carbon tetrachloride poisoning

Summary

Summary: Poisoning that results from ingestion, injection, inhalation, or skin absorption of CARBON TETRACHLORIDE.

Top Publications

  1. Park J, Ki M, Lee H, Hong I, Ji A, Ishigami A, et al. Vitamin C deficiency attenuates liver fibrosis by way of up-regulated peroxisome proliferator-activated receptor-gamma expression in senescence marker protein 30 knockout mice. Hepatology. 2010;51:1766-77 pubmed publisher
  2. Reyes Gordillo K, Segovia J, Shibayama M, Vergara P, Moreno M, Muriel P. Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress. Biochim Biophys Acta. 2007;1770:989-96 pubmed
    ..These findings suggest that curcumin prevents acute liver damage by at least two mechanisms: acting as an antioxidant and by inhibiting NF-kappaB activation and thus production of proinflammatory cytokines...
  3. Domitrovic R, Jakovac H. Antifibrotic activity of anthocyanidin delphinidin in carbon tetrachloride-induced hepatotoxicity in mice. Toxicology. 2010;272:1-10 pubmed publisher
  4. Jeong W, Park O, Radaeva S, Gao B. STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity. Hepatology. 2006;44:1441-51 pubmed
    ..STAT1 could be a new therapeutic target for treating liver fibrosis...
  5. Su P, Takehashi M, Tanaka S, Banasik M, Stedeford T, Ueda K, et al. Hepatocellular accumulation of poly(ADP-ribose) in male ICR mice treated with a necrogenic dose of carbon tetrachloride. Res Commun Mol Pathol Pharmacol. 2003;113-114:171-9 pubmed
    ..These results demonstrate the role of PARP-1 overactivation in chemical-induced pathologies and suggest the potential role of PARP-1 inhibitors at preventing toxicity...
  6. Terai S, Sakaida I, Nishina H, Okita K. Lesson from the GFP/CCl4 model--translational research project: the development of cell therapy using autologous bone marrow cells in patients with liver cirrhosis. J Hepatobiliary Pancreat Surg. 2005;12:203-7 pubmed
    ..Here we describe the findings from the GFP/CCl(4) model and the scope of the translational research project...
  7. Kataoka T, Nomura T, Wang D, Taguchi T, Yamaoka K. Effects of post low-dose X-ray irradiation on carbon tetrachloride-induced acatalasemic mice liver damage. Physiol Chem Phys Med NMR. 2005;37:109-26 pubmed
  8. Rai S, Wahile A, Mukherjee K, Saha B, Mukherjee P. Antioxidant activity of Nelumbo nucifera (sacred lotus) seeds. J Ethnopharmacol. 2006;104:322-7 pubmed
    ..Nelumbo nucifera seeds contain alkaloids, saponins, phenolics and carbohydrates. The results support significant antioxidant nature of HANN...
  9. Banasik M, Stedeford T, Ueda K, Muro Cacho C, Su P, Tanaka S, et al. Hepatoprotective effects of 6(5H)-phenanthridinone from chemical-induced centrilobular necrosis. Res Commun Mol Pathol Pharmacol. 2004;115-116:15-20 pubmed
    ..In conclusion, the results of this study demonstrate that the hepatotoxicity of CCl4 can be blocked independently of its metabolism and suggest the predominant role of PARP-1 overactivation in chemical-induced toxicity...

More Information

Publications62

  1. Guarner C, Runyon B, Young S, Heck M, Sheikh M. Intestinal bacterial overgrowth and bacterial translocation in cirrhotic rats with ascites. J Hepatol. 1997;26:1372-8 pubmed
  2. Weber L, Boll M, Stampfl A. Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit Rev Toxicol. 2003;33:105-36 pubmed
    ..Mixed halogenated methanes and ethanes, found as so-called disinfection byproducts at low concentration in drinking water, elicit symptoms of toxicity very similar to carbon tetrachloride, including carcinogenicity...
