adrenergic antagonists


Summary: Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.

Top Publications

  1. Nakazawa T, Tomita H, Yamaguchi K, Sato Y, Shimura M, Kuwahara S, et al. Neuroprotective effect of nipradilol on axotomized rat retinal ganglion cells. Curr Eye Res. 2002;24:114-22 pubmed
    ..Carboxy-PTIO and KT5832 decreased the neuroprotective effect of nipradilol. These results indicate that nipradilol has a possibility of neuroprotective effect on axotomized RGCs, and the effect depended mainly on its NO-donor property. ..
  2. Nikolaidis L, Poornima I, Parikh P, Magovern M, Shen Y, Shannon R. The effects of combined versus selective adrenergic blockade on left ventricular and systemic hemodynamics, myocardial substrate preference, and regional perfusion in conscious dogs with dilated cardiomyopathy. J Am Coll Cardiol. 2006;47:1871-81 pubmed
    ..These data suggest important advantages of blocking all three adrenergic receptor subtypes in DCM. ..
  3. Luchette F, Robinson B, Friend L, McCarter F, Frame S, James J. Adrenergic antagonists reduce lactic acidosis in response to hemorrhagic shock. J Trauma. 1999;46:873-80 pubmed
    ..In this study, we tested whether adrenergic antagonists can block lactate production during shock...
  4. Phelan C, Alaigh V, Fortunato G, Staff I, Sansing L. Effect of β-Adrenergic Antagonists on In-Hospital Mortality after Ischemic Stroke. J Stroke Cerebrovasc Dis. 2015;24:1998-2004 pubmed publisher
    ..Recent studies of β-adrenergic antagonists suggest they may have neuroprotective effects that lead to improved functional outcomes in rodent models ..
  5. Auteri M, Zizzo M, Amato A, Serio R. Dopamine induces inhibitory effects on the circular muscle contractility of mouse distal colon via D1- and D2-like receptors. J Physiol Biochem. 2016;73:395-404 pubmed publisher
    ..adenosine 3',5'-diphosphate diammonium salt (MRS 2179), purinergic P2Y1 antagonist, or adrenergic antagonists were ineffective. DA also reduced the amplitude of neurally evoked cholinergic contractions...
  6. Araie M. [Topical adrenergic antagonists--for understanding of their ocular and systemic effects]. Nippon Ganka Gakkai Zasshi. 2003;107:45-58 pubmed
  7. . Art Hancock memorial special issue: adrenergic and histaminergic pharmacology. Biochem Pharmacol. 2007;73:1041-255 pubmed
  8. Baltrusch S, Lenzen S. Regulation of [Ca2+]i oscillations in mouse pancreatic islets by adrenergic agonists. Biochem Biophys Res Commun. 2007;363:1038-43 pubmed
    ..These results support a cAMP mediated regulation and indicate that glucagon release from pancreatic alpha-cells acts in a paracrine fashion as a modulator of glucose-induced [Ca2+]i oscillations in mouse pancreatic islets. ..
  9. Groszek G, Nowak Król A, Wdowik T, Swierczyński D, Bednarski M, Otto M, et al. Synthesis and adrenolytic activity of 1-(1H-indol-4-yloxy)-3-(2-(2-methoxy phenoxy)ethylamino)propan-2-ol analogs and its enantiomers. Part 2. Eur J Med Chem. 2009;44:5103-11 pubmed publisher
    ..The antagonist potency of the new compounds was compared with carvedilol and (RS)-9. ..

More Information

Publications118 found, 100 shown here

  1. Lin Q, Wang F, Yang R, Zheng X, Gao H, Zhang P. Effect of chronic restraint stress on human colorectal carcinoma growth in mice. PLoS ONE. 2013;8:e61435 pubmed publisher
    ..We conclude that CRS promotes CRC xenograft tumor growth in nude mice by stimulating CRC cell proliferation through the AR signaling-dependent activation of ERK1/2. ..
