prenylation

Summary

Summary: Attachment of isoprenoids (TERPENES) to other compounds, especially PROTEINS and FLAVONOIDS.

Top Publications

  1. Jansen J, Wartchow C, Jahnke W, Fong S, Tsang T, Pfister K, et al. Inhibition of prenylated KRAS in a lipid environment. PLoS ONE. 2017;12:e0174706 pubmed publisher
    ..of key physiological factors regulating RAS biology, namely a negatively charged lipid environment and prenylation, into the in vitro assays...
  2. Chen Y, Zhao J, Qiu Y, Yuan H, Khan S, Hussain N, et al. Prenylated flavonoids from the stems and roots of Tripterygium wilfordii. Fitoterapia. 2017;119:64-68 pubmed publisher
    ..Additionally, significant antimalarial activities of tripteryols A-B (1-2) against chloroquine-sensitive D6 and resistant W2 clones of Plasmodium falciparum were observed and none of the compounds 1-5 were cytotoxic to Vero cells. ..
  3. Mizoguchi T, Isaji M, Yamano N, Harada J, Fujii R, Tamiaki H. Molecular Structures and Functions of Chlorophylls-a Esterified with Geranylgeranyl, Dihydrogeranylgeranyl, and Tetrahydrogeranylgeranyl Groups at the 17-Propionate Residue in a Diatom, Chaetoceros calcitrans. Biochemistry. 2017;56:3682-3688 pubmed publisher
    ..Chls-a esterified with GG, DHGG, and THGG were detected by HPLC, indicating that such Chls-a were not merely biosynthetic precursors, but photosynthetically active pigments. ..
  4. Marshall S, Payne K, Leys D. The UbiX-UbiD system: The biosynthesis and use of prenylated flavin (prFMN). Arch Biochem Biophys. 2017;632:209-221 pubmed publisher
    ..The proposed reversible 1,3-dipolar cycloaddition between the cofactor and substrate serves as a model to explain many of the key UbiD family features. However, considerable variation exists in the many branches of the UbiD family tree. ..
  5. Huang J, Yang X, Peng X, Huang W. Inhibiting prenylation augments chemotherapy efficacy in renal cell carcinoma through dual inhibition on mitochondrial respiration and glycolysis. Biochem Biophys Res Commun. 2017;493:921-927 pubmed publisher
    b>Prenylation is a posttranslational lipid modification required for the proper functions of a number of proteins involved in cell regulation...
  6. Araya Cloutier C, Vincken J, van Ederen R, den Besten H, Gruppen H. Rapid membrane permeabilization of Listeria monocytogenes and Escherichia coli induced by antibacterial prenylated phenolic compounds from legumes. Food Chem. 2018;240:147-155 pubmed publisher
    ..Bent conformation and chain prenylation, were molecular features of main prenylated phenolics found in pools with high antibacterial activity.
  7. Terao J. Factors modulating bioavailability of quercetin-related flavonoids and the consequences of their vascular function. Biochem Pharmacol. 2017;139:15-23 pubmed publisher
    ..Glucosylation increases its bioavailability by elevating the accessibility to the absorptive cells. Prenylation may enhance bioaccumulation at the target site by increasing the cellular uptake...
  8. Fehrenbacher N, Tojal da Silva I, Ramírez C, Zhou Y, Cho K, Kuchay S, et al. The G protein-coupled receptor GPR31 promotes membrane association of KRAS. J Cell Biol. 2017;216:2329-2338 pubmed publisher
    ..Silencing of GPR31 expression partially mislocalized KRAS4B, slowed the growth of KRAS-dependent tumor cells, and blocked KRAS-stimulated macropinocytosis. Our data suggest that GPR31 acts as a secretory pathway chaperone for KRAS4B. ..
  9. Vochyánová Z, Pokorná M, Rotrekl D, Smékal V, Fictum P, Suchy P, et al. Prenylated flavonoid morusin protects against TNBS-induced colitis in rats. PLoS ONE. 2017;12:e0182464 pubmed publisher
    ..Our results suggest that morusin possesses therapeutic potential for the treatment of chronic inflammatory diseases. ..

More Information

Publications16

  1. Genovese S, Taddeo V, Epifano F, Fiorito S, Bize C, Rives A, et al. Characterization of the Degradation Profile of Umbelliprenin, a Bioactive Prenylated Coumarin of a Ferulago Species. J Nat Prod. 2017;80:2424-2431 pubmed publisher
    ..The study provides useful information for the preclinical development of umbelliprenin as an original chemopreventive agent. ..
  2. Huang Q, Lei C, Wang P, Li J, Li J, Hou A. Isoprenylated phenolic compounds with PTP1B inhibition from Morus alba. Fitoterapia. 2017;122:138-143 pubmed publisher
    ..All the new compounds and most of the known ones showed significant inhibitory effects on PTP1B in vitro with IC50 values ranging from 0.57 to 7.49?M. ..
  3. Wen Z, Zhang Y, Wang X, Zeng X, Hu Z, Liu Y, et al. Novel 3',5'-diprenylated chalcones inhibited the proliferation of cancer cells in vitro by inducing cell apoptosis and arresting cell cycle phase. Eur J Med Chem. 2017;133:227-239 pubmed publisher
    ..Preliminary structure-activity relationship studies indicated that, in all cancer cell lines evaluated, the 3-pyridinyl group was essential for cytotoxicity. ..
  4. Akihara Y, Ohta E, Nehira T, Omura H, Ohta S. New Prenylated ortho-Dihydroxycoumarins from the Fruits of Ficus nipponica. Chem Biodivers. 2017;14: pubmed publisher
    ..Their structures were established by spectroscopic data and X-ray crystallographic analysis. Compound 1 exhibited antibacterial activity against Bacillus subtilis with an MIC value of 61 ?m, while 2 and 3 showed very weak activity. ..
  5. El Gamal A, Al Massarani S, Abdel Mageed W, El Shaibany A, Al Mahbashi H, Basudan O, et al. Prenylated flavonoids from Commiphora opobalsamum stem bark. Phytochemistry. 2017;141:80-85 pubmed publisher
    ..Comophoroside A revealed to retain the strongest cytotoxic activity against MCF-7 and HepG-2 cell lines with IC50 values of 8 and 12 ?g/mL, respectively. ..
  6. Zarev Y, Foubert K, Lucia de Almeida V, Anthonissen R, Elgorashi E, Apers S, et al. Antigenotoxic prenylated flavonoids from stem bark of Erythrina latissima. Phytochemistry. 2017;141:140-146 pubmed publisher
    ..Sigmoidin A and B showed the highest activity, with an IC50 value of 18.7 ?g/mL, equivalent to that of curcumin (IC50 18.4 ?g/mL), used as a reference antigenotoxic compound. ..
  7. Tanaka S, Shiomi S, Ishikawa H. Bioinspired Indole Prenylation Reactions in Water. J Nat Prod. 2017;80:2371-2378 pubmed publisher
    ..We have developed a direct bioinspired indole prenylation reaction using DMAPP or its equivalents as the electrophile in homogeneous aqueous acidic media in the absence ..