dihydrofolate reductase (DHFR) are analyzed with our system and these results are compared with the experimental free energies of binding...
- Calcium regulation of inositol 1,4,5-trisphosphate receptorsSuresh K Joseph
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Rm 230A JAH, 1020 Locust Street, Philadelphia, PA 19107, USA
Cell Calcium 38:539-46. 2005..The data support the view that all IP3R isoforms may display a range of Ca2+ sensitivities that are determined by multiple sites within the protein and markedly influenced by the affinity of the receptor for IP3...
- Ion-ion and ion-molecule reactions at the surface of proteins produced by nanospray. Information on the number of acidic residues and control of the number of ionized acidic and basic residuesUdo H Verkerk
Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada
J Am Soc Mass Spectrom 16:1325-41. 2005....
- Piv site-specific invertase requires a DEDD motif analogous to the catalytic center of the RuvC Holliday junction resolvasesJohn M Buchner
Department of Microbiology, University of Georgia, Athens, GA 30602 2605, USA
J Bacteriol 187:3431-7. 2005..On the basis of these results, a working model for Piv-mediated inversion that includes resolution of a Holliday junction is presented...
- Characterization of calcium binding properties of lithostathineByung In Lee
Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA
J Biol Inorg Chem 8:341-7. 2003....
- Are acidic and basic groups in buried proteins predicted to be ionized?Jinrang Kim
Physics Department J 419, City College of New York, 138th Street and Convent Avenue, New York, NY 10031, USA
J Mol Biol 348:1283-98. 2005..Thus, hydroxyls are better hydrogen bond donors than acceptors. Buried ionized residues are more likely to be conserved than those on the surface. There are 3.95 residues buried per 100 residues in an average protein...
- Structure of calmodulin complexed with an olfactory CNG channel fragment and role of the central linker: residual dipolar couplings to evaluate calmodulin binding modes outside the kinase familyGian Marco Contessa
Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133, Rome, Italy
J Biomol NMR 31:185-99. 2005..Excluded regions comprise calcium binding loops and loops connecting the EF-hand motifs...
- The luteinizing hormone receptor: influence of buffer composition on ligand binding and signaling of wild type and mutant receptorsKrassimira Angelova
Department of Biochemistry and Molecular Biology, University of Georgia, Life Sciences Building, Green Street, Athens, GA 30602 7229, USA
Mol Cell Endocrinol 204:1-9. 2003....
- Low and high affinity amino acid H+-cotransporters for cellular import of neutral and charged amino acidsWolf N Fischer
Plant Physiology, Zentrum für Molekularbiologie der Pflanzen, Tubingen, Germany
Plant J 29:717-31. 2002Amides and acidic amino acids represent the major long distance transport forms of organic nitrogen. Six amino acid permeases (AAPs) from Arabidopsis mediating transport of a wide spectrum of amino acids were isolated...
- Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)Y Kanai
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181, Japan
J Biol Chem 273:23629-32. 1998..neutral amino acids with branched or aromatic side chains and did not accept basic amino acids or acidic amino acids. The transport via LAT1 was Na+-independent and sensitive to a system L-specific inhibitor 2-aminobicyclo-(2,..
- Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase IIJ A Girault
Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York 10021
J Biol Chem 264:21748-59. 1989..2-fold increase in the Vmax and a 1.4-fold increase in the apparent Km. Phosphorylation of DARPP-32 by casein kinase II in intact cells may therefore modulate its phosphorylation in response to increased levels of cAMP...
- Rat kidney carboxylesterase. Cloning, sequencing, cellular localization, and relationship to rat liver hydrolaseB Yan
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City 66160 7417
J Biol Chem 269:29688-96. 1994....
- A two-alpha-helix extra domain mediates the halophilic character of a plant-type ferredoxin from halophilic archaeaBianca Lucia Marg
Max Planck Institut fur Biochemie, Abteilung Membranbiochemie, Am Klopferspitz 18a, 82152 Martinsried, Germany
Biochemistry 44:29-39. 2005..ferredoxins except for an insertion of 30 amino acids near its N-terminus which is extremely rich in acidic amino acids. Unfolding studies reveal that HsFdx has an unfolding temperature of approximately 85 degrees C in 4...
