ccr5 receptor antagonists


Summary: Compounds and drugs that inhibit or block the activity of CCR5 RECEPTORS.

Top Publications

  1. Martin Blondel G, Bauer J, Uro Coste E, Biotti D, Averseng Peaureaux D, Fabre N, et al. Therapeutic use of CCR5 antagonists is supported by strong expression of CCR5 on CD8(+) T cells in progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory syndrome. Acta Neuropathol. 2015;129:463-5 pubmed publisher
  2. Baba M, Nishimura O, Kanzaki N, Okamoto M, Sawada H, Iizawa Y, et al. A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity. Proc Natl Acad Sci U S A. 1999;96:5698-703 pubmed
    ..6-3.7 nM in peripheral blood mononuclear cells, though it was totally inactive against T-cell line-tropic (CXCR4-using or X4) HIV-1. ..
  3. Feng Y, Leavitt M, Tritz R, Duarte E, Kang D, Mamounas M, et al. Inhibition of CCR5-dependent HIV-1 infection by hairpin ribozyme gene therapy against CC-chemokine receptor 5. Virology. 2000;276:271-8 pubmed
    ..These results suggest a novel gene therapy approach to preventing or slowing the disease progression of HIV-1 infection. ..
  4. Corbeau P, Reynes J. CCR5 antagonism in HIV infection: ways, effects, and side effects. AIDS. 2009;23:1931-43 pubmed publisher
  5. Yla Herttuala S, Bentzon J, Daemen M, Falk E, Garcia Garcia H, Herrmann J, et al. Stabilization of atherosclerotic plaques: an update. Eur Heart J. 2013;34:3251-8 pubmed publisher
  6. Garbelli A, Riva V, Crespan E, Maga G. How to win the HIV-1 drug resistance hurdle race: running faster or jumping higher?. Biochem J. 2017;474:1559-1577 pubmed publisher
  7. Zheng Y, Han G, Abagyan R, Wu B, Stevens R, Cherezov V, et al. Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV. Immunity. 2017;46:1005-1017.e5 pubmed publisher
  8. Bai J, Gorantla S, Banda N, Cagnon L, Rossi J, Akkina R. Characterization of anti-CCR5 ribozyme-transduced CD34+ hematopoietic progenitor cells in vitro and in a SCID-hu mouse model in vivo. Mol Ther. 2000;1:244-54 pubmed
    ..The expression of anti-CCR5 ribozymes in HIV-1 target cells offers a novel gene therapy strategy to control HIV infection. ..
  9. Giacomini P, Rozenberg A, Metz I, Araujo D, Arbour N, Bar Or A. Maraviroc and JC virus-associated immune reconstitution inflammatory syndrome. N Engl J Med. 2014;370:486-8 pubmed publisher