ccr5 receptor antagonists
Summary: Compounds and drugs that inhibit or block the activity of CCR5 RECEPTORS.
Martin Blondel G, Bauer J, Uro Coste E, Biotti D, Averseng Peaureaux D, Fabre N, et al
. Therapeutic use of CCR5 antagonists is supported by strong expression of CCR5 on CD8(+) T cells in progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory syndrome. Acta Neuropathol. 2015;129:463-5 pubmed publisher
Baba M, Nishimura O, Kanzaki N, Okamoto M, Sawada H, Iizawa Y, et al
. A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity. Proc Natl Acad Sci U S A. 1999;96:5698-703 pubmed
..6-3.7 nM in peripheral blood mononuclear cells, though it was totally inactive against T-cell line-tropic (CXCR4-using or X4) HIV-1. ..
Feng Y, Leavitt M, Tritz R, Duarte E, Kang D, Mamounas M, et al
. Inhibition of CCR5-dependent HIV-1 infection by hairpin ribozyme gene therapy against CC-chemokine receptor 5. Virology. 2000;276:271-8 pubmed
..These results suggest a novel gene therapy approach to preventing or slowing the disease progression of HIV-1 infection. ..
Corbeau P, Reynes J. CCR5 antagonism in HIV infection: ways, effects, and side effects. AIDS. 2009;23:1931-43 pubmed publisher
Yla Herttuala S, Bentzon J, Daemen M, Falk E, Garcia Garcia H, Herrmann J, et al
. Stabilization of atherosclerotic plaques: an update. Eur Heart J. 2013;34:3251-8 pubmed publisher
Garbelli A, Riva V, Crespan E, Maga G. How to win the HIV-1 drug resistance hurdle race: running faster or jumping higher?. Biochem J. 2017;474:1559-1577 pubmed publisher
Zheng Y, Han G, Abagyan R, Wu B, Stevens R, Cherezov V, et al
. Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV. Immunity. 2017;46:1005-1017.e5 pubmed publisher
Bai J, Gorantla S, Banda N, Cagnon L, Rossi J, Akkina R. Characterization of anti-CCR5 ribozyme-transduced CD34+ hematopoietic progenitor cells in vitro and in a SCID-hu mouse model in vivo. Mol Ther. 2000;1:244-54 pubmed
..The expression of anti-CCR5 ribozymes in HIV-1 target cells offers a novel gene therapy strategy to control HIV infection. ..
Giacomini P, Rozenberg A, Metz I, Araujo D, Arbour N, Bar Or A. Maraviroc and JC virus-associated immune reconstitution inflammatory syndrome. N Engl J Med. 2014;370:486-8 pubmed publisher