plant poisoning

Summary

Summary: Poisoning by the ingestion of plants or its leaves, berries, roots or stalks. The manifestations in both humans and animals vary in severity from mild to life threatening. In animals, especially domestic animals, it is usually the result of ingesting moldy or fermented forage.

Top Publications

  1. Eddleston M, Senarathna L, Mohamed F, Buckley N, Juszczak E, Sheriff M, et al. Deaths due to absence of an affordable antitoxin for plant poisoning. Lancet. 2003;362:1041-4 pubmed
    ..Treatments for poisoning and envenoming should be included in the present campaign to increase availability of affordable treatments in the developing world...
  2. Al Shaikh A, Sablay Z. Hallucinogenic plant poisoning in children. Saudi Med J. 2005;26:118-21 pubmed
    ..We report a case of acute Datura stramonium intoxication in a 6-year-old boy from Khamis Mushayt, KSA, who presented with restlessness, hallucinations and mydriasis 8 hours after ingesting the seeds of Datura plant...
  3. Rajapakse S. Management of yellow oleander poisoning. Clin Toxicol (Phila). 2009;47:206-12 pubmed publisher
    ..High cost and lack of availability limit the widespread use of digoxin-specific antibody fragments in developing countries...
  4. Caksen H, Odabas D, Akbayram S, Cesur Y, Arslan S, Uner A, et al. Deadly nightshade (Atropa belladonna) intoxication: an analysis of 49 children. Hum Exp Toxicol. 2003;22:665-8 pubmed
    ..Lastly, we suggest that neostigmine may be used in cases of deadly nightshade intoxication if physostigmine cannot be available...
  5. Eddleston M, Persson H. Acute plant poisoning and antitoxin antibodies. J Toxicol Clin Toxicol. 2003;41:309-15 pubmed
    b>Plant poisoning is normally a problem of young children who unintentionally ingest small quantities of toxic plants with little resulting morbidity and few deaths...
  6. Cikla U, Turkmen S, Karaca Y, Ayaz F, Ayaz A, Turedi S, et al. An Atropa belladonna L. poisoning with acute subdural hematoma. Hum Exp Toxicol. 2011;30:1998-2001 pubmed publisher
    ..At least one anti-cholinesterase toxidrome finding was determined in all the nine cases of belladonna poisoning in this series. No elevated creatine kinase was reported in one case with acute subdural hematoma and hyperamylasemia...
  7. Medeiros R, Barbosa R, Riet Correa F, Lima E, Tabosa I, de Barros S, et al. Tremorgenic syndrome in goats caused by Ipomoea asarifolia in Northeastern Brazil. Toxicon. 2003;41:933-5 pubmed
    ..001%). It is concluded that I. asarifolia causes a tremorgenic syndrome due to an unknown tremorgenic phytotoxins or mycotoxins...
  8. Dantas A, Riet Correa F, Gardner D, Medeiros R, Barros S, Anjos B, et al. Swainsonine-induced lysosomal storage disease in goats caused by the ingestion of Turbina cordata in Northeastern Brazil. Toxicon. 2007;49:111-6 pubmed
    ..cordata causes an acquired glycoprotein lysosomal storage disease. The intoxication occurs at least in an area of 27,000 km2 causing severe losses in goats, and some farmers report the disease also in cattle...
  9. Schep L, Slaughter R, Beasley D. Nicotinic plant poisoning. Clin Toxicol (Phila). 2009;47:771-81 pubmed publisher
    ..The toxicokinetics and mechanisms of toxicity of these alkaloids are reviewed and the clinical features and management of poisoning due to these plants are described...

More Information

Publications62

  1. Colodel E, Gardner D, Zlotowski P, Driemeier D. Identification of swainsonine as a glycoside inhibitor responsible for Sida carpinifolia poisoning. Vet Hum Toxicol. 2002;44:177-8 pubmed
  2. Stegelmeier B, Edgar J, Colegate S, Gardner D, Schoch T, Coulombe R, et al. Pyrrolizidine alkaloid plants, metabolism and toxicity. J Nat Toxins. 1999;8:95-116 pubmed
    ..Additional discussion includes current and future research objectives with an emphasis on the development of better diagnostics, pyrrole kinetics, and the effects of low dose PA exposure...
  3. Taylor J, Strickland J. Appearance and disappearance of swainsonine in serum and milk of lactating ruminants with nursing young following a single dose exposure to swainsonine (locoweed; Oxytropis sericea). J Anim Sci. 2002;80:2476-84 pubmed
    ..Neither swainsonine nor changes in alkaline phosphatase activity was detected in the serum of the lambs and calves nursing the ewes and cows dosed with swainsonine...
