Summary: A broad category of chemical actions and uses that result in the prevention, treatment, cure or diagnosis of disease. Included here are drugs and chemicals that act by altering normal body functions, such as the REPRODUCTIVE CONTROL AGENTS and ANESTHETICS. Effects of chemicals on the environment are also included.
- Bao W, Luo Y, Wang D, Li J, Wu X, Mei W. Sodium salicylate modulates inflammatory responses through AMP-activated protein kinase activation in LPS-stimulated THP-1 cells. J Cell Biochem. 2018;119:850-860 pubmed publisherSodium salicylate (NaSal) is a nonsteroidal anti-inflammatory drug. The putative mechanisms for NaSal's pharmacologic actions include the inhibition of cyclooxygenases, platelet-derived thromboxane A2, and NF-?B signaling...
- Mateu M. Assembly, Engineering and Applications of Virus-Based Protein Nanoparticles. Adv Exp Med Biol. 2016;940:83-120 pubmed
- Deng S, Huang R, Zhou M, Chen F, Fu Q. Hydrophobic cellulose films with excellent strength and toughness via ball milling activated acylation of microfibrillated cellulose. Carbohydr Polym. 2016;154:129-38 pubmed publisher..Our work can largely expand the application of this biodegradable resource and ultimately reduce the need for petroleum-based plastics. ..
- Santana A, Gracher A, Rüdiger A, Zanchin N, Carvalho P, Cipriani T, et al. Identification of potential targets for an anticoagulant pectin. J Proteomics. 2017;151:243-250 pubmed publisher..binding to components of the coagulation cascade to decrease side effects and facilitate the control of pharmacologic actions in patient's body...
- Fazzari M, Khoo N, Woodcock S, Jorkasky D, Li L, Schopfer F, et al. Nitro-fatty acid pharmacokinetics in the adipose tissue compartment. J Lipid Res. 2017;58:375-385 pubmed publisher..This pattern of NO2-FA deposition lends new insight into the unique pharmacokinetics and pharmacologic actions that could be expected for this chemically-reactive class of endogenous signaling mediators and synthetic ..
- Ursu O, Holmes J, Knockel J, Bologa C, Yang J, Mathias S, et al. DrugCentral: online drug compendium. Nucleic Acids Res. 2017;45:D932-D939 pubmed publisher..org) is an open-access online drug compendium. DrugCentral integrates structure, bioactivity, regulatory, pharmacologic actions and indications for active pharmaceutical ingredients approved by FDA and other regulatory agencies...
- Walsh L, George R. Activation of Alkaline Irrigation Fluids in Endodontics. Materials (Basel). 2017;10: pubmed publisher..Fluid streaming further enhances the activity of the fluids. While agitation enhances performance of irrigants, extrusion of fluids from the root canal during activation is a hazard that must be controlled. ..
- Wang A, Leong D, Cardoso L, Sun H. Nutraceuticals and osteoarthritis pain. Pharmacol Ther. 2018;187:167-179 pubmed publisher..Furthermore, we discuss the biologic and pharmacologic actions underlying the nutraceutical effects on pain relief based on the potential active ingredients identified ..