  2. Chatterjee K. Congestive heart failure: what should be the initial therapy and why?. Am J Cardiovasc Drugs. 2002;2:1-6 pubmed
  3. Wada N, Matsumoto S, Kita M, Hashizume K, Kakizaki H. Improvement of Overactive Bladder Symptoms and Bladder Ischemia with Dutasteride in Patients with Benign Prostatic Enlargement. Low Urin Tract Symptoms. 2015;7:37-41 pubmed publisher
    ..40 ± 17 cmH2 O, P < 0.01). Reduction of obstruction and improvement of bladder ischemia might play an important role in a beneficial impact of dutasteride on overactive bladder symptoms. ..
  4. Krumpl G, Ulc I, Trebs M, Kadlecová P, Hodisch J. Bolus application of landiolol and esmolol: comparison of the pharmacokinetic and pharmacodynamic profiles in a healthy Caucasian group. Eur J Clin Pharmacol. 2017;73:417-428 pubmed publisher
    ..PK), pharmacodynamics (PD), safety, and tolerability of two short-acting cardioselective β1-adrenergic antagonists, landiolol and esmolol, after administration of three different bolus dosages...
  5. Castro Alamancos M, Calcagnotto M. High-pass filtering of corticothalamic activity by neuromodulators released in the thalamus during arousal: in vitro and in vivo. J Neurophysiol. 2001;85:1489-97 pubmed
    ..were mimicked by muscarinic and alpha(2)-adrenergic receptor agonists and blocked by muscarinic and alpha-adrenergic antagonists, respectively...
  6. Gavi S, Yin D, Shumay E, Wang H, Malbon C. Insulin-like growth factor-I provokes functional antagonism and internalization of beta1-adrenergic receptors. Endocrinology. 2007;148:2653-62 pubmed
    ..IGF-I attenuates the ability of beta(1)-adrenergic receptors to accumulate intracellular cAMP in response to Iso and promotes internalization of beta(1)-adrenergic receptors in these cardiac myocytes. ..
  7. Sterin Borda L, Furlan C, Orman B, Borda E. Differential regulation on human skin fibroblast by alpha1 adrenergic receptor subtypes. Biochem Pharmacol. 2007;74:1401-12 pubmed
    ..Results suggest that the expression of alpha1-AR subtypes on human skin fibroblast may differentially activate signaling pathways that modulate physiological response of the cells. ..
  8. Robinson E, Tyacke R, Finch L, Willmott G, Husbands S, Nutt D, et al. Pharmacological characterisation of novel alpha 2-adrenoceptor antagonists as potential brain imaging agents. Neuropharmacology. 2004;46:847-55 pubmed
    ..Further studies using radiolabelled forms of these ligands and a more extensive characterisation of their binding profiles are necessary but these initial evaluations demonstrate their potential. ..
  9. Gao Y, Gao H, Di N, Kong Y, Li W. [Effects of beta3-adrenergic receptor antagonist on myocardial UCP2 expression and energy metabolism in chronic heart failure rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2013;29:376-9, 384 pubmed
    ..In the chronic stage of HF, the expression of UCP2 increases, which causes myocardial energy shortage, SR59230A improves myocardia energy efficiency and cardiac function by means of suppressing the expression of UCP2. ..
  10. Hoy S. Tafluprost/Timolol: A Review in Open-Angle Glaucoma or Ocular Hypertension. Drugs. 2015;75:1807-13 pubmed publisher
  11. Jolly C, Katsiadaki I, Morris S, Le Belle N, Dufour S, Mayer I, et al. Detection of the anti-androgenic effect of endocrine disrupting environmental contaminants using in vivo and in vitro assays in the three-spined stickleback. Aquat Toxicol. 2009;92:228-39 pubmed publisher
    ..In addition, our study represents the first attempt to develop a combined in vivo/in vitro screening strategy for assessing the effects of (anti-)androgenic endocrine disrupters. ..
  12. Wang J, Tang M, Jiang H, Wu B, Cai W, Hu C, et al. The role of adrenergic activation on murine luteal cell viability and progesterone production. Theriogenology. 2016;86:1182-8 pubmed publisher
    ..3?-Hydroxysteroid dehydrogenase, LHR, steroidogenic acute regulatory protein (StAR), and PGF2? contribute to the progesterone production induced by NE and ISO. ..