- LSA: a new liver-specific antigen in the rat. I. Purification and characterizationA A Mihas
Division of Digestive Diseases, University of Mississippi School of Medicine, Jackson
Int Arch Allergy Immunol 98:35-49. 1992..The amino acid composition of the LSA revealed that the acidic amino acids out-number the basic amino acids, with glutamic acid being the most abundant of them...
- A-type ATP binding consensus sequences are critical for the catalytic activity of the calmodulin-sensitive adenylyl cyclase from Bacillus anthracisZ G Xia
Department of Pharmacology, School of Medicine, University of Washington, Seattle 98195
J Biol Chem 265:6517-20. 1990..It is concluded that Lys-346 and Lys-353 in B. anthracis adenylyl cyclase may interact directly with ATP and contribute to the binding of the nucleotide to the enzyme...
- Replacements of single basic amino acids in the pleckstrin homology domain of phospholipase C-delta1 alter the ligand binding, phospholipase activity, and interaction with the plasma membraneH Yagisawa
Department of Life Science, Faculty of Science, Himeji Institute of Technology, Harima Science Garden City, Hyogo 678 12, Japan
J Biol Chem 273:417-24. 1998..All residues (with the exception of the K43E substitution) found to be critical for the analyzed PLC-delta1 functions are present at the surface of the PH domain shown to contain the Ins(1,4,5)P3 binding pocket...
- Electron transfer in Paracoccus denitrificans with the modified fbc operonV Dadak
Institute of Biochemistry, Faculty of Science, Masaryk University, Brno, Czechia
Folia Microbiol (Praha) 54:475-82. 2009..The mutant strain M 71 expressing the truncated copy of cytochrome c(1) (devoid of a stretch of 150 mainly acidic amino acids) was less sensitive to increasing concentration of cytochrome c and changes in ionic strength of the medium, ..
- Phosphorylation of the angiotensin II (AT1A) receptor carboxyl terminus: a role in receptor endocytosisW G Thomas
Baker Medical Research Institute, Melbourne, Australia
Mol Endocrinol 12:1513-24. 1998..sites (Thr332, Ser335, Thr336, and Ser338) were substituted with either neutral [alanine (A)] or acidic amino acids [glutamic acid (E) and aspartic acid (D)], the former to prevent phosphorylation and the latter to reproduce ..
- Electrostatic attraction between cytochrome bc1 and cytochrome c affects kinetics of cytochrome c reductionV Dadak
Institute of Biochemistry, Faculty of Science, Masaryk University, Brno, Czech Republic
Biochemistry (Mosc) 73:870-80. 2008..The cytochrome c(1) of the WT samples possessed an additional stretch of acidic amino acids, which was lacking in the mutant...
- Involvement of phylogenetically conserved acidic amino acid residues in catalysis by an oxidative DNA damage enzyme formamidopyrimidine glycosylaseO V Lavrukhin
Sealy Center for Molecular Science, Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555 1071, USA
Biochemistry 39:15266-71. 2000..However, in contrast to other enzymes in this class, in which acidic amino acids have been shown to be essential for glycosyl and phosphodiester bond scission, the catalytically essential ..
- Molecular cloning of a histidine-rich Ca2+-binding protein of sarcoplasmic reticulum that contains highly conserved repeated elementsS L Hofmann
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
J Biol Chem 264:18083-90. 1989..tandem repeats of 29 residues, each consisting of a histidine-rich sequence HRHRGH, a stretch of 10-11 acidic amino acids, and a sequence containing 2 serines and a threonine in a negatively charged context; 3) a 13-residue ..
- Homology models of the Yersinia pseudotuberculosis and Yersinia pestis general porins and comparative analysis of their functional and antigenic regionsG N Likhatskaya
Pacific Institute of Bioorganic Chemistry of Far East Branch of Russian Academy of Sciences, Vladivostok, Pr 100 Let Vladivostoku 159, 690022 Russia
J Biomol Struct Dyn 23:163-74. 2005..located in the loop L3 tip that disturbs the functionally important cluster of the acidic amino acids in the constriction site. Comparative analysis of structural organization of YPS and E...
