Summary: Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION.

Top Publications

  1. Markman T, Markman M. Cardiotoxicity of antineoplastic agents: what is the present and future role for imaging?. Curr Oncol Rep. 2014;16:396 pubmed
    ..Here we discuss the current and future role of cardiac imaging in the assessment of cardiotoxicity of antineoplastic agents...
  2. Shah K, Yang E, Maisel A, Fonarow G. The Role of Biomarkers in Detection of Cardio-toxicity. Curr Oncol Rep. 2017;19:42 pubmed publisher
    ..Finally, future directions for potential utilization of novel biomarkers for the improvement of care of patients in the field of cardio-oncology are discussed. ..
  3. Gear R, Kendziorski J, Belcher S. Effects of bisphenol A on incidence and severity of cardiac lesions in the NCTR-Sprague-Dawley rat: A CLARITY-BPA study. Toxicol Lett. 2017;275:123-135 pubmed publisher
    ..In BPA or EE treated females cardiomyopathy incidence and severity was significantly increased compared to control females at PND21 with myocardial degeneration observed in both males and females at PND21 and PND90. ..
  4. Kimura T, Uesugi M, Takase K, Miyamoto N, Sawada K. Hsp90 inhibitor geldanamycin attenuates the cytotoxicity of sunitinib in cardiomyocytes via inhibition of the autophagy pathway. Toxicol Appl Pharmacol. 2017;329:282-292 pubmed publisher
    ..further investigation of combination or sequential treatment with an Hsp90 inhibitor and sunitinib is warranted as a potential strategy of attenuating the cardiotoxicity associated with sunitinib administration in the clinical setting.
  5. Patanè S. Cardiotoxicity: anthracyclines and long term cancer survivors. Int J Cardiol. 2014;176:1326-8 pubmed publisher
  6. Cypher A, Consiglio J, Bagatto B. Hypoxia exacerbates the cardiotoxic effect of the polycyclic aromatic hydrocarbon, phenanthrene in Danio rerio. Chemosphere. 2017;183:574-581 pubmed publisher
    ..This study shows that phenanthrene decreases cardiac parameters, most significantly heart rate and that this effect is exacerbated by simultaneous exposure to hypoxia. ..
  7. Iqbal S, Lemmens Gruber R. Voltage gated ion channels blockade is the underlying mechanism of BIMU8 induced cardiotoxicity. Toxicol Lett. 2017;277:64-68 pubmed publisher
    ..87mV in fast inactivation of NaV1.5 channel. These experimental findings indicate that BIMU8 is a potent blocker of hERG, NaV1.5 and CaV1.2 cardiac ion channels thus revealing its proarrhythmic potential. ..
  8. Reyes L, Restrepo M, Hinojosa C, Soni N, Anzueto A, Babu B, et al. Severe Pneumococcal Pneumonia Causes Acute Cardiac Toxicity and Subsequent Cardiac Remodeling. Am J Respir Crit Care Med. 2017;196:609-620 pubmed publisher
    ..In mice, Streptococcus pneumoniae can invade the myocardium, induce cardiomyocyte death, and disrupt cardiac function following bacteremia, but it is unknown whether the same occurs in humans with severe pneumonia...
  9. Sharma A, Burridge P, McKeithan W, Serrano R, Shukla P, Sayed N, et al. High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells. Sci Transl Med. 2017;9: pubmed publisher
    ..TKIs with low cardiac safety indices exhibit cardiotoxicity in patients...

More Information


  1. Shabalala S, Muller C, Louw J, Johnson R. Polyphenols, autophagy and doxorubicin-induced cardiotoxicity. Life Sci. 2017;180:160-170 pubmed publisher dysregulation of autophagy, has been implicated as a major contributor associated with doxorubicin-induced cardiotoxicity. Increased oxidative stress and lipid peroxidation are known to enhance the production of reactive oxygen ..
