Summary: Chemical reaction in which monomeric components are combined to form POLYMERS (e.g., POLYMETHYLMETHACRYLATE).

Top Publications

  1. Raghav D, Ashraf S, Mohan L, Rathinasamy K. Berberine Induces Toxicity in HeLa Cells through Perturbation of Microtubule Polymerization by Binding to Tubulin at a Unique Site. Biochemistry. 2017;56:2594-2611 pubmed publisher
  2. Josselyn S, Frankland P. mTORC2: actin on your memory. Nat Neurosci. 2013;16:379-80 pubmed publisher
  3. Smulski C, Decossas M, Chekkat N, Beyrath J, Willen L, Guichard G, et al. Hetero-oligomerization between the TNF receptor superfamily members CD40, Fas and TRAILR2 modulate CD40 signalling. Cell Death Dis. 2017;8:e2601 pubmed publisher
    ..Altogether, these data reveal that selective interactions between different TNFRSF members may modulate ligand-induced responses upstream signalling events. ..
  4. Collares F, Leitune V, Franken P, Parollo C, Ogliari F, Samuel S. Influence of addition of [2-(methacryloyloxy)ethyl]trimethylammonium chloride to an experimental adhesive. Braz Oral Res. 2017;31:e31 pubmed publisher
    ..05). The results of the present study indicate that METAC is a promising antibacterial agent when added to an adhesive system. ..
  5. Delferro M, Marks T. Multinuclear olefin polymerization catalysts. Chem Rev. 2011;111:2450-85 pubmed publisher
  6. Garcia F, Viruela P, Matesanz E, Ortí E, Sanchez L. Cooperative supramolecular polymerization and amplification of chirality in C3-symmetrical OPE-based trisamides. Chemistry. 2011;17:7755-9 pubmed publisher
  7. Zhou Y, Yan W, Cao D, Shao M, Li D, Wang F, et al. Design, synthesis and biological evaluation of 4-anilinoquinoline derivatives as novel potent tubulin depolymerization agents. Eur J Med Chem. 2017;138:1114-1125 pubmed publisher
    ..All the results indicated that 14h could be a promising candidate for the treatment of cancer. ..
  8. Zhu C, Schneider E, Nikolaou V, Klein T, Li J, Davis T, et al. Hydrolyzable Poly[Poly(Ethylene Glycol) Methyl Ether Acrylate]-Colistin Prodrugs through Copper-Mediated Photoinduced Living Radical Polymerization. Bioconjug Chem. 2017;28:1916-1924 pubmed publisher
    Through the recently developed copper-mediated photoinduced living radical polymerization (CP-LRP), a novel and well-defined polymeric prodrug of the antimicrobial lipopeptide colistin has been developed...
  9. Kip Ç, Demir C, Tuncel A. One pot synthesis of carboxyl functionalized-polyhedral oligomeric siloxane based monolith via photoinitiated thiol-methacrylate polymerization for nano-hydrophilic interaction chromatography. J Chromatogr A. 2017;1502:14-23 pubmed publisher
    ..in hydrophilic interaction chromatography (HILIC) was obtained by one-pot photoinitiated thiol-methacrylate polymerization. Polyhedral oligomeric silsesquioxane containing methacrylate units (POSS-MA) was used as the main monomer and ..

More Information


  1. Fukumura T, Makino F, Dietsche T, Kinoshita M, Kato T, Wagner S, et al. Assembly and stoichiometry of the core structure of the bacterial flagellar type III export gate complex. PLoS Biol. 2017;15:e2002281 pubmed publisher
    ..We propose that the assembly of the export gate complex begins with FliP6 ring formation with the help of the FliO scaffold, followed by FliQ, FliR, and FlhB and finally FlhA during MS ring formation. ..
  2. Blotnick E, Sol A, Muhlrad A. Histones bundle F-actin filaments and affect actin structure. PLoS ONE. 2017;12:e0183760 pubmed publisher
    ..The actin-histone interaction in the nucleus might affect gene expression. ..
