pharmacologic actions


Summary: A broad category of chemical actions and uses that result in the prevention, treatment, cure or diagnosis of disease. Included here are drugs and chemicals that act by altering normal body functions, such as the REPRODUCTIVE CONTROL AGENTS and ANESTHETICS. Effects of chemicals on the environment are also included.

Top Publications

  1. Nguyen L, Thomas K, Lucke Wold B, Cavendish J, Crowe M, Matsumoto R. Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders. Pharmacol Ther. 2016;159:1-22 pubmed publisher
    ..Its safety profile and diverse pharmacologic actions in the central nervous system have stimulated new interest for repurposing it...
  2. Zhu S, Tang S, Su F. Dioscin inhibits ischemic stroke?induced inflammation through inhibition of the TLR4/MyD88/NF??B signaling pathway in a rat model. Mol Med Rep. 2017;: pubmed publisher
    ..It exhibits antitumor, anti?inflammatory, antioxidation and several other significant pharmacologic actions, and is of high pharmaceutical value...
  3. Huang L, Xie D, Yu Y, Liu H, Shi Y, Shi T, et al. TCMID 2.0: a comprehensive resource for TCM. Nucleic Acids Res. 2017;: pubmed publisher
    ..With the significant increase of data, TCMID 2.0 will further facilitate TCM's modernization and enhance the exploration of underlying biological processes that are response to the diverse pharmacologic actions of TCM.
  4. Huang P, Zhao Y, Kuga S, Wu M, Huang Y. A versatile method for producing functionalized cellulose nanofibers and their application. Nanoscale. 2016;8:3753-9 pubmed publisher
    ..The polyethylene-cellulose nanofiber composite presents overall enhancement of mechanical properties. This method opens a new way to the production of functionalized cellulose nanofibers. ..
  5. Liang S, Xia Y, Hou J, Ge G, Zhang J, He Y, et al. Methylation, Glucuronidation, and Sulfonation of Daphnetin in Human Hepatic Preparations In Vitro: Metabolic Profiling, Pathway Comparison, and Bioactivity Analysis. J Pharm Sci. 2016;105:808-816 pubmed publisher
    ..In conclusion, methylation is a crucial pathway for daphnetin clearance and might be involved in pharmacologic actions of daphnetin in humans.
  6. Rodríguez Villanueva J, Martín Esteban J. An Insight into a Blockbuster Phytomedicine; Marrubium vulgare L. Herb. More of a Myth than a Reality?. Phytother Res. 2016;30:1551-1558 pubmed publisher
    ..For decades, scientists have carried out extensive research trying to explain these and other pharmacologic actions. It is time to systematize and critically analyse the quality of results found to date...
  7. Xiao C, Pinol R, Carlin J, Li C, Deng C, Gavrilova O, et al. Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism. Mol Metab. 2017;6:1540-1550 pubmed publisher
    ..In these experiments, no function was identified for Brs3 in GABAergic neurons. The data suggest that the anti-obesity pharmacologic actions of BRS-3 agonists occur via agonism of receptors on glutamatergic neurons.
  8. Blazer L, Storaska A, Jutkiewicz E, Turner E, Calcagno M, Wade S, et al. Selectivity and anti-Parkinson's potential of thiadiazolidinone RGS4 inhibitors. ACS Chem Neurosci. 2015;6:911-9 pubmed publisher
    ..interactions that localize or regulate their function could enhance selectivity and provide unique pharmacologic actions. Regulators of G protein signaling (RGS) proteins, especially RGS4, play significant roles in epilepsy and ..
  9. Daryabor M, Ahmadi A, Zilouei H. Solvent extraction of cadmium and zinc from sulphate solutions: Comparison of mechanical agitation and ultrasonic irradiation. Ultrason Sonochem. 2017;34:931-937 pubmed publisher
    ..mixing) inducing at low ultrasonic powers (below 60W) mainly results in increasing solvent extraction rate, while the chemical actions applied at the higher powers have a negative outcome on the extraction rate particularly for cadmium. ..

More Information


  1. Bao W, Luo Y, Wang D, Li J, Wu X, Mei W. Sodium salicylate modulates inflammatory responses through AMP-activated protein kinase activation in LPS-stimulated THP-1 cells. J Cell Biochem. 2018;119:850-860 pubmed publisher
    Sodium salicylate (NaSal) is a nonsteroidal anti-inflammatory drug. The putative mechanisms for NaSal's pharmacologic actions include the inhibition of cyclooxygenases, platelet-derived thromboxane A2, and NF-?B signaling...
  2. Mateu M. Assembly, Engineering and Applications of Virus-Based Protein Nanoparticles. Adv Exp Med Biol. 2016;940:83-120 pubmed
  3. Deng S, Huang R, Zhou M, Chen F, Fu Q. Hydrophobic cellulose films with excellent strength and toughness via ball milling activated acylation of microfibrillated cellulose. Carbohydr Polym. 2016;154:129-38 pubmed publisher
    ..Our work can largely expand the application of this biodegradable resource and ultimately reduce the need for petroleum-based plastics. ..
  4. Santana A, Gracher A, Rüdiger A, Zanchin N, Carvalho P, Cipriani T, et al. Identification of potential targets for an anticoagulant pectin. J Proteomics. 2017;151:243-250 pubmed publisher
    ..binding to components of the coagulation cascade to decrease side effects and facilitate the control of pharmacologic actions in patient's body...
  5. Fazzari M, Khoo N, Woodcock S, Jorkasky D, Li L, Schopfer F, et al. Nitro-fatty acid pharmacokinetics in the adipose tissue compartment. J Lipid Res. 2017;58:375-385 pubmed publisher
    ..This pattern of NO2-FA deposition lends new insight into the unique pharmacokinetics and pharmacologic actions that could be expected for this chemically-reactive class of endogenous signaling mediators and synthetic ..
  6. Ursu O, Holmes J, Knockel J, Bologa C, Yang J, Mathias S, et al. DrugCentral: online drug compendium. Nucleic Acids Res. 2017;45:D932-D939 pubmed publisher is an open-access online drug compendium. DrugCentral integrates structure, bioactivity, regulatory, pharmacologic actions and indications for active pharmaceutical ingredients approved by FDA and other regulatory agencies...
  7. Walsh L, George R. Activation of Alkaline Irrigation Fluids in Endodontics. Materials (Basel). 2017;10: pubmed publisher
    ..Fluid streaming further enhances the activity of the fluids. While agitation enhances performance of irrigants, extrusion of fluids from the root canal during activation is a hazard that must be controlled. ..
  8. Wang A, Leong D, Cardoso L, Sun H. Nutraceuticals and osteoarthritis pain. Pharmacol Ther. 2018;187:167-179 pubmed publisher
    ..Furthermore, we discuss the biologic and pharmacologic actions underlying the nutraceutical effects on pain relief based on the potential active ingredients identified ..