methylation

Summary

Summary: Addition of methyl groups. In histo-chemistry methylation is used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid. (From Stedman, 25th ed)

Top Publications

  1. Ayrapetov M, Gursoy Yuzugullu O, Xu C, Xu Y, Price B. DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin. Proc Natl Acad Sci U S A. 2014;111:9169-74 pubmed publisher
    ..However, how H3K9 methylation is regulated during DSB repair is not known...
  2. Mazur P, Reynoird N, Khatri P, Jansen P, Wilkinson A, Liu S, et al. SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer. Nature. 2014;510:283-7 pubmed publisher
    Deregulation of lysine methylation signalling has emerged as a common aetiological factor in cancer pathogenesis, with inhibitors of several histone lysine methyltransferases (KMTs) being developed as chemotherapeutics...
  3. Zhang Q, Wang D, Zheng Q, Zheng Y, Wang H, Xu Y, et al. Joint effects of urinary arsenic methylation capacity with potential modifiers on arsenicosis: a cross-sectional study from an endemic arsenism area in Huhhot Basin, northern China. Environ Res. 2014;132:281-9 pubmed publisher
    A lower arsenic methylation capacity is believed to be associated with various arsenic-related diseases. However, the synergistic effect of the arsenic methylation capacity and potential modifiers on arsenicosis risk is unclear...
  4. Kim J, Banerjee T, Vinckevicius A, Luo Q, Parker J, Baker M, et al. A role for WDR5 in integrating threonine 11 phosphorylation to lysine 4 methylation on histone H3 during androgen signaling and in prostate cancer. Mol Cell. 2014;54:613-25 pubmed publisher
    ..with H3T11P, and this interaction facilitates the recruitment of the MLL1 complex and subsequent H3K4 tri-methylation (H3K4me3)...
  5. Béguelin W, Popovic R, Teater M, Jiang Y, Bunting K, Rosén M, et al. EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation. Cancer Cell. 2013;23:677-92 pubmed publisher
    ..GC B cell (GCB)-type diffuse large B cell lymphomas (DLBCLs) are mostly addicted to EZH2 but not the more differentiated activated B cell (ABC)-type DLBCLs, thus clarifying the therapeutic scope of EZH2 targeting. ..
  6. Zheng S, Moehlenbrink J, Lu Y, Zalmas L, Sagum C, Carr S, et al. Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1. Mol Cell. 2013;52:37-51 pubmed publisher
    ..We describe the residue-specific methylation of E2F-1 by the asymmetric dimethylating protein arginine methyltransferase 1 (PRMT1) and symmetric ..
  7. Lu T, Yang M, Huang D, Wei H, Ozer G, Ghosh G, et al. Role of lysine methylation of NF-?B in differential gene regulation. Proc Natl Acad Sci U S A. 2013;110:13510-5 pubmed publisher
    Lysine methylation of the p65 subunit of nuclear factor ?B (NF-?B) on K218 and K221 together or K37 alone strongly enhances gene expression in response to cytokines...
  8. Chen D, Zhang L, Pang B, Chen J, Xu Z, Abe I, et al. FK506 maturation involves a cytochrome p450 protein-catalyzed four-electron C-9 oxidation in parallel with a C-31 O-methylation. J Bacteriol. 2013;195:1931-9 pubmed publisher
    ..at C-9 to give a rarely found ?-keto amide group, whereas a methyltransferase, FkbM, is responsible for O-methylation at C-31 to afford a methoxy group...
  9. Li B, Forseth R, Bowers A, Schroeder F, Walsh C. A backup plan for self-protection: S-methylation of holomycin biosynthetic intermediates in Streptomyces clavuligerus. Chembiochem. 2012;13:2521-6 pubmed publisher
    ..In these metabolites the enethiols have been incapacitated by a combination of mono- and di-S-methylation. We also observed an intriguing dimeric thioether adduct in low quantities in the wild-type strain and at much ..