- Contribution of amino acid region 659-663 of Factor Va heavy chain to the activity of factor Xa within prothrombinase JAMILA HIRBAWI
Department of Chemistry, Cleveland State University, Cleveland, Ohio 44115, USA
Biochemistry 49:8520-34. 2010....
- Identification of a novel Na+-independent acidic amino acid transporter with structural similarity to the member of a heterodimeric amino acid transporter family associated with unknown heavy chainsHirotaka Matsuo
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
J Biol Chem 277:21017-26. 2002..proteins were sorted to the plasma membrane and expressed the Na(+)-independent transport activity for acidic amino acids. Distinct from the Na(+)-independent cystine/glutamate transporter xCT structurally related to AGT1, AGT1 ..
- cDNA cloning of a novel protein containing two zinc-finger domains that may function as a transcription factor for the human heme-oxygenase-1 geneY Muraosa
Department of Applied Physiology and Molecular Biology, Tohoku University School of Medicine, Sendai, Japan
Eur J Biochem 235:471-9. 1996..possesses other structural features characteristic of transcription factors, including a long stretch of acidic amino acids (amino acids 67 - 95), a proline-rich region (positions 733-849), a region rich in basic amino acids (..
- Evaluation of the RBE4 cell line to explore carrier-mediated drug delivery to the CNS via the L-system amino acid transporter at the blood-brain barrierAndreas Reichel
Blood Brain Barrier Research Group, Centre for Neuroscience Research, GKT School of Biomedical Sciences, King s College London, UK
J Drug Target 10:277-83. 2002..such as L-phenylalanine and 2-aminobicyclo-heptanecarboxylic acid (BCH), whereas small neutral, basic and acidic amino acids had no significant effect...
- The computer modelling of human TRH receptor, TRH and TRH-like peptidesR Bilek
Institute of Endocrinology, First Faculty of Medicine, Charles University, Narodni 8, 11694 Prague 1, Cech Republic
Physiol Res 54:141-50. 2005..Desamido-TRH or glutamyl metabolites will be repelled by the negative potential of ASP195 (E: D93) and GLU298 (G: E137)...
- The c-erbA alpha-encoded thyroid hormone receptor is phosphorylated in its amino terminal domain by casein kinase IIC Glineur
INSERM U186 CNRS UA 1160, Institut Pasteur, Lille, France
Oncogene 4:1247-54. 1989....
- Aspartic acid 405 contributes to the substrate specificity of aminopeptidase BKayoko M Fukasawa
Department of Hard Tissue Research, Graduate School of Oral Medicine, Matsumoto Dental University, School of Dentistry, Shiojiri, Nagano 399 0781, Japan
Biochemistry 45:11425-31. 2006..These data strongly suggest that the Asp 405 residue is involved in substrate binding via an interaction with the P1 amino group of the substrate's side chain...
- Molecular cloning and characterization of a cellular protein that interacts with the human immunodeficiency virus type 1 Tat transactivator and encodes a strong transcriptional activation domainL Yu
Institute for Molecular Virology, Saint Louis University School of Medicine, Missouri 63110, USA
J Virol 69:3007-16. 1995..By deletion analysis, we have identified a TAP C-terminal region rich in acidic amino acids and leucine residues which acts as a strong transcriptional activator when bound through GAL4 sites upstream ..
- Mutation effects of a conserved alanine (Ala510) in type I polyhydroxyalkanoate synthase from Ralstonia eutropha on polyester biosynthesisTakeharu Tsuge
Department of Innovative and Engineered Materials, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama, Kanagawa 226 8502, Japan
Macromol Biosci 4:963-70. 2004..In particular, substitution by acidic amino acids, A510D(E), led to remarkable increases in molecular weights...
- Modulators of the activation of the proteasome by PA28 (11S reg)S Wilk
Department of Pharmacology, Mount Sinai School of Medicine, New York, NY 10029, USA
Mol Biol Rep 26:39-44. 1999..PA28- proteasome modulators by modifying the profile of peptides produced by the activated proteasome, may either enhance or suppress the immune response...
