adenosine a2 receptor agonists
Summary: Compounds that selectively bind to and activate ADENOSINE A2 RECEPTORS.
Navarro G, Aguinaga D, Moreno E, Hradsky J, Reddy P, CortÃ©s A, et al
. Intracellular calcium levels determine differential modulation of allosteric interactions within G protein-coupled receptor heteromers. Chem Biol. 2014;21:1546-56 pubmed publisher
Carpenter B, NehmÃ© R, Warne T, Leslie A, Tate C. Structure of the adenosine A(2A) receptor bound to an engineered G protein. Nature. 2016;536:104-7 pubmed
..The A(2A)R-mini-Gs structure highlights both the diversity and similarity in G-protein coupling to GPCRs and hints at the potential complexity of the molecular basis for G-protein specificity. ..
Cui C, Lin H, Shi Y, Pan R. Hypoxic postconditioning attenuates apoptosis via inactivation of adenosine A2a receptor through NDRG3-Raf-ERK pathway. Biochem Biophys Res Commun. 2017;491:277-284 pubmed publisher
..However, the protective effect of hypoxia postconditioning treatment could be inhibited by adding CGS21680, a selective adenosine A2a receptor agonist (all P values < 0.05). ..
Hage F. Regadenoson for myocardial perfusion imaging: Is it safe?. J Nucl Cardiol. 2014;21:871-6 pubmed publisher
Jackson S, George R, Lodge M, Piotrowski A, Wahl R, Gujar S, et al
. The effect of regadenoson on the integrity of the human blood-brain barrier, a pilot study. J Neurooncol. 2017;132:513-519 pubmed publisher
Ahmad S, Ansari M, Nadeem A, Bakheet S, Almutairi M, Attia S. Adenosine A2A receptor signaling affects IL-21/IL-22 cytokines and GATA3/T-bet transcription factor expression in CD4+ T cells from a BTBR T+ Itpr3tf/J mouse model of autism. J Neuroimmunol. 2017;311:59-67 pubmed publisher
..Our results indicate that A2AR agonists may represent a new class of compounds that can be developed for use in the treatment of autistic and neuroimmune dysfunctions. ..