  13. Fisher S, Van Zutphen A, Romitti P, Browne M. Maternal Hypertension, Antihypertensive Medication Use, and Small for Gestational Age Births in the National Birth Defects Prevention Study, 1997-2011. Matern Child Health J. 2018;22:237-246 pubmed publisher
    ..We did not observe an appreciably increased SGA risk associated with antihypertensive medication use beyond that of the underlying maternal hypertension. ..
  14. Marinella M. Labetalol-induced hepatitis in a patient with chronic hepatitis B infection. J Clin Hypertens (Greenwich). 2002;4:120-1 pubmed
    ..Extensive evaluation revealed evidence of chronic hepatitis B infection, of which the patient was previously not aware. Hepatic transaminases normalized after discontinuation of labetalol. ..
  15. Gibbs M, Summers R. Alpha 2-adrenoceptors in the basal ganglia have a role in memory consolidation and reinforcement. Neuropharmacology. 2003;45:355-67 pubmed
    ..The LPO may be responsible for the reinforcement of memory in the IMHV. ..
  16. Wu B, Chen C, Hong Y, Howng S, Lin Y, Chen I. Activation of BKCa channels via cyclic AMP- and cyclic GMP-dependent protein kinases by eugenosedin-A in rat basilar artery myocytes. Br J Pharmacol. 2007;152:374-85 pubmed
    ..Physiologically, this activation would result in the closure of voltage-dependent calcium channels and thereby relax cerebral SMCs. ..
  17. Kuo C, Wang R, Shen L, Lien L, Lien E. G-protein coupled receptors: SAR analyses of neurotransmitters and antagonists. J Clin Pharm Ther. 2004;29:279-98 pubmed
    ..It appears that all neurotransmitters examined in this study operate by a similar mechanism with the G-protein coupled receptors. ..
  18. Bernardi R, Lattal K. A role for alpha-adrenergic receptors in extinction of conditioned fear and cocaine conditioned place preference. Behav Neurosci. 2010;124:204-10 pubmed publisher
    ..These results confirm the involvement of the alpha-adrenergic receptor in extinction processes in both appetitive and aversive preparations. ..
  19. Kagoma Y, Weir M, Iansavichus A, Hemmelgarn B, Akbari A, Patel U, et al. Impact of estimated GFR reporting on patients, clinicians, and health-care systems: a systematic review. Am J Kidney Dis. 2011;57:592-601 pubmed publisher
    ..eGFR reporting has been associated with greater identification of patients with decreased kidney function in most health care systems that have reported its impact. ..
  20. Segev A, Ramot A, Akirav I. Stress hormones receptors in the amygdala mediate the effects of stress on the consolidation, but not the retrieval, of a non aversive spatial task. PLoS ONE. 2012;7:e29988 pubmed publisher
  21. Gadek Michalska A, Bugajski J, Bugajski A, Głód R. Effect of adrenergic antagonists and cyclooxygenase inhibitors on the nicotine-induced hypothalamic-pituitary-adrenocortical activity. J Physiol Pharmacol. 2002;53:275-87 pubmed
    ..Noradrenaline, stimulating postsynaptic alpha1-adrenergic receptors, and prostaglandins, synthesized by COX-1 isoenzyme, are of crucial significance in the nicotine-induced ACTH and corticosterone secretion. ..
  22. Mink S, Jacobs H, Bose D, Duke K, Cheng Z, Liu G, et al. Lysozyme: a mediator of myocardial depression and adrenergic dysfunction in septic shock in dogs. J Mol Cell Cardiol. 2003;35:265-75 pubmed
    ..The mechanism may relate to its binding or hydrolysis of a cardiac membrane glycoprotein thereby interfering with myocardial excitation-contraction coupling in sepsis. ..
  23. Tamayo M, Manzanares E, Bas M, Martín Nunes L, Val Blasco A, Jesús Larriba M, et al. Calcitriol (1,25-dihydroxyvitamin D3) increases L-type calcium current via protein kinase A signaling and modulates calcium cycling and contractility in isolated mouse ventricular myocytes. Heart Rhythm. 2017;14:432-439 pubmed publisher
    ..Calcitriol induces a rapid response in mouse ventricular myocytes that involves a VDR-PKA-dependent increase in ICaL density, enhancing [Ca2+]i transients and contraction. ..