- Caspase-dependent N-terminal cleavage of influenza virus nucleocapsid protein in infected cellsO P Zhirnov
D I Ivanovsky Institute of Virology, 123098 Moscow, Russia
J Virol 73:10158-63. 1999..With D at position -1, acidic amino acids at position -3, and aliphatic ones at positions -2 and +1, the NP cleavage sites show a recognition motif ..
- Genes for a second terminal oxidase in Bradyrhizobium japonicumM Bott
Mikrobiologisches Institut, Eidgenossische Technische Hochschule, ETH Zentrum, Zurich, Switzerland
Arch Microbiol 158:335-43. 1992..This shows that the coxMNOP genes are not essential for respiration in the N2 fixing bacteroid...
- Select nutrients and their associated transporters are increased in the ovine uterus following early progesterone administrationM Carey Satterfield
Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
Biol Reprod 82:224-31. 2010..Thus, select nutrients are increased in the uterine lumen by P4 concomitant with the upregulation of epithelial transporters for glucose and basic amino acids, suggesting that these nutrients stimulate blastocyst growth and development...
- Comparative inhibition by hard and soft metal ions of steroid-binding capacity of renal mineralocorticoid receptor cross-linked to the 90-kDa heat-shock protein heterocomplexM D Galigniana
Departamento de Qu approximately ímica Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, and PHROM CONICET, 1428 Buenos Aires, Argentina
Biochem J 341:585-92. 1999..chemical modification of cysteines with dithionitrobenzoic acid, histidines with diethyl pyrocarbonate and acidic amino acids with Woodward's reagent (N-ethyl-5-phenylisoxazolium-3'-sulphonate)...
- Characterization of a rat Na+-dicarboxylate cotransporterX Z Chen
Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 273:20972-81. 1998..Of note, the acidic amino acids L- and D-glutamate and aspartate were also transported, although with lower affinity (Km = 2-18 mM)...
- Normal expression and the effects of ectopic expression of the Drosophila muscle segment homeobox (msh) gene suggest a role in differentiation and patterning of embryonic musclesP C Lord
Department of Biochemistry M C 536, University of Illinois, College of Medicine, Chicago 60612, USA
Dev Biol 171:627-40. 1995..spiracles gene and encodes several stretches of amino acids rich in serine, alanine, proline, glutamine, and acidic amino acids, indicating potential domains of regulatory activity...
- Aspartate-444 is essential for productive substrate interactions in a neuronal glutamate transporterShlomit Teichman
Department of Biochemistry, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
J Gen Physiol 129:527-39. 2007..In contrast to acidic amino acids, dicarboxylic acids are not recognized by glutamate transporters, but the related bacterial DctA ..
- Identification of acidic and aromatic residues in the Zta activation domain essential for Epstein-Barr virus reactivationZ Deng
The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
J Virol 75:10334-47. 2001....
- Acidic amino acids flanking phosphorylation sites in the M2 muscarinic receptor regulate receptor phosphorylation, internalization, and interaction with arrestinsK B Lee
Department of Molecular Pharmacology and Biological Chemistry, The Institute for Neuroscience, Northwestern University Medical School, Evanston, Illinois 60208, USA
J Biol Chem 275:35767-77. 2000..L., and Hosey, M. M. (1997) J. Biol. Chem. 272, 23682-26389). The present study investigated the role of acidic amino acids between P1 and P2 in regulating receptor phosphorylation, internalization, and receptor/arrestin ..
- Purification and biochemical characterization of a putative [6Fe-6S] prismane-cluster-containing protein from Desulfovibrio vulgaris (Hildenborough)A J Pierik
Department of Biochemistry, Agricultural University, Wageningen, The Netherlands
Eur J Biochem 206:697-704. 1992..vulgaris (Monticello) and Desulfovibrio desulfuricans (ATCC 27774). We have not yet identified a physiological function for the prismane protein despite trials for some relevant enzyme activities...
- Influence of an anion-binding site in the stabilization of halophilic malate dehydrogenase from Haloarcula marismortuiDominique Madern
Institut de Biologie Structurale Jean Pierre Ebel, UMR 5075, CEA, CNRS, Universite Joseph Fourier, 41 rue Jules Horowitz, F 38027 Grenoble, France
Biochimie 89:981-7. 2007..Crystallographic studies have shown that surface enrichment by acidic amino acids is a common structural feature of halophilic proteins...
- Nucleotide sequence and evolutionary relationships of cucumber mosaic virus (CMV) strains: CMV RNA 1T M Rizzo
Department of Plant Pathology, Cornell University, Ithaca, New York 14853
J Gen Virol 70:1-11. 1989..While the C-terminal 141 amino acids contain more basic than acidic amino acids, the region of greatest amino acid sequence heterogeneity, amino acids 503 to 600, contained a preponderance ..
- Role of the HCF-1 basic region in sustaining cell proliferationMarco Mangone
Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
PLoS ONE 5:e9020. 2010..b>acidic amino acids) that is required for cell proliferation and has been shown to associate with the Sin3 histone deacetylase (..
- TRH-like peptides in prostate gland and other tissuesR Bilek
Institute of Endocrinology, Prague, Czech Republic
Physiol Res 49:S19-26. 2000..characterized by substitution of the basic amino acid histidine (related to authentic TRH) for neutral or acidic amino acids, such as glutamic acid, phenylalanine, glutamine or tyrosine...
- Rapid evolution of variants in a rodent multigene family encoding salivary proteinsD P Dickinson
Department of Biological Chemistry, University of Texas Health Science Center, Houston 77025
Mol Biol Evol 6:80-102. 1989..The spot protein sequence comprises three domains: an N-terminal domain rich in hydroxy and acidic amino acids, a central domain consisting of repeats of a 9-amino-acid sequence, and a C-terminal domain that in the ..
- Cooperation of the conserved aspartate 439 and bound amino acid substrate is important for high-affinity Na+ binding to the glutamate transporter EAAC1Zhen Tao
University of Miami School of Medicine, Miami, FL 33136, USA
J Gen Physiol 129:331-44. 2007The neuronal glutamate transporter EAAC1 contains several conserved acidic amino acids in its transmembrane domain, which are possibly important in catalyzing transport and/or binding of co/countertransported cations...
- NRC-interacting factor 1 is a novel cotransducer that interacts with and regulates the activity of the nuclear hormone receptor coactivator NRCMuktar A Mahajan
Department of Pharmacology and Medicine, New York University School of Medicine, New York 10016, USA
Mol Cell Biol 22:6883-94. 2002..containing a number of conserved domains, including six Cys-2/His-2 zinc fingers, an N-terminal stretch of acidic amino acids, and a C-terminal leucine zipper-like motif...
- Amino acid adsorption on mesoporous materials: influence of types of amino acids, modification of mesoporous materials, and solution conditionsQiang Gao
State Key Laboratory of Coal Conversion, Institute of Coal Chemistry, Chinese Academy of Sciences, Taiyuan 030001, P R China
J Phys Chem B 112:2261-7. 2008..Thus, all the adsorption of amino acids on mesoporous silica materials can be decided by the combined influence of two fundamental interactions: electrostatic attraction and hydrophobic effect...
- Two clusters of acidic amino acids near the NH2 terminus of complement component C4 alpha'-chain are important for C2 bindingQ Pan
Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
J Immunol 165:2518-27. 2000..Taken together, these results strongly suggest that the NH2-terminal acidic residue-rich segment of C4 alpha'-chain contributes importantly to the interaction of C4b with C2...
- Rat kidney glutamyl aminopeptidase (aminopeptidase A): molecular identity and cellular localizationL Song
Department of Pharmacology, Mount Sinai School of Medicine, City University of New York, New York 10029
Am J Physiol 267:F546-57. 1994....
- Mutation at a single acidic amino acid enhances the halophilic behaviour of malate dehydrogenase from Haloarcula marismortui in physiological saltsD Madern
Institut de Biologie Structurale, Grenoble, France
Eur J Biochem 230:1088-95. 1995In a statistical analysis of the amino acid compositions of 26 halophilic proteins, 24 showed an increase in acidic amino acids and a decrease in basic ones when compared to their non-halophilic homologues...