  2. Chen J, Du F, Hu B, Chi C, Chu H, Jiang L, et al. Severe Cardiotoxicity in a Patient with Colorectal Cancer Treated with Bevacizumab. Anticancer Res. 2017;37:4557-4561 pubmed
    ..Hypertension, third-degree albuminuria, thrombosis and cardiotoxicity are the reported side-effects of bevacizumab. Among them, cardiotoxicity is a most severe, but rare outcome...
  3. Petroni K, Trinei M, Fornari M, Calvenzani V, Marinelli A, Micheli L, et al. Dietary cyanidin 3-glucoside from purple corn ameliorates doxorubicin-induced cardiotoxicity in mice. Nutr Metab Cardiovasc Dis. 2017;27:462-469 pubmed publisher
    ..However, their use is limited because of a cumulative dose-dependent and irreversible cardiotoxicity that can cause progressive cardiomyopathy and congestive heart failure...
  4. Rotz S, Ryan T, Hlavaty J, George S, El Bietar J, Dandoy C. Cardiotoxicity and cardiomyopathy in children and young adult survivors of hematopoietic stem cell transplant. Pediatr Blood Cancer. 2017;64: pubmed publisher
    ..Herein we review the causes of cardiac injury, discuss strategies for detection of cardiomyopathy, and evaluate therapeutic options for long-term HSCT survivors. ..
  5. Baggish A, Weiner R, Kanayama G, Hudson J, Lu M, Hoffmann U, et al. Cardiovascular Toxicity of Illicit Anabolic-Androgenic Steroid Use. Circulation. 2017;135:1991-2002 pubmed publisher
    ..These forms of AAS-associated adverse cardiovascular phenotypes may represent a previously underrecognized public-health problem. ..
  6. Dokmanovic M, King K, Mohan N, Endo Y, Wu W. Cardiotoxicity of ErbB2-targeted therapies and its impact on drug development, a spotlight on trastuzumab. Expert Opin Drug Metab Toxicol. 2017;13:755-766 pubmed publisher
    ..This finding, subsequently corroborated by multiple clinical studies, raised concerns that the observed cardiotoxicity induced by trastuzumab might adversely impact the clinical development of other therapeutics targeting ErbB ..
  7. Klee N, McCarthy C, Martinez Quinones P, Webb R. Out of the frying pan and into the fire: damage-associated molecular patterns and cardiovascular toxicity following cancer therapy. Ther Adv Cardiovasc Dis. 2017;11:297-317 pubmed publisher
  8. Qiu M, Ke L, Zhang S, Zeng X, Fang Z, Liu J. JS-K, a GST-activated nitric oxide donor prodrug, enhances chemo-sensitivity in renal carcinoma cells and prevents cardiac myocytes toxicity induced by Doxorubicin. Cancer Chemother Pharmacol. 2017;80:275-286 pubmed publisher
    ..effective and widely used anthracycline antibiotic in multiple chemotherapy regimens, has been limited by its cardiotoxicity. The aim of this study is to investigate the effect of nitric oxide donor prodrug JS-K on proliferation and ..
  9. Adaramoye O, Lawal S. Kolaviron, a biflavonoid fraction from Garcinia kola, protects against isoproterenol-induced injury by mitigating cardiac dysfunction and oxidative stress in rats. J Basic Clin Physiol Pharmacol. 2015;26:65-72 pubmed publisher
    ..The aim of this study was to evaluate the cardioprotective effects of kolaviron (KV), a biflavonoid from Garcinia kola seeds, in rats intoxicated with isoproterenol chloride (ISO) while quercetin (QUE) served as standard...
  10. Shoukry H, Ammar H, Rashed L, Zikri M, Shamaa A, Abou Elfadl S, et al. Prophylactic supplementation of resveratrol is more effective than its therapeutic use against doxorubicin induced cardiotoxicity. PLoS ONE. 2017;12:e0181535 pubmed publisher
    ..Therefore, prophylactic use of resveratrol may be projected as a possible future adjuvant therapy to minimize cardiotoxic side effects of doxorubicin in cancer patients. ..