  4. Sang A Gad P, Guharat S, Wananukul W. A mass cyanide poisoning from pickling bamboo shoots. Clin Toxicol (Phila). 2011;49:834-9 pubmed publisher
    ..Cyanide poisoning from cyanogenic glycosides commonly occurs following ingestion. However, toxicity caused by inhalation of hydrogen cyanide gas (HCN) produced from pickled shoots has never been reported...
  5. Kim I, Choi K, An B, Choi I, Kim B, Oh Y, et al. Effect on abortion of feeding Korean pine needles to pregnant Korean native cows. Can J Vet Res. 2003;67:194-7 pubmed
    ..These results suggest that the ingestion of pine needles may play a role in abortion in Korean native cows by increasing the serum 17beta-estradiol concentration and decreasing the serum progesterone concentration...
  6. Woods L, Filigenzi M, Booth M, Rodger L, Arnold J, Puschner B. Summer pheasant's eye (Adonis aestivalis) poisoning in three horses. Vet Pathol. 2004;41:215-20 pubmed
    ..Although Adonis spp. contain cardiac glycosides, cardiac lesions have not previously been described in livestock associated with consumption of adonis, and this is the first report of adonis toxicosis in North America...
  7. Berg R, Francey T, Segev G. Resolution of acute kidney injury in a cat after lily (Lilium lancifolium) intoxication. J Vet Intern Med. 2007;21:857-9 pubmed
  8. De Haro L, Pommier P, Tichadou L, Hayek Lanthois M, Arditti J. Poisoning by Coriaria myrtifolia Linnaeus: a new case report and review of the literature. Toxicon. 2005;46:600-3 pubmed
  9. Sula M, Morgan S, Bailey K, Schumpert M, Njaa B. Characterization of cardiac lesions in calves after ingestion of Japanese yew (Taxus cuspidata). J Vet Diagn Invest. 2013;25:522-6 pubmed publisher
    ..Moderate fibrinosuppurative interstitial pneumonia was the only other significant finding. Cardiac changes were attributed to damage from the initial exposure to Taxus 6 days prior to death. ..
  10. Stríbrný J, Dogosi M, Snupárek Z, Toupalík P, Balaz P, Bartos P. [3,5-dimethoxyfenol--marker intoxication with Taxus baccata]. Soud Lek. 2010;55:36-9 pubmed
    ..In both cases the presence of 3,5-dimethoxyphenol was also proved in the gastric contents and urine...
  11. Hung Y, Hung S, Olson K, Chou K, Lin S, Chung H, et al. Yam bean seed poisoning mimicking cyanide intoxication. Intern Med J. 2007;37:130-2 pubmed
    ..Yam bean is a common food in southern Taiwan. However, its seeds are rarely consumed. We describe five patients of yam bean seed poisoning in Taiwan, one of them life-threatening...
  12. Fretz R, Schmid D, Brueller W, Girsch L, Pichler A, Riediger K, et al. Food poisoning due to Jimson weed mimicking Bacillus cereus food intoxication in Austria, 2006. Int J Infect Dis. 2007;11:557-8 pubmed
  13. Cooper R. Poisoning in ostriches following ingestion of toxic plants--field observations. Trop Anim Health Prod. 2007;39:439-42 pubmed
    ..Poisoning in these cases is usually associated with the farmer allowing his/her birds to roam free-range in paddocks in which toxic plants are growing. Toxic plants should be removed from grass cut for hay...
  14. Singh M, Cowan S, Child G. Brunfelsia spp (yesterday, today, tomorrow) toxicity in four dogs. Aust Vet J. 2008;86:214-8 pubmed publisher
    ..Examination of faeces was required for diagnosis in all cases. Owners should also be questioned thoroughly about their dogs' access to such plants...
  15. Grace O, Simmonds M, Smith G, van Wyk A. Therapeutic uses of Aloe L. (Asphodelaceae) in southern Africa. J Ethnopharmacol. 2008;119:604-14 pubmed publisher
    ..The African-Arabian succulent genus Aloe L. (Aloaceae/Asphodelaceae) is represented by approximately 120 infrageneric taxa in southern Africa, including A. ferox Mill., a species long used in commercial natural products...