More Information

Publications62

  1. Yao X, Feng H, Yu Y, Dong A, Shen W. SDG2-mediated H3K4 methylation is required for proper Arabidopsis root growth and development. PLoS ONE. 2013;8:e56537 pubmed publisher
    ..We conclude that SDG2-mediated H3K4me3 plays a distinctive role in the regulation of chromatin structure and genome integrity, which are key features in pluripotency of stem cells and crucial for root growth and development. ..
  2. Chan K, Fang D, Gan H, Hashizume R, Yu C, Schroeder M, et al. The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression. Genes Dev. 2013;27:985-90 pubmed publisher
    ..These results indicate that H3.3K27M mutation reprograms epigenetic landscape and gene expression, which may drive tumorigenesis. ..
  3. Yin L, Cai W, Liu C, Chen Y, Hu J, Jiang J, et al. Analysis of PTEN methylation patterns in soft tissue sarcomas by MassARRAY spectrometry. PLoS ONE. 2013;8:e62971 pubmed publisher
    ..PTEN mutations are rare in STSs, suggesting that PTEN expression may be lost by alternative mechanisms such as methylation. In order to reveal whether aberrant PTEN methylation occurs in STSs, MassARRAY Spectrometry was carried to ..
  4. Li X, Geng Z, Wang S, Song X, Hu X, Wang Z. Functional evaluation of Asp76, 84, 102 and 150 in human arsenic(III) methyltransferase (hAS3MT) interacting with S-adenosylmethionine. FEBS Lett. 2013;587:2232-40 pubmed publisher
    ..The affinity of all the mutants for SAM were weakened. All the mutants except for D150N completely lost their methylation activities...
  5. Bremang M, Cuomo A, Agresta A, Stugiewicz M, Spadotto V, Bonaldi T. Mass spectrometry-based identification and characterisation of lysine and arginine methylation in the human proteome. Mol Biosyst. 2013;9:2231-47 pubmed publisher
    Protein methylation is a post-translational modification (PTM) by which a variable number of methyl groups are transferred to lysine and arginine residues within proteins...
  6. Fujimori D. Radical SAM-mediated methylation reactions. Curr Opin Chem Biol. 2013;17:597-604 pubmed publisher
    A subset of enzymes that belong to the radical S-adenosylmethionine (SAM) superfamily is able to catalyze methylation reactions...
  7. Black J, Manning A, Van Rechem C, Kim J, Ladd B, Cho J, et al. KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors. Cell. 2013;154:541-55 pubmed publisher
    ..Suv39h1/KMT1A or HP1? overexpression suppresses the copy gain, whereas H3K9/K36 methylation interference promotes gain...
  8. Yu R, Reinfelder J, Hines M, Barkay T. Mercury methylation by the methanogen Methanospirillum hungatei. Appl Environ Microbiol. 2013;79:6325-30 pubmed publisher
    ..To date, mercury (Hg) methylation has been attributed to sulfate- and iron-reducing bacteria (SRB and IRB, respectively)...
  9. Wang R, Luo M. A journey toward Bioorthogonal Profiling of Protein Methylation inside living cells. Curr Opin Chem Biol. 2013;17:729-37 pubmed publisher
    ..It is very challenging to profile global methylation (or methylome) in the context of relevant cellular settings...
  10. Schmeisser K, Mansfeld J, Kuhlow D, Weimer S, Priebe S, Heiland I, et al. Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nat Chem Biol. 2013;9:693-700 pubmed publisher
    ..elegans longevity. Taken together, sirtuin-mediated lifespan extension depends on methylation of NAM, providing an unexpected mechanistic role for sirtuins beyond histone deacetylation.
  11. Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, et al. A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat Chem Biol. 2014;10:93-5 pubmed publisher
    ..We report here that human methyltransferase-like 14 (METTL14) catalyzes m(6)A RNA methylation. Together with METTL3, the only previously known m(6)A methyltransferase, these two proteins form a stable ..
