adenosine a3 receptor agonists

Summary

Summary: Drugs that selectively bind to and activate ADENOSINE A3 RECEPTORS.

Top Publications

  1. Yu J, Zhao L, Park J, Lee H, Sahu P, Cui M, et al. N6-Substituted 5'-N-Methylcarbamoyl-4'-selenoadenosines as Potent and Selective A3 Adenosine Receptor Agonists with Unusual Sugar Puckering and Nucleobase Orientation. J Med Chem. 2017;60:3422-3437 pubmed publisher
    ..This suggests the potential for the development of 4'-selenonucleoside A3AR agonists as novel antistroke agents. ..
  2. Yu J, Ahn S, Kim H, Lee M, Ahn S, Kim J, et al. Polypharmacology of N6-(3-Iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA) and Related A3 Adenosine Receptor Ligands: Peroxisome Proliferator Activated Receptor (PPAR) ? Partial Agonist and PPAR? Antagonist Activity Suggests Their Antidiabetic Pot. J Med Chem. 2017;60:7459-7475 pubmed publisher
    ..These findings indicate that the polypharmacophore of these compounds may provide therapeutic insight into their multipotent efficacy against various human diseases. ..