  16. Caloni F, Cortinovis C, Rivolta M, Alonge S, Davanzo F. Plant poisoning in domestic animals: epidemiological data from an Italian survey (2000-2011). Vet Rec. 2013;172:580 pubmed publisher
    ..Epidemiological data from this Italian survey provide useful information on animal exposure to plants and confirm the importance of plants as causative agents of animal poisoning...
  17. Renier A, Kass P, Magdesian K, Madigan J, Aleman M, Pusterla N. Oleander toxicosis in equids: 30 cases (1995-2010). J Am Vet Med Assoc. 2013;242:540-9 pubmed publisher
    ..To determine clinical, laboratory analysis, and necropsy findings for equids with oleander toxicosis and to identify factors associated with outcome...
  18. Ferreiro D, Orozco J, Miron C, Real T, Hernández Moreno D, Soler F, et al. Chinaberry tree (Melia azedarach) poisoning in dog: a case report. Top Companion Anim Med. 2010;25:64-7 pubmed publisher
    ..In addition, we compare clinical and gross postmortem findings in other similar cases reported in the literature. There is a general lack of information of such poisoning in pets...
  19. Ahid S, El Cadi M, Meddah B, Cherrah Y. [Atractylis gummifera: from poisoning to the analytic methods]. Ann Biol Clin (Paris). 2012;70:263-8 pubmed publisher
    ..The aim of our paper is to describe the poisoning by this plant and to review the methods of toxicological analysis used from the colorimetric technique until the news recent chromatographic methods...
  20. Tokarnia C, Döbereiner J, Peixoto P. Poisonous plants affecting livestock in Brazil. Toxicon. 2002;40:1635-60 pubmed
    b>Plant poisoning, together with rabies and botulism, are the main causes of death in adult cattle in Brazil. Estimates indicate that about one million head of cattle die annually through plant poisoning in this country...
  21. Kawohl W, Habermeyer E. Plant poisonings - a problem extending the scope of ethnopharmacology. J Ethnopharmacol. 2005;100:138-9 pubmed
  22. Forrester M. Jimsonweed (Datura stramonium) exposures in Texas, 1998-2004. J Toxicol Environ Health A. 2006;69:1757-62 pubmed
    ..The pattern of reported jimsonweed exposures in Texas was consistent with previously published literature...
  23. Ralphs M, Gardner D, Turner D, Pfister J, Thacker E. Predicting toxicity of tall larkspur (Delphinium barbeyi): measurement of the variation in alkaloid concentration among plants and among years. J Chem Ecol. 2002;28:2327-41 pubmed
    ..76 to 0.99. This predictive equation can provide a tool for ranchers and land managers to make management decisions of when to graze cattle in larkspur areas...
  24. Lee S, Davis T, Cook D, Stegelmeier B. Evaluation of drying methods and toxicity of rayless goldenrod ( Isocoma pluriflora ) and white snakeroot ( Ageratina altissima ) in goats. J Agric Food Chem. 2012;60:4849-53 pubmed publisher
    ..Also demonstrated is that tremetone is stable and that dried white snakeroot and rayless goldenrod are capable of inducing toxicosis in livestock...
  25. Woods L, Puschner B, Filigenzi M, Woods D, George L. Evaluation of the toxicity of Adonis aestivalis in sheep. Vet Rec. 2011;168:49 pubmed publisher
    ..No gross or microscopic lesions were seen when the ewes were examined postmortem at the end of the study...
  26. Pfister J, Gardner D, Stegelmeier B, Hackett K, Secrist G. Catastrophic cattle loss to low larkspur (Delphinium nuttallianum) in Idaho. Vet Hum Toxicol. 2003;45:137-9 pubmed
    ..It is important for livestock owners and managers to recognize toxic plants growing in their area. If there is an unusual abundance of larkspur or other toxic plants, correct identification can provoke caution in grazing management...
  27. Tegzes J, Puschner B, Melton L. Cyanide toxicosis in goats after ingestion of California Holly (Heteromeles arbutifolia). J Vet Diagn Invest. 2003;15:478-80 pubmed
    ..This study describes a case that resulted in significant morbidity and mortality in a herd of goats after exposure to California holly (Heteromeles arbutifolia)...
  28. Declercq J. Suspected wood poisoning caused by Simarouba amara (marupá/caixeta) shavings in two dogs with erosive stomatitis and dermatitis. Vet Dermatol. 2004;15:188-93 pubmed
    ..This assumption was supported by the clinical course as healing of skin lesions occurred when the dogs were no longer exposed to the bedding...