  24. Auerbach D, Biton Y, Polonsky B, McNitt S, Gross R, Dirksen R, et al. Risk of cardiac events in Long QT syndrome patients when taking antiseizure medications. Transl Res. 2018;191:81-92.e7 pubmed publisher
  25. Gavras H. Adrenergic receptors in hypertension and heart failure. Am J Hypertens. 2004;17:98-9 pubmed
  26. Conde S, Nunes da Silva T, Gonzalez C, Mota Carmo M, Monteiro E, Guarino M. Chronic caffeine intake decreases circulating catecholamines and prevents diet-induced insulin resistance and hypertension in rats. Br J Nutr. 2012;107:86-95 pubmed publisher
    ..We concluded that long-term caffeine intake prevented the development of insulin resistance and hypertension in HF and HSu models and that this effect was related to a decrease in circulating catecholamines...
  27. Ma M, Zhu X, Wang L, Hu X, Wang Z, Zhao J, et al. ?3-adrenoceptor impacts apoptosis in cultured cardiomyocytes via activation of PI3K/Akt and p38MAPK. J Huazhong Univ Sci Technolog Med Sci. 2016;36:1-7 pubmed publisher
    ..In contrast, the ?3-blocker reduced apoptosis of CMs and the associated elevated Akt expression. We identified a novel and potent anti-apoptosis mechanism via the PI3K/Akt pathway and a pro-apoptosis pathway mediated by p38MAPK. ..
  28. Zinner N, Koke S, Viktrup L. Pharmacotherapy for stress urinary incontinence : present and future options. Drugs. 2004;64:1503-16 pubmed
    ..A medication such as duloxetine, if approved, would go a long way towards expanding the available treatment options for patients with SUI. ..
  29. Richter F, Mikulik O, Ebersberger A, Schaible H. Noradrenergic agonists and antagonists influence migration of cortical spreading depression in rat-a possible mechanism of migraine prophylaxis and prevention of postischemic neuronal damage. J Cereb Blood Flow Metab. 2005;25:1225-35 pubmed
    ..The effect of beta-receptor antagonists in human migraine needs further exploration, since these drugs also work in migraine without aura. ..
  30. Pourkhalili N, Pournourmohammadi S, Rahimi F, Vosough Ghanbari S, Baeeri M, Ostad S, et al. Comparative effects of calcium channel blockers, autonomic nervous system blockers, and free radical scavengers on diazinon-induced hyposecretion of insulin from isolated islets of Langerhans in rats. Arh Hig Rada Toksikol. 2009;60:157-64 pubmed publisher
    ..These findings suggest that diazinon affects insulin secretion mainly by disturbing the balance between free radicals and antioxidants in the islets of Langerhans and by inducing toxic stress. ..
  31. Shaashua L, Shabat Simon M, Haldar R, Matzner P, Zmora O, Shabtai M, et al. Perioperative COX-2 and ?-Adrenergic Blockade Improves Metastatic Biomarkers in Breast Cancer Patients in a Phase-II Randomized Trial. Clin Cancer Res. 2017;23:4651-4661 pubmed publisher
    ..i>Clin Cancer Res; 23(16); 4651-61. ©2017 AACR. ..
  32. Oelkrug R, Herrmann B, Geissler C, Harder L, Koch C, Lehnert H, et al. Dwarfism and insulin resistance in male offspring caused by α1-adrenergic antagonism during pregnancy. Mol Metab. 2017;6:1126-1136 pubmed publisher
    ..The findings are of immediate clinical relevance as combined α/β-adrenergic blockers are first-line treatment of maternal hypertension. ..
  33. Crossley D, Altimiras J. Ontogeny of cholinergic and adrenergic cardiovascular regulation in the domestic chicken (Gallus gallus). Am J Physiol Regul Integr Comp Physiol. 2000;279:R1091-8 pubmed
    ..Injections of the alpha-adrenergic antagonists prazosin or phentolamine (1 mg/kg) reduced arterial pressure significantly on all days of incubation ..