  3. Ostrowska Z, Moraczewska J. Cofilin - a protein controlling dynamics of actin filaments. Postepy Hig Med Dosw (Online). 2017;71:339-351 pubmed
    ..Cofilin interactions with monomeric actin decreases availability of polymerization-competent actin subunits...
  4. Zhou S, Runge T, Karlen S, Ralph J, Gonzales Vigil E, Mansfield S. Chemical Pulping Advantages of Zip-lignin Hybrid Poplar. ChemSusChem. 2017;10:3565-3573 pubmed publisher
    ..The resulting pulps were analyzed for yield, residual lignin content, and cellulose DP (degree of polymerization), as well as changes in carbohydrates and lignin structure...
  5. Radhakrishnan A, Jokhun D, Venkatachalapathy S, Shivashankar G. Nuclear Positioning and Its Translational Dynamics Are Regulated by Cell Geometry. Biophys J. 2017;112:1920-1928 pubmed publisher
    ..that nuclear positional dynamics is sensitive to the cytoskeletal organization by studying the effect of actin polymerization and nuclear rigidity on the diffusive behavior of the nucleus...
  6. Carmali S, Murata H, Cummings C, Matyjaszewski K, Russell A. Polymer-Based Protein Engineering: Synthesis and Characterization of Armored, High Graft Density Polymer-Protein Conjugates. Methods Enzymol. 2017;590:347-380 pubmed publisher
    Atom transfer radical polymerization (ATRP) from the surface of a protein can generate remarkably dense polymer shells that serve as armor and rationally tune protein function...
  7. Dogan M, Han Y, Delmotte P, Sieck G. TNF? enhances force generation in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2017;312:L994-L1002 pubmed publisher
    ..24 h of exposure to TNF? increases ASM force by changing actin and myosin heavy chain (MyHC) content and/or polymerization. Porcine ASM strips were permeabilized with 10% Triton X-100, and force was measured in response to increasing ..
  8. Hayashi J, Shimada Y, Tagami J, Sumi Y, Sadr A. Real-Time Imaging of Gap Progress during and after Composite Polymerization. J Dent Res. 2017;96:992-998 pubmed publisher
    ..this study were to observe the behavior of composite and formation of gaps during and immediately after light polymerization using swept source optical coherence tomography (OCT) and to compare the interfacial integrity of adhesives in ..
  9. Zhang Y, McMullen A, Pontani L, He X, Sha R, Seeman N, et al. Sequential self-assembly of DNA functionalized droplets. Nat Commun. 2017;8:21 pubmed publisher
    ..and thus release its complement, which in turn activates the next droplet in the sequence, akin to living polymerization. Our strategy provides time and logic control during the self-assembly process, and offers a new perspective ..
  10. Huang Z, Zhao Y, Zhu K, Guo X, Peng W, Zhou H. Effect of Barley ?-Glucan on the Gluten Polymerization Process in Dough during Heat Treatment. J Agric Food Chem. 2017;65:6063-6069 pubmed publisher
    ..The results showed that BBG delayed the gluten thermopolymerization reaction during heating and affected polymerization of specific molecular weight protein subunits. These impacts depended upon the heating temperature and time...
  11. Guggilapu S, Guntuku L, Reddy T, Nagarsenkar A, Sigalapalli D, Naidu V, et al. Synthesis of thiazole linked indolyl-3-glyoxylamide derivatives as tubulin polymerization inhibitors. Eur J Med Chem. 2017;138:83-95 pubmed publisher
    ..The target compounds were also evaluated for their inhibition activity of tubulin polymerization. Further, the treatment of compound 13d on DU145 cells led to the inhibition of cell migration ability...
  12. Kanfer G, Peterka M, Arzhanik V, Drobyshev A, Ataullakhanov F, Volkov V, et al. CENP-F couples cargo to growing and shortening microtubule ends. Mol Biol Cell. 2017;28:2400-2409 pubmed publisher
    ..on these and previous observations, we suggest that CENP-F might act as a transporter of mitochondria and other cellular cargoes by attaching them to dynamic microtubule ends during both polymerization and depolymerization of tubulin.
