Genomes and Genes
Summary: Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS.
- Specht I, Toft G, Hougaard K, Lindh C, Lenters V, Jonsson B, et al. Associations between serum phthalates and biomarkers of reproductive function in 589 adult men. Environ Int. 2014;66:146-56 pubmed publisher..Metabolic pathways differed significantly between the three study sites, but without major effect on semen quality or reproductive hormones. ..
- Sonne C, Gustavson K, Riget F, Dietz R, Krüger T, Bonefeld Jørgensen E. Physiologically based pharmacokinetic modeling of POPs in Greenlanders. Environ Int. 2014;64:91-7 pubmed publisher..Based on these results we suggest that PBPK modeling is implemented as a tool in future human health exposure and effect assessments in Greenland. ..
- Verner M, McDougall R, Glynn A, Andersen M, Clewell H, Longnecker M. Is the relationship between prenatal exposure to PCB-153 and decreased birth weight attributable to pharmacokinetics?. Environ Health Perspect. 2013;121:1219-24 pubmed publisher..Our findings suggest that associations previously noted between PCB levels and birth weight may be attributable to confounding by maternal weight gain during pregnancy. ..
- Jeon C, Madsen E. In situ microbial metabolism of aromatic-hydrocarbon environmental pollutants. Curr Opin Biotechnol. 2013;24:474-81 pubmed publisher..12C and 2H to 1H in contaminant pools in field sites) have deepened our insights into the mechanisms (how), the occurrence (what), and the identity (who) of active players that effect biodegradation of organic environmental pollutants.
- Tang R, Chen M, Ding G, Chen X, Han X, Zhou K, et al. Associations of prenatal exposure to phenols with birth outcomes. Environ Pollut. 2013;178:115-20 pubmed publisher..In conclusion, we found prenatal phenol exposure was sex-specifically related to birth outcomes. ..
- Vandenberg L, Colborn T, Hayes T, Heindel J, Jacobs D, Lee D, et al. Regulatory decisions on endocrine disrupting chemicals should be based on the principles of endocrinology. Reprod Toxicol. 2013;38:1-15 pubmed publisher..This discussion should result in a better understanding of these issues, and allow for additional dialog on their impact on risk assessment. ..
- Greaves A, Letcher R, Sonne C, Dietz R. Brain region distribution and patterns of bioaccumulative perfluoroalkyl carboxylates and sulfonates in east greenland polar bears (Ursus maritimus). Environ Toxicol Chem. 2013;32:713-22 pubmed publisher..The present study demonstrates that both PFCAs and perfluoroalkyl sulfonates cross the blood-brain barrier in polar bears and that wet-weight concentrations are brain region-specific. ..
- Gomes H, Dias Ferreira C, Ribeiro A. Overview of in situ and ex situ remediation technologies for PCB-contaminated soils and sediments and obstacles for full-scale application. Sci Total Environ. 2013;445-446:237-60 pubmed publisher..The successful remediation of a site will depend on proper selection, design and adjustment of the technology or combined technologies to the site characteristics. ..
- Vandenberg L, Hunt P, Myers J, vom Saal F. Human exposures to bisphenol A: mismatches between data and assumptions. Rev Environ Health. 2013;28:37-58 pubmed publisher..Our conclusions are consistent with the large number of hazards and adverse effects identified in laboratory animals exposed to low doses of BPA. ..
- Buck Louis G, Peterson C, Chen Z, Croughan M, Sundaram R, Stanford J, et al. Bisphenol A and phthalates and endometriosis: the Endometriosis: Natural History, Diagnosis and Outcomes Study. Fertil Steril. 2013;100:162-9.e1-2 pubmed publisher..The lack of consistency of findings across cohorts underscores the impact of methodology on findings. ..
- Moon S. Association of lead, mercury and cadmium with diabetes in the Korean population: the Korea National Health and Nutrition Examination Survey (KNHANES) 2009-2010. Diabet Med. 2013;30:e143-8 pubmed publisherDespite increasing concern regarding health problems as a result of environmental pollutants, no association of toxic heavy metals with diabetes has been demonstrated in the general population...
- Callan A, Hinwood A, Heffernan A, Eaglesham G, Mueller J, Odland J. Urinary bisphenol A concentrations in pregnant women. Int J Hyg Environ Health. 2013;216:641-4 pubmed publisher..Given the potential impacts of prenatal bisphenol A exposure, further research in this area is warranted. ..
