organophosphate poisoning

Summary

Summary: Poisoning due to exposure to ORGANOPHOSPHORUS COMPOUNDS, such as ORGANOPHOSPHATES; ORGANOTHIOPHOSPHATES; and ORGANOTHIOPHOSPHONATES.

Top Publications

  1. Kamijo Y, Soma K, Uchimiya H, Asari Y, Ohwada T. A case of serious organophosphate poisoning treated by percutaneus cardiopulmonary support. Vet Hum Toxicol. 1999;41:326-8 pubmed
    ..Percutaneous cardiopulmonary support may be used for severe but potentially reversible pulmonary or cardiovascular toxicity induced by organophosphates as well as complicated severe hypothermia. ..
  2. Wiwanitkit V. Acute organo-phosphorus pesticide poisoning, oxidative damage, haemoglobin level and total leukocyte. Afr Health Sci. 2014;14:778 pubmed publisher
  3. Karasova J, Maderycova Z, Tumova M, Jun D, Rehacek V, Kuca K, et al. Activity of cholinesterases in a young and healthy middle-European population: Relevance for toxicology, pharmacology and clinical praxis. Toxicol Lett. 2017;277:24-31 pubmed publisher
    ..be useful in routine clinical practice where the monitoring of blood AChE and plasma BChE activity is crucial for prognosis and diagnosis of organophosphate poisoning, in occupational medicine and in relevant mass casualty scenarios.
  4. Masson P, Nachon F. Cholinesterase reactivators and bioscavengers for pre- and post-exposure treatments of organophosphorus poisoning. J Neurochem. 2017;142 Suppl 2:26-40 pubmed publisher
    ..Novel generation of broad spectrum reactivators are designed for crossing the blood-brain barrier and reactivate central AChE. This is an article for the special issue XVth International Symposium on Cholinergic Mechanisms. ..
  5. Turkdogan K, Duman A, Avcil M, Akoz A, Canakci S, Kantekin B. Treatment methods following suicidal self-administration of IV organophosphate: What can additional lipid administration change?. Am J Emerg Med. 2017;35:1388.e3-1388.e5 pubmed publisher
    ..Third, we aimed to emphasize that with these treatments, patients' intensive care needs, intermediate symptoms, and hospitalization periods can be decreased and thus mortality and morbidity increase can be prevented. ..
  6. Herbert J, Thiermann H, Worek F, Wille T. Precision cut lung slices as test system for candidate therapeutics in organophosphate poisoning. Toxicology. 2017;389:94-100 pubmed publisher
    ..Now, candidate therapeutic compounds can be evaluated, based on their ability to counteract the irreversible airway contraction in OP poisoned PCLS. ..
  7. Parikh F. Changing trends in poisoning. J Assoc Physicians India. 2009;57:739 pubmed
  8. Krause K, van Thriel C, De Sousa P, Leist M, Hengstler J. Monocrotophos in Gandaman village: India school lunch deaths and need for improved toxicity testing. Arch Toxicol. 2013;87:1877-81 pubmed publisher
  9. Adinew G, Asrie A, Birru E. Pattern of acute organophosphorus poisoning at University of Gondar Teaching Hospital, Northwest Ethiopia. BMC Res Notes. 2017;10:149 pubmed publisher
    ..There is paucity of evidence from Ethiopia showing the pattern of organophosphate poisoning (OPP) in healthcare facilities...

More Information

Publications11

  1. Gorecki L, Korabecny J, Musilek K, Nepovimova E, Malinak D, Kucera T, et al. Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016). Expert Opin Ther Pat. 2017;27:971-985 pubmed publisher
    ..The importance of detection of OP also has to be taken into consideration. Especially, with the fast spreading toxic effect when death can occur within minutes. ..
  2. Dong H, Weng Y, Zhen G, Li F, Jin A, Liu J. Clinical emergency treatment of 68 critical patients with severe organophosphorus poisoning and prognosis analysis after rescue. Medicine (Baltimore). 2017;96:e7237 pubmed publisher
    ..Hemoperfusion and hemodialysis on the basis of routine emergency treatment for critical patients with organophosphorus poisoning can improve rescue outcomes and improve the prognosis of patients, which should be popularized. ..