Summary: Viscoelastic solutions that are injected into JOINTS in order to alleviate symptoms of joint-related disorders such as OSTEOARTHRITIS.

Top Publications

  1. McAlindon T, Bannuru R. Osteoarthritis: Is viscosupplementation really so unsafe for knee OA?. Nat Rev Rheumatol. 2012;8:635-6 pubmed publisher
  2. Bannuru R, Schmid C, Kent D, Vaysbrot E, Wong J, McAlindon T. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Ann Intern Med. 2015;162:46-54 pubmed publisher
    ..This information, along with the safety profiles and relative costs of included treatments, will be helpful for individualized patient care decisions. Agency for Healthcare Research and Quality. ..
  3. Shavlovskaya O. [Chondroprotectors: A range of application in general somatic practice]. Ter Arkh. 2017;89:98-104 pubmed publisher
  4. Lee N, Callahan A, Migliori M, Freitag S. Minimally invasive approaches to eyebrow lifting. Int Ophthalmol Clin. 2013;53:47-57 pubmed publisher
  5. He M, Sheu M, Huang Z, Tsai C, Tsai R. Sudden bilateral vision loss and brain infarction following cosmetic hyaluronic acid injection. JAMA Ophthalmol. 2013;131:1234-5 pubmed publisher
  6. Ishijima M, Nakamura T, Shimizu K, Hayashi K, Kikuchi H, Soen S, et al. Intra-articular hyaluronic acid injection versus oral non-steroidal anti-inflammatory drug for the treatment of knee osteoarthritis: a multi-center, randomized, open-label, non-inferiority trial. Arthritis Res Ther. 2014;16:R18 pubmed publisher
    ..UMIN Clinical Trials Registry (UMIN-CTR), UMIN000001026. ..
  7. Battaglia M, Guaraldi F, Vannini F, Rossi G, Timoncini A, Buda R, et al. Efficacy of ultrasound-guided intra-articular injections of platelet-rich plasma versus hyaluronic acid for hip osteoarthritis. Orthopedics. 2013;36:e1501-8 pubmed
    ..0005). Intra-articular injections of PRP are efficacious in terms of functional improvement and pain reduction but are not superior to HA in patients with symptomatic hip OA at 12-month follow-up. ..
  8. Bitterman A, Alland J, Lin J, Lee S. Assessment steps and treatment tips for ankle arthritis. J Fam Pract. 2017;66:288-292 pubmed
    ..The tibiotalar joint's unique biomechanics and associated structures carry management implications that vary from those in knee or hip arthritis. ..
  9. Poddar S, Widstrom L. Nonoperative Options for Management of Articular Cartilage Disease. Clin Sports Med. 2017;36:447-456 pubmed publisher
    ..Future studies to individualize treatment options based on patient phenotype and genotype may hold promise. ..

More Information


  1. Makhni E, Stone A, Ukwuani G, Zuke W, Garabekyan T, Mei Dan O, et al. A Critical Review: Management and Surgical Options for Articular Defects in the Hip. Clin Sports Med. 2017;36:573-586 pubmed publisher
    ..Operative treatment in the form of arthroscopic techniques continues to decrease morbidity and offer innovative solutions and new applications for microfracture, ACT, and AMIC. ..
  2. Bowden D, Byrne C, Alkhayat A, Eustace S, Kavanagh E. Injectable Viscoelastic Supplements: A Review for Radiologists. AJR Am J Roentgenol. 2017;209:883-888 pubmed publisher
    ..Clinicians offering intraarticular HA injection should be familiar with the common preparations available and the principal differences between them, its mechanism of action, and the profile of adverse effects associated with its use. ..
  3. Labiris G, Sideroudi H, Rousopoulos K, Kozobolis V. Cohesive versus dispersive-cohesive ophthalmic viscosurgical device in torsional intelligent phaco. J Cataract Refract Surg. 2015;41:681-2 pubmed publisher
  4. Kang Y, Im J, Shin J, Kim I, Park D. Short-term Analysis of the Residual Volume of an Eye Drop Following 23-Gauge Microincision Vitrectomy Surgery. Korean J Ophthalmol. 2017;31:439-445 pubmed publisher
    ..Thus, checking proper use of eye drops and teaching about instillation technique by physician is necessary for patients with 23-gauge MIVS. ..
  5. de Maio M, DeBoulle K, Braz A, Rohrich R. Facial Assessment and Injection Guide for Botulinum Toxin and Injectable Hyaluronic Acid Fillers: Focus on the Midface. Plast Reconstr Surg. 2017;140:540e-550e pubmed publisher
    ..Injections made in the midcheek must be performed with caution to avoid the infraorbital artery. ..