tudor domain


Summary: A conserved, approximately 50 amino acid, protein sequence that adopts a characteristic strongly bent, five stranded anti-parallel beta-sheet barrel-like fold. The Tudor domain recognizes dimethylated ARGININE through its negatively-charged surface and occurs in many proteins that co-localize with RNA; RIBONUCLEOPROTEINS or SINGLE-STRANDED DNA complexes in the CELL NUCLEUS; MITOCHONDRIA; or KINETOCHORES.

Top Publications

  1. Sanders K, Lin C, Smith A, Cronin N, Fisher G, Eftychidis V, et al. The structure and function of an RNA polymerase interaction domain in the PcrA/UvrD helicase. Nucleic Acids Res. 2017;45:3875-3887 pubmed publisher
    ..The implications of this work for our understanding of the role of PcrA/UvrD at the interface of DNA replication, transcription and repair are discussed. ..
  2. Shanle E, Shinsky S, Bridgers J, Bae N, Sagum C, Krajewski K, et al. Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions. Epigenetics Chromatin. 2017;10:12 pubmed publisher
    ..peptide microarray platform to interrogate 83 known and putative histone reader domains from the chromo and Tudor domain families to identify their interactions and characterize the influence of neighboring PTMs on these ..
  3. Ferry L, Fournier A, Tsusaka T, Adelmant G, Shimazu T, Matano S, et al. Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation. Mol Cell. 2017;67:550-565.e5 pubmed publisher
    ..These results further elucidate the function of UHRF1, identify a non-histone target of G9a and GLP, and provide an example of a histone mimic that coordinates DNA replication and DNA methylation maintenance. ..
  4. Morgan M, Rickels R, Collings C, He X, Cao K, Herz H, et al. A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation. Genes Dev. 2017;31:2003-2014 pubmed publisher