cadmium poisoning

Summary

Summary: Poisoning occurring after exposure to cadmium compounds or fumes. It may cause gastrointestinal syndromes, anemia, or pneumonitis.

Top Publications

  1. Tandon S, Singh S, Prasad S, Khandekar K, Dwivedi V, Chatterjee M, et al. Reversal of cadmium induced oxidative stress by chelating agent, antioxidant or their combination in rat. Toxicol Lett. 2003;145:211-7 pubmed
    ..The results suggest that the administration of an antioxidant during chelation of cadmium may provide beneficial effects by reducing oxidative stress without its cadmium removing ability...
  2. Satoh M. [Cadmium]. Nihon Rinsho. 2004;62 Suppl 12:334-8 pubmed
  3. Matovic V, Buha A, Bulat Z, Dukić Ćosić D. Cadmium toxicity revisited: focus on oxidative stress induction and interactions with zinc and magnesium. Arh Hig Rada Toksikol. 2011;62:65-76 pubmed publisher
    ..At present, there is no clinically efficient agent to treat cadmium poisoning due to predominantly intracellular location of cadmium ions...
  4. Benoff S, Jacob A, Hurley I. Male infertility and environmental exposure to lead and cadmium. Hum Reprod Update. 2000;6:107-21 pubmed
    ..Reverse transcriptase-polymerase chain reaction assays for Ca2+ and K+ channel isoforms may identify susceptibility subgroups with lower resistance to environmental exposures...
  5. Nishijo M, Nakagawa H, Morikawa Y, Kuriwaki J, Katsuyuki M, Kido T, et al. Mortality in a cadmium polluted area in Japan. Biometals. 2004;17:535-8 pubmed
  6. Umemura T. Experimental reproduction of itai-itai disease, a chronic cadmium poisoning of humans, in rats and monkeys. Jpn J Vet Res. 2000;48:15-28 pubmed
  7. Fowler B. Monitoring of human populations for early markers of cadmium toxicity: a review. Toxicol Appl Pharmacol. 2009;238:294-300 pubmed publisher
    ..The emphasis will be on the detection of early toxic effects from exposure to Cd in new products such as nano-materials and identification of populations at special risk for Cd toxicity...
  8. Ogawa T, Kobayashi E, Okubo Y, Suwazono Y, Kido T, Nogawa K. Relationship among prevalence of patients with Itai-itai disease, prevalence of abnormal urinary findings, and cadmium concentrations in rice of individual hamlets in the Jinzu River basin, Toyama prefecture of Japan. Int J Environ Health Res. 2004;14:243-52 pubmed
    ..This study demonstrated that Itai-itai disease is induced by exposure to environmental Cd and that renal dysfunction plays an important role in its development...
  9. Julin B, Wolk A, Johansson J, Andersson S, Andrén O, Akesson A. Dietary cadmium exposure and prostate cancer incidence: a population-based prospective cohort study. Br J Cancer. 2012;107:895-900 pubmed publisher
    ..Experimental data convincingly propose the toxic metal cadmium as a prostate carcinogen. Cadmium is widely dispersed into the environment and, consequently, food is contaminated...

More Information

Publications62

  1. Abu Bakar A, Satarug S, Marks G, Lang M, Moore M. Acute cadmium chloride administration induces hepatic and renal CYP2A5 mRNA, protein and activity in the mouse: involvement of transcription factor NRF2. Toxicol Lett. 2004;148:199-210 pubmed
    ..Upregulation of CYP2A5 by cadmium in the Nrf2 +/+ mice but not in the Nrf2-/- mice indicates a role for this transcription factor in the regulation...
  2. Kazantzis G. Cadmium, osteoporosis and calcium metabolism. Biometals. 2004;17:493-8 pubmed
    ..The identification of cadmium, an environmental pollutant, as one causal factor is highly significant in helping to control the incidence of this complex condition...
  3. Tanhan P, Sretarugsa P, Pokethitiyook P, Kruatrachue M, Upatham E. Histopathological alterations in the edible snail, Babylonia areolata (spotted babylon), in acute and subchronic cadmium poisoning. Environ Toxicol. 2005;20:142-9 pubmed
    ..The epithelial lining of the digestive tract showed similar alterations such as increased size of mucous vacuoles, reduced length of cilia, and dilation of nuclei. In addition, fragmentation of the muscle sheath was observed...
