adenylyl cyclase inhibitors
Summary: Compounds that bind to and inhibit the action of ADENYLYL CYCLASES.
Bouhelal R, Smounya L, Bockaert J. 5-HT1B receptors are negatively coupled with adenylate cyclase in rat substantia nigra. Eur J Pharmacol. 1988;151:189-96 pubmed
..Our conclusion is that, in addition to the 5-HT1A receptor, the 5-HT1B receptor is also negatively coupled to adenylate cyclase. ..
Rzeszotarski W, McPherson D, Ferkany J, Kinnier W, Noronha Blob L, Kirkien Rzeszotarski A. Affinity and selectivity of the optical isomers of 3-quinuclidinyl benzilate and related muscarinic antagonists. J Med Chem. 1988;31:1463-6 pubmed
..In fact, the latter diastereomer was as potent and selective as pirenzepine for M1-AChRs. ..
Wang Z, Cui Y, Ding G, Zhou M, Ma X, Hou Y, et al
. Mahuannin B an adenylate cyclase inhibitor attenuates hyperhidrosis via suppressing ?2-adrenoceptor/cAMP signaling pathway. Phytomedicine. 2017;30:18-27 pubmed publisher
..The present work not only sheds light on the hidroschesis action of mahuannin B, but also presents a potential target of AC in the treatment of hyperhidrosis. ..
Carvalho de Freitas R, Lonien S, Malvezi A, Silveira G, Wowk P, da Silva R, et al
. Trypanosoma cruzi: Inhibition of infection of human monocytes by aspirin. Exp Parasitol. 2017;182:26-33 pubmed publisher
..Altogether, these results reinforce the idea that the cyclooxygenase pathway plays a fundamental role in the process of parasite invasion in an in vitro model of T. cruzi infection. ..