  13. Díaz Celis C, Risca V, Hurtado F, Polka J, Hansen S, Maturana D, et al. Bacterial Tubulins A and B Exhibit Polarized Growth, Mixed-Polarity Bundling, and Destabilization by GTP Hydrolysis. J Bacteriol. 2017;199: pubmed publisher
    ..Previous biochemical studies revealed that BtubA/B polymerization is reversible and that BtubA/B folding does not require chaperones...
  14. Whitaker A, Smith M, Schaich M, Freudenthal B. Capturing a mammalian DNA polymerase extending from an oxidized nucleotide. Nucleic Acids Res. 2017;45:6934-6944 pubmed publisher
    ..These results provide novel insights into the impact of damage at the primer terminus on genomic stability and DNA synthesis. ..
  15. Eaton W, Bunn H. Treating sickle cell disease by targeting HbS polymerization. Blood. 2017;129:2719-2726 pubmed publisher
    Although the root cause of sickle cell disease is the polymerization of hemoglobin S (HbS) to form fibers that make red cells less flexible, most drugs currently being assessed in clinical trials are targeting the downstream sequelae of ..
  16. HARKINS W. A general theory of the mechanism of emulsion polymerization. J Am Chem Soc. 1947;69:1428-44 pubmed
  17. Palermo V, Pieri L, Silvestri R, La Regina G, Falcone C, Mazzoni C. Drug-induced inhibition of tubulin polymerization induces mitochondrion-mediated apoptosis in yeast. Cell Cycle. 2011;10:3208-9 pubmed
  18. Xu Y, Bu T, Li M, Qin T, Yin C, Wang N, et al. Non-Conjugated Polymer as an Efficient Dopant-Free Hole-Transporting Material for Perovskite Solar Cells. ChemSusChem. 2017;10:2578-2584 pubmed publisher
    ..PVCz-OMeDAD was simply prepared by the free-radical polymerization of vinyl monomers, which were synthesized from low-cost raw materials through three high-yield synthesis steps...
  19. Roth S, Funk I, Hofer M, Sieber V. Chemoenzymatic Synthesis of a Novel Borneol-Based Polyester. ChemSusChem. 2017;10:3574-3580 pubmed publisher
    ..These results show that whole-cell catalytic biotransformation of terpenes could lead to bio-based, higher-functionalized monomers, which might be basic raw materials for different fields of application, such as biopolymers. ..
  20. Kolesnikova S, Hubalek M, Bednarova L, Cvacka J, Curtis E. Multimerization rules for G-quadruplexes. Nucleic Acids Res. 2017;45:8684-8696 pubmed publisher
    ..Taken together, these experiments provide new insights into the sequence requirements and structures of both homomultimeric and heteromultimeric G-quadruplexes. ..
  21. Kobayashi Y, Saito Y, Goto M, Nakagawa Goto K. Antitubulin effects of aminobenzothiophene-substituted triethylated chromones. Bioorg Med Chem Lett. 2017;27:2731-2735 pubmed publisher
    ..Compounds 6 and 7 inhibited tubulin polymerization, induced both depolymerization of interphase microtubules and multiple spindle formations, and caused cell ..
  22. Ohn N, Shin J, Kim S, Kim J. Mechanochemical Ring-Opening Polymerization of Lactide: Liquid-Assisted Grinding for the Green Synthesis of Poly(lactic acid) with High Molecular Weight. ChemSusChem. 2017;10:3529-3533 pubmed publisher
    Mechanochemical polymerization of lactide is carried out by using ball milling...
  23. Liu Y, Zou X. Mathematical modeling and quantitative analysis of HIV-1 Gag trafficking and polymerization. PLoS Comput Biol. 2017;13:e1005733 pubmed publisher
    ..An in-depth understanding of its trafficking and polymerization is important for gaining further insights into the mechanisms of HIV-1 replication and the design of antiviral ..