  3. Yamaoka K, Kataoka T, Nomura T, Taguchi T, Wang D, Mori S, et al. Inhibitory effects of prior low-dose X-ray irradiation on carbon tetrachloride-induced hepatopathy in acatalasemic mice. J Radiat Res. 2004;45:89-95 pubmed
  4. Szymonik Lesiuk S, Czechowska G, Stryjecka Zimmer M, Słomka M, Madro A, Celinski K, et al. Catalase, superoxide dismutase, and glutathione peroxidase activities in various rat tissues after carbon tetrachloride intoxication. J Hepatobiliary Pancreat Surg. 2003;10:309-15 pubmed
    ..The aim of this study was to determine the possible relationship between the activity of three different antioxidant enzymes--peroxidase superoxide dismutase, catalase, and glutathione peroxidase--and carbon tetrachloride-induced injury...
  5. Yoshioka T, Yoshida S, Kurosaki T, Teshima M, Nishida K, Nakamura J, et al. Cationic liposomes-mediated plasmid DNA delivery in murine hepatitis induced by carbon tetrachloride. J Liposome Res. 2009;19:141-7 pubmed publisher
    ..The extent of influences was also affected by lipid contents. These results indicate the necessity of considering the timing and the formulation for gene therapy according to the disease stage...
  6. Dranoff J, Kruglov E, Abreu Lanfranco O, Nguyen T, Arora G, Aurora G, et al. Prevention of liver fibrosis by the purinoceptor antagonist pyridoxal-phosphate-6-azophenyl-2',4'-disulfonate (PPADS). In Vivo. 2007;21:957-65 pubmed
    ..Pyridoxal-phosphate-6-azophenyl-2', 4'-disulfonate (PPADS) is a highly bioavailable purinoceptor inhibitor. We sought to determine whether PPADS could prevent experimental liver fibrosis in rats...
  7. Xue Q, Sun Z, Guo M, Wang Y, Zhang G, Wang X. Two new compounds from Semen celosiae and their protective effects against CCl?-induced hepatotoxicity. Nat Prod Res. 2011;25:772-80 pubmed publisher
    ..The results indicate that they have significant hepatoprotective effects, and that these hepatoprotective effects may be due to the antioxidant capability...
  8. Ramadori G, Moriconi F, Malik I, Dudas J. Physiology and pathophysiology of liver inflammation, damage and repair. J Physiol Pharmacol. 2008;59 Suppl 1:107-17 pubmed
    ..Furthermore, each cell type of the liver, including the hepatocytes, possesses its own defense apparatus...
  9. Okada K, Ueshima S, Kawao N, Okamoto C, Matsuo K, Akao M, et al. Binding of plasminogen to hepatocytes isolated from injured mouse liver and nonparenchymal-cell-dependent proliferation of hepatocytes. Blood Coagul Fibrinolysis. 2008;19:503-11 pubmed publisher
    ..These results indicate that the plasminogen-plasmin system on the surface of mouse hepatocytes plays an important role in liver regeneration...
  10. Wang S, Kao M, Wu S, Lo D, Wu J, Chang J, et al. Oral administration of Trapa taiwanensis Nakai fruit skin extracts conferring hepatoprotection from CCl4-caused injury. J Agric Food Chem. 2011;59:3686-92 pubmed publisher
    ..05) in lowering CCl(4)-caused increases of alanine aminotransferase and aspartate aminotransferase activities. It is of merit to demonstrate HWETT as a potent source of antioxidants and hepatoprotective agents...
  11. Khan R, Khan M, Sahreen S, Bokhari J. Prevention of CCl4-induced nephrotoxicity with Sonchus asper in rat. Food Chem Toxicol. 2010;48:2469-76 pubmed publisher
    ..The present data suggests that SAME protect the kidneys possibly by alleviating the oxidative stress induced with CCl(4) in rat...
  12. Sawant S, Dnyanmote A, Mehendale H. Mechanisms of inhibited liver tissue repair in toxicant challenged type 2 diabetic rats. Toxicology. 2007;232:200-15 pubmed
    ..In conclusion, decreased p-pRB may contribute to blocked advance of cells from G(0)/G(1) to S-phase and failed cell division in DB rats exposed to CCl(4) or TA, leading to progression of liver injury and hepatic failure...