  12. Jacob Y, Bergamin E, Donoghue M, Mongeon V, Leblanc C, Voigt P, et al. Selective methylation of histone H3 variant H3.1 regulates heterochromatin replication. Science. 2014;343:1249-53 pubmed publisher
    ..Our results suggest a simple model for the mitotic inheritance of the heterochromatic mark H3K27me1 and the protection of H3.3-enriched genes against heterochromatization during DNA replication...
  13. Fu Y, Dominissini D, Rechavi G, He C. Gene expression regulation mediated through reversible m?A RNA methylation. Nat Rev Genet. 2014;15:293-306 pubmed publisher
    ..In this Review, we focus on reversible methylation through the most prevalent mammalian mRNA internal modification, N(6)-methyladenosine (m(6)A)...
  14. Ling B, Gopinadhan S, Kok W, Shankar S, Gopal P, Bharathy N, et al. G9a mediates Sharp-1-dependent inhibition of skeletal muscle differentiation. Mol Biol Cell. 2012;23:4778-85 pubmed publisher
    ..Concomitant with a differentiation block, G9a-dependent histone H3 lysine 9 dimethylation (H3K9me2) and MyoD methylation are apparent upon Sharp-1 overexpression in muscle cells...
  15. Lothrop A, Torres M, Fuchs S. Deciphering post-translational modification codes. FEBS Lett. 2013;587:1247-57 pubmed publisher
    ..This manuscript highlights several examples of combinatorial PTMs in proteins, and describes recent technological developments, which are driving our ability to understand how PTM patterns may "code" for biological outcomes. ..
  16. Jia G, Fu Y, He C. Reversible RNA adenosine methylation in biological regulation. Trends Genet. 2013;29:108-15 pubmed publisher
    ..Therefore, reversible RNA methylation, analogous to reversible DNA and histone modifications, may affect gene expression and cell fate decisions by ..
  17. Dubuc A, Remke M, Korshunov A, Northcott P, Zhan S, Mendez Lago M, et al. Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma. Acta Neuropathol. 2013;125:373-84 pubmed publisher
    ..demonstrate somatic copy number aberrations, and transcriptional profiles that converge on modifiers of H3K27-methylation (EZH2, KDM6A, KDM6B), leading to silencing of PRC2-target genes...
  18. Zhong Q, Kowluru R. Epigenetic modification of Sod2 in the development of diabetic retinopathy and in the metabolic memory: role of histone methylation. Invest Ophthalmol Vis Sci. 2013;54:244-50 pubmed publisher
    ..The objective of this study is to investigate the role of histone methylation of Sod2, the gene that encodes MnSOD, in the development of diabetic retinopathy and in the metabolic memory ..
  19. Hattori Y, Furuita K, Ohki I, Ikegami T, Fukada H, Shirakawa M, et al. Utilization of lysine ¹³C-methylation NMR for protein-protein interaction studies. J Biomol NMR. 2013;55:19-31 pubmed publisher
    Chemical modification is an easy way for stable isotope labeling of non-labeled proteins. The reductive (13)C-methylation of the amino group of the lysine side-chain by (13)C-formaldehyde is a post-modification and is applicable to most ..
  20. Herz H, Mohan M, Garruss A, Liang K, Takahashi Y, Mickey K, et al. Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4. Genes Dev. 2012;26:2604-20 pubmed publisher
    ..Although in yeast all H3K4 methylation patterns, including H3K4me1, are implemented by Set1/COMPASS (complex of proteins associated with Set1), there ..
  21. Liu C, Xu D, Han H, Fan Y, Schain F, Xu Z, et al. Transcriptional regulation of 15-lipoxygenase expression by histone h3 lysine 4 methylation/demethylation. PLoS ONE. 2012;7:e52703 pubmed publisher
    ..Recent experimental evidence reveals that dynamic histone methylation/demethylation mediated by histone methyltransferases and demethylases plays a critical role in regulation of ..