  24. Sun W, Ji Y, Wan Y, HAN H, Lin H, Lu G, et al. Design and synthesis of piperazine acetate podophyllotoxin ester derivatives targeting tubulin depolymerization as new anticancer agents. Bioorg Med Chem Lett. 2017;27:4066-4074 pubmed publisher
    ..Meanwhile, it seems that the effect of C5 on MCF-7 cells apoptosis inducing was observed to be not obvious enough. In addition, docking analysis demonstrated that the congeners occupy the colchicine binding pocket of tubulin. ..
  25. Fugolin A, Pfeifer C. New Resins for Dental Composites. J Dent Res. 2017;96:1085-1091 pubmed publisher
    ..On the organic matrix side, concerns over the polymerization stress and the potential damage to the bonded interface have dominated research in the past 20 y, with many &..
  26. Sharma R, Kapusetti G, Bhong S, Roy P, Singh S, Singh S, et al. Osteoconductive Amine-Functionalized Graphene-Poly(methyl methacrylate) Bone Cement Composite with Controlled Exothermic Polymerization. Bioconjug Chem. 2017;28:2254-2265 pubmed publisher
    ..Thus, this newly developed nanocomposite can create natural bonding with bone tissues for improved bioactivity, longer sustainability, and better strength in the prosthesis...
  27. Hennen J, Hur K, Saunders C, Luxton G, MUELLER J. Quantitative Brightness Analysis of Protein Oligomerization in the Nuclear Envelope. Biophys J. 2017;113:138-147 pubmed publisher
  28. Karam A, De Oliveira Vigier K, Marinkovic S, Estrine B, Oldani C, Jérôme F. Conversion of Cellulose into Amphiphilic Alkyl Glycosides Catalyzed by Aquivion, a Perfluorosulfonic Acid Polymer. ChemSusChem. 2017;10:3604-3610 pubmed publisher
  29. Copos C, Walcott S, Del Alamo J, Bastounis E, Mogilner A, Guy R. Mechanosensitive Adhesion Explains Stepping Motility in Amoeboid Cells. Biophys J. 2017;112:2672-2682 pubmed publisher
    ..Thus, our work highlights the prominent role of biomechanics in determining the emergent features of amoeboid locomotion. ..
  30. Long L, Tian D, Hu J, Wang F, Saddler J. A xylanase-aided enzymatic pretreatment facilitates cellulose nanofibrillation. Bioresour Technol. 2017;243:898-904 pubmed publisher
    ..cellulose/hemicellulose content, gross fiber properties, fiber morphologies, cellulose accessibility/degree of polymerization (DP)/crystallinity were systematically evaluated before and after enzymatic pretreatment...
  31. Gorman K, Roby L, Giuffre A, Huang R, Kay B. Tandem phage-display for the identification of non-overlapping binding pairs of recombinant affinity reagents. Nucleic Acids Res. 2017;45:e158 pubmed publisher
    ..For each target, we could identify between five and fifteen unique pairs and successfully used a single pair in a sandwich assay. MegaSTAR is a versatile tool for generating sandwich ELISA-grade and bispecific reagents. ..
  32. Wright T, Lucius Dougherty M, Schmitz B, Burridge K, Makaroff K, Stewart J, et al. Polymer Conjugation to Enhance Cellulase Activity and Preserve Thermal and Functional Stability. Bioconjug Chem. 2017;28:2638-2645 pubmed publisher
    ..The new FnCel5a conjugates represent an advance in the production of cellulases that maintain activity at high temperatures or in the presence of denaturing organic solvents...
  33. Lui P, Wong L, Ho T, Au S, Chan C, Kok K, et al. PACT Facilitates RNA-Induced Activation of MDA5 by Promoting MDA5 Oligomerization. J Immunol. 2017;199:1846-1855 pubmed publisher
    ..Taken together, these findings suggest that PACT functions as an essential cellular coactivator of RIG-I, as well as MDA5, and it facilitates RNA-induced formation of MDA5 oligomers. ..
