adenosine a2 receptor agonists


Summary: Compounds that selectively bind to and activate ADENOSINE A2 RECEPTORS.

Top Publications

  1. Navarro G, Aguinaga D, Moreno E, Hradsky J, Reddy P, Cortés A, et al. Intracellular calcium levels determine differential modulation of allosteric interactions within G protein-coupled receptor heteromers. Chem Biol. 2014;21:1546-56 pubmed publisher
  2. Carpenter B, Nehmé R, Warne T, Leslie A, Tate C. Structure of the adenosine A(2A) receptor bound to an engineered G protein. Nature. 2016;536:104-7 pubmed
    ..The A(2A)R-mini-Gs structure highlights both the diversity and similarity in G-protein coupling to GPCRs and hints at the potential complexity of the molecular basis for G-protein specificity. ..
  3. Cui C, Lin H, Shi Y, Pan R. Hypoxic postconditioning attenuates apoptosis via inactivation of adenosine A2a receptor through NDRG3-Raf-ERK pathway. Biochem Biophys Res Commun. 2017;491:277-284 pubmed publisher
    ..However, the protective effect of hypoxia postconditioning treatment could be inhibited by adding CGS21680, a selective adenosine A2a receptor agonist (all P values < 0.05). ..
  4. Hage F. Regadenoson for myocardial perfusion imaging: Is it safe?. J Nucl Cardiol. 2014;21:871-6 pubmed publisher
  5. Jackson S, George R, Lodge M, Piotrowski A, Wahl R, Gujar S, et al. The effect of regadenoson on the integrity of the human blood-brain barrier, a pilot study. J Neurooncol. 2017;132:513-519 pubmed publisher
  6. Ahmad S, Ansari M, Nadeem A, Bakheet S, Almutairi M, Attia S. Adenosine A2A receptor signaling affects IL-21/IL-22 cytokines and GATA3/T-bet transcription factor expression in CD4+ T cells from a BTBR T+ Itpr3tf/J mouse model of autism. J Neuroimmunol. 2017;311:59-67 pubmed publisher
    ..Our results indicate that A2AR agonists may represent a new class of compounds that can be developed for use in the treatment of autistic and neuroimmune dysfunctions. ..