mitosis modulators


Summary: Agents that affect MITOSIS of CELLS.

Top Publications

  1. Comstock C, Knudsen K. The complex role of AR signaling after cytotoxic insult: implications for cell-cycle-based chemotherapeutics. Cell Cycle. 2007;6:1307-13 pubmed
  2. Lee Y, Bae E. Inhibition of mitotic clonal expansion mediates fisetin-exerted prevention of adipocyte differentiation in 3T3-L1 cells. Arch Pharm Res. 2013;36:1377-84 pubmed publisher
    ..Altogether, our results suggest that the inhibition of adipocyte differentiation by fisetin may be at least in part mediated by cell cycle arrest during adipogenesis. ..
  3. Tipton A, Wang K, Oladimeji P, Sufi S, Gu Z, Liu S. Identification of novel mitosis regulators through data mining with human centromere/kinetochore proteins as group queries. BMC Cell Biol. 2012;13:15 pubmed publisher
    ..The molecular players participating in mitosis regulation are still being unravelled experimentally or using in silico methods...
  4. Lee A, Roylance R, Sander J, Gorman P, Endesfelder D, Kschischo M, et al. CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction. J Pathol. 2012;226:482-94 pubmed publisher
  5. Dulla K, Santamaria A. Large-scale mitotic cell synchronization. Methods Mol Biol. 2011;761:65-74 pubmed publisher
    ..In particular, we discuss the technical aspects of adherent or suspension cell isolation, the methods necessary to enrich cells at different mitotic stages and the optimized culture conditions. ..
  6. Manukyan A, Abraham L, Dungrawala H, Schneider B. Synchronization of yeast. Methods Mol Biol. 2011;761:173-200 pubmed publisher
  7. Karabanovas V, Zitkus Z, Kučiauskas D, Rotomskis R, Valius M. Surface properties of quantum dots define their cellular endocytic routes, mitogenic stimulation and suppression of cell migration. J Biomed Nanotechnol. 2014;10:775-86 pubmed
    ..Data show that surface coating of QD with the biologically active proteins redirects their intracellular traffic routes and changes their biological activity. ..
  8. Pérez Fidalgo J, Roda D, Rosello S, Rodriguez Braun E, Cervantes A. Aurora kinase inhibitors: a new class of drugs targeting the regulatory mitotic system. Clin Transl Oncol. 2009;11:787-98 pubmed
    ..Future strategies and challenges for trials with Aurora kinase inhibitors are also discussed. ..
  9. Shufaro Y, Reubinoff B. Cell cycle synchronization for the purpose of somatic cell nuclear transfer (SCNT). Methods Mol Biol. 2011;761:239-47 pubmed publisher
    ..In this section, we will describe how mouse SCNT is performed and survey the importance of donor cell cycle synchronization and the methods to perform it. ..

More Information


  1. Banfalvi G. Overview of cell synchronization. Methods Mol Biol. 2011;761:1-23 pubmed publisher
  2. Li C. Specific cell cycle synchronization with butyrate and cell cycle analysis. Methods Mol Biol. 2011;761:125-36 pubmed publisher
    ..By combining BrdU incorporation and DNA content analysis, not only can the overlapping of different cell populations be eliminated, but the frequency and nature of individual cells that have synthesized DNA can also be determined. ..
  3. Svärd S, Troell K. Synchronization of pathogenic protozoans. Methods Mol Biol. 2011;761:201-10 pubmed publisher
    ..It has recently been possible to synchronize its cell cycle using compounds that inhibit different steps of the cell cycle and the detailed protocol is described here. ..
  4. Fischer J, CARADONNA S. Analysis of nuclear uracil-DNA glycosylase (nUDG) turnover during the cell cycle. Methods Mol Biol. 2011;761:137-49 pubmed publisher
    ..Immunoblot analysis of immunoprecipitated or affinity-isolated nUDG reveals ubiquitin-conjugated nUDG when proteolysis is inhibited by agents that block proteasomal-dependent protein degradation. ..
  5. Somfai T, Hirao Y. Synchronization of in vitro maturation in porcine oocytes. Methods Mol Biol. 2011;761:211-25 pubmed publisher
    ..A protocol for each approach is described. ..
  6. Ma H, Poon R. Synchronization of HeLa cells. Methods Mol Biol. 2011;761:151-61 pubmed publisher
    ..We also describe several protocols, including flow cytometry, BrdU labeling, immunoblotting, and time-lapse microscopy, for validating the synchrony of the cells and monitoring the progression of the cell cycle after release. ..
  7. Scaife R. Microtubule disassembly and inhibition of mitosis by a novel synthetic pharmacophore. J Cell Biochem. 2006;98:102-14 pubmed
    ..Similar to other microtubule drugs, this new pharmacophore blocks mitotic spindle assembly and mitotic cell division. ..
  8. Zhang D, Park W, Sun S, Xu Y, Li Y, Cui X, et al. Regulation of maternal gene expression by MEK/MAPK and MPF signaling in porcine oocytes during in vitro meiotic maturation. J Reprod Dev. 2011;57:49-56 pubmed
    ..Together, these results provide the first demonstration in a mammalian system that MAPK and MPF play important roles in regulation of maternal gene expression during oocyte maturation. ..
  9. Wang X, Liu Y, Qing C, Lu S. A review of the effectiveness of antimitotic drug injections for hypertrophic scars and keloids. Ann Plast Surg. 2009;63:688-92 pubmed publisher
    ..The current accepted treatment for hypertrophic scar and keloid are combination therapy and the early treatment which could achieve better efficacy and less adverse effect. ..
  10. Daga R, Nurse P. Interphase microtubule bundles use global cell shape to guide spindle alignment in fission yeast. J Cell Sci. 2008;121:1973-80 pubmed publisher
  11. Buchert M, Poon C, King J, Baechi T, D Abaco G, Hollande F, et al. AF6/s-afadin is a dual residency protein and localizes to a novel subnuclear compartment. J Cell Physiol. 2007;210:212-23 pubmed
    ..AF6/s-afadin is a candidate for mediating control of cellular growth processes by regulated translocation to the nucleus. ..
  12. Casado P, Prado M, Zuazua Villar P, Del Valle E, Artime N, Cabal Hierro L, et al. Microtubule interfering agents and KSP inhibitors induce the phosphorylation of the nuclear protein p54(nrb), an event linked to G2/M arrest. J Proteomics. 2009;71:592-600 pubmed publisher
    ..We show that the G2/M arrest induced by MIAs is required for p54(nrb) phosphorylation. Finally, we demonstrate that CDK activity is required for MIA-induced phosphorylation of p54(nrb). ..
  13. Voigt T, Gerding Reimers C, Ngoc Tran T, Bergmann S, Lachance H, Schölermann B, et al. A natural product inspired tetrahydropyran collection yields mitosis modulators that synergistically target CSE1L and tubulin. Angew Chem Int Ed Engl. 2013;52:410-4 pubmed publisher
    ..These compounds were termed tubulexins as they target the CSE1L protein and the vinca alkaloid binding site of tubulin. ..