  11. Potocnik N, Perse M, Cerar A, Injac R, Finderle Z. Cardiac autonomic modulation induced by doxorubicin in a rodent model of colorectal cancer and the influence of fullerenol pretreatment. PLoS ONE. 2017;12:e0181632 pubmed publisher
    ..Autonomic disbalance might even be an initiating mechanism underlying DOX-induced cardiotoxicity and can be studied noninvasively by the analysis of heart rate variability (HRV)...
  12. Bansal N, Amdani S, Lipshultz E, Lipshultz S. Chemotherapy-induced cardiotoxicity in children. Expert Opin Drug Metab Toxicol. 2017;13:817-832 pubmed publisher
    ..Treatment-related cardiac damage is progressive and often irreversible. Primary prevention of cardiotoxicity during treatment is possible with strategies like limiting the cumulative anthracycline dose, the use of ..
  13. Deng L, Wang L, Peng C, Li Y, Huang M, Chen M, et al. Fibroblast Activation Protein ? Activated Tripeptide Bufadienolide Antitumor Prodrug with Reduced Cardiotoxicity. J Med Chem. 2017;60:5320-5333 pubmed publisher
    ..Our study suggests that FAP? prodrug strategy is an effective approach for successful increasing the therapeutic window of bufadienolides. ..
  14. Giza D, Iliescu G, Hassan S, Marmagkiolis K, Iliescu C. Cancer as a Risk Factor for Cardiovascular Disease. Curr Oncol Rep. 2017;19:39 pubmed publisher
    ..Better knowledge of these early and late cardiac effects in cancer patients will enable adoption of both primary and secondary prevention measures of long-term treatment complications in cancer survivors. ..
  15. Wang S, Zhang Y, Zhang Q, Peng S, Shen C, Yu Y, et al. Content decline of SERCA inhibitors saikosaponin a and d attenuates cardiotoxicity and hepatotoxicity of vinegar-baked Radix bupleuri. Environ Toxicol Pharmacol. 2017;52:129-137 pubmed publisher
    Improper usage of unprocessed Radix bupleuri root (chaihu) may cause cardiotoxicity and liver injury. Baking herb with vinegar is believed to attenuate the adverse responses...
  16. Sun X, Wan L, Yang Q, Huo Y, Han Y, Guo C. Scutellarin protects against doxorubicin-induced acute cardiotoxicity and regulates its accumulation in the heart. Arch Pharm Res. 2017;40:875-883 pubmed publisher
    The clinical use of doxorubicin (DOX) is limited by its dose-dependent cardiotoxicity. The present study investigated the effects of scutellarin against DOX-induced cardiotoxicity in rats using pharmacodynamic and pharmacokinetic ..
  17. Tocchetti C, Carpi A, Coppola C, Quintavalle C, Rea D, Campesan M, et al. Ranolazine protects from doxorubicin-induced oxidative stress and cardiac dysfunction. Eur J Heart Fail. 2014;16:358-66 pubmed
    ..oxygen species (ROS) production, our aim was to assess whether ranolazine prevents doxorubicin-induced cardiotoxicity, and whether blunted oxidative stress is a mechanism accounting for such protection...
  18. Wu I, Yu J, Lin C, Seak C, Olson K, Chen H. Fatal cardiac glycoside poisoning due to mistaking foxglove for comfrey. Clin Toxicol (Phila). 2017;55:670-673 pubmed publisher
    ..The patient died despite treatment with digoxin-specific antibody fragments (DSFab) and veno-arterial extracorporeal membrane oxygenation (VA-ECMO)...
  19. Cornet C, Calzolari S, Miñana Prieto R, Dyballa S, van Doornmalen E, Rutjes H, et al. ZeGlobalTox: An Innovative Approach to Address Organ Drug Toxicity Using Zebrafish. Int J Mol Sci. 2017;18: pubmed publisher
    ..Finally, it might allow the Replacement of classical species, such as rodents and larger mammals, thanks to its high predictivity (Specificity: 89%, Sensitivity: 68% and Accuracy: 78%). ..