  29. Green B, Welch K, Gardner D, Stegelmeier B, Davis T, Cook D, et al. Serum elimination profiles of methyllycaconitine and deltaline in cattle following oral administration of larkspur (Delphinium barbeyi). Am J Vet Res. 2009;70:926-31 pubmed publisher
    ..To describe the simple elimination kinetics of methyllycaconitine (MLA) and deltaline and evaluate the heart rate response in cattle following oral administration of larkspur...
  30. Snyman L, Carstens A, Schultz R, Joubert J, Labuschagne L. Changes in sheep oesophageal diameter and function during Geigeria ornativa (vermeerbos) poisoning and subsequent recovery. J S Afr Vet Assoc. 2008;79:178-84 pubmed
    ..The CPFI returned to normal after termination of G. ornativa intake...
  31. Lin T, Nelson L, Tsai J, Hung D, Hu S, Chan H, et al. Common toxidromes of plant poisonings in Taiwan. Clin Toxicol (Phila). 2009;47:161-8 pubmed publisher
    ..To describe the toxidromes associated with plant poisonings in Taiwan...
  32. Burda A, Wahl M, Fischbein C, DesLauriers C. Atypical poisonings with botanicals raise suspicion of malicious activity. Vet Hum Toxicol. 2004;46:341 pubmed
    ..Heightened toxicovigilance since the terrorist actions of 9/11 has raised concerns for malicious use of highly toxic botanicals, as the 3 cases reported illustrate...
  33. Barceloux D. Potatoes, tomatoes, and solanine toxicity (Solanum tuberosum L., Solanum lycopersicum L.). Dis Mon. 2009;55:391-402 pubmed publisher
  34. Bourke C. Are ovine fenugreek (Trigonella foenum-graecum) staggers and kangaroo gait of lactating ewes two clinically and pathologically similar nervous disorders?. Aust Vet J. 2009;87:99-101 pubmed publisher
    ..Although the diet associated with each is different the causal agent may be the same...
  35. Zanuzzi C, Fontana P, Barbeito C, Portiansky E, Gimeno E. Paneth cells: histochemical and morphometric study in control and Solanum glaucophyllum intoxicated rabbits. Eur J Histochem. 2008;52:93-100 pubmed
    ..A time and dose-dependent increase in the size and number of Paneth cells was found in both intoxicated groups. We suggest that the changes described in these cells may be directly or indirectly induced by S. glaucophyllum intoxication...
  36. Wilkins A, Meagher L, Smith B, Miles C. Ovine metabolism of diosgenin coated on cellulose in relation to hepatogenous photosensitization of ruminants. Vet Hum Toxicol. 2003;45:24-7 pubmed
    ..Deconjugation and the epimerization of smilagenin to epismilagenin appeared to continue in the cecum and colon. Epismilagenin was the dominant conjugated sapogenin constituent identified in a bile sample...
  37. Sevketoglu E, Tatli B, Tuğcu B, Demirelli Y, Hatipoglu S. An unusual cause of fulminant Guillain-Barré syndrome: angel's trumpet. Pediatr Neurol. 2010;43:368-70 pubmed publisher
    ..Datura suaveolens). Understanding the signs and symptoms of angel's trumpet toxicity can allow for early diagnosis and proper case management...
  38. Langston C. Acute renal failure caused by lily ingestion in six cats. J Am Vet Med Assoc. 2002;220:49-52, 36 pubmed
    ..Although the prognosis for full recovery of cats with lily toxicosis is poor, long-term survival is possible with supportive care. The prognosis appears to be better for cats with nonoliguric renal failure...
  39. Wisløff H, Flåøyen A, Ottesen N, Hovig T. Narthecium ossifragum (L.) huds. causes kidney damage in goats: morphologic and functional effects. Vet Pathol. 2003;40:317-27 pubmed
    ..Our findings indicate a fast-acting toxic principle inducing damage by both direct toxic and secondary ischemic effects...
  40. Rao S, Banack S, Cox P, Weiss J. BMAA selectively injures motor neurons via AMPA/kainate receptor activation. Exp Neurol. 2006;201:244-52 pubmed
    ..Present findings support the hypothesis that BMAA may contribute to the selective MN loss in ALS/PDC...
  41. McKeough V, Collett M, Parton K. Suspected Vestia foetida poisoning in young goats. N Z Vet J. 2005;53:352-5 pubmed
    ..Two crossbred, castrated male goats, a 5-month-old and an 8-month-old, were observed ingesting Vestia foetida (Solanaceae). Later, the goats were seen standing splay-legged and apparently disoriented...