  34. Kaczmarczyk Sedlak I, Cegieła U, Nowińska B, Folwarczna J. Effects of catecholamines on the intramedullary pressure in the femur in rats with prednisolone-induced osteoporosis. Pharmacol Rep. 2006;58:540-50 pubmed
    ..In addition, a disordered effect of catecholamines on intramedullary pressure of osteoporotic bone was observed. ..
  35. Tripovic D, Al Abed A, Rummery N, Johansen N, McLachlan E, Brock J. Nerve-evoked constriction of rat tail veins is potentiated and venous diameter is reduced after chronic spinal cord transection. J Neurotrauma. 2011;28:821-9 pubmed publisher
    ..Furthermore, the smaller lumen diameter after SCI will increase the pressure that the veins exert on the luminal contents when they are neurally activated. ..
  36. Jakubík J, El Fakahany E, Doležal V. Towards predictive docking at aminergic G-protein coupled receptors. J Mol Model. 2015;21:284 pubmed publisher
    ..This procedure also worked well for cross-docking of tested β2-adrenergic antagonists. Thus, this procedure represents a possible way to predict interactions of antagonists with aminergic ..
  37. Villain H, Benkahoul A, Birmes P, Ferry B, Roullet P. Influence of early stress on memory reconsolidation: Implications for post-traumatic stress disorder treatment. PLoS ONE. 2018;13:e0191563 pubmed publisher
    ..These data are critical to understanding the effect of propranolol treatment, in order to improve the therapeutic protocol currently used in humans. ..
  38. Starodubtsev A, Arkhipova D, Sychev D, Maksimov M, Mchkin I. [Functional changes of myocardial adrenoreceptors in patients with chronic cardiac insufficiency]. Eksp Klin Farmakol. 2005;68:59-66 pubmed
  39. Berkseth K, Thirumalai A, Amory J. Pharmacologic Therapy in Men's Health: Hypogonadism, Erectile Dysfunction, and Benign Prostatic Hyperplasia. Med Clin North Am. 2016;100:791-805 pubmed publisher
    ..intrapenile alprostadil injections for patients who do not respond to oral medications, and the role of alpha1-adrenergic antagonists, 5-alpha-reductase inhibitors, anticholinergic agents, and herbal therapies in the management of BPH.
  40. Goudie DeAngelis E, Abdelhamid R, Nunez M, Kissel C, Kovács K, Portoghese P, et al. Modulation of musculoskeletal hyperalgesia by brown adipose tissue activity in mice. Pain. 2016;157:2561-2570 pubmed
    ..Together, these data provide a convergence of evidence suggesting that activation of brown adipose contributes to stress-induced musculoskeletal hyperalgesia. ..
  41. Lai C, Chen C, Kuo T, Chern C, Yang C. Sympathetic Hyperactivity, Sleep Fragmentation, and Wake-Related Blood Pressure Surge During Late-Light Sleep in Spontaneously Hypertensive Rats. Am J Hypertens. 2016;29:590-7 pubmed publisher
  42. Asouhidou I, Trikoupi A. Esmolol reduces anesthetic requirements thereby facilitating early extubation; a prospective controlled study in patients undergoing intracranial surgery. BMC Anesthesiol. 2015;15:172 pubmed publisher Identifier: NCT02455440 . Registered 26 May 2015. ..
  43. Macedo S, Rodrigues J, Schenkman S, Yoshida N. Beta-adrenergic antagonist propranolol inhibits mammalian cell lysosome spreading and invasion by Trypanosoma cruzi metacyclic forms. Microbes Infect. 2017;19:295-301 pubmed publisher
    ..The effect of propranolol in inhibiting MT internalization was not due to the prevention of gp82 interaction with ?-AR. It was mainly associated with its ability to impair lysosome spreading. ..
  44. Gurrieri C, Butz J, Weingarten T, Bancos I, Young W, Cassivi S, et al. Resection of Intrathoracic Paraganglioma With and Without Cardiopulmonary Bypass. Ann Thorac Surg. 2018;105:1160-1167 pubmed publisher
    ..Although intraoperative bleeding in most complex cases may be uncontrollable, as for 1 of our patients, those who survived hospital discharge had favorable long-term outcomes. ..