  34. Sekine J, Luo S, Wang S, Zhu B, Tseng H, Yu H. Functionalized conducting polymer nanodots for enhanced cell capturing: the synergistic effect of capture agents and nanostructures. Adv Mater. 2011;23:4788-92 pubmed publisher
  35. Higgs P. Chemical Evolution and the Evolutionary Definition of Life. J Mol Evol. 2017;84:225-235 pubmed publisher
    ..Chemical evolution applies to short oligonucleotides that can be generated by random polymerization, as well as by template-directed replication, and which may be too short to encode a specific function...
  36. Duran G, Wang Y, Moisan F, Francisco E, Sikic B. Decreased levels of baseline and drug-induced tubulin polymerisation are hallmarks of resistance to taxanes in ovarian cancer cells and are associated with epithelial-to-mesenchymal transition. Br J Cancer. 2017;116:1318-1328 pubmed publisher
    ..These alterations may serve as biomarkers for predicting taxane effectiveness in ovarian cancer and should be considered as therapeutic targets. ..
  37. Lou S, Zhang X, Zhang M, Ji S, Wang W, Zhang J, et al. Preparation of a dual cored hepatoma-specific star glycopolymer nanogel via arm-first ATRP approach. Int J Nanomedicine. 2017;12:3653-3664 pubmed publisher
    ..thermo-responsive star-shaped polymer nanogel was prepared via an "arm-first" atom transfer radical polymerization approach. The nanogel consists of a thermo- and redox-sensitive core and a zwitterionic copolymer block...
  38. Nishii K, Murase M, Shiono T. Quasi-Living Polymerization of Propene with an Isotactic-Specific Zirconocene Catalyst. Molecules. 2017;22: pubmed publisher
    Propene polymerization with isotactic (iso)-specific C₂-symmetric rac-Me₂Si(2-Me-Benz(e)-Ind)₂ZrCl₂ (1) and rac-Me₂Si(2-Me-4-Ph-1-Ind)₂ZrCl₂ (2) were conducted under various ..
  39. Zaganjor E, Spinelli J, Haigis M. Strength in numbers: Phosphofructokinase polymerization prevails in the liver. J Cell Biol. 2017;216:2239-2241 pubmed publisher
    ..1083/jcb.201701084) show that the liver-specific isoform of phosphofructokinase-1 forms filaments in vitro and localizes as puncta in cells along the plasma membrane. This suggests spatial organization of glycolysis in higher organisms. ..
  40. Rueggeberg F, Giannini M, Arrais C, Price R. Light curing in dentistry and clinical implications: a literature review. Braz Oral Res. 2017;31:e61 pubmed publisher
    ..Understanding of the basic events occurring in any dental polymerization mechanism, regardless of the mode of activating the process, will allow clinicians to both better appreciate ..
  41. Xu Q, Sun M, Bai Z, Wang Y, Wu Y, Tian H, et al. Design, synthesis and bioevaluation of antitubulin agents carrying diaryl-5,5-fused-heterocycle scaffold. Eur J Med Chem. 2017;139:242-249 pubmed publisher
    ..In addition, molecular docking studies supported the biological assay data and suggested that 4f may be a potential antitubulin agent. ..
  42. Shaik S, Vishnuvardhan M, Sultana F, Subba Rao A, Bagul C, Bhattacharjee D, et al. Design and synthesis of 1,2,3-triazolo linked benzo[d]imidazo[2,1-b]thiazole conjugates as tubulin polymerization inhibitors. Bioorg Med Chem. 2017;25:3285-3297 pubmed publisher
    ..Molecular docking studies indicated that these conjugates occupy the colchicine binding site of the tubulin protein. ..
  43. Raghupathi K, THAYUMANAVAN S. Nano-Armoring of Enzymes: Rational Design of Polymer-Wrapped Enzymes. Methods Enzymol. 2017;590:381-411 pubmed publisher
    ..self-cross-linkable polymer was used to encapsulate capsase-3 enzyme in the nanogel, while inverse emulsion polymerization method was used to entrap α-glucosidase enzyme in the nanogel...
