Summary: A class of compounds that adversely affect the transmission of impulses through the NERVOUS SYSTEM.
Seto Y, Tachikawa M, Kanamori Kataoka M, Sasamoto K, Ochiai N. Target analysis of tert-butyldimethylsilyl derivatives of nerve agent hydrolysis products by selectable one-dimensional or two-dimensional gas chromatography-mass spectrometry. J Chromatogr A. 2017;1501:99-106 pubmed publisher
..However, under 1D/2D GC-MS conditions, baseline separation of the MPA derivative and sulfuric acid derivative was achieved, enabling highly sensitive MPA detection at 20ng/ml. ..
Baygildiev T, Zatirakha A, Rodin I, Braun A, Stavrianidi A, Koryagina N, et al
. Rapid IC-MS/MS determination of methylphosphonic acid in urine of rats exposed to organophosphorus nerve agents. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1058:32-39 pubmed publisher
A direct approach for the determination of a specific hydrolysis product of organophosphorus nerve agents such as methylphosphonic acid (MPA) in urine by ion chromatography and tandem mass spectrometry (IC-MS/MS) has been developed...
Weissberg A, Madmon M, Elgarisi M, Dagan S. Determination of trace amounts of G-type nerve agents in aqueous samples utilizing "in vial" instantaneous derivatization and liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2017;1512:71-77 pubmed publisher
..methodology is appropriate for routine evaluation of contaminated water supplies and has the advantage of a simultaneous analysis of both derivatized G-nerve agents and their intact hydrolysis products within a single LC-MS analysis.
Herbert J, Thiermann H, Worek F, Wille T. Precision cut lung slices as test system for candidate therapeutics in organophosphate poisoning. Toxicology. 2017;389:94-100 pubmed publisher
..Now, candidate therapeutic compounds can be evaluated, based on their ability to counteract the irreversible airway contraction in OP poisoned PCLS. ..
Dafferner A, Schopfer L, Xiao G, Cashman J, Yerramalla U, Johnson R, et al
. Immunopurification of Acetylcholinesterase from Red Blood Cells for Detection of Nerve Agent Exposure. Chem Res Toxicol. 2017;30:1897-1910 pubmed publisher
b>Nerve agents and organophosphorus pesticides make a covalent bond with the active site serine of acetylcholinesterase (AChE), resulting in inhibition of AChE activity and toxic symptoms...