- Dietz R, Riget F, Sonne C, Born E, Bechshøft T, McKinney M, et al. Three decades (1983-2010) of contaminant trends in East Greenland polar bears (Ursus maritimus). Part 1: legacy organochlorine contaminants. Environ Int. 2013;59:485-93 pubmed publisher..Despite declines as a result of international regulations, relatively high levels of these historic pollutants persist in East Greenland polar bear tissues. ..
- Suen J, Hsu S, Hung C, Chao Y, Lee C, Lin C, et al. A common environmental pollutant, 4-nonylphenol, promotes allergic lung inflammation in a murine model of asthma. Allergy. 2013;68:780-7 pubmed publisher..These results suggested that NP may disturb physiologic function of DCs through, in part, AhR-dependent mechanisms, supporting the importance of NP exposure on the regulation of DC functions and allergic inflammation. ..
- Wan Ibrahim W, Tofighi R, Onishchenko N, Rebellato P, Bose R, Uhlen P, et al. Perfluorooctane sulfonate induces neuronal and oligodendrocytic differentiation in neural stem cells and alters the expression of PPAR? in vitro and in vivo. Toxicol Appl Pharmacol. 2013;269:51-60 pubmed publisher..These data suggest that PPAR? plays a role in the alteration of spontaneous differentiation of NSCs induced by nanomolar concentrations of PFOS. ..
- Buck Louis G, Sundaram R, Schisterman E, Sweeney A, Lynch C, Gore Langton R, et al. Persistent environmental pollutants and couple fecundity: the LIFE study. Environ Health Perspect. 2013;121:231-6 pubmed publisherEvidence suggesting that persistent environmental pollutants may be reproductive toxicants underscores the need for prospective studies of couples for whom exposures are measured...
- Parajuli R, Fujiwara T, Umezaki M, Watanabe C. Association of cord blood levels of lead, arsenic, and zinc with neurodevelopmental indicators in newborns: a birth cohort study in Chitwan Valley, Nepal. Environ Res. 2013;121:45-51 pubmed publisher..These results suggest that high levels of Pb or As exposure during the prenatal period may induce retardation during in utero neurodevelopment. ..
- Aylward L, Kirman C, Schoeny R, Portier C, Hays S. Evaluation of biomonitoring data from the CDC National Exposure Report in a risk assessment context: perspectives across chemicals. Environ Health Perspect. 2013;121:287-94 pubmed publisher..The results of these comparisons can be used to focus more detailed chemical-specific examination of the data and inform priorities for chemical risk management and research. ..
- Lind P, Riserus U, Salihovic S, Bavel B, Lind L. An environmental wide association study (EWAS) approach to the metabolic syndrome. Environ Int. 2013;55:1-8 pubmed publisher..002 for all variables). Using a cross-sectional EWAS approach, certain environmental contaminants and lifestyle factors were found to be associated with prevalent metabolic syndrome in an additive fashion in an elderly population. ..
- Tice R, Austin C, Kavlock R, Bucher J. Improving the human hazard characterization of chemicals: a Tox21 update. Environ Health Perspect. 2013;121:756-65 pubmed publisher..However, even at this stage, the information obtained has attracted the attention of the international scientific community, and we believe these efforts foretell the future of toxicology. ..
- Buttke D, Sircar K, Martin C. Exposures to endocrine-disrupting chemicals and age of menarche in adolescent girls in NHANES (2003-2008). Environ Health Perspect. 2012;120:1613-8 pubmed publisher..Our findings suggest an association between 2,5-DCP, a potential EDC, and earlier age of menarche in the general U.S. population. ..
- Agas D, Sabbieti M, Marchetti L. Endocrine disruptors and bone metabolism. Arch Toxicol. 2013;87:735-51 pubmed publisher..This review highlights the effects of the EDCs on mammalian bone turnover and development providing a macro and molecular view of their action. ..
- Ansara Ross T, Ross M, Wepener V. The use of feathers in monitoring bioaccumulation of metals and metalloids in the South African endangered African grass-owl (Tyto capensis). Ecotoxicology. 2013;22:1072-83 pubmed publisher..capensis. Preliminary results support the feasibility of using feathers as non-destructive indicators of environmental contamination in T. capensis although caution needs to be taken when interpreting the results...
