lipogenesis

Summary

Summary: De novo fat synthesis in the body. This includes the synthetic processes of FATTY ACIDS and subsequent TRIGLYCERIDES in the LIVER and the ADIPOSE TISSUE. Lipogenesis is regulated by numerous factors, including nutritional, hormonal, and genetic elements.

Top Publications

  1. Hwang Y, Kim H, Choi J, Do M, Chung Y, Jeong T, et al. S-allyl cysteine attenuates free fatty acid-induced lipogenesis in human HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway. J Nutr Biochem. 2013;24:1469-78 pubmed publisher
    ..Our results demonstrate that SAC activates AMPK through CaMKK and inhibits SREBP-1-mediated hepatic lipogenesis. Therefore, SAC has therapeutic potential for preventing nonalcoholic fatty liver disease.
  2. Wang L, Jiang Z, Lei X. Knockout of SOD1 alters murine hepatic glycolysis, gluconeogenesis, and lipogenesis. Free Radic Biol Med. 2012;53:1689-96 pubmed publisher
    ..This striking comparison was possibly due to unique impacts of these two knockouts on intracellular tone of H(2)O(2) and key regulators of liver gluconeogenesis, glycolysis, and lipogenesis.
  3. Danai L, Guilherme A, Guntur K, Straubhaar J, Nicoloro S, Czech M. Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling. J Lipid Res. 2013;54:2697-707 pubmed publisher
    Adipose tissue lipogenesis is paradoxically impaired in human obesity, promoting ectopic triglyceride (TG) deposition, lipotoxicity, and insulin resistance...
  4. Mukherjee R, Yun J. Bromocriptine inhibits adipogenesis and lipogenesis by agonistic action on ?2-adrenergic receptor in 3T3-L1 adipocyte cells. Mol Biol Rep. 2013;40:3783-92 pubmed publisher
    ..goals of the present study were to investigate the inhibitory effects of bromocriptine (BC) on adipogenesis and lipogenesis in 3T3-L1 adipocyte cells as well as to elucidate its molecular mechanism of action...
  5. Lambert J, Bain V, Ryan E, Thomson A, Clandinin M. Elevated lipogenesis and diminished cholesterol synthesis in patients with hepatitis C viral infection compared to healthy humans. Hepatology. 2013;57:1697-704 pubmed publisher
    ..The purpose of this study was to measure lipogenesis and cholesterol synthesis using stable isotopes in patients with HCV (n = 5) and healthy control (n = 9) ..
  6. Basseri S, Lhotak S, Fullerton M, Palanivel R, Jiang H, Lynn E, et al. Loss of TDAG51 results in mature-onset obesity, hepatic steatosis, and insulin resistance by regulating lipogenesis. Diabetes. 2013;62:158-69 pubmed publisher
    ..Taken together, our findings suggest that TDAG51 is involved in energy homeostasis at least in part by regulating lipogenesis in liver and WAT, and hence, may constitute a novel therapeutic target for the treatment of obesity and IR.
  7. Marcelino H, Veyrat Durebex C, Summermatter S, Sarafian D, Miles Chan J, Arsenijevic D, et al. A role for adipose tissue de novo lipogenesis in glucose homeostasis during catch-up growth: a Randle cycle favoring fat storage. Diabetes. 2013;62:362-72 pubmed publisher
    ..refeeding on a high-fat (HF) diet blunts the enhanced in vivo insulin-dependent glucose utilization for de novo lipogenesis (DNL) in adipose tissue...
  8. Jeong Y, Hong J, Cho K, Jung H. Grape skin extract reduces adipogenesis- and lipogenesis-related gene expression in 3T3-L1 adipocytes through the peroxisome proliferator-activated receptor-? signaling pathway. Nutr Res. 2012;32:514-21 pubmed publisher
    ..These findings demonstrate the antiadipogenic effects of GSE on 3T3-L1 adipocytes at the genetic level, primarily on the PPAR? signaling pathway...
  9. Li W, Tai Y, Zhou J, Gu W, Bai Z, Zhou T, et al. Repression of endometrial tumor growth by targeting SREBP1 and lipogenesis. Cell Cycle. 2012;11:2348-58 pubmed publisher
    The aberrantly increased lipogenesis is a universal metabolic feature of proliferating tumor cells...
  10. Knobloch M, Braun S, Zurkirchen L, von Schoultz C, Zamboni N, Arauzo Bravo M, et al. Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis. Nature. 2013;493:226-30 pubmed publisher
    ..Here we show that fatty acid synthase (Fasn), the key enzyme of de novo lipogenesis, is highly active in adult NSPCs and that conditional deletion of Fasn in mouse NSPCs impairs adult ..

Detail Information

Publications62

  1. Hwang Y, Kim H, Choi J, Do M, Chung Y, Jeong T, et al. S-allyl cysteine attenuates free fatty acid-induced lipogenesis in human HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway. J Nutr Biochem. 2013;24:1469-78 pubmed publisher
    ..Our results demonstrate that SAC activates AMPK through CaMKK and inhibits SREBP-1-mediated hepatic lipogenesis. Therefore, SAC has therapeutic potential for preventing nonalcoholic fatty liver disease.
  2. Wang L, Jiang Z, Lei X. Knockout of SOD1 alters murine hepatic glycolysis, gluconeogenesis, and lipogenesis. Free Radic Biol Med. 2012;53:1689-96 pubmed publisher
    ..This striking comparison was possibly due to unique impacts of these two knockouts on intracellular tone of H(2)O(2) and key regulators of liver gluconeogenesis, glycolysis, and lipogenesis.
  3. Danai L, Guilherme A, Guntur K, Straubhaar J, Nicoloro S, Czech M. Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling. J Lipid Res. 2013;54:2697-707 pubmed publisher
    Adipose tissue lipogenesis is paradoxically impaired in human obesity, promoting ectopic triglyceride (TG) deposition, lipotoxicity, and insulin resistance...
  4. Mukherjee R, Yun J. Bromocriptine inhibits adipogenesis and lipogenesis by agonistic action on ?2-adrenergic receptor in 3T3-L1 adipocyte cells. Mol Biol Rep. 2013;40:3783-92 pubmed publisher
    ..goals of the present study were to investigate the inhibitory effects of bromocriptine (BC) on adipogenesis and lipogenesis in 3T3-L1 adipocyte cells as well as to elucidate its molecular mechanism of action...
  5. Lambert J, Bain V, Ryan E, Thomson A, Clandinin M. Elevated lipogenesis and diminished cholesterol synthesis in patients with hepatitis C viral infection compared to healthy humans. Hepatology. 2013;57:1697-704 pubmed publisher
    ..The purpose of this study was to measure lipogenesis and cholesterol synthesis using stable isotopes in patients with HCV (n = 5) and healthy control (n = 9) ..
  6. Basseri S, Lhotak S, Fullerton M, Palanivel R, Jiang H, Lynn E, et al. Loss of TDAG51 results in mature-onset obesity, hepatic steatosis, and insulin resistance by regulating lipogenesis. Diabetes. 2013;62:158-69 pubmed publisher
    ..Taken together, our findings suggest that TDAG51 is involved in energy homeostasis at least in part by regulating lipogenesis in liver and WAT, and hence, may constitute a novel therapeutic target for the treatment of obesity and IR.
  7. Marcelino H, Veyrat Durebex C, Summermatter S, Sarafian D, Miles Chan J, Arsenijevic D, et al. A role for adipose tissue de novo lipogenesis in glucose homeostasis during catch-up growth: a Randle cycle favoring fat storage. Diabetes. 2013;62:362-72 pubmed publisher
    ..refeeding on a high-fat (HF) diet blunts the enhanced in vivo insulin-dependent glucose utilization for de novo lipogenesis (DNL) in adipose tissue...
  8. Jeong Y, Hong J, Cho K, Jung H. Grape skin extract reduces adipogenesis- and lipogenesis-related gene expression in 3T3-L1 adipocytes through the peroxisome proliferator-activated receptor-? signaling pathway. Nutr Res. 2012;32:514-21 pubmed publisher
    ..These findings demonstrate the antiadipogenic effects of GSE on 3T3-L1 adipocytes at the genetic level, primarily on the PPAR? signaling pathway...
  9. Li W, Tai Y, Zhou J, Gu W, Bai Z, Zhou T, et al. Repression of endometrial tumor growth by targeting SREBP1 and lipogenesis. Cell Cycle. 2012;11:2348-58 pubmed publisher
    The aberrantly increased lipogenesis is a universal metabolic feature of proliferating tumor cells...
  10. Knobloch M, Braun S, Zurkirchen L, von Schoultz C, Zamboni N, Arauzo Bravo M, et al. Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis. Nature. 2013;493:226-30 pubmed publisher
    ..Here we show that fatty acid synthase (Fasn), the key enzyme of de novo lipogenesis, is highly active in adult NSPCs and that conditional deletion of Fasn in mouse NSPCs impairs adult ..
  11. Eissing L, Scherer T, Tödter K, Knippschild U, Greve J, Buurman W, et al. De novo lipogenesis in human fat and liver is linked to ChREBP-? and metabolic health. Nat Commun. 2013;4:1528 pubmed publisher
    Clinical interest in de novo lipogenesis has been sparked by recent studies in rodents demonstrating that de novo lipogenesis specifically in white adipose tissue produces the insulin-sensitizing fatty acid palmitoleate...
  12. Zhong D, Huang G, Zhang Y, Zeng Y, Xu Z, Zhao Y, et al. MicroRNA-1 and microRNA-206 suppress LXR?-induced lipogenesis in hepatocytes. Cell Signal. 2013;25:1429-37 pubmed publisher
    ..element-binding protein and acetyl-CoA carboxylase 1, which are important effectors of LXR? implicated in lipogenesis. Moreover, ectopic expression of LXR? without the 3'-UTR dramatically attenuated the miR-1/miR-206-induced ..
  13. Hwang Y, Choi J, Kim H, Khanal T, Song G, Nam M, et al. Saponins, especially platycodin D, from Platycodon grandiflorum modulate hepatic lipogenesis in high-fat diet-fed rats and high glucose-exposed HepG2 cells. Toxicol Appl Pharmacol. 2013;267:174-83 pubmed publisher
    ..The aim of this study was to investigate the effects of CKS on hepatic lipogenesis and on the expression of genes involved in lipogenesis, and the mechanisms involved...
  14. Liao C, Ou T, Wu C, Wang C. Prevention of diet-induced hyperlipidemia and obesity by caffeic acid in C57BL/6 mice through regulation of hepatic lipogenesis gene expression. J Agric Food Chem. 2013;61:11082-8 pubmed publisher
    ..acid on obesity in mice fed a high fat diet and its underlying mechanisms base on adipose and hepatic lipid lipogenesis. C57BL/6 mice were fed a normal diet or a HFD (20% fat, w/w) with or without caffeic acid (0.02% and 0...
  15. Yang W, Thein S, Guo X, Xu F, Venkatesh B, Sugii S, et al. Seipin differentially regulates lipogenesis and adipogenesis through a conserved core sequence and an evolutionarily acquired C-terminus. Biochem J. 2013;452:37-44 pubmed publisher
    ..We propose that seipin is involved in lipid homoeostasis by restricting lipogenesis and LD accumulation in non-adipocytes, while promoting adipogenesis to accommodate excess energy storage.
  16. Bouchard Mercier A, Rudkowska I, Lemieux S, Couture P, Vohl M. Polymorphisms, de novo lipogenesis, and plasma triglyceride response following fish oil supplementation. J Lipid Res. 2013;54:2866-73 pubmed publisher
    ..associations between single-nucleotide polymorphisms (SNPs) within genes encoding proteins involved in de novo lipogenesis and the relative change in plasma TG levels following a fish oil supplementation...
  17. Delgado T, Sanchez E, Camarda R, Lagunoff M. Global metabolic profiling of infection by an oncogenic virus: KSHV induces and requires lipogenesis for survival of latent infection. PLoS Pathog. 2012;8:e1002866 pubmed publisher
    ..Furthermore, this analysis raises the possibility that metabolic pathways may provide novel therapeutic targets for the inhibition of latent KSHV infection and ultimately KS tumors. ..
  18. Ducheix S, Podechard N, Lasserre F, Polizzi A, Pommier A, Murzilli S, et al. A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPAR?. Biochimie. 2013;95:556-67 pubmed publisher
    ..In the liver, pharmacological activation of LXRs leads to the over-expression of genes involved in de novo lipogenesis, while PPAR? is critical for fatty acid catabolism in nutrient deprivation...
  19. Beaven S, MATVEYENKO A, Wroblewski K, Chao L, Wilpitz D, Hsu T, et al. Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance. Cell Metab. 2013;18:106-17 pubmed publisher
    Liver X receptors (LXRs) regulate lipogenesis and inflammation, but their contribution to the metabolic syndrome is unclear. We show that LXRs modulate key aspects of the metabolic syndrome in mice...
  20. Hodson L, Fielding B. Stearoyl-CoA desaturase: rogue or innocent bystander?. Prog Lipid Res. 2013;52:15-42 pubmed publisher
    ..However, results have been somewhat counterintuitive and confusing, so the purpose of this review is to try to summarise our current understanding of this fascinating enzyme. ..
  21. Wang Y, Wong R, Tang T, Hudak C, Yang D, Duncan R, et al. Phosphorylation and recruitment of BAF60c in chromatin remodeling for lipogenesis in response to insulin. Mol Cell. 2013;49:283-97 pubmed publisher
    ..Consequently, BAF60c promotes lipogenesis in vivo and increases triglyceride levels, demonstrating its role in metabolic adaption to activate the ..
  22. Ortega F, Moreno Navarrete J, Mayas D, García Santos E, Gomez Serrano M, Rodriguez Hermosa J, et al. Breast cancer 1 (BrCa1) may be behind decreased lipogenesis in adipose tissue from obese subjects. PLoS ONE. 2012;7:e33233 pubmed publisher
    ..The specular findings of BrCa1 and lipogenic enzymes in adipose tissue and adipocytes reported here suggest that BrCa1 might help to control fatty acid biosynthesis in adipocytes and adipose tissue from obese subjects. ..
  23. Kawano Y, Cohen D. Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease. J Gastroenterol. 2013;48:434-41 pubmed publisher
    ..to a precise balance between acquisition by uptake of non-esterified fatty acids from the plasma and by de novo lipogenesis, versus triglyceride disposal by fatty acid oxidation and by the secretion of triglyceride-rich lipoproteins...
  24. Wu J, Lemaitre R, Manichaikul A, Guan W, Tanaka T, Foy M, et al. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) cons. Circ Cardiovasc Genet. 2013;6:171-83 pubmed publisher
    ..They are synthesized via de novo lipogenesis and are the main saturated and monounsaturated fatty acids in the diet...
  25. Pil Hwang Y, Gyun Kim H, Choi J, Truong Do M, Tran T, Chun H, et al. 3-Caffeoyl, 4-dihydrocaffeoylquinic acid from Salicornia herbacea attenuates high glucose-induced hepatic lipogenesis in human HepG2 cells through activation of the liver kinase B1 and silent information regulator T1/AMPK-dependent pathway. Mol Nutr Food Res. 2013;57:471-82 pubmed publisher
    ..4-dihydrocaffeoylquinic acid (CDCQ) from Salicornia herbacea, in the prevention of high glucose-induced lipogenesis in human HepG2 cells. Nile red staining assays were used to demonstrate lipid accumulation in the cells...
  26. Tang C, Huang H, Lee Y, Tang Y, Wang C. Hepatoprotective effect of mulberry water extracts on ethanol-induced liver injury via anti-inflammation and inhibition of lipogenesis in C57BL/6J mice. Food Chem Toxicol. 2013;62:786-96 pubmed publisher
    ..This may be mediated by multiple pathways, including reduced lipid accumulation and lipid synthesis, increased fatty acid transport and fatty acid oxidation responses, decreased oxidative stress and facilitated anti-inflammation. ..
  27. Zong G, Zhu J, Sun L, Ye X, Lu L, Jin Q, et al. Associations of erythrocyte fatty acids in the de novo lipogenesis pathway with risk of metabolic syndrome in a cohort study of middle-aged and older Chinese. Am J Clin Nutr. 2013;98:319-26 pubmed publisher
    Experimental studies suggest that elevated de novo lipogenesis (DNL) might be involved in the pathogenesis of metabolic disorders...
  28. Li Q, Pène V, Krishnamurthy S, Cha H, Liang T. Hepatitis C virus infection activates an innate pathway involving IKK-? in lipogenesis and viral assembly. Nat Med. 2013;19:722-9 pubmed publisher
    ..Chemical inhibitors of IKK-? suppress HCV infection and IKK-?-induced lipogenesis, offering a proof-of-concept approach for new HCV therapeutic development...
  29. Lee E, Kang M, Kim Y. Platycodin D inhibits lipogenesis through AMPK?-PPAR?2 in 3T3-L1 cells and modulates fat accumulation in obese mice. Planta Med. 2012;78:1536-42 pubmed
    ..The results suggested that PD could be used to decrease the expression of adipogenic factors related to the AMPK pathway. Hence, PD could be an alternative treatment for controlling obesity by downregulating lipid accumulation...
  30. Flannery C, Dufour S, Rabøl R, Shulman G, Petersen K. Skeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis, hyperlipidemia, and hepatic steatosis in the elderly. Diabetes. 2012;61:2711-7 pubmed publisher
    ..We examined the hypothesis that muscle insulin resistance in healthy aging promotes increased hepatic de novo lipogenesis (DNL) and hyperlipidemia by altering the distribution pattern of postprandial energy storage...
  31. Bowlby S, Thomas M, D Agostino R, Kridel S. Nicotinamide phosphoribosyl transferase (Nampt) is required for de novo lipogenesis in tumor cells. PLoS ONE. 2012;7:e40195 pubmed publisher
    ..However, a specific role for NAD(+) in tumor cell lipogenesis has yet to be described...
  32. Lambert J, Ramos Román M, Browning J, Parks E. Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease. Gastroenterology. 2014;146:726-35 pubmed publisher
    There have been few studies of the role of de novo lipogenesis in the development of nonalcoholic fatty liver disease (NAFLD)...
  33. Jin S, Yang J, Shin B, Seo K, Shin S, Cho I, et al. Resveratrol inhibits LXR?-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction. Toxicol Appl Pharmacol. 2013;271:95-105 pubmed publisher
    ..This study investigated the effect of resveratrol in LXR?-mediated lipogenesis and the underlying molecular mechanism...
  34. DeBosch B, Chen Z, Saben J, Finck B, Moley K. Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis. J Biol Chem. 2014;289:10989-98 pubmed publisher
    ..We further show diminished fructose uptake and de novo lipogenesis in fructose-challenged GLUT8-deficient hepatocytes...
  35. You X, Liu F, Zhang T, Li Y, Ye L, Zhang X. Hepatitis B virus X protein upregulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells. Carcinogenesis. 2013;34:1644-52 pubmed publisher
    ..HBx) contributes to the development of hepatocellular carcinoma (HCC) through inducing dysregulation of lipogenesis. However, the mechanism by which HBx induces the abnormal lipogenesis is not well known...
  36. Lee C, Wen J, Hsu Y, Pan T. Monascus-fermented yellow pigments monascin and ankaflavin showed antiobesity effect via the suppression of differentiation and lipogenesis in obese rats fed a high-fat diet. J Agric Food Chem. 2013;61:1493-500 pubmed publisher
    Monascus-fermented monascin and ankaflavin are found to strongly inhibit differentiation and lipogenesis and stimulate lipolysis effects in a 3T3-L1 preadipocyte model, but the in vivo regulation mechanism is unclear...
  37. Xia M, Liu Y, Guo H, Wang D, Wang Y, Ling W. Retinol binding protein 4 stimulates hepatic sterol regulatory element-binding protein 1 and increases lipogenesis through the peroxisome proliferator-activated receptor-? coactivator 1?-dependent pathway. Hepatology. 2013;58:564-75 pubmed publisher
    ..However, the impact of RBP4 on aberrant lipogenesis, the common hepatic manifestation in insulin resistance states, and the underlying mechanism remain elusive...
  38. Liu S, Brown J, Stanya K, Homan E, Leidl M, Inouye K, et al. A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use. Nature. 2013;502:550-4 pubmed publisher
    Food intake increases the activity of hepatic de novo lipogenesis, which mediates the conversion of glucose to fats for storage or use...
  39. Bernