ankyrin repeat

Summary

Summary: Protein motif that contains a 33-amino acid long sequence that often occurs in tandem arrays. This repeating sequence of 33-amino acids was discovered in ANKYRIN where it is involved in interaction with the anion exchanger (ANION EXCHANGE PROTEIN 1, ERYTHROCYTE). Ankyrin repeats cooperatively fold into domains that mediate molecular recognition via protein-protein interactions.

Top Publications

  1. Kojic S, Nestorovic A, Rakicevic L, Belgrano A, Stankovic M, Divac A, et al. A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein. Arch Biochem Biophys. 2010;502:60-7 pubmed publisher
    The muscle ankyrin repeat protein (MARP) family member Ankrd1/CARP is a part of the titin-mechanosensory signaling complex in the sarcomere and in response to stretch it translocates to the nucleus where it participates in the regulation ..
  2. Webb J, Murányi A, Pugh C, Ratcliffe P, Coleman M. MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH). Biochem J. 2009;420:327-33 pubmed publisher
    ..More recently, several ARD [AR (ankyrin repeat) domain]-containing proteins were identified as FIH substrates using FIH interaction assays...
  3. Zahnd C, Wyler E, Schwenk J, Steiner D, Lawrence M, McKern N, et al. A designed ankyrin repeat protein evolved to picomolar affinity to Her2. J Mol Biol. 2007;369:1015-28 pubmed
    Designed ankyrin repeat proteins (DARPins) are a novel class of binding molecules, which can be selected to recognize specifically a wide variety of target proteins...
  4. Theurillat J, Dreier B, Nagy Davidescu G, Seifert B, Behnke S, Zürrer Härdi U, et al. Designed ankyrin repeat proteins: a novel tool for testing epidermal growth factor receptor 2 expression in breast cancer. Mod Pathol. 2010;23:1289-97 pubmed publisher
    Designed ankyrin repeat proteins are a novel class of specific binding molecules, which display increased thermodynamic stability, smaller size and at least equal target affinity compared to immunoglobulins, making them potentially ..
  5. Werbeck N, Rowling P, Chellamuthu V, Itzhaki L. Shifting transition states in the unfolding of a large ankyrin repeat protein. Proc Natl Acad Sci U S A. 2008;105:9982-7 pubmed publisher
    ..we use site-directed mutagenesis to investigate the kinetic unfolding mechanism of D34, a 426-residue, 12-ankyrin repeat fragment of the protein ankyrinR...
  6. Phelps C, Procko E, Lishko P, Wang R, Gaudet R. Insights into the roles of conserved and divergent residues in the ankyrin repeats of TRPV ion channels. Channels (Austin). 2007;1:148-51 pubmed
    ..We recently identified a multiligand-binding site in the N-terminal ankyrin repeat domain (ARD) of TRPV1 that binds ATP and sensitizes the channel...
  7. Steiner D, Forrer P, Plückthun A. Efficient selection of DARPins with sub-nanomolar affinities using SRP phage display. J Mol Biol. 2008;382:1211-27 pubmed publisher
    ..system allows efficient filamentous phage display of highly stable and fast-folding proteins, such as designed ankyrin repeat proteins (DARPins) that are virtually refractory to conventional phage display employing the post-..
  8. Blanié S, Mortier J, Delverdier M, Bertagnoli S, Camus Bouclainville C. M148R and M149R are two virulence factors for myxoma virus pathogenesis in the European rabbit. Vet Res. 2009;40:11 pubmed publisher
    ..Moreover, histological analysis suggests that M148R plays a role in the subversion of host inflammatory response by MYXV...
  9. Coleman M, McDonough M, Hewitson K, Coles C, Mecinovic J, Edelmann M, et al. Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. J Biol Chem. 2007;282:24027-38 pubmed
    ..factor inhibiting HIF (FIH), also catalyzes hydroxylation of highly conserved asparaginyl residues within ankyrin repeat (AR) domains (ARDs) of endogenous Notch receptors...
  10. Phelps C, Wang R, Choo S, Gaudet R. Differential regulation of TRPV1, TRPV3, and TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain. J Biol Chem. 2010;285:731-40 pubmed publisher
    ..TRPV1-V4, have large cytoplasmic regions flanking the transmembrane domain, including an N-terminal ankyrin repeat domain...

Detail Information

Publications62

  1. Kojic S, Nestorovic A, Rakicevic L, Belgrano A, Stankovic M, Divac A, et al. A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein. Arch Biochem Biophys. 2010;502:60-7 pubmed publisher
    The muscle ankyrin repeat protein (MARP) family member Ankrd1/CARP is a part of the titin-mechanosensory signaling complex in the sarcomere and in response to stretch it translocates to the nucleus where it participates in the regulation ..
  2. Webb J, Murányi A, Pugh C, Ratcliffe P, Coleman M. MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH). Biochem J. 2009;420:327-33 pubmed publisher
    ..More recently, several ARD [AR (ankyrin repeat) domain]-containing proteins were identified as FIH substrates using FIH interaction assays...
  3. Zahnd C, Wyler E, Schwenk J, Steiner D, Lawrence M, McKern N, et al. A designed ankyrin repeat protein evolved to picomolar affinity to Her2. J Mol Biol. 2007;369:1015-28 pubmed
    Designed ankyrin repeat proteins (DARPins) are a novel class of binding molecules, which can be selected to recognize specifically a wide variety of target proteins...
  4. Theurillat J, Dreier B, Nagy Davidescu G, Seifert B, Behnke S, Zürrer Härdi U, et al. Designed ankyrin repeat proteins: a novel tool for testing epidermal growth factor receptor 2 expression in breast cancer. Mod Pathol. 2010;23:1289-97 pubmed publisher
    Designed ankyrin repeat proteins are a novel class of specific binding molecules, which display increased thermodynamic stability, smaller size and at least equal target affinity compared to immunoglobulins, making them potentially ..
  5. Werbeck N, Rowling P, Chellamuthu V, Itzhaki L. Shifting transition states in the unfolding of a large ankyrin repeat protein. Proc Natl Acad Sci U S A. 2008;105:9982-7 pubmed publisher
    ..we use site-directed mutagenesis to investigate the kinetic unfolding mechanism of D34, a 426-residue, 12-ankyrin repeat fragment of the protein ankyrinR...
  6. Phelps C, Procko E, Lishko P, Wang R, Gaudet R. Insights into the roles of conserved and divergent residues in the ankyrin repeats of TRPV ion channels. Channels (Austin). 2007;1:148-51 pubmed
    ..We recently identified a multiligand-binding site in the N-terminal ankyrin repeat domain (ARD) of TRPV1 that binds ATP and sensitizes the channel...
  7. Steiner D, Forrer P, Plückthun A. Efficient selection of DARPins with sub-nanomolar affinities using SRP phage display. J Mol Biol. 2008;382:1211-27 pubmed publisher
    ..system allows efficient filamentous phage display of highly stable and fast-folding proteins, such as designed ankyrin repeat proteins (DARPins) that are virtually refractory to conventional phage display employing the post-..
  8. Blanié S, Mortier J, Delverdier M, Bertagnoli S, Camus Bouclainville C. M148R and M149R are two virulence factors for myxoma virus pathogenesis in the European rabbit. Vet Res. 2009;40:11 pubmed publisher
    ..Moreover, histological analysis suggests that M148R plays a role in the subversion of host inflammatory response by MYXV...
  9. Coleman M, McDonough M, Hewitson K, Coles C, Mecinovic J, Edelmann M, et al. Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. J Biol Chem. 2007;282:24027-38 pubmed
    ..factor inhibiting HIF (FIH), also catalyzes hydroxylation of highly conserved asparaginyl residues within ankyrin repeat (AR) domains (ARDs) of endogenous Notch receptors...
  10. Phelps C, Wang R, Choo S, Gaudet R. Differential regulation of TRPV1, TRPV3, and TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain. J Biol Chem. 2010;285:731-40 pubmed publisher
    ..TRPV1-V4, have large cytoplasmic regions flanking the transmembrane domain, including an N-terminal ankyrin repeat domain...
  11. Landoure G, Zdebik A, Martinez T, Burnett B, Stanescu H, Inada H, et al. Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C. Nat Genet. 2010;42:170-4 pubmed publisher
    ..The CMT2C-associated mutations lie in a distinct region of the TRPV4 ankyrin repeats, suggesting that this phenotypic variability may be due to differential effects on regulatory protein-protein interactions. ..
  12. Li Y, Meng X, Xiang Y, Deng J. Structure function studies of vaccinia virus host range protein k1 reveal a novel functional surface for ankyrin repeat proteins. J Virol. 2010;84:3331-8 pubmed publisher
    ..Altogether, our data showed that K1 residues on a continuous convex ANK repeat surface are critical for the host range function, suggesting that K1 functions through ligand interaction and does so with a novel ANK interaction surface...
  13. Mosavi L, Cammett T, Desrosiers D, Peng Z. The ankyrin repeat as molecular architecture for protein recognition. Protein Sci. 2004;13:1435-48 pubmed
    The ankyrin repeat is one of the most frequently observed amino acid motifs in protein databases...
  14. Wetzel S, Ewald C, Settanni G, Jurt S, Plückthun A, Zerbe O. Residue-resolved stability of full-consensus ankyrin repeat proteins probed by NMR. J Mol Biol. 2010;402:241-58 pubmed publisher
    We investigated the stability determinants and the unfolding characteristics of full-consensus designed ankyrin repeat proteins (DARPins) by NMR...
  15. Yu F, Shi J, Zhou J, Gu J, Chen Q, Li J, et al. ANK6, a mitochondrial ankyrin repeat protein, is required for male-female gamete recognition in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2010;107:22332-7 pubmed publisher
    ..We report that an ankyrin repeat protein (ANK6) is essential for fertilization, specifically for gamete recognition...
  16. Lamboy J, Kim H, Lee K, Ha T, Komives E. Visualization of the nanospring dynamics of the IkappaBalpha ankyrin repeat domain in real time. Proc Natl Acad Sci U S A. 2011;108:10178-83 pubmed publisher
    ..I?B? has a weakly folded ankyrin repeat 5-6 (AR5-6) region that is critical in establishing its short intracellular half-life...
  17. De Waard V, Van Achterberg T, Beauchamp N, Pannekoek H, de Vries C. Cardiac ankyrin repeat protein (CARP) expression in human and murine atherosclerotic lesions: activin induces CARP in smooth muscle cells. Arterioscler Thromb Vasc Biol. 2003;23:64-8 pubmed
    Cardiac ankyrin repeat protein (CARP) is a transcription factor-related protein that has been studied most extensively in the heart...
  18. Mou S, Liu Z, Guan D, Qiu A, Lai Y, He S. Functional analysis and expressional characterization of rice ankyrin repeat-containing protein, OsPIANK1, in basal defense against Magnaporthe oryzae attack. PLoS ONE. 2013;8:e59699 pubmed publisher
    The ankyrin repeat-containing protein gene OsPIANK1 (AK068021) in rice (Oryza sativa L.) was previously shown to be upregulated following infection with the rice leaf blight pathogen Xanthomonas oryzae pv oryzae (Xoo)...
  19. Zhou S, Fujimuro M, Hsieh J, Chen L, Miyamoto A, Weinmaster G, et al. SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. Mol Cell Biol. 2000;20:2400-10 pubmed
    ..Contact with SKIP is required for biological activity of NotchIC. A mutation in the fourth ankyrin repeat that abolished Notch signal transduction did not affect interaction with CBF1 but abolished interaction with ..
  20. Kemp T, Sadusky T, Saltisi F, Carey N, Moss J, Yang S, et al. Identification of Ankrd2, a novel skeletal muscle gene coding for a stretch-responsive ankyrin-repeat protein. Genomics. 2000;66:229-41 pubmed
    ..We have named this gene ankyrin-repeat domain 2 (stretch-responsive muscle) (Ankrd2). We hypothesize that Ankrd2 plays an important role in skeletal muscle hypertrophy. ..
  21. Coleman M, Ratcliffe P. Signalling cross talk of the HIF system: involvement of the FIH protein. Curr Pharm Des. 2009;15:3904-7 pubmed
    ..are targeted for hydroxylation at conserved Asn residues within a protein interaction domain known as the Ankyrin Repeat Domain (ARD). Many ARD-containing proteins bind to FIH more tightly than does HIF...
  22. Manavalan B, Govindaraj R, Lee G, Choi S. Molecular modeling-based evaluation of dual function of I?B? ankyrin repeat domain in toll-like receptor signaling. J Mol Recognit. 2011;24:597-607 pubmed publisher
    ..Induced I?B?, especially its C-terminal ankyrin repeat domain (ARD), interacts with NF-?B in the nucleus, where it regulates the transcriptional activity of target ..
  23. Sonnberg S, Fleming S, Mercer A. A truncated two-alpha-helix F-box present in poxvirus ankyrin-repeat proteins is sufficient for binding the SCF1 ubiquitin ligase complex. J Gen Virol. 2009;90:1224-8 pubmed publisher
    ..Here we show that, despite this truncation, the F-box of a prototypical poxvirus ANK protein, containing two alpha-helices, is not only necessary but also sufficient for interaction with SCF1. ..
  24. Wang L, Lei M, Xiong Y. Molecular characterization and different expression patterns of the muscle ankyrin repeat protein (MARP) family during porcine skeletal muscle development in vitro and in vivo. Anim Biotechnol. 2011;22:87-99 pubmed publisher
    CARP, ANKRD2, and DARP belong to the ankyrin repeat protein (MARP) family and play a critical role in the integration of cytoskeletal architecture, stress response, and transcriptional regulation...
  25. Magkrioti C, Iatrou K, Labropoulou V. Differential inhibition of BmRelish1-dependent transcription in lepidopteran cells by bracovirus ankyrin-repeat proteins. Insect Biochem Mol Biol. 2011;41:993-1002 pubmed publisher
    ..Thus, our results suggest that functional and spatial differences among the various CcBV Ank family members may be responsible for the observed differential inhibition of R1d2 activity. ..
  26. Chen L, Haider K, Ponda M, Cariappa A, Rowitch D, Pillai S. Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase. J Biol Chem. 2001;276:21737-44 pubmed
    ..However, PKK itself may be phosphorylated by PKCbeta. PKK represents a developmentally regulated protein kinase that can associate with membranes. The functional significance of its association with PKCbeta remains to be ascertained. ..
  27. Binz H, Amstutz P, Kohl A, Stumpp M, Briand C, Forrer P, et al. High-affinity binders selected from designed ankyrin repeat protein libraries. Nat Biotechnol. 2004;22:575-82 pubmed
    We report here the evolution of ankyrin repeat (AR) proteins in vitro for specific, high-affinity target binding...
  28. Kawe M, Forrer P, Amstutz P, Plückthun A. Isolation of intracellular proteinase inhibitors derived from designed ankyrin repeat proteins by genetic screening. J Biol Chem. 2006;281:40252-63 pubmed
    ..We demonstrate here the use of designed ankyrin repeat proteins (DARPins) as tailor-made intracellular proteinase inhibitors...
  29. Löw C, Weininger U, Zeeb M, Zhang W, Laue E, Schmid F, et al. Folding mechanism of an ankyrin repeat protein: scaffold and active site formation of human CDK inhibitor p19(INK4d). J Mol Biol. 2007;373:219-31 pubmed
    ..We propose that the graded stability and the facile unfolding of repeats 1 and 2 is a prerequisite for the down-regulation of the inhibitory activity of p19(INK4d) during the cell-cycle. ..
  30. Binz H, Stumpp M, Forrer P, Amstutz P, Plückthun A. Designing repeat proteins: well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins. J Mol Biol. 2003;332:489-503 pubmed
    We describe an efficient way to generate combinatorial libraries of stable, soluble and well-expressed ankyrin repeat (AR) proteins...
  31. Walker T, Klasson L, Sebaihia M, Sanders M, Thomson N, Parkhill J, et al. Ankyrin repeat domain-encoding genes in the wPip strain of Wolbachia from the Culex pipiens group. BMC Biol. 2007;5:39 pubmed
    ..The sequencing of the wPip strain of Wolbachia revealed the presence of 60 ankyrin repeat domain (ANK) encoding genes and expression studies of these genes were carried out in adult mosquitoes...
  32. McDaneld T, Moody D. Characterization of a bovine gene encoding an ankyrin repeat and SOCS box protein (ASB15). Anim Genet. 2003;34:235-6 pubmed
  33. Werden S, McFadden G. The role of cell signaling in poxvirus tropism: the case of the M-T5 host range protein of myxoma virus. Biochim Biophys Acta. 2008;1784:228-37 pubmed
  34. Merz T, Wetzel S, Firbank S, Plückthun A, Grutter M, Mittl P. Stabilizing ionic interactions in a full-consensus ankyrin repeat protein. J Mol Biol. 2008;376:232-40 pubmed
    Full-consensus designed ankyrin repeat proteins (DARPins), in which randomized positions of the previously described DARPin library have been fixed, are characterized...
  35. Wetzel S, Settanni G, Kenig M, Binz H, Plückthun A. Folding and unfolding mechanism of highly stable full-consensus ankyrin repeat proteins. J Mol Biol. 2008;376:241-57 pubmed publisher
    Full-consensus designed ankyrin repeat proteins were designed with one to six identical repeats flanked by capping repeats. These proteins express well in Escherichia coli as soluble monomers...
  36. Feiguin F, Hannus M, Mlodzik M, Eaton S. The ankyrin repeat protein Diego mediates Frizzled-dependent planar polarization. Dev Cell. 2001;1:93-101 pubmed
    ..Our data suggest that Frizzled acts through Diego to promote local clustering of Flamingo, and that clustering of Diego and Flamingo in one cell nonautonomously propagates to others. ..
  37. Harada T, Matsuzaki O, Hayashi H, Sugano S, Matsuda A, Nishida E. AKRL1 and AKRL2 activate the JNK pathway. Genes Cells. 2003;8:493-500 pubmed
    ..The C-terminal transmembrane domain of AKRL1/2 is required for localization to the Golgi. AKRL1 and AKRL2 are localized to Golgi and the novel activators of the JNK pathway. ..
  38. Gustafsson M, Hussain A, Mohammad D, Mohamed A, Nguyen V, Metalnikov P, et al. Regulation of nucleocytoplasmic shuttling of Bruton's tyrosine kinase (Btk) through a novel SH3-dependent interaction with ankyrin repeat domain 54 (ANKRD54). Mol Cell Biol. 2012;32:2440-53 pubmed publisher
    ..characterize the interaction with ankryin repeat domain 54 protein (ANKRD54), also known as Lyn-interacting ankyrin repeat protein (Liar)...
  39. Inada H, Procko E, Sotomayor M, Gaudet R. Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel. Biochemistry. 2012;51:6195-206 pubmed
    ..Recent studies reported that mutations in TRPV4, including some in its ankyrin repeat domain (ARD), are associated with human inherited diseases, including neuropathies and skeletal dysplasias, ..
  40. Guo C, Chen W, Yuan L, Yang L, Weng S, Yu X, et al. The viral ankyrin repeat protein (ORF124L) from infectious spleen and kidney necrosis virus attenuates nuclear factor-?B activation and interacts with I?B kinase ?. J Gen Virol. 2011;92:1561-70 pubmed publisher
    ..This work may help to improve our understanding of the function of fish iridovirus ANK repeat proteins...
  41. Cheng W, Sun C, Zheng J. Heteromerization of TRP channel subunits: extending functional diversity. Protein Cell. 2010;1:802-10 pubmed publisher
    ..Heteromeric TRP channels exhibit many novel properties compared to their homomeric counterparts, indicating that co-assembly of TRP channel subunits has an important contribution to the diversity of TRP channel functions. ..
  42. McWilliams R, Gidey E, Fouassier L, Weed S, Doctor R. Characterization of an ankyrin repeat-containing Shank2 isoform (Shank2E) in liver epithelial cells. Biochem J. 2004;380:181-91 pubmed
    ..binding protein 1) or Spank-3] has been described as a truncated family member without an N-terminal ankyrin repeat domain...
  43. Kaur S, Rahman M, Ammerman N, Beier Sexton M, Ceraul S, Gillespie J, et al. TolC-dependent secretion of an ankyrin repeat-containing protein of Rickettsia typhi. J Bacteriol. 2012;194:4920-32 pubmed publisher
    ..In this study, we characterized a gene (RT0218) encoding a C-terminal ankyrin repeat domain-containing protein, named Rickettsia ankyrin repeat protein 1 (RARP-1), and identified it as a secreted ..
  44. Nangola S, Minard P, Tayapiwatana C. Appraisal of translocation pathways for displaying ankyrin repeat protein on phage particles. Protein Expr Purif. 2010;74:156-61 pubmed publisher
    ..assessed the influence of different leader peptides on the display of a premature cytoplasmic folding protein, ankyrin repeat protein (ARP), via the minor coat protein pIII. These peptides include the Sec, SRP and Tat pathways...
  45. McCleverty C, Koesema E, Patapoutian A, Lesley S, Kreusch A. Crystal structure of the human TRPV2 channel ankyrin repeat domain. Protein Sci. 2006;15:2201-6 pubmed
    ..An ankyrin repeat domain (ARD), which is a common protein-protein recognition domain, is conserved in the N-terminal ..
  46. Devi V, Binz H, Stumpp M, Plückthun A, Bosshard H, Jelesarov I. Folding of a designed simple ankyrin repeat protein. Protein Sci. 2004;13:2864-70 pubmed
    ..This work demonstrates that a designed minimal ankyrin repeat protein has the thermodynamic and kinetic properties of a compactly folded protein, and explains the favorable ..
  47. Tripp K, Barrick D. The tolerance of a modular protein to duplication and deletion of internal repeats. J Mol Biol. 2004;344:169-78 pubmed
    b>Ankyrin repeat polypeptides contain repeated structural elements that pack to produce modular architectures lacking in close contacts between distant segments of the polypeptide chain...
  48. Li J, Kuick R, Thompson R, Misek D, Lai Y, Liu Y, et al. Arcuate nucleus transcriptome profiling identifies ankyrin repeat and suppressor of cytokine signalling box-containing protein 4 as a gene regulated by fasting in central nervous system feeding circuits. J Neuroendocrinol. 2005;17:394-404 pubmed
    ..7% (P < 0.05). Based on its differential expression, neuroanatomical distribution and colocalisation, we hypothesise that Asb-4 is a gene involved in energy homeostasis. ..
  49. Phelps C, Huang R, Lishko P, Wang R, Gaudet R. Structural analyses of the ankyrin repeat domain of TRPV6 and related TRPV ion channels. Biochemistry. 2008;47:2476-84 pubmed publisher
    ..All members of the vanilloid family of TRP channels (TRPV) possess an N-terminal ankyrin repeat domain (ARD)...
  50. Barash I, Bang M, Mathew L, Greaser M, Chen J, Lieber R. Structural and regulatory roles of muscle ankyrin repeat protein family in skeletal muscle. Am J Physiol Cell Physiol. 2007;293:C218-27 pubmed
    ..However, the cellular basis for this response remains unclear. Previous studies identified the muscle ankyrin repeat protein (MARP) family, consisting of cardiac ankyrin repeat protein (CARP), ankyrin repeat domain 2/ankyrin ..
  51. Milovnik P, Ferrari D, Sarkar C, Plückthun A. Selection and characterization of DARPins specific for the neurotensin receptor 1. Protein Eng Des Sel. 2009;22:357-66 pubmed publisher
    We describe here the selection and characterization of designed ankyrin repeat proteins (DARPins) that bind specifically to the rat neurotensin receptor 1 (NTR1), a G-protein coupled receptor (GPCR)...
  52. Zhang Y, Zhang H, Liang J, Yu W, Shang Y. SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm. EMBO J. 2007;26:2645-57 pubmed
    ..During genome-wide screening for SRC-interacting proteins, we identified a novel ankyrin repeat containing protein, SIP (SRC-Interacting Protein), which interacts with SRC coactivators in the cytoplasm...
  53. Böttner S, Iven T, Carsjens C, Dröge Laser W. Nuclear accumulation of the ankyrin repeat protein ANK1 enhances the auxin-mediated transcription accomplished by the bZIP transcription factors BZI-1 and BZI-2. Plant J. 2009;58:914-26 pubmed publisher
    ..to the identification of two BZI-1 protein interaction partners: the heterodimerizing bZIP factor BZI-2 and an ankyrin repeat domain protein, ANK1...
  54. Pan X, Lührmann A, Satoh A, Laskowski Arce M, Roy C. Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors. Science. 2008;320:1651-4 pubmed publisher
    ..IV secretion system to deliver into eukaryotic cells a large number of different bacterial proteins containing ankyrin repeat homology domains called Anks. The L...
  55. Sue S, Cervantes C, Komives E, Dyson H. Transfer of flexibility between ankyrin repeats in IkappaB* upon formation of the NF-kappaB complex. J Mol Biol. 2008;380:917-31 pubmed publisher
    ..studies suggested that IkappaB* , a modular protein with an NF-kappaB binding domain consisting of six ankyrin repeat domains (ANKs), shows differential flexibility, with ANK 1-4 apparently more rigid in solution in the absence ..
  56. Gaudet R. A primer on ankyrin repeat function in TRP channels and beyond. Mol Biosyst. 2008;4:372-9 pubmed publisher
    ..Recent progress in the field has provided new insights into the structure and function of the ankyrin repeat motifs present in the N-terminal cytosolic domain of many TRP channels...
  57. Shi M, Chen Y, Huang F, Liu P, Zhou X, Chen X. Characterization of a novel gene encoding ankyrin repeat domain from Cotesia vestalis polydnavirus (CvBV). Virology. 2008;375:374-82 pubmed publisher
    ..This protein contains an ankyrin repeat domain with a high degree of similarity with IkappaB-like genes...
  58. Löw C, Weininger U, Neumann P, Klepsch M, Lilie H, Stubbs M, et al. Structural insights into an equilibrium folding intermediate of an archaeal ankyrin repeat protein. Proc Natl Acad Sci U S A. 2008;105:3779-84 pubmed publisher
    ..Recent folding studies of ankyrin repeat (AR) proteins revealed a new mechanism of protein folding...
  59. Collins R, Northrop J, Horton J, Lee D, Zhang X, Stallcup M, et al. The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules. Nat Struct Mol Biol. 2008;15:245-50 pubmed publisher
    ..Here we demonstrate that the ankyrin repeat domains of G9a and GLP bind with strong preference to N-terminal H3 peptides containing mono- or dimethyl K9...
  60. Kramer M, Wetzel S, Plückthun A, Mittl P, Grutter M. Structural determinants for improved stability of designed ankyrin repeat proteins with a redesigned C-capping module. J Mol Biol. 2010;404:381-91 pubmed publisher
    Designed ankyrin repeat proteins (DARPins) that specifically bind to almost any target can be obtained by ribosome display or phage display from combinatorial libraries...
  61. Bergqvist S, Ghosh G, Komives E. The IkappaBalpha/NF-kappaB complex has two hot spots, one at either end of the interface. Protein Sci. 2008;17:2051-8 pubmed publisher
    IkappaBalpha binds to and inhibits the transcriptional activity of NF-kappaB family members via its ankyrin repeat (AR) domain...
  62. Pecqueur L, Duellberg C, Dreier B, Jiang Q, Wang C, Plückthun A, et al. A designed ankyrin repeat protein selected to bind to tubulin caps the microtubule plus end. Proc Natl Acad Sci U S A. 2012;109:12011-6 pubmed publisher
    ..Here, we identified a designed ankyrin repeat protein (DARPin) that interferes with microtubule assembly in a unique manner...