adenosine a1 receptor antagonists


Summary: Compounds that bind to and block the stimulation of ADENOSINE A1 RECEPTORS.

Top Publications

  1. Zakaria E, Althani A, Fawzi A, FITURI O. Molecular mechanisms of peritoneal dialysis-induced microvascular vasodilation. Adv Perit Dial. 2014;30:98-109 pubmed
    ..Adenosine receptor-activated NO release and K(ATP) channel-mediated endothelium hyperpolarization significantly contribute to vasodilation in the smaller peritoneal pre-capillary arterioles. ..
  2. Silva I, Costa A, Moreira S, Ferreirinha F, Magalhães Cardoso M, Calejo I, et al. Inhibition of cholinergic neurotransmission by ?3-adrenoceptors depends on adenosine release and A1-receptor activation in human and rat urinary bladders. Am J Physiol Renal Physiol. 2017;313:F388-F403 pubmed publisher
  3. Blundon J, Roy N, Teubner B, Yu J, Eom T, Sample K, et al. Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling. Science. 2017;356:1352-1356 pubmed publisher
    ..We conclude that, in adult mice, disrupting adenosine signaling in the thalamus rejuvenates plasticity in the auditory cortex and improves auditory perception. ..
  4. Lefin R, van der Walt M, Milne P, Terre Blanche G. Imidazo[1,2-?]pyridines possess adenosine A1 receptor affinity for the potential treatment of cognition in neurological disorders. Bioorg Med Chem Lett. 2017;27:3963-3967 pubmed publisher
  5. Janse van Rensburg H, Terre Blanche G, van der Walt M, Legoabe L. 5-Substituted 2-benzylidene-1-tetralone analogues as A1 and/or A2A antagonists for the potential treatment of neurological conditions. Bioorg Chem. 2017;74:251-259 pubmed publisher