  45. White S, Black P, Samathanam G, Paros K. Prazosin suppresses development of axonal damage in rats inoculated for experimental allergic encephalomyelitis. J Neuroimmunol. 1992;39:211-8 pubmed
  46. Alessi N, Spalding S. Atomoxetine and pregnancy. J Am Acad Child Adolesc Psychiatry. 2003;42:883-4, author reply 884-5 pubmed
  47. Zubidat A, Nelson R, Haim A. Urinary adrenalin and cortisol secretion patterns of social voles in response to adrenergic blockade under basal conditions. Physiol Behav. 2008;93:243-9 pubmed
    ..The simultaneous decrease in adrenal hormones induced by PRAZ suggests that alpha(1)-adrenoceptors may contribute to the mechanism of integrated stress responses. ..
  48. Fan Z, Si L, Xu L, Ma Y, Hu L, Qiu J, et al. Determination of TJ0711 hydrochloride in rat plasma by high performance liquid chromatography with fluorescence detection and its application to pharmacokinetics. J Chromatogr B Analyt Technol Biomed Life Sci. 2010;878:2035-8 pubmed publisher
    ..9%. The lower limit of quantification (LLOQ) was 20 ng/mL. Finally, this method was successfully applied to the estimation of pharmacokinetic parameters of TJ0711 hydrochloride after intravenous doses of 4, 8 and 16 mg/kg in rats. ..
  49. Yoon M, Choi J, Jeong S. Spinal gabapentin and antinociception: mechanisms of action. J Korean Med Sci. 2003;18:255-61 pubmed
  50. McCutcheon K, Manga P. Left ventricular remodelling in chronic primary mitral regurgitation: implications for medical therapy. Cardiovasc J Afr. 2018;29:51-65 pubmed publisher
  51. Hemstreet B. Evaluation of carvedilol for the treatment of portal hypertension. Pharmacotherapy. 2004;24:94-104 pubmed
    ..Further multiple-dose trials comparing carvedilol with standard therapy are needed to assess the agent's long-term safety and effectiveness in preventing variceal bleeding. ..
  52. Nakamura S. [Treatment for hypertension in patients with renal diseases]. Nihon Rinsho. 2004;62 Suppl 3:452-9 pubmed
  53. Chen Q, Li D, Pan H. Presynaptic alpha1 adrenergic receptors differentially regulate synaptic glutamate and GABA release to hypothalamic presympathetic neurons. J Pharmacol Exp Ther. 2006;316:733-42 pubmed
    ..Thus, these data suggest that activation of alpha (1)adrenergic receptors increases the excitability of PVN presympathetic neurons primarily through augmentation of glutamatergic tone and attenuation of GABAergic inputs. ..
  54. Wang S, Cyronak M, Yang E. Does a stable isotopically labeled internal standard always correct analyte response? A matrix effect study on a LC/MS/MS method for the determination of carvedilol enantiomers in human plasma. J Pharm Biomed Anal. 2007;43:701-7 pubmed
    ..This difference was significant enough to change the analyte to internal standard peak area ratio and affect the accuracy of the method. ..
  55. Mehrotra S, Gupta S, Chan K, Villalón C, Centurión D, Saxena P, et al. Current and prospective pharmacological targets in relation to antimigraine action. Naunyn Schmiedebergs Arch Pharmacol. 2008;378:371-94 pubmed publisher
    ..Finally, the cardiovascular safety of current and prospective antimigraine therapies is touched upon. ..
  56. Hysek C, Schmid Y, Rickli A, Simmler L, Donzelli M, Grouzmann E, et al. Carvedilol inhibits the cardiostimulant and thermogenic effects of MDMA in humans. Br J Pharmacol. 2012;166:2277-88 pubmed publisher
    ..Carvedilol could be useful in the treatment of cardiovascular and hyperthermic complications associated with ecstasy use. ..
  57. Wu H, Huang J, Lin H, Liao W, Peng Y, Hung K, et al. Comparative effectiveness of renin-angiotensin system blockers and other antihypertensive drugs in patients with diabetes: systematic review and bayesian network meta-analysis. BMJ. 2013;347:f6008 pubmed publisher
    ..Calcium channel blockers might be the preferred treatment in combination with ACE inhibitors if adequate blood pressure control cannot be achieved by ACE inhibitors alone. ..