- Influence of the magnesium aspartate hydrochloride administration to the maternal circuit on the aspartate concentration of the fetal circuit under in vitro perfusion of human placentaA Malek
Department of Obstetrics and Gynecology, University of Berne, Inselspital, Switzerland
Eur J Obstet Gynecol Reprod Biol 142:12-7. 2009..Animal experiments have demonstrated that highly increased fetal levels of acidic amino acids such as Asp could be associated with neurotoxic damage in the fetal brain...
- An aspartate aminotransferase from an extremely thermophilic bacterium, Thermus thermophilus HB8A Okamoto
Department of Biology, Faculty of Science, Osaka University, Toyonaka
J Biochem 119:135-44. 1996..Despite the high degree of conservation of active-site residues, Arg292 in E. coli AspAT, which interacts with the distal carboxylate of the substrate, was not found in T. thermophilus AspAT. Arg89 may complement the function of Arg292...
- Characterization of porcine osteonectin extracted from foetal calvariaeC Domenicucci
Medical Research Council Group in Periodontal Physiology, Faculty of Dentistry, University of Toronto, Ontario, Canada
Biochem J 253:139-51. 1988..one-half of the subsequent 35 residues identified as small hydrophobic amino acids and one-quarter as acidic amino acids. The only significant difference between the N-terminal sequences of the bovine and porcine proteins was the ..
- Identification of amino acids in the transmembrane and juxtamembrane domains of the platelet-derived growth factor receptor required for productive interaction with the bovine papillomavirus E5 proteinL M Petti
Department of Microbiology, Immunology, and Molecular Genetics, Albany Medical College, New York, USA
J Virol 71:7318-27. 1997..These results establish that the E5 protein and v-Sis recognize distinct binding sites on the PDGF beta receptor and further clarify the nature of the interaction between the viral transforming protein and its cellular target...
- Catalytic site studies on tuna (Thunnus albacares) pyloric caeca aminopeptidaseM Hajjou
Laboratoire de Biologie Marine, Concarneau, France
Biochim Biophys Acta 1251:139-44. 1995..Diethylpyrocarbonate did not affect the activity of both native and zinc-depleted tAP suggesting that histidine is not involved in the zinc-ligand formation...
- Serine phosphorylation by casein kinase II controls endocytic L1 trafficking and axon growthAsuka Nakata
Laboratory for Neuronal Growth Mechanisms, RIKEN Brain Science Institute, Wako, Saitama, Japan
J Neurosci Res 85:723-34. 2007..Neurosci. 21:9194-9203). Adjacent to the AP-2 recognition site, the L1 cytoplasmic domain has a cluster of acidic amino acids containing Ser1181 that can be phosphorylated by casein kinase II (CKII; Wong et al. [1996a] J. Neurochem...
- Acidic residues in the purine binding site govern the 6-oxopurine specificity of the Leishmania donovani xanthine phosphoribosyltransferaseBuddy Ullman
Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland, OR 97239, USA
Int J Biochem Cell Biol 42:253-62. 2010..Analysis of the purine binding domains showed two conserved acidic amino acids; glutamate residues in the xanthine phosphoribosyltransferase (E198 and E215) and aspartate residues in the ..
- Specific phosphorylation of the acidic central region of the N-myc protein by casein kinase IIT Hagiwara
Laboratory of Biological Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
Eur J Biochem 209:945-50. 1992..We have noted that the sequence of serine followed by a cluster of acidic amino acids is exactly the same as that of a typical substrate of casein kinase II (CKII)...
- GLUTAMATE TRANSPORTERS IN THE CNSMICHAEL BYRNE ROBINSON; Fiscal Year: 2011..The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page i_ Description, ..
- PROTEIN SEQUENCING BY TANDEM MASS SPECTROMETRYDonald F Hunt; Fiscal Year: 2013..Accordingly, we will conduct experiments to identify these proteins and determine the n-terminal motif required for trimethylation by NRMT. ..
- REGULATION OF EXTRACELLULAR EXCITOTOXINSMICHAEL BYRNE ROBINSON; Fiscal Year: 2012..We propose to characterize two novel mechanisms that regulate transporter levels and determine how these mechanisms are altered in an animal model of temporal lobe epilepsy. ..