  22. Schalinske K, Smazal A. Homocysteine imbalance: a pathological metabolic marker. Adv Nutr. 2012;3:755-62 pubmed publisher
    ..However, homocysteine balance and its role in health and disease are not as clearly understood. This review presents our current understanding of homocysteine metabolism and its link to specific pathologies. ..
  23. Walter D, Matter A, Fahrenkrog B. Loss of histone H3 methylation at lysine 4 triggers apoptosis in Saccharomyces cerevisiae. PLoS Genet. 2014;10:e1004095 pubmed publisher
    Monoubiquitination of histone H2B lysine 123 regulates methylation of histone H3 lysine 4 (H3K4) and 79 (H3K79) and the lack of H2B ubiquitination in Saccharomyces cerevisiae coincides with metacaspase-dependent apoptosis...
  24. Fustin J, Doi M, Yamaguchi Y, Hida H, Nishimura S, Yoshida M, et al. RNA-methylation-dependent RNA processing controls the speed of the circadian clock. Cell. 2013;155:793-806 pubmed publisher
    ..RNA sequencing then reveals methylation inhibition causes widespread changes in the transcription of the RNA processing machinery, associated with m(6)..
  25. Kumar S, Maiti S. The effect of N-acetylation and N-methylation of lysine residue of Tat peptide on its interaction with HIV-1 TAR RNA. PLoS ONE. 2013;8:e77595 pubmed publisher
    ..In contrast, lysine methylation did not affect the binding affinity of Tat peptide to TAR RNA at K50, nonetheless three fold enhancement in ..
  26. Lapinaite A, Simon B, Skjaerven L, Rakwalska Bange M, Gabel F, Carlomagno T. The structure of the box C/D enzyme reveals regulation of RNA methylation. Nature. 2013;502:519-23 pubmed publisher
    ..Two methylation guide sequences are combined on each guide RNA, the significance of which has remained unclear...
  27. Peifer C, Sharma S, Watzinger P, Lamberth S, Kötter P, Entian K. Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA. Nucleic Acids Res. 2013;41:1151-63 pubmed publisher
    ..This highlights the dual functionality of Rrp8 in the biogenesis of both subunits. ..
  28. Acquaviva L, Szekvolgyi L, Dichtl B, Dichtl B, de La Roche Saint André C, Nicolas A, et al. The COMPASS subunit Spp1 links histone methylation to initiation of meiotic recombination. Science. 2013;339:215-8 pubmed publisher
    ..Thus, by interacting with H3K4me3 and Mer2, Spp1 promotes recruitment of potential meiotic DSB sites to the chromosomal axis, allowing Spo11 cleavage at nearby nucleosome-depleted regions. ..
  29. McCord R, Nazario Toole A, Zhang H, Chines P, Zhan Y, Erdos M, et al. Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome. Genome Res. 2013;23:260-9 pubmed publisher
    ..These changes may result in transcriptional misregulation and eventually trigger the global loss of spatial chromatin compartmentalization in late passage HGPS fibroblasts. ..
  30. Munthe Kaas M, Bertelsen R, Torjussen T, Hjorthaug H, Undlien D, Lyle R, et al. Pet keeping and tobacco exposure influence CD14 methylation in childhood. Pediatr Allergy Immunol. 2012;23:747-54 pubmed publisher
    ..We recently showed that CD14 methylation increased during childhood, parallelling a decreased impact of CD14 polymorphisms on soluble CD14 levels...
  31. Lindner D, Wu Y, Haney R, Jacobs B, Fruehauf J, Tuthill R, et al. Thrombospondin-1 expression in melanoma is blocked by methylation and targeted reversal by 5-Aza-deoxycytidine suppresses angiogenesis. Matrix Biol. 2013;32:123-32 pubmed publisher
    Reversibility of aberrant methylation via pharmacological means is an attractive target for therapies through epigenetic reprogramming...
  32. Mikael L, Pancer J, Jiang X, Wu Q, Caudill M, Rozen R. Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of ApoAI and IFN-? in spleen and placenta, and through reduction of methylation potential. Mol Nutr Food Res. 2013;57:661-70 pubmed publisher
    ..Folate-dependent homocysteine remethylation is required for methylation reactions and may influence choline/betaine metabolism...