  4. Martynowicz H, Skoczynska A, Wojakowska A, Turczyn B. Serum vasoactive agents in rats poisoned with cadmium. Int J Occup Med Environ Health. 2004;17:479-85 pubmed
    ..The aim of this study was to evaluate the impact of subchronic Cd poisoning on blood nitric oxide or endothelin in blood and to relate it to the redox system activity in vessel walls and to blood Cd concentration...
  5. Prozialeck W, Edwards J, Woods J. The vascular endothelium as a target of cadmium toxicity. Life Sci. 2006;79:1493-506 pubmed
    ..In addition the possible roles of the vascular endothelium in mediating the tumor promoting and anticarcinogenic effects of Cd are discussed...
  6. Haswell Elkins M, Satarug S, O Rourke P, Moore M, Ng J, McGrath V, et al. Striking association between urinary cadmium level and albuminuria among Torres Strait Islander people with diabetes. Environ Res. 2008;106:379-83 pubmed
    ..This study explored associations between albuminuria and an index of cadmium exposure (urinary cadmium excretion) in the presence and absence of Type 2 diabetes...
  7. Kobayashi E, Suwazono Y, Dochi M, Honda R, Kido T. Influence of consumption of cadmium-polluted rice or Jinzu River water on occurrence of renal tubular dysfunction and/or Itai-itai disease. Biol Trace Elem Res. 2009;127:257-68 pubmed publisher
  8. Baker J, Satarug S, Edwards R, Moore M, Williams D, Reilly P. Potential for early involvement of CYP isoforms in aspects of human cadmium toxicity. Toxicol Lett. 2003;137:85-93 pubmed
    ..Potential mechanisms by which Cd may alter CYP4A11 expression are discussed briefly...
  9. Kobayashi E, Suwazono Y, Dochi M, Honda R, Kido T, Nakagawa H. Influence of drinking and/or cooking with Jinzu River water on the development of Itai-itai disease. Biol Trace Elem Res. 2009;129:46-57 pubmed publisher
  10. Andujar P, Bensefa Colas L, Descatha A. [Acute and chronic cadmium poisoning]. Rev Med Interne. 2010;31:107-15 pubmed publisher
    ..According to literature, no chelating agent can be still used in human cadmium poisonings. In France, some diseases caused by occupational exposure to cadmium may be compensated...
  11. Fouad A, Jresat I. Captopril and telmisartan treatments attenuate cadmium-induced testicular toxicity in rats. Fundam Clin Pharmacol. 2013;27:152-60 pubmed publisher
    ..The differences between the results obtained with captopril and telmisartan were insignificant, suggesting that both drugs equally protected the testicular tissue from the detrimental effects of cadmium...
  12. Martin P, Poggi M, Chambard J, Boulukos K, Pognonec P. Low dose cadmium poisoning results in sustained ERK phosphorylation and caspase activation. Biochem Biophys Res Commun. 2006;350:803-7 pubmed
    b>Cadmium poisoning has been known to result in a wide variety of cellular responses, including oxidative stress and kinase activation...
  13. Uetani M, Kobayashi E, Suwazono Y, Kido T, Nogawa K. Cadmium exposure aggravates mortality more in women than in men. Int J Environ Health Res. 2006;16:273-9 pubmed
    ..This study revealed that Cd exposure aggravates mortality more in women than in men...
  14. Adams S, Newcomb P, White E. Dietary cadmium and risk of invasive postmenopausal breast cancer in the VITAL cohort. Cancer Causes Control. 2012;23:845-54 pubmed publisher
    ..The aim of the study was to estimate the association between dietary intake of cadmium, a carcinogenic heavy metal, and risk of invasive postmenopausal breast cancer...
  15. Shagirtha K, Muthumani M, Prabu S. Melatonin abrogates cadmium induced oxidative stress related neurotoxicity in rats. Eur Rev Med Pharmacol Sci. 2011;15:1039-50 pubmed
  16. Gil H, Kang E, Lee K, Yang J, Lee E, Hong S. Effect of glutathione on the cadmium chelation of EDTA in a patient with cadmium intoxication. Hum Exp Toxicol. 2011;30:79-83 pubmed publisher
    ..These results suggest that glutathione administration with EDTA might be an effective treatment modality for patients with cadmium intoxication...
  17. Kelley C. Cadmium therapeutic agents. Curr Pharm Des. 1999;5:229-40 pubmed
    ..Preliminary attempts to combat acute cadmium poisoning included the use of the chelating agents ethylenediaminetetraacetic acid (EDTA) and British anti-Lewisite (..