  44. An R, Li Q, Fan Y, Li J, Pan X, Komiyama M, et al. Highly efficient preparation of single-stranded DNA rings by T4 ligase at abnormally low Mg(II) concentration. Nucleic Acids Res. 2017;45:e139 pubmed publisher
    ..This strategy is based on our unexpected finding that, in diluted T4 buffers, intermolecular polymerization of DNA fragments is greatly suppressed with respect to their intramolecular cyclization...
  45. Crevenna A, Arciniega M, Dupont A, Mizuno N, Kowalska K, Lange O, et al. Side-binding proteins modulate actin filament dynamics. elife. 2015;4: pubmed publisher
    ..In this study, using direct visualization of single actin filament elongation, we show that actin polymerization kinetics at both filament ends are strongly influenced by the binding of proteins to the lateral filament ..
  46. Rigolin F, Miranda M, Flório F, Basting R. Evaluation of bond strength between leucite-based and lithium disilicate-based ceramics to dentin after cementation with conventional and self-adhesive resin agents. Acta Odontol Latinoam. 2014;27:16-24 pubmed
    ..Leucite-based and lithium disilicate-based cements present similar bond strength to the dentin with conventional dual resin cement (Variolink II) and a dual self-adhesive cement (RelyX U100). ..
  47. Feuer G, Molnar F. Studies on the composition and polymerization of actin. Hung Acta Physiol. 1948;1:150-63 pubmed
  48. Magne P, Malta D, Enciso R, Monteiro Junior S. Heat Treatment Influences Monomer Conversion and Bond Strength of Indirect Composite Resin Restorations. J Adhes Dent. 2015;17:559-66 pubmed publisher
    ..Z100 showed better bond strength but lower DC. Heat treatment and a 24-h delay before delivery can benefit DC of Premise Indirect. The increase in DC of Premise and Premise Indirect did not affect their bond strength. ..
  49. Brianezzi L, Maenosono R, Bim O, Zabeu G, Palma Dibb R, Ishikiriama S. Does laser diode irradiation improve the degree of conversion of simplified dentin bonding systems?. J Appl Oral Sci. 2017;25:381-386 pubmed publisher
    ..05): SB>SU. Irradiation with a laser diode improved the degree of conversion of all tested simplified dentin bonding systems, with no impact on water sorption and solubility. ..
  50. Sun H, Chen X, Chen X, Liu J, Ma L, Wu H, et al. PALLD Regulates Phagocytosis by Enabling Timely Actin Polymerization and Depolymerization. J Immunol. 2017;199:1817-1826 pubmed publisher
    ..PALLD mechanistically facilitates phagocytic receptor clustering by regulating actin polymerization and c-Src dynamic activation during particle binding and early phagosome formation...
  51. Welsch N, Lyon L. Oligo(ethylene glycol)-sidechain microgels prepared in absence of cross-linking agent: Polymerization, characterization and variation of particle deformability. PLoS ONE. 2017;12:e0181369 pubmed publisher
    We present a systematic study of self-cross-linked microgels formed by precipitation polymerization of oligo ethylene glycol methacrylates...
  52. Marchan S, White D, Smith W, Dhuru V. The Influence of Sonic and Ultrasonic Vibration on the Shear Bond Strength of a Selected Resin Luting Cement. Eur J Prosthodont Restor Dent. 2015;23:29-32 pubmed
    ..The effect of type of instrumentation immediately following polymerization setting had no effect on the shear bond strengths however a delay of 1 hour for all types of instrumentation ..
  53. Temprana C, Prieto M, Igartúa D, Femia A, Amor M, Alonso S. Diacetylenic lipids in the design of stable lipopolymers able to complex and protect plasmid DNA. PLoS ONE. 2017;12:e0186194 pubmed publisher
    ..Thus, this work represents the first steps toward developing a cationic lipopolymer-based gene delivery system using polymerizable and cationic lipids...