chloride channel agonists

Summary

Summary: A class of drugs that stimulate chloride ion influx through cell membrane channels.

Top Publications

  1. Talamo Guevara M, McColley S. The safety of lumacaftor and ivacaftor for the treatment of cystic fibrosis. Expert Opin Drug Saf. 2017;16:1305-1311 pubmed publisher
    ..Dyspnea occurs, especially during initiation of treatment. Potential drug interactions should be evaluated in patients taking combination therapy. The risk benefit ratio of lumacaftor-ivacaftor favors therapy. ..
  2. Virant Young D, Thomas J, Woiderski S, Powers M, Carlier J, McCarty J, et al. Cystic Fibrosis: A Novel Pharmacologic Approach to Cystic Fibrosis Transmembrane Regulator Modulation Therapy. J Am Osteopath Assoc. 2015;115:546-55 pubmed publisher
    ..Drug therapy monitoring, adverse effects, and indications for discontinuation must also be considered. ..
  3. Char J, Dunn C, Davies Z, Milla C, Moss R, Wine J. The magnitude of ivacaftor effects on fluid secretion via R117H-CFTR channels: Human in vivo measurements. PLoS ONE. 2017;12:e0175486 pubmed publisher
    ..We conclude that in vivo, R117H PO is strongly increased by ivacaftor, but channel number, mainly determined by variable deletion of exon 10, has a marked influence on outcomes. ..
  4. Fajac I, Wainwright C. New treatments targeting the basic defects in cystic fibrosis. Presse Med. 2017;46:e165-e175 pubmed publisher
    ..All these strategies are needed to develop disease-modifying therapies for all patients with CF. ..
  5. Zeng M, Szymczak M, Ahuja M, Zheng C, Yin H, Swaim W, et al. Restoration of CFTR Activity in Ducts Rescues Acinar Cell Function and Reduces Inflammation in Pancreatic and Salivary Glands of Mice. Gastroenterology. 2017;153:1148-1159 pubmed publisher
    ..Our findings reveal that correcting ductal function is sufficient to rescue acinar cell function and suggests that CFTR correctors are strong candidates for the treatment of Sjögren's syndrome and pancreatitis. ..