  33. Hartlerode A, Guan Y, Rajendran A, Ura K, Schotta G, Xie A, et al. Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks. PLoS ONE. 2012;7:e49211 pubmed publisher
    ..We determined the impact of altered H4K20 methylation on 53BP1 MPL response kinetics in mouse embryonic fibroblasts (MEFs) lacking key H4K20 histone ..
  34. Lim E, Mitchell P, Brown N, Drummond R, Brown G, Kaye P, et al. Regiospecific methylation of a dietary flavonoid scaffold selectively enhances IL-1? production following Toll-like receptor 2 stimulation in THP-1 monocytes. J Biol Chem. 2013;288:21126-35 pubmed publisher
    ..Importantly, this costimulation of TLR2-induced cytokine secretion was dependent on regiospecific methylation of the flavonol scaffold with a rank order of quercetin-3,4'-dimethylether > quercetin-3-methylether > ..
  35. Serrano L, Martínez Redondo P, Marazuela Duque A, Vazquez B, Dooley S, Voigt P, et al. The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation. Genes Dev. 2013;27:639-53 pubmed publisher
    ..Our studies suggest that the dynamic cross-talk between the environment and the genome during mitosis determines the fate of the subsequent cell cycle. ..
  36. Jia Y, Huang H, Zhong M, Wang F, Zhang L, Zhu Y. Microbial arsenic methylation in soil and rice rhizosphere. Environ Sci Technol. 2013;47:3141-8 pubmed publisher
    ..Recent studies have shown that higher plants are unlikely to methylate As in vivo suggesting that As methylation is a microbial mediated process that occurs in soils prior to plant uptake...
  37. Kennedy P, Feng J, Robison A, Maze I, Badimon A, Mouzon E, et al. Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation. Nat Neurosci. 2013;16:434-40 pubmed publisher
    ..of HDAC1 in NAc of mice increased global levels of histone acetylation, but also induced repressive histone methylation and antagonized cocaine-induced changes in behavior, an effect mediated in part through a chromatin-mediated ..
  38. Jamieson K, Rountree M, Lewis Z, Stajich J, Selker E. Regional control of histone H3 lysine 27 methylation in Neurospora. Proc Natl Acad Sci U S A. 2013;110:6027-32 pubmed publisher
    ..Loss of H3K27me3, caused by deletion of the gene encoding the catalytic PRC2 subunit, set-7, resulted in up-regulation of 130 genes, including genes in both H3K27me3-marked and unmarked regions...
  39. Cai L, Rothbart S, Lu R, Xu B, Chen W, Tripathy A, et al. An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Mol Cell. 2013;49:571-82 pubmed publisher
    ..Collectively, our data suggest that PCL recognition of H3K36me3 promotes intrusion of PRC2 complexes into active chromatin regions to promote gene silencing and modulate the chromatin landscape during development. ..
  40. Cong P, Zhu K, Ji Q, Zhao H, Chen Y. Effects of trichostatin A on histone acetylation and methylation characteristics in early porcine embryos after somatic cell nuclear transfer. Anim Sci J. 2013;84:639-49 pubmed publisher
    ..These findings suggest a positive effect of TSA treatment (either treating NT embryos or donor cells) on the development of porcine NT embryos, which is achieved by improving epigenetic reprogramming. ..
  41. Chen Y, Hu F, Zhou Y, Chen W, Shao H, Zhang Y. MGMT promoter methylation and glioblastoma prognosis: a systematic review and meta-analysis. Arch Med Res. 2013;44:281-90 pubmed publisher
    We undertook this study to comprehensively summarize the associations between MGMT promoter methylation and prognosis of glioblastoma (GBM)...