- Buck Louis G, Sundaram R, Sweeney A, Schisterman E, Maisog J, Kannan K. Urinary bisphenol A, phthalates, and couple fecundity: the Longitudinal Investigation of Fertility and the Environment (LIFE) Study. Fertil Steril. 2014;101:1359-66 pubmed publisher..65 0.92, respectively). Select male but not female phthalate exposures were associated with an approximately 20% reduction in fecundity, underscoring the importance of assessing both partners' exposure to minimize erroneous conclusions. ..
- McKay J, Maher C. Relationship between blood mercury levels and components of male song in Nelson's sparrows (Ammodramus nelsoni). Ecotoxicology. 2012;21:2391-7 pubmed publisher..Hg influences hormones and alters brain development, raising questions about specific effects on the brains and singing behavior of male Nelson's sparrows. ..
- Braun J, Sathyanarayana S, Hauser R. Phthalate exposure and children's health. Curr Opin Pediatr. 2013;25:247-54 pubmed publisher..Although anticipatory guidance is not evidence-based at this time, providers can counsel concerned patients to reduce phthalate exposures in order to protect the developing fetus and child from potential adverse health outcomes. ..
- Enke U, Schleussner E, Pälmke C, Seyfarth L, Koch H. Phthalate exposure in pregnant women and newborns - the urinary metabolite excretion pattern differs distinctly. Int J Hyg Environ Health. 2013;216:735-42 pubmed publisher..The skewed metabolite distribution in the newborns urine warrants further investigation in terms of early phthalate metabolism, the quantity of internal phthalate exposure of the fetus/newborn and its possible health effects. ..
- McLaggan D, Amezaga M, Petra E, Frost A, Duff E, Rhind S, et al. Impact of sublethal levels of environmental pollutants found in sewage sludge on a novel Caenorhabditis elegans model biosensor. PLoS ONE. 2012;7:e46503 pubmed publisher..Results demonstrate subtle adverse effects on C. elegans of a complex mixture of environmental pollutants that are present, individually, in very low concentrations and indicate that our biosensor of energy ..
- Cheng W, Yu Z, Feng L, Wang Y. Perfluorooctane sulfonate (PFOS) induced embryotoxicity and disruption of cardiogenesis. Toxicol In Vitro. 2013;27:1503-12 pubmed publisher..In conclusion, PFOS altered the expression of crucial genes, reduced ATP production, induced ROS, and stimulated apoptosis during the early stages of cardiogenesis; these effects may result in poor developmental outcomes. ..
- Kreider M, Doyle Eisele M, Russell R, McDonald J, Panko J. Evaluation of potential for toxicity from subacute inhalation of tire and road wear particles in rats. Inhal Toxicol. 2012;24:907-17 pubmed publisher..Therefore, from this study we identified a no-observable-adverse-effect-level (NOAEL) of 112 ?g/m³ of TRWP in rats for future use in risk assessment of TRWP. ..
- Landis W, Durda J, Brooks M, Chapman P, Menzie C, Stahl R, et al. Ecological risk assessment in the context of global climate change. Environ Toxicol Chem. 2013;32:79-92 pubmed publisher..Good communication is essential for making risk-related information understandable and useful for managers and stakeholders to implement a successful risk-assessment and decision-making process. ..
- Verner M, Sonneborn D, Lancz K, Muckle G, Ayotte P, Dewailly E, et al. Toxicokinetic modeling of persistent organic pollutant levels in blood from birth to 45 months of age in longitudinal birth cohort studies. Environ Health Perspect. 2013;121:131-7 pubmed publisher..Estimates can be used in epidemiologic studies to evaluate the impact of exposure during hypothesized postnatal periods of susceptibility on health. ..
- Taylor K, Novak R, Anderson H, Birnbaum L, Blystone C, Devito M, et al. Evaluation of the association between persistent organic pollutants (POPs) and diabetes in epidemiological studies: a national toxicology program workshop review. Environ Health Perspect. 2013;121:774-83 pubmed publisher..This new information should be considered by governmental bodies involved in the regulation of environmental contaminants. ..