  20. Wilkinson E, Sidaway J, Cross M. Statin regulated ERK5 stimulates tight junction formation and reduces permeability in human cardiac endothelial cells. J Cell Physiol. 2018;233:186-200 pubmed publisher
    ..Statin mediated ERK5 activation and the resulting decrease in cardiac endothelial cell permeability may contribute to the cardioprotective effects of statins in reducing doxorubicin-induced cardiotoxicity.
  21. Radchenko E, Rulev Y, Safanyaev A, Palyulin V, Zefirov N. Computer-aided estimation of the hERG-mediated cardiotoxicity risk of potential drug components. Dokl Biochem Biophys. 2017;473:128-131 pubmed publisher
    The hERG potassium channel is one of the most important anti-targets determining cardiotoxicity of potential drugs...
  22. Gholami S, Hosseini M, Jafari L, Omidvar F, Kamalinejad M, Mashayekhi V, et al. Mitochondria as a Target for the Cardioprotective Effects of Cydonia oblonga Mill. and Ficus carica L. in Doxorubicin-Induced Cardiotoxicity. Drug Res (Stuttg). 2017;67:358-365 pubmed publisher
    ..fruit (ACO) and Ficus carica L. fruit (AFC) against DOX-induced cardiotoxicity. Cardiomyocytes toxicity was induced in male Sprague Dawley rats by intraperitoneal (ip) injections of 2...
  23. Koci B, Luerman G, Duenbostell A, Kettenhofen R, Bohlen H, Coyle L, et al. An impedance-based approach using human iPSC-derived cardiomyocytes significantly improves in vitro prediction of in vivo cardiotox liabilities. Toxicol Appl Pharmacol. 2017;329:121-127 pubmed publisher
    ..Outside of the Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative, structural and functional cardiotoxicity related to chronic dosing effects are of great concern as these effects can impact compound attrition...
  24. Aghel N, Delgado D, Lipton J. Cardiovascular toxicities of BCR-ABL tyrosine kinase inhibitors in chronic myeloid leukemia: preventive strategies and cardiovascular surveillance. Vasc Health Risk Manag. 2017;13:293-303 pubmed publisher
    ..Methodological challenges of studies that reported the cardiovascular safety of TKIs are discussed. We also propose management strategies for cardiovascular surveillance and risk factor modification during treatment with these agents. ..
  25. Salvatorelli E, Menna P, Minotti G. Managing anthracycline-induced cardiotoxicity: beginning with the end in mind. Future Cardiol. 2015;11:363-6 pubmed publisher
  26. Maharsy W, Aries A, Mansour O, Komati H, Nemer M. Ageing is a risk factor in imatinib mesylate cardiotoxicity. Eur J Heart Fail. 2014;16:367-76 pubmed
    Chemotherapy-induced heart failure is increasingly recognized as a major clinical challenge. Cardiotoxicity of imatinib mesylate, a highly selective and effective anticancer drug belonging to the new class of tyrosine kinase inhibitors, ..
  27. Zhang Y, Yi M, Huang Y. Oxymatrine Ameliorates Doxorubicin-Induced Cardiotoxicity in Rats. Cell Physiol Biochem. 2017;43:626-635 pubmed publisher
    ..In this study, we aimed to investigate the effects of oxymatrine on doxorubicin-induced cardiotoxicity in rat hearts and H9c2 cells...
  28. Rickner S, Cao D, Kleinschmidt K, Fleming S. A little "dab" will do ya' in: a case report of neuro-and cardiotoxicity following use of cannabis concentrates. Clin Toxicol (Phila). 2017;55:1011-1013 pubmed publisher
    ..Psychosis and cardiotoxicity have been reported following cannabis use; however, myocardial injury from "dabbing" has not yet ..