  58. Pericic D, Svob D, Jazvinsćak Jembrek M, Mirković Kos K. The involvement of alpha2-adrenoceptors in the anticonvulsive effect of swim stress in mice. Psychopharmacology (Berl). 2001;158:87-93 pubmed
    ..Additionally, they show the anticonvulsive effect of niguldipine in unstressed and stressed animals. Hence, the results suggest that alpha2-adrenoceptors are involved in the anticonvulsive effect of swim stress in mice. ..
  59. Siawrys G, Bogacka I, Okrasa S, Kaminski T, Przala J. The effect of stimulators and blockers of adrenergic receptors on LH secretion and cyclic nucleotide (cAMP and cGMP) production by porcine pituitary cells in vitro. Anim Reprod Sci. 2002;69:73-89 pubmed
    ..In conclusion, our results suggest that adrenergic agents can modulate LH release by porcine pituitary cells acting through guanyl and adenylyl cyclase and in a manner dependent on hormonal status of gilts. ..
  60. Carlyle M, Jones O, Kuo J, Hall J. Chronic cardiovascular and renal actions of leptin: role of adrenergic activity. Hypertension. 2002;39:496-501 pubmed
    ..0 microg/kg/min) for 7 days along with vehicle or adrenergic antagonists, followed by a 7-day recovery period...
  61. Huang L, Weil M, Sun S, Tang W, Fang X. Carvedilol mitigates adverse effects of epinephrine during cardiopulmonary resuscitation. J Cardiovasc Pharmacol Ther. 2005;10:113-20 pubmed
  62. Galgut J, Ali S. Effect and mechanism of action of resveratrol: a novel melanolytic compound from the peanut skin of Arachis hypogaea. J Recept Signal Transduct Res. 2011;31:374-80 pubmed publisher
    ..The present study opens new vistas for the use of A. hypogaea and its active ingredient, resveratrol for its clinical application as a nontoxic melanolytic compound for the treatment of hyperpigmentation. ..
  63. Murai S, Saito H, Shirato R, Kawaguchi T. Dual adrenergic control of in vivo choline levels in the mouse major salivary glands. Auton Autacoid Pharmacol. 2002;22:17-27 pubmed
  64. Amira C, Okubadejo N. Antihypertensive pharmacotherapy in a developing economy: pattern, acquisition costs and conformity to international guidelines in a tertiary-care setting. J Hum Hypertens. 2006;20:894-7 pubmed
  65. Hoeger S, Gottmann U, Liu Z, Schnuelle P, Birck R, Braun C, et al. Dopamine treatment in brain-dead rats mediates anti-inflammatory effects: the role of hemodynamic stabilization and D-receptor stimulation. Transpl Int. 2007;20:790-9 pubmed
    ..Hence, DA might reduce BD-induced monocyte infiltration possibly by hemodynamic stabilization, D-receptor activation, or a combination of both. ..
  66. Sullivan G, Neria Y. Pharmacotherapy in post-traumatic stress disorder: evidence from randomized controlled trials. Curr Opin Investig Drugs. 2009;10:35-45 pubmed
    ..Where appropriate, RCT methodological problems that limit the conclusions drawn are discussed. In addition, recommendations for research to fill critical gaps in the knowledge of PTSD treatment are offered. ..
  67. Vasudevan S, Gupta V, Crowston J. Neuroprotection in glaucoma. Indian J Ophthalmol. 2011;59 Suppl:S102-13 pubmed publisher
  68. Yanagawa Y, Hiraide S, Iizuka K. Isoform-specific regulation of transforming growth factor-? mRNA expression in macrophages in response to adrenoceptor stimulation. Microbiol Immunol. 2016;60:56-63 pubmed publisher
    ..Adrenoceptor-mediated TGF-?3 expression by macrophages may influence immune regulation and tissue repair in conditions of stress, during which the sympathetic-nervous system releases catecholamines. ..
  69. Fan M, Qin W, Mustafa S. Characterization of adenosine receptor(s) involved in adenosine-induced bronchoconstriction in an allergic mouse model. Am J Physiol Lung Cell Mol Physiol. 2003;284:L1012-9 pubmed
    ..Finally, whether the airway effects of the receptor agonists/antagonists are direct or indirect needs further investigations. ..