- Tellez Plaza M, Guallar E, Howard B, Umans J, Francesconi K, Goessler W, et al. Cadmium exposure and incident cardiovascular disease. Epidemiology. 2013;24:421-9 pubmed publisher..Urine cadmium, a biomarker of long-term exposure, was associated with increased cardiovascular mortality and increased incidence of cardiovascular disease. These findings support that cadmium exposure is a cardiovascular risk factor. ..
- Wu H, Bertrand K, Choi A, Hu F, Laden F, Grandjean P, et al. Persistent organic pollutants and type 2 diabetes: a prospective analysis in the nurses' health study and meta-analysis. Environ Health Perspect. 2013;121:153-61 pubmed publisher..13, 3.53; I2 = 21.4%, pheterogeneity = 0.28) and 1.70 (95% CI: 1.28, 2.27; I2 = 16.3%, pheterogeneity = 0.30) for HCB and total PCBs, respectively. These findings support an association between POP exposure and the risk of T2D. ..
- Mohandass R, Rout P, Jiwal S, Sasikala C. Biodegradation of benzo[a]pyrene by the mixed culture of Bacillus cereus and Bacillus vireti isolated from the petrochemical industry. J Environ Biol. 2012;33:985-9 pubmed..The results indicate that the bacterial consortium is a new bacterial resource for biodegrading benzo(a)pyrene and might be used for bioremediation of sites heavily contaminated by benzo[a]pyrene and its derivatives...
- Frederiksen H, Kranich S, Jørgensen N, Taboureau O, Petersen J, Andersson A. Temporal variability in urinary phthalate metabolite excretion based on spot, morning, and 24-h urine samples: considerations for epidemiological studies. Environ Sci Technol. 2013;47:958-67 pubmed publisher..The only slightly higher ICCs for 24-h pools compared to first-morning and spot urine samples does not seem to justify the extra effort needed to collect 24-h pools. ..
- Arora M, Austin C. Teeth as a biomarker of past chemical exposure. Curr Opin Pediatr. 2013;25:261-7 pubmed publisher..Such a retrospective biomarker that precisely measures exposure intensity and timing during prenatal development would substantially aid epidemiologic investigations, particularly case-control studies of rare health outcomes. ..
- Lassen T, Frederiksen H, Jensen T, Petersen J, Main K, Skakkebæk N, et al. Temporal variability in urinary excretion of bisphenol A and seven other phenols in spot, morning, and 24-h urine samples. Environ Res. 2013;126:164-70 pubmed publisher..Our data do not support that collection of 24-h samples will improve individual exposure assessment for any of the analysed phenols. ..
- Schantz M, Eppe G, Focant J, Hamilton C, Heckert N, Heltsley R, et al. Milk and serum standard reference materials for monitoring organic contaminants in human samples. Anal Bioanal Chem. 2013;405:1203-11 pubmed publisher..This agreement suggests that there were no significant biases existing among the multiple methods used for analysis. ..
- Lewis R, Meeker J, Peterson K, Lee J, Pace G, Cantoral A, et al. Predictors of urinary bisphenol A and phthalate metabolite concentrations in Mexican children. Chemosphere. 2013;93:2390-8 pubmed publisher..Due to rapid development, children may be susceptible to impacts from exposure to endocrine disrupting chemicals; thus, reduced or delayed use of certain personal care products among children may be warranted. ..
- Chevrier C, Warembourg C, Gaudreau E, Monfort C, Le Blanc A, Guldner L, et al. Organochlorine pesticides, polychlorinated biphenyls, seafood consumption, and time-to-pregnancy. Epidemiology. 2013;24:251-60 pubmed publisher..Our findings were robust in sensitivity analyses, including analysis restricted to primiparous women. These results suggest that PCBs, p,p'-DDE, and other shellfish contaminants may impair human fertility. ..
- Warner M, Mocarelli P, Brambilla P, Wesselink A, Samuels S, Signorini S, et al. Diabetes, metabolic syndrome, and obesity in relation to serum dioxin concentrations: the Seveso women's health study. Environ Health Perspect. 2013;121:906-11 pubmed publisher..29; pinteraction = 0.01). We found an increased prevalence of metabolic syndrome associated with TCDD, but only among women who were the youngest at the time of the explosion. Continued follow-up of the SWHS cohort will be informative. ..