- Development of Chemical Receptors for ProteinsSanku Mallik; Fiscal Year: 2005..Testing of the synthetic receptors for possible applications in detection of metastatic cancer, imaging and delivery of anti- cancer drugs. ..
- BENZODIAZEPINES AND THE GABA A RECEPTORJOSEPH NEALE; Fiscal Year: 1999....
- Factor Va regulation of prothrombinase activityJAMILA HIRBAWI; Fiscal Year: 2010..Proteins will be screened for clotting activity in one-and two-stage clotting assays. Kinetic analyses will be done by measuring thrombin formation. ..
- NEUROTRANSMITTER FUNCTION IN SPINAL SENSORY TRANSMISSIONThomas Jessell; Fiscal Year: 1993..Studies over the past decade have identified acidic amino acids and neuropeptides as two major classes of excitatory neurotransmitters that appear to be release from ..
- Tyrosine Sulfation and Chemokine Receptor FunctionKevin Moore; Fiscal Year: 2006..domains of all known chemokine receptors (CCRs) contain tyrosine residues in the context of several flanking acidic amino acids, features shared by all known tyrosine sulfated proteins...
- FUNCTIONAL DOMAINS IN CARDIAC TROPONIN CJOHN PUTKEY; Fiscal Year: 1992..Finally, specific acidic amino acids in helices C, D and F will be selected for mutagenesis to determine if they represent critical sites of ..
- NOVEL METHODS FOR PREPARING SYNTHETIC ANTIBODIESSanku Mallik; Fiscal Year: 1999..abstract_text> ..
- HEPATIC MICROSOMAL DRUG OXIDATIONRonald Estabrook; Fiscal Year: 2000..Particular interest will focus of a cluster of acidic amino acids associated with the FMN-binding region of the flavoprotein...
- REGULATION OF EXTRACELLULAR EXCITOTOXINSMichael Robinson; Fiscal Year: 2006DESCRIPTION (provided by applicant): The acidic amino acids, glutamate and aspartate, are the predominant excitatory neurotransmitters in the mammalian CNS...
- CHARACTERIZATION OF CHROMATIN SUBUNITSRANDOLPH RILL; Fiscal Year: 1980..Presently we are exploring the uses of staphylococcal protease, which recognizes acidic amino acids, for probing the regions of histone chains that are on the accessible surface of the nucleosome and for ..
- BIOENERGETICS OF THE CYTOCHROME BC1 COMPLEXDIANA BEATTIE; Fiscal Year: 2001..The suggestion that acidic amino acids localized in extra-membranous, yet hydrophobic, helix cd of cytochrome b are involved in proton pumping will ..
- EXCITATORY TRANSMITTERS AND SEIZURE RELATED BRAINCHARLES ZORUMSKI; Fiscal Year: 1991..Accordingly, the proposed research includes experiments aimed at clarifying the mechanisms underlying the interaction of lithium with the cholinergic system...
- PHOSPHATE TRANSPORT PATHS WITHIN HOMODIMERIC PTPHartmut Wohlrab; Fiscal Year: 2001..The structure will permit the accurate localization of the functionally relevant residues and regions of PTP and should lead to a good understanding of transmembrane metabolite transport. ..
- Water-Soluble and Metabolically Stable Calpain Inhibitors as CardioprotectantsISAAC DONKOR; Fiscal Year: 2008..Furthermore, the proposed studies will provide mechanistic insight into the mode of action of calpain inhibitors as cardioprotectants. ..
- Glycoside Inhibitors of Tumor MetastasisJeffrey Esko; Fiscal Year: 2009..Solid tumor formation and inflammatory reactions will be analyzed to confirm the selective inhibitory action of the analog on tumor metastasis. ..
- Centrifugal Precipitation Chromatography for BiotechnologyMartha Knight; Fiscal Year: 2008..New manufacturing techniques will be applied to make an improved instrument for introduction on the market. [unreadable] [unreadable] [unreadable]..
- Adherence of malaria-infected red cellsAlan Cowman; Fiscal Year: 2009..These studies will contribute to and increased understanding of the pathophysiology of falciparum malaria. ..