  29. Ferreira A, Cunha Oliveira T, Simões R, Carvalho F, Burgeiro A, Nordgren K, et al. Altered mitochondrial epigenetics associated with subchronic doxorubicin cardiotoxicity. Toxicology. 2017;390:63-73 pubmed publisher
    ..The mechanisms responsible for DOX cardiotoxicity remain poorly understood, but seem to involve mitochondrial dysfunction on several levels...
  30. Nikitovic D, Juranek I, Wilks M, Tzardi M, Tsatsakis A, Tzanakakis G. Anthracycline-dependent cardiotoxicity and extracellular matrix remodeling. Chest. 2014;146:1123-1130 pubmed publisher
    The mechanisms of anthracycline-dependent cardiotoxicity have been studied widely, with the suggested principal mechanism of anthracycline damage being the generation of reactive oxygen species by iron-anthracycline complexes, leading to ..
  31. Wen S, Velmurugan B, Day C, Shen C, Chun L, Tsai Y, et al. High density lipoprotein (HDL) reverses palmitic acid induced energy metabolism imbalance by switching CD36 and GLUT4 signaling pathways in cardiomyocyte. J Cell Physiol. 2017;232:3020-3029 pubmed publisher
    ..Rat neonatal cardiomyocytes showed similar results. In conclusion, HDL reversed palmatic acid-induced lipotoxicity and energy metabolism imbalance in H9c2 cardiomyoblast cells and in neonatal rat cardiomyocyte cells. ..
  32. Vardon Bounes F, Tardif E, Ruiz S, Gallart J, Conil J, Delmas C. Suicide attempt with self-made Taxus baccata leaf capsules: survival following the application of extracorporeal membrane oxygenation for ventricular arrythmia and refractory cardiogenic shock. Clin Toxicol (Phila). 2017;55:925-928 pubmed publisher
  33. Polak S, Pugsley M, Stockbridge N, Garnett C, Wiśniowska B. Early Drug Discovery Prediction of Proarrhythmia Potential and Its Covariates. AAPS J. 2015;17:1025-32 pubmed publisher
  34. McGowan J, Chung R, Maulik A, Piotrowska I, Walker J, Yellon D. Anthracycline Chemotherapy and Cardiotoxicity. Cardiovasc Drugs Ther. 2017;31:63-75 pubmed publisher
    ..The basic mechanisms of cardiotoxicity may involve direct pathways for reactive oxygen species generation and topoisomerase 2 as well as other ..
  35. Ichikawa Y, Zemljic Harpf A, Zhang Z, McKirnan M, Manso A, Ross R, et al. Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits. PLoS ONE. 2017;12:e0177660 pubmed publisher
    ..Mechanisms involved in anthracycline cardiotoxicity are an area of relevant investigation...
  36. Chen R, Sun G, Ye J, Wang J, Zhang M, Sun X. Salvianolic acid B attenuates doxorubicin-induced ER stress by inhibiting TRPC3 and TRPC6 mediated Ca2+ overload in rat cardiomyocytes. Toxicol Lett. 2017;276:21-30 pubmed publisher
    Doxorubicin (DOX)-induced cardiotoxicity is a clinically complex syndrome that leads to significant pain to cancer survivors...
  37. Bauckneht M, Ferrarazzo G, Fiz F, Morbelli S, Sarocchi M, Pastorino F, et al. Doxorubicin Effect on Myocardial Metabolism as a Prerequisite for Subsequent Development of Cardiac Toxicity: A Translational 18F-FDG PET/CT Observation. J Nucl Med. 2017;58:1638-1645 pubmed publisher
    The present translational study aimed to verify whether serial 18F-FDG PET/CT predicts doxorubicin cardiotoxicity. Methods: Fifteen athymic mice were treated intravenously with saline (n = 5) or with 5 or 7...
  38. Martel S, Maurer C, Lambertini M, Pondé N, de Azambuja E. Breast cancer treatment-induced cardiotoxicity. Expert Opin Drug Saf. 2017;16:1021-1038 pubmed publisher
    ..covered: This review aims to thoroughly describe the current state of the evidence regarding the potential cardiotoxicity of agents commonly used in the treatment of breast cancer...
  39. Oliveira Carvalho V, Ferreira L, Bocchi E. Circulating mir-208a fails as a biomarker of doxorubicin-induced cardiotoxicity in breast cancer patients. J Appl Toxicol. 2015;35:1071-2 pubmed publisher
  40. Kunarajah K, Hennig S, Norris R, Lobb M, Charles B, Pinkerton R, et al. Population pharmacokinetic modelling of doxorubicin and doxorubicinol in children with cancer: is there a relationship with cardiac troponin profiles?. Cancer Chemother Pharmacol. 2017;80:15-25 pubmed publisher
    ..a mainstay of the treatment of several childhood malignancies, but their utility is limited by dose-related cardiotoxicity. This study is aimed to explore the link between exposure of paediatric cancer patients to doxorubicin and its ..
  41. Wang T, Wang C, Wu Q, Zheng K, Chen J, Lan Y, et al. Evaluation of Tanshinone IIA Developmental Toxicity in Zebrafish Embryos. Molecules. 2017;22: pubmed publisher
    ..This study evaluated the cardiotoxicity and developmental malformations of Tan-IIA by using zebrafish normal embryos and dechorionated embryos...
  42. Levis B, Binkley P, Shapiro C. Cardiotoxic effects of anthracycline-based therapy: what is the evidence and what are the potential harms?. Lancet Oncol. 2017;18:e445-e456 pubmed publisher
    ..anthracyclines, no evidence-based guidelines exist for the surveillance and prevention of chemotherapy-induced cardiotoxicity in adult survivors of breast cancer who have had limited previous doses of anthracyclines (ie, total ..
  43. Kolla B, Roy S, Duval S, Weisdorf D, Valeti U, Blaes A. Cardiac Imaging Methods for Chemotherapy-related Cardiotoxicity Screening and Related Radiation Exposure: Current Practice and Trends. Anticancer Res. 2017;37:2445-2449 pubmed
    ..8mSv/study) for chemotherapy-related cardiotoxicity (CRC) screening...
  44. Santoni M, Guerra F, Conti A, Lucarelli A, Rinaldi S, Belvederesi L, et al. Incidence and risk of cardiotoxicity in cancer patients treated with targeted therapies. Cancer Treat Rev. 2017;59:123-131 pubmed publisher
    ..of this study was to evaluate the incidence and Relative Risk (RR) of developing all-grade and high-grade cardiotoxicity in patients with solid tumors receiving targeted agents through a revised meta-analysis of available clinical ..
  45. Guglin M, Munster P, Fink A, Krischer J. Lisinopril or Coreg CR in reducing cardiotoxicity in women with breast cancer receiving trastuzumab: A rationale and design of a randomized clinical trial. Am Heart J. 2017;188:87-92 pubmed publisher
    ..The use of TZB is commonly associated with cardiotoxicity manifesting as asymptomatic decrease in left ventricular ejection fraction (LVEF) or overt heart failure...
  46. Hahn E, Jiang H, Ng A, Bashir S, Ahmed S, Tsang R, et al. Late Cardiac Toxicity After Mediastinal Radiation Therapy for Hodgkin Lymphoma: Contributions of Coronary Artery and Whole Heart Dose-Volume Variables to Risk Prediction. Int J Radiat Oncol Biol Phys. 2017;98:1116-1123 pubmed publisher
    Mediastinal radiation therapy (RT) for Hodgkin lymphoma (HL) is associated with late cardiotoxicity, but there are limited data to indicate which dosimetric parameters are most valuable for predicting this risk...
  47. Antman E. Evaluating the Cardiovascular Safety of Nonsteroidal Anti-Inflammatory Drugs. Circulation. 2017;135:2062-2072 pubmed publisher