  42. Gerber R, Naude T, De Kock S. Confirmed Datura poisoning in a horse most probably due to D. ferox in contaminated tef hay. J S Afr Vet Assoc. 2006;77:86-9 pubmed
    ..Extraction and detection methods for atropine and scopolamine in urine are described employing enzymatic hydrolysis followed by liquid-liquid extraction and liquid chromatography tandem mass spectrometry (LC/MS/MS)...
  43. Haupt H. [Poisonous and less poisonous plants]. Kinderkrankenschwester. 2002;21:195 pubmed
  44. Spiller H, Beuhler M, Ryan M, Borys D, Aleguas A, Bosse G. Evaluation of changes in poisoning in young children: 2000 to 2010. Pediatr Emerg Care. 2013;29:635-40 pubmed publisher
    ..We evaluated poisoning in children younger than 6 years for trends during an 11-year period regarding the substances involved in the poisoning, medical outcomes, and health care use...
  45. Sharma R, Bhat T, Sharma O. The environmental and human effects of ptaquiloside-induced enzootic bovine hematuria: a tumorous disease of cattle. Rev Environ Contam Toxicol. 2013;224:53-95 pubmed publisher
    ..Although preliminary therapeutic vaccine trials with inactivated BPV-2 against EBH have been performed, further work is needed to standardize and validate vaccine doses for animals...
  46. Riet Correa F, Timm C, Barros S, Summers B. Symmetric focal degeneration in the cerebellar and vestibular nuclei in swine caused by ingestion of Aeschynomene indica seeds. Vet Pathol. 2003;40:311-6 pubmed
    ..These results suggest that A. indica seeds are toxic, causing functional derangement of the vestibulocerebellar system, followed by alterations in the microvasculature in the cerebellar and vestibular nuclei...
  47. Stella L, Vitelli M, Palazzo E, Oliva P, De Novellis V, Capuano A, et al. Datura stramonium intake: a report on three cases. J Psychoactive Drugs. 2010;42:507-12 pubmed
    ..stramonium a tempting alternative to other psychoactive substances. Thus, it is extremely important to be able to recognize its symptoms so as to be able to diagnose any signs of intoxication properly...
  48. Brevis C, Quezada M, Bustamante P, Carrasco L, Ruiz A, Donoso S. Huevil (Vestia foetida) poisoning of cattle in Chile. Vet Rec. 2005;156:452-3 pubmed
  49. Maiga A, Diallo D, Fane S, Sanogo R, Paulsen B, Cisse B. A survey of toxic plants on the market in the district of Bamako, Mali: traditional knowledge compared with a literature search of modern pharmacology and toxicology. J Ethnopharmacol. 2005;96:183-93 pubmed
    ..The information includes the botanical name, literature survey on the pharmacology of the plants, the healers' knowledge on plant toxicity and its prevention by some of the healers...
  50. Snyman L, Schultz R, Botha C, Labuschagne L, Joubert J. Evaluation of activated charcoal as treatment for Yellow tulp (Moraea pallida) poisoning in cattle. J S Afr Vet Assoc. 2009;80:274-5 pubmed
    ..For instance, despite treatment, 1 of 7 cattle succumbed after manifesting mild posterior paresis 6 to 8 h after initial exposure and 3 of 3 treated cattle died after developing severe posterior paresis within 6 to 12 h...
  51. Mouaffak Y, Boutbaoucht M, Ejlaidi A, Toufiki R, Younous S. [Fatal poisoning by Atractylis gummifera L.: a case report]. Arch Pediatr. 2013;20:496-8 pubmed publisher
    ..Beyond this observation, we review this intoxication, whose diagnosis is clinical, treatment is symptomatic and prevention is crucial...
  52. Cerqueira V, Riet Correa G, Barbosa J, Duarte M, Oliveira C, de Oliveira C, et al. Colic caused by Panicum maximum toxicosis in equidae in northern Brazil. J Vet Diagn Invest. 2009;21:882-8 pubmed
    ..The toxin or toxins causing disease and the reason for the toxicity of the plant in the northern region are unknown...
  53. Borelli V, Lucioli J, Furlan F, Hoepers P, Roveda J, Traverso S, et al. Fatal onion (Allium cepa) toxicosis in water buffalo (Bubalus bubalis). J Vet Diagn Invest. 2009;21:402-5 pubmed
    ..A diagnosis of hemolytic anemia caused by onion toxicosis was based on the epidemiological data, clinical signs, macroscopic changes, and histological lesions...