  18. Clemens S, Aarts M, Thomine S, Verbruggen N. Plant science: the key to preventing slow cadmium poisoning. Trends Plant Sci. 2013;18:92-9 pubmed publisher
    ..The emerging molecular understanding of Cd uptake, root retention, root-to-shoot translocation and grain loading will enable the development of low Cd-accumulating crops...
  19. Soodvilai S, Nantavishit J, Muanprasat C, Chatsudthipong V. Renal organic cation transporters mediated cadmium-induced nephrotoxicity. Toxicol Lett. 2011;204:38-42 pubmed publisher
    ..Taken together, this study provides for the first time, evidence showing OCT1 and OCT2 mediating cadmium transport across the basolateral membrane into the renal proximal tubular cells...
  20. Skoczynska A, Martynowicz H. The impact of subchronic cadmium poisoning on the vascular effect of nitric oxide in rats. Hum Exp Toxicol. 2005;24:353-61 pubmed
    ..05) in both groups of cadmium-treated rats. These results suggest that cadmium in hypertensive doses modifies the vascular effect of NO in basal conditions and after stimulation by ACh...
  21. Hogarth G. Metal-dithiocarbamate complexes: chemistry and biological activity. Mini Rev Med Chem. 2012;12:1202-15 pubmed
    ..been noted for gold and copper complexes, technetium and copper complexes have been used in PET-imaging, dithiocarbamates have been used to treat acute cadmium poisoning and copper complexes also have been investigated as SOD inhibitors.
  22. Sethi P, Khandelwal D. Cadmium exposure: health hazards of silver cottage industry in developing countries. J Med Toxicol. 2006;2:14-5 pubmed
    ..Cadmium is a neurotoxic and nephrotoxic heavy metal, and there are no national policies to prevent exposure to such chemicals. We will present a case of cadmium induced peripheral neuropathy, nephropathy, and decreased bone density...
  23. Bernhoft R. Cadmium toxicity and treatment. ScientificWorldJournal. 2013;2013:394652 pubmed publisher
    ..Detoxification of cadmium with EDTA and other chelators is possible and has been shown to be therapeutically beneficial in humans and animals when done using established protocols. ..
  24. Barbier O, Jacquillet G, Tauc M, Poujeol P, Cougnon M. Acute study of interaction among cadmium, calcium, and zinc transport along the rat nephron in vivo. Am J Physiol Renal Physiol. 2004;287:F1067-75 pubmed
  25. Ngo D, Hough R, Le T, Nyberg Y, Le B, Nguyen C, et al. Assessing dietary exposure to cadmium in a metal recycling community in Vietnam: age and gender aspects. Sci Total Environ. 2012;416:164-71 pubmed publisher
    ..WHO standard of 0.4mg Cd/kg rice may not be protective where people consume large amounts of rice/have relatively low body weight...
  26. Nordberg G. Cadmium and health in the 21st century--historical remarks and trends for the future. Biometals. 2004;17:485-9 pubmed
    ..In many countries, Cd exposures are now under better control than in the past. The target for the 21st century is to achieve a totally acceptable exposure situation without adverse health effects from Cd...
  27. Dilworth C, Hamilton G, George E, Timbrell J. The use of liver spheroids as an in vitro model for studying induction of the stress response as a marker of chemical toxicity. Toxicol In Vitro. 2000;14:169-76 pubmed
    ..However, the increase in stress proteins appears to be a relatively insensitive parameter compared to other more conventionally used toxicity endpoints and the response appears to vary with individual toxins under study...
  28. Piłat Marcinkiewicz B, Sawicki B, Brzóska M, Moniuszko Jakoniuk J. Effect of chronic administration of cadmium on the rat thyroid: radioimmunological and immunohistochemical studies. Folia Histochem Cytobiol. 2002;40:189-90 pubmed
    ..Serum T3 concentration was not affected by Cd, while T4 was reduced but only at the exposure to the higher Cd concentration. Moreover, the rats exposed to Cd showed a decrease in serum Ca concentration...
  29. Fotakis G, Cemeli E, Anderson D, Timbrell J. Cadmium chloride-induced DNA and lysosomal damage in a hepatoma cell line. Toxicol In Vitro. 2005;19:481-9 pubmed
    ..It is possible that cadmium induced lysosomal damage is an earlier event than DNA damage and can mediate other cellular events that lead to cell death...