- New Hydropathy-Based computer Tools for Drug DiscoveryGLEN KELLOGG; Fiscal Year: 2009..Specific collaborative arrangements are in place to apply these tools to a range of current drug discovery problems. ..
- Biology of Mercapturic Acid Mediated NephrotoxicityAlexander Pushkin; Fiscal Year: 2009..Successful completion of this project will enhance our understanding of the mechanism of mercapturic acid-mediated nephrotoxicity. ..
- Characterization of cardiovascular purinoceptorsTERRANCE EGAN; Fiscal Year: 2009..This is important because the receptors may present a new and potentially exciting means of increasing the rate of survival of patients affected by a number of cardiovascular diseases including hypertension and heart failure. ..
- Chemoprevention Potential of Calpain InhibitorsISAAC DONKOR; Fiscal Year: 2007..The proposal is significant and innovative because it seeks to investigate calpain as a pharmacological target for the discovery of a new class of chemoprevention agents. [unreadable] [unreadable] [unreadable]..
- Altered endothelial heparan sulfate causes diaphragmatic hernias resembling CDHJeffrey Esko; Fiscal Year: 2007..Heparan sulfate-deficient mice will be crossed with Slit3+/- and Robo+/- mice to test if the combination of these mutations potentiates the CDH phenotype (onset, penetrance, and severity). [unreadable] [unreadable] [unreadable]..
- Gating and conduction of ATP-gated ion channelsTERRANCE EGAN; Fiscal Year: 2007..In the second set of experiments, fluorescence resonance energy transfer (FRET) will be used to determine intra- and inter-molecular distances in the absence and presence of ATP. ..
- PROBING THE S' SUBSITES OF CALPAINISAAC DONKOR; Fiscal Year: 2002..Selected potent and cell permeable inhibitors will be tested in the rat isolated heart ischemia model for cardioprotective effect. ..
- RNA PSEUDOKNOT STRUCTURE AND STABILITYDavid Hoffman; Fiscal Year: 2002..A series of NMR experiments will be used to investigate in detail these dynamic aspects of the RNA pseudoknots. ..
- AUTOANTIGEN RNA HELICASE II/GUBenigno Valdez; Fiscal Year: 2003..This study may also provide an impetus for understanding the pathological roles of RH-II/Gu on the elicitation of autoimmune responses. ..
- THE MECHANISM OF OUTER HAIR CELL MOTILITYRichard Hallworth; Fiscal Year: 2004..In Aim 3, the role of the cortex, a subcellular structure in OHC stiffness will be determined using a developmental approach. ..
- Enzyme Targets-Sterol Synthesis-Opportunistic PathogensWILLIAM NES; Fiscal Year: 2004..The results from these studies will facilitate the design of therapeutic strategies aimed to provide species-specific discrimination of inhibition in the ergosterol biosynthetic pathway. ..
- Heparan Sulfate--a Novel Target for Cancer TherapeuticsJeffrey Esko; Fiscal Year: 2004..Identification of active components coupled with large scale synthesis would allow us to test if the compounds have anti-tumor activity in mice. ..
- MECHANISMS OF INTESTINAL IRON ABSORPTIONMatthias Hediger; Fiscal Year: 2004....
- New Perspectives in Transporter Biology (FASEB Conference)Michael Robinson; Fiscal Year: 2005..The long-term goal of this meeting is to cultivate consortiums of individuals who will work together programmatically to study this important class of membrane proteins. ..
- BRAIN ENDOPEPTIDASES AND NEUROPEPTIDE METABOLISMSherwin Wilk; Fiscal Year: 2001....
- PEPTIDE SYNTHESIZERSherwin Wilk; Fiscal Year: 2001..The instrument will be operated and maintained by Dr. Imre Wolf, an accomplished peptide chemist and instrumentation specialist who has operated the Mount Sinai Core facility Milligen peptide synthesizer. ..
- Targeting Calpain for Novel Anticancer AgentsISAAC DONKOR; Fiscal Year: 2005..Additionally, the compounds are useful biomedical tools for investigating the intracellular roles of Calpain due to their metabolic stability. The compounds are also potential anticancer agents. ..