  70. Clarke R, Zhang H, Gamlin P. Characteristics of the pupillary light reflex in the alert rhesus monkey. J Neurophysiol. 2003;89:3179-89 pubmed
    ..The rhesus monkey thus provides an excellent model for experimental studies of the neural control of the pupil. ..
  71. Haug S, Segal S. Sympathetic neural inhibition of conducted vasodilatation along hamster feed arteries: complementary effects of alpha1- and alpha2-adrenoreceptor activation. J Physiol. 2005;563:541-55 pubmed
  72. Iida H, Iida M. Effects of spinal analgesics on spinal circulation: the safety standpoint. J Neurosurg Anesthesiol. 2008;20:180-7 pubmed publisher
    ..This review therefore focuses on the effects on the spinal circulation induced by well-known spinal analgesics employed in the treatment of acute and chronic pain disorders. ..
  73. Bonnet N, Pierroz D, Ferrari S. Adrenergic control of bone remodeling and its implications for the treatment of osteoporosis. J Musculoskelet Neuronal Interact. 2008;8:94-104 pubmed
    ..Furthermore, we will examine the similarities and disparities that may exist in the effects of beta-adrenergic and PTH stimulation on bone metabolism. ..
  74. Van Tassell B, Rondina M, Huggins F, Gilbert E, Munger M. Carvedilol increases blood pressure response to phenylephrine infusion in heart failure subjects with systolic dysfunction: evidence of improved vascular alpha1-adrenoreceptor signal transduction. Am Heart J. 2008;156:315-21 pubmed publisher
    ..This effect is evident despite no detectable tolerance to preinfusion BP reductions. The varying affinities of alpha(1)-AR subtypes for carvedilol and PE may have contributed to this finding. ..
  75. Cromwell P, Munn N, Zolkowski Wynne J. Evaluation and management of hypertension in children and adolescents (part two): evaluation and management. J Pediatr Health Care. 2005;19:309-13 pubmed
  76. van Dijk M, de la Rosette J, Michel M. Effects of alpha(1)-adrenoceptor antagonists on male sexual function. Drugs. 2006;66:287-301 pubmed
    ..We propose that such differences between drugs should be weighed against differences in cardiovascular tolerability when choosing the optimal treatment for each patient. ..
  77. Othman A, Tenero D, Boyle D, Eddington N, Fossler M. Population pharmacokinetics of S(-)-carvedilol in healthy volunteers after administration of the immediate-release (IR) and the new controlled-release (CR) dosage forms of the racemate. AAPS J. 2007;9:E208-18 pubmed
    ..The model performed well in simulation and leverage analysis indicated its robustness. The model will be a useful tool for future simulation studies. ..
  78. Tebbe U, Bramlage P, von Löwis of Menar P, Lawall H, Gaudron P, Lüders S, et al. [Treatment of the acute coronary syndrome in Germany: experiences in a German cluster of the GRACE registry]. Dtsch Med Wochenschr. 2007;132:2000-5 pubmed
  79. Macfarlane D, Paterson K, Fisher M. Cardiovascular drugs as antidiabetic agents: evidence for the prevention of type 2 diabetes. Diabetes Obes Metab. 2008;10:533-44 pubmed publisher
    ..With current guidelines, the use of cardiovascular drugs modifying the RAS will increase in at-risk individuals, but at present, they cannot be recommended to prevent diabetes. ..
  80. Turcani M. Biphasic dose-dependent modulation of cardiac parasympathetic activity by moxonidine, an imidazoline I1-receptor agonist. J Cardiovasc Pharmacol. 2008;52:524-35 pubmed publisher
    ..However, high doses of moxonidine are strongly parasympathomimetic through the activation of central alpha2-adrenoceptors. Recruitment of alpha2-adrenoceptors also results in manifestation of several side effects. ..
  81. Fisher W, Johnson A, Elkins G, Otte J, Burns D, Yu M, et al. Risk factors, pathophysiology, and treatment of hot flashes in cancer. CA Cancer J Clin. 2013;63:167-92 pubmed publisher
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