  42. Li F, Mao G, Tong D, Huang J, Gu L, Yang W, et al. The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutS?. Cell. 2013;153:590-600 pubmed publisher
    ..This work reveals that a histone mark regulates MMR in human cells and explains the long-standing puzzle of MSI-positive cancer cells that lack detectable mutations in known MMR genes. ..
  43. Dhar S, Lee S, Kan P, Voigt P, Ma L, Shi X, et al. Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4. Genes Dev. 2012;26:2749-62 pubmed publisher
  44. Xu J, Wang A, Oses Prieto J, Makhijani K, Katsuno Y, Pei M, et al. Arginine Methylation Initiates BMP-Induced Smad Signaling. Mol Cell. 2013;51:5-19 pubmed publisher
    ..We now show that arginine methylation, which is known to regulate gene expression, yet also modifies some signaling mediators, initiates BMP-induced ..
  45. Oudhoff M, Freeman S, Couzens A, Antignano F, Kuznetsova E, Min P, et al. Control of the hippo pathway by Set7-dependent methylation of Yap. Dev Cell. 2013;26:188-94 pubmed publisher
    b>Methylation of nonhistone proteins is emerging as a regulatory mechanism to control protein function...
  46. Melak D, Ferreccio C, Kalman D, Parra R, Acevedo J, Perez L, et al. Arsenic methylation and lung and bladder cancer in a case-control study in northern Chile. Toxicol Appl Pharmacol. 2014;274:225-31 pubmed publisher
  47. VERMILLION K, Lidberg K, Gammill L. Cytoplasmic protein methylation is essential for neural crest migration. J Cell Biol. 2014;204:95-109 pubmed publisher
    As they initiate migration in vertebrate embryos, neural crest cells are enriched for methylation cycle enzymes, including S-adenosylhomocysteine hydrolase (SAHH), the only known enzyme to hydrolyze the feedback inhibitor of trans-..
  48. Su X, Zhu G, Ding X, Lee S, Dou Y, Zhu B, et al. Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1. Genes Dev. 2014;28:622-36 pubmed publisher
    ..Here we characterized Spindlin1 as a histone effector that senses a cis-tail histone H3 methylation pattern involving trimethyllysine 4 (H3K4me3) and asymmetric dimethylarginine 8 (H3R8me2a) marks...
  49. Krishnan S, Trievel R. Structural and functional analysis of JMJD2D reveals molecular basis for site-specific demethylation among JMJD2 demethylases. Structure. 2013;21:98-108 pubmed publisher
    ..Together, these studies reveal the molecular basis for JMJD2 site specificity and provide a framework for structure-based design of selective inhibitors of JMJD2 KDMs implicated in disease. ..
  50. Crona F, Dahlberg O, Lundberg L, Larsson J, Mannervik M. Gene regulation by the lysine demethylase KDM4A in Drosophila. Dev Biol. 2013;373:453-63 pubmed publisher
    Lysine methylation of histones is associated with both transcriptionally active chromatin and with silent chromatin, depending on what residue is modified...
  51. Shyh Chang N, Locasale J, Lyssiotis C, Zheng Y, Teo R, Ratanasirintrawoot S, et al. Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science. 2013;339:222-6 pubmed publisher
    ..S-adenosylmethionine (SAM) metabolism are coupled in pluripotent stem cells, resulting in regulation of histone methylation. Isotope labeling of mESCs revealed that threonine provides a substantial fraction of both the cellular glycine ..
  52. Jørgensen S, Schotta G, Sørensen C. Histone H4 lysine 20 methylation: key player in epigenetic regulation of genomic integrity. Nucleic Acids Res. 2013;41:2797-806 pubmed publisher
    ..Intense research during the past few years has revealed histone H4 lysine 20 methylation (H4K20me) as critically important for the biological processes that ensure genome integrity, such as DNA damage ..
  53. Dhar S, Vemulapalli V, Patananan A, Huang G, Di Lorenzo A, Richard S, et al. Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs. Sci Rep. 2013;3:1311 pubmed publisher
    Arginine methylation is a common posttranslational modification that is found on both histone and non-histone proteins...