  13. Wang L, Zhao L, Tang H, Liu L, Li C, Yao F, et al. [Experimental study of two histological quantitative methods of hepatic fibrosis]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2007;24:166-9 pubmed
    ..01). The result suggests that both SSS marks of hepatic fibrosis and image analysis by computer can be taken as reliable histological quantitative method of hepatic fibrosis...
  14. Maiti K, Mukherjee K, Murugan V, Saha B, Mukherjee P. Enhancing bioavailability and hepatoprotective activity of andrographolide from Andrographis paniculata, a well-known medicinal food, through its herbosome. J Sci Food Agric. 2010;90:43-51 pubmed publisher
    ..The aim of this study was to formulate a herbosome of andrographolide with a naturally occurring phospholipid in order to enhance the bioavailability and hepatoprotective activity of andrographolide in rats...
  15. Adebajo A, Iwalewa E, Obuotor E, Ibikunle G, Omisore N, Adewunmi C, et al. Pharmacological properties of the extract and some isolated compounds of Clausena lansium stem bark: anti-trichomonal, antidiabetic, anti-inflammatory, hepatoprotective and antioxidant effects. J Ethnopharmacol. 2009;122:10-9 pubmed publisher
  16. Sar T, Mandal T, Patra P, Samanta I. Disposition of ceftriaxone in hepatopathic goats following single-intramuscular dosing. Eur J Drug Metab Pharmacokinet. 2013;38:269-73 pubmed publisher
    ..Therefore, the reabsorption and metabolism of ceftriaxone in goats should be taken into consideration for drug monitoring...
  17. Pérez Vargas J, Zarco N, Vergara P, Shibayama M, Segovia J, Tsutsumi V, et al. l-Theanine prevents carbon tetrachloride-induced liver fibrosis via inhibition of nuclear factor κB and down-regulation of transforming growth factor β and connective tissue growth factor. Hum Exp Toxicol. 2016;35:135-46 pubmed publisher
    ..In conclusion, L-theanine prevents CCl4-induced experimental hepatic cirrhosis in rats by blocking the main pro-inflammatory and pro-fibrogenic signals. ..
  18. Delgado I, Carrasco M, Cano E, Carmona R, Garcia Carbonero R, Marín Gómez L, et al. GATA4 loss in the septum transversum mesenchyme promotes liver fibrosis in mice. Hepatology. 2014;59:2358-70 pubmed publisher
    ..Haploinsufficiency of Gata4 accelerated CCl4 -induced liver fibrosis in adult mice. Moreover, Gata4 expression was dramatically reduced in advanced hepatic fibrosis and cirrhosis in humans...
  19. Wu S, Yue Y, Tian H, Li Z, Li X, He W, et al. Carthamus red from Carthamus tinctorius L. exerts antioxidant and hepatoprotective effect against CCl(4)-induced liver damage in rats via the Nrf2 pathway. J Ethnopharmacol. 2013;148:570-8 pubmed publisher
    ..Carthamus red isolated from safflower (Carthamus tinctorius L., a Chinese traditional medicine) is evaluated for antioxidant and hepatoprotective activity...
  20. Knockaert L, Berson A, Ribault C, Prost P, Fautrel A, Pajaud J, et al. Carbon tetrachloride-mediated lipid peroxidation induces early mitochondrial alterations in mouse liver. Lab Invest. 2012;92:396-410 pubmed publisher
    ..Antioxidant therapy may not be an efficient strategy to block early liver damage after CCl(4) intoxication...
  21. de Oliveira E Silva A, Vidal Novoa A, Batista González A, Pinto J, Portari Mancini D, Reina Urquijo W, et al. In vivo and in vitro antioxidant activity and hepatoprotective properties of polyphenols from Halimeda opuntia (Linnaeus) Lamouroux. Redox Rep. 2012;17:47-53 pubmed publisher
    ..These data suggest that the phenolic fractions from H. opuntia may protect the liver against oxidative stress-inducing effects of chemicals by modulating its antioxidant enzymes and oxidative status...
