adenosine a1 receptor agonists
Summary: Compounds that bind to and stimulate ADENOSINE A1 RECEPTORS.
Petrelli R, Scortichini M, Kachler S, Boccella S, Cerchia C, Torquati I, et al
. Exploring the Role of N6-Substituents in Potent Dual Acting 5'-C-Ethyltetrazolyladenosine Derivatives: Synthesis, Binding, Functional Assays, and Antinociceptive Effects in Mice ?. J Med Chem. 2017;60:4327-4341 pubmed publisher
..This study demonstrated for the first time the advantages of a single molecule activating two AR pathways both leading to benefit in this acute pain model. ..
Meibom D, Albrecht KÃ¼pper B, Diedrichs N, HÃ¼bsch W, Kast R, KrÃ¤mer T, et al
. Neladenoson Bialanate Hydrochloride: A Prodrug of a Partial Adenosineâ€…A1 Receptor Agonist for the Chronic Treatment of Heart Diseases. ChemMedChem. 2017;12:728-737 pubmed publisher
..Neladenoson bialanate hydrochloride is currently being evaluated in clinical trials for the treatment of heart failure. ..
Shao Q, Casin K, Mackowski N, Murphy E, Steenbergen C, Kohr M. Adenosine A1 receptor activation increases myocardial protein S-nitrosothiols and elicits protection from ischemia-reperfusion injury in male and female hearts. PLoS ONE. 2017;12:e0177315 pubmed publisher
..In addition, a number of the SNO proteins identified with CHA treatment were also observed with other forms of cardioprotective stimuli in prior studies, further supporting a role for protein SNO in cardioprotection. ..
Bailey I, Laughlin B, Moore L, Bogren L, Barati Z, Drew K. Optimization of Thermolytic Response to A1 Adenosine Receptor Agonists in Rats. J Pharmacol Exp Ther. 2017;362:424-430 pubmed publisher
..v. administration in combination with dynamic surface temperature control. Results show that after CHA administration control of surface temperature maintains desired target Tb better than dose or ambient temperature. ..
Blundon J, Roy N, Teubner B, Yu J, Eom T, Sample K, et al
. Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling. Science. 2017;356:1352-1356 pubmed publisher
..We conclude that, in adult mice, disrupting adenosine signaling in the thalamus rejuvenates plasticity in the auditory cortex and improves auditory perception. ..