  30. Staneviciene I, Sadauskiene I, Lesauskaite V, Ivanoviene L, Kasauskas A, Ivanov L. Subacute effects of cadmium and zinc ions on protein synthesis and cell death in mouse liver. Medicina (Kaunas). 2008;44:131-8 pubmed
    ..The aim of this study was to evaluate in vivo the effects of cadmium and zinc ions on translational machinery and death of mouse liver cells...
  31. Brzóska M, Moniuszko Jakoniuk J, Piłat Marcinkiewicz B, Sawicki B. Liver and kidney function and histology in rats exposed to cadmium and ethanol. Alcohol Alcohol. 2003;38:2-10 pubmed
    ..The present study was performed to assess the function and histology of the liver and kidney in rats exposed to 50 mg Cd/l (as cadmium chloride) and/or 10% (w/v) ethanol (EtOH) for 12 weeks...
  32. Wang C, Zhao M, Yang J, Li X, Peng S. Synthesis and evaluations of pentahydroxylhexyl-L-cysteine and its dimer as chelating agents for cadmium or lead decorporation. Toxicol Appl Pharmacol. 2004;200:229-36 pubmed
    ..The cytogenetic effects of compound 4 were evaluated in the Ames assay, mouse bone marrow micronucleus test, and sperms shape abnormality assay, and all of them show the negative reactions...
  33. De Smet H, De Wachter B, Lobinski R, Blust R. Dynamics of (Cd,Zn)-metallothioneins in gills, liver and kidney of common carp Cyprinus carpio during cadmium exposure. Aquat Toxicol. 2001;52:269-81 pubmed
  34. . Electronic waste--time to take stock. Lancet. 2013;381:2223 pubmed publisher
  35. Lee M, Park S, Hu H, Lee S. Cadmium exposure and cardiovascular disease in the 2005 Korea National Health and Nutrition Examination Survey. Environ Res. 2011;111:171-6 pubmed publisher
    ..We examined the associations of cadmium exposure with cardiovascular disease in nationally representative general Korean adults...
  36. Zhang Y, Pi S, Chen F, Li J. [Investigation of health status of workers exposed to low concentration cadmium in a zinc powder factory]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2011;29:936-8 pubmed
    ..To explore the health status of workers exposed to Cd at low concentration...
  37. Bulat Z, Djukic Cosic D, Malicević Z, Bulat P, Matovic V. Zinc or magnesium supplementation modulates cd intoxication in blood, kidney, spleen, and bone of rabbits. Biol Trace Elem Res. 2008;124:110-7 pubmed publisher
    ..Supplementation with Zn or Mg in Cd-intoxicated rabbits caused similar reduction of blood Cd concentration; however, reduction of tissue Cd content was more pronounced in Zn- than in Mg-supplemented group...
  38. Hubs kyĭ I, Ersteniuk H. [Study of hemoglobin system components and antioxidation enzymes in cadmium intoxication]. Ukr Biokhim Zh (1999). 2002;74:124-7 pubmed
    ..Alongside with the latter there is observed a violation of antioxydation protection including the activity of erythrocytic catalase, ceruloplasmin, ferrum saturation of transferrine...
  39. Kido T, Kobayashi E, Hayano M, Nogawa K, Tsuritani I, Nishijo M, et al. Significance of elevated urinary human intestinal alkaline phosphatase in Japanese people exposed to environmental cadmium. Toxicol Lett. 1995;80:49-54 pubmed
    ..However, in the stage of severe renal damage, the combination of IAP and beta 2-MG is considered to be more useful...
  40. Sabolic I, Herak Kramberger C, Brown D. Subchronic cadmium treatment affects the abundance and arrangement of cytoskeletal proteins in rat renal proximal tubule cells. Toxicology. 2001;165:205-16 pubmed
  41. Roast S, Widdows J, Jones M. Impairment of mysid (Neomysis integer) swimming ability: an environmentally realistic assessment of the impact of cadmium exposure. Aquat Toxicol. 2001;52:217-27 pubmed
    ..This conclusion would not be achieved from standard LC(50) tests (e.g. 7 day LC50 = 2.95 microg Cd2+ (aq) l(-1)), highlighting the value of behavioural disruption as a sensitive indicator of environmental chemical contamination...
  42. Hubs kyĭ I, Ersteniuk H, Briuzhina T, Zadorina O. [Fatty acid composition of lipids in erythrocytes and blood plasma in cadmium intoxication and its correction with unitiol]. Ukr Biokhim Zh (1999). 2003;75:103-5 pubmed
    ..It makes possible to assume the disturbance of both the erythrocytes membrane structure and metabolism in the erythrocyte. Unitiol injection promotes the normalisation of the indices under investigation...
  43. Breton J, Daniel C, Dewulf J, Pothion S, Froux N, Sauty M, et al. Gut microbiota limits heavy metals burden caused by chronic oral exposure. Toxicol Lett. 2013;222:132-8 pubmed publisher
    ..Collectively, these data illustrate the complex host-microbes interplay occurring with environmental pollutants inside the gut. ..
  44. Ma L, Zhang Y, Bu N, Wang S. Alleviation effect of alginate-derived oligosaccharides on Vicia faba root tip cells damaged by cadmium. Bull Environ Contam Toxicol. 2010;84:161-4 pubmed publisher
    ..05) and chromosomal aberration frequency decreased (p < 0.05) under all the ADO concentrations. This indicated that ADO had a significant alleviation effect on Vicia faba root tip cells damaged by cadmium...
  45. Nawrot T, Van Hecke E, Thijs L, Richart T, Kuznetsova T, Jin Y, et al. Cadmium-related mortality and long-term secular trends in the cadmium body burden of an environmentally exposed population. Environ Health Perspect. 2008;116:1620-8 pubmed publisher
    ..Few population studies have reported on the long-term changes in the internal cadmium dose and simultaneously occurring mortality...
  46. Nunia V, Goyal P. Protective effect of diltiazem (a calcium channel blocker) against cadmium-induced toxicity in mice. J Environ Pathol Toxicol Oncol. 2007;26:185-93 pubmed
    ..Thus, Diltiazem administration before cadmium intoxication protects bone marrow and hematological constituents in mice...
  47. Friedman L, Lukyanova E, Kundiev Y, Shkiryak Nizhnyk Z, Chislovska N, Mucha A, et al. Anthropometric, environmental, and dietary predictors of elevated blood cadmium levels in Ukrainian children: Ukraine ELSPAC group. Environ Res. 2006;102:83-9 pubmed
    ..Whole-blood cadmium levels observed in this group of Ukrainian children appear to be similar to those reported in other Eastern European countries...
  48. Omote S, Kido T, Nishijo M, Nakagawa H, Suwazono Y, Kobayashi E, et al. Urinary type I collagen cross-linked N-telopeptides in inhabitants 18 years after cessation of exposure to cadmium in Japan. Bull Environ Contam Toxicol. 2006;76:187-94 pubmed
  49. Satarug S, Nishijo M, Ujjin P, Vanavanitkun Y, Baker J, Moore M. Effects of chronic exposure to low-level cadmium on renal tubular function and CYP2A6-mediated coumarin metabolism in healthy human subjects. Toxicol Lett. 2004;148:187-97 pubmed
    ..001). These data suggest that Cd may increase the expression of CYP2A6 in liver, resulting in enhanced coumarin metabolism in subjects with high Cd body burden...
  50. Takebayashi S, Jimi S, Segawa M, Takaki A. Mitochondrial DNA deletion of proximal tubules is the result of itai-itai disease. Clin Exp Nephrol. 2003;7:18-26 pubmed
    ..An animal model for itai-itai disease was produced in rats by low-dose Cd treatment, intraperitoneally for a period of 70-80 weeks. Osteomalacia followed the renal damage...
  51. Choi J, Rhee I, Park K, Park K, Kim J, Rhee S. Action of green tea catechin on bone metabolic disorder in chronic cadmium-poisoned rats. Life Sci. 2003;73:1479-89 pubmed
    ..The cause of decreasing bone mineral density and bone mineral content by cadmium poisoning was due to the fast bone turnover rate, where bone resorption occurred at a higher rate than bone formation...
  52. Leroyer A, Hemon D, Nisse C, Auque G, Mazzuca M, Haguenoer J. Determinants of cadmium burden levels in a population of children living in the vicinity of nonferrous smelters. Environ Res. 2001;87:147-59 pubmed
    ..14; 95% CI=[1.07-1.21] and x 1.25; 95% CI=[1.04-1.50]. Neither sex nor age was associated with CdB. Mean CdU was associated with paternal occupational cadmium exposure...
  53. Xu B, Xu Z, Deng Y, Yang J. Protective effects of Chlorpromazine and Verapamil against cadmium-induced kidney damage in vivo. Exp Toxicol Pathol. 2010;62:27-34 pubmed publisher
    ..Both CPZ and Ver possess some ability to prevent cadmium-induced kidney damage via antioxidative action and by maintaining calcium homeostasis...