  22. Cheng N, Ren N, Gao H, Lei X, Zheng J, Cao W. Antioxidant and hepatoprotective effects of Schisandra chinensis pollen extract on CCl4-induced acute liver damage in mice. Food Chem Toxicol. 2013;55:234-40 pubmed publisher
    ..The hepatoprotective effect may be related to its free radical scavenging effect, increasing antioxidant activity and inhibiting lipid peroxidation...
  23. Tan L, Li X, Liu Z, Liu L. [Effects of combination therapy of rehin and tetramethylpyrazine on experimental hepatic fibrosis induced by tetrachloride]. Zhonghua Gan Zang Bing Za Zhi. 2004;12:692-3 pubmed
  24. Wu Y, Chen K, Lin W. Effect of Ganoderma tsugae on chronically carbon tetrachloride-intoxicated rats. Am J Chin Med. 2004;32:841-50 pubmed
    ..All these results clearly demonstrated that GTE has hepatoprotective and anti-fibrotic activities...
  25. Hwang Y, Kim M, Song I, Lim J, Park B, Yun H. Altered pharmacokinetics of enrofloxacin in experimental models of hepatic and renal impairment. Vet Res Commun. 2009;33:481-7 pubmed publisher
    ..05) by renal impairment. In conclusion, these results suggested that renal impairment could affect the pharmacokinetics of enrofloxacin...
  26. Chen A, Taguchi T, Sakai K, Matahira Y, Wang M, Miwa I. Effect of chitobiose and chitotriose on carbon tetrachloride-induced acute hepatotoxicity in rats. Biol Pharm Bull. 2005;28:1971-3 pubmed
    ..The results indicate that chitobiose and chitotriose have the ability to exert a protective action against CCl4-induced acute hepatoxicity, probably by their antioxidant activity...
  27. Tu C, Guo J, Wang M, Wang J. Antifibrotic activity of rofecoxib in vivo is associated with reduced portal hypertension in rats with carbon tetrachloride-induced liver injury. J Gastroenterol Hepatol. 2007;22:877-84 pubmed
    ..The aim of this study was to investigate the effects of selective inhibition of COX-2 on the development of liver cirrhosis and portal hypertension in rats...
  28. Wu Y, Li L, Wen T, Li Y. Protective effects of echinacoside on carbon tetrachloride-induced hepatotoxicity in rats. Toxicology. 2007;232:50-6 pubmed
    ..It is therefore suggested that echinacoside can provide a definite protective effect against acute hepatic injury caused by CCl(4) in rats, which may mainly be associated with its antioxidative effect...
  29. El Laithy H. Self-nanoemulsifying drug delivery system for enhanced bioavailability and improved hepatoprotective activity of biphenyl dimethyl dicarboxylate. Curr Drug Deliv. 2008;5:170-6 pubmed
    ..7 and 6-folds that of commercial chinese pilules and Pennel capsules respectively. This improvement was also confirmed histopathologically in chemically injured rats and by the significant decrease in elevated liver enzymes level...
  30. Rajeswary H, Vasuki R, Samudram P, Geetha A. Hepatoprotective action of ethanolic extracts of Melia azedarach Linn. and Piper longum Linn and their combination on CCl4 induced hepatotoxicity in rats. Indian J Exp Biol. 2011;49:276-81 pubmed
    ..Among these extracts, BHE showed similar hepatoprotective action to silymarin, which was the positive control in this study...
  31. Serbetçi K, Uysal O, Erkasap N, Koken T, Baydemir C, Erkasap S. Anti-apoptotic and antioxidant effect of leptin on CCl?-induced acute liver injury in rats. Mol Biol Rep. 2012;39:1173-80 pubmed publisher
    ..It plays a role as a potent free radical scavenger, a powerful antioxidant and it also has anti-apoptotic effects...
  32. Arıcı O, Cetin N. Protective role of ghrelin against carbon tetrachloride (CCl?)-induced coagulation disturbances in rats. Regul Pept. 2011;166:139-42 pubmed publisher
    ..05) fibrinogen level when compared with CCl?-treated only group. The results of this study suggest that exogenously administered ghrelin may play a protective role against CCl?-induced coagulation disturbances in rats...
  33. Briukhin G, Nikolina O, Barysheva S. [Morphological and functional characteristics of thyroid gland in the offspring of female rats with experimental chronic liver disease of various etiology]. Morfologiia. 2005;128:56-9 pubmed
    ..Morphological changes of the thyroid gland in the offspring of female rats with chronic liver disease were accompanied by the impairment of the gland endocrine function (decreased serum levels of T3 and T4)...
  34. Iida C, Fujii K, Kishioka T, Nagae R, Onishi Y, Ichi I, et al. Activation of mitogen activated protein kinase (MAPK) during carbon tetrachloride intoxication in the rat liver. Arch Toxicol. 2007;81:489-93 pubmed
    ..These results indicated that the change in MAPKs (mitogen activated protein kinases) slightly preceded that in vitamin C, the most sensitive chemical indicator of oxidative stress...
  35. Kawao N, Okada K, Kawata S, Okamoto C, Tsuritani M, Ueshima S, et al. Plasmin decreases the BH3-only protein BimEL via the ERK1/2 signaling pathway in hepatocytes. Biochim Biophys Acta. 2007;1773:718-27 pubmed
    ..Our data suggest that the plasminogen/plasmin system could decrease Bim(EL) expression via the ERK1/2 signaling pathway during liver regeneration...
  36. Zhong M, Chen F, Yuan L, Wang X, Wu F, Yuan F, et al. Protective effect of total flavonoids from Bidens bipinnata L. against carbon tetrachloride-induced liver injury in mice. J Pharm Pharmacol. 2007;59:1017-25 pubmed
    ..Further research is required to investigate the detailed mechanism of the protective effect of TFB on acute liver injury...
  37. Fan J, Tian L, Cai X, Qian Y, Yang Z, Xu Z. [Effect of hyperglycemia on the progress of rat liver fibrosis induced by carbon tetrachloride]. Zhonghua Gan Zang Bing Za Zhi. 2006;14:58-60 pubmed
  38. Pacheco G, Panatto J, Fagundes D, Scaini G, Bassani C, Jeremias I, et al. Brain creatine kinase activity is inhibited after hepatic failure induced by carbon tetrachloride or acetaminophen. Metab Brain Dis. 2009;24:383-94 pubmed publisher
    ..Although it is difficult to extrapolate our findings to the human condition, the inhibition of brain CK activity after hepatic failure may be involved in the pathogenesis of hepatic encephalopathy...
  39. Balbis E, Patriarca S, Furfaro A, Millanta S, Sukkar S, Marinari U, et al. Whey proteins influence hepatic glutathione after CCl4 intoxication. Toxicol Ind Health. 2009;25:325-8 pubmed publisher
  40. Popovic M, Kaurinovic B, Trivic S, Mimica Dukic N, Bursać M. Effect of celery (Apium graveolens) extracts on some biochemical parameters of oxidative stress in mice treated with carbon tetrachloride. Phytother Res. 2006;20:531-7 pubmed
    ..The differences observed in the action of particular extracts are probably due to the different contents of flavonoids and some other antioxidant compounds...
  41. Song A, Ko H, Lai M, Ng L. Protective effects of Wu-Ling-Shen (Xylaria nigripes) on carbon tetrachloride-induced hepatotoxicity in mice. Immunopharmacol Immunotoxicol. 2011;33:454-60 pubmed publisher
    ..These results conclude that XN exerts effective protection against CCl(4)-induced liver injury in mice, and its mechanism of action could be through the effects of antioxidants on reducing the oxidative stress...
  42. Jia R, Cao L, Xu P, Jeney G, Yin G. In vitro and in vivo hepatoprotective and antioxidant effects of Astragalus polysaccharides against carbon tetrachloride-induced hepatocyte damage in common carp (Cyprinus carpio). Fish Physiol Biochem. 2012;38:871-81 pubmed publisher
    ..Overall results proved the hepatoprotective action of APS, which is likely related to its antioxidant activity. The results support the use of APS as a hepatoprotective and antioxidant agent in fish...
  43. Jiao J, Sastre D, Fiel M, Lee U, Ghiassi Nejad Z, Ginhoux F, et al. Dendritic cell regulation of carbon tetrachloride-induced murine liver fibrosis regression. Hepatology. 2012;55:244-55 pubmed publisher
    ..In contrast, transfer of DCs from MMP-9-deficient mice failed to improve fibrosis regression...
  44. Akowuah G, Zhari I, Mariam A, Yam M. Absorption of andrographolides from Andrographis paniculata and its effect on CCl(4)-induced oxidative stress in rats. Food Chem Toxicol. 2009;47:2321-6 pubmed publisher
    ..Treatment of rats with CCl(4) did not showed significant alteration (p>0.05) in plasma total antioxidant status (TAS) as compare to values of control group...
  45. Shen X, Tang Y, Yang R, Yu L, Fang T, Duan J. The protective effect of Zizyphus jujube fruit on carbon tetrachloride-induced hepatic injury in mice by anti-oxidative activities. J Ethnopharmacol. 2009;122:555-60 pubmed publisher
    ..The study was aimed to investigate the protective effect against hepatic injury induced by CCl(4) for the ethanolic extract of FZJ...
  46. Ramachandran P, Pellicoro A, Vernon M, Boulter L, Aucott R, Ali A, et al. Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. Proc Natl Acad Sci U S A. 2012;109:E3186-95 pubmed publisher
    ..Critically, induced phagocytic behavior in vivo, through administration of liposomes, increased restorative macrophage number and accelerated fibrosis resolution, offering a therapeutic strategy to this orphan pathological process...
  47. Zhang G, Zeng T, Wang Q, Zhao X, Song F, Xie K. [Protective effect of garlic oil given at different time against acute liver injury induced by CCl4]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2010;28:190-4 pubmed
    ..To observe and compare the protective effect of garlic oil against carbon tetrachloride (CCL)-induced acute liver injury...
  48. Zhang C, Han C, Zhao B, Yu H. The protective effects of aqueous extracts of wild-growing and fermented Royal Sun mushroom, Agaricus brasiliensis S. Wasser et al. (higher basidiomycetes), in CCl4-induced oxidative damage in rats. Int J Med Mushrooms. 2012;14:557-61 pubmed
    ..The studies demonstrate that both the fermented and wild-growing A. brasiliensis could protect the liver against CCl4-induced oxidative damage in rats...
  49. Shaker M, Houssen M, Abo Hashem E, Ibrahim T. Comparison of vitamin E, L-carnitine and melatonin in ameliorating carbon tetrachloride and diabetes induced hepatic oxidative stress. J Physiol Biochem. 2009;65:225-33 pubmed publisher
    ..Meanwhile, potency of L-carnitine was nearly the same in CCl(4) and diabetes-induced liver damage...
  50. Verma A, Vijayakumar M, Rao C, Mathela C. In vitro and in vivo antioxidant properties and DNA damage protective activity of green fruit of Ficus glomerata. Food Chem Toxicol. 2010;48:704-9 pubmed publisher
    ..Based on these results, it is concluded that F. glomerata protects tissues from oxidative stress and these effects are probably related to the antioxidant properties...
  51. Ma J, Luo R, Jiang H, Liu C. Quercitrin offers protection against brain injury in mice by inhibiting oxidative stress and inflammation. Food Funct. 2016;7:549-56 pubmed publisher
    ..Taken together, our findings suggested that quercitrin may be a potential candidate to be developed as a neuroprotective agent. ..
  52. Shi B, Zhu L, Xie W, Zhang Z, Wu G. [Change of zero-stress state of portal vein in the rat during the pathogenesis of intrahepatic portal hypertension]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2006;23:753-5 pubmed
  53. Nakatsuka R, Taniguchi M, Hirata M, Shiota G, Sato K. Transient expression of bone morphogenic protein-2 in acute liver injury by carbon tetrachloride. J Biochem. 2007;141:113-9 pubmed
    ..These observations suggest that BMP-2 secreted from oval-like cells plays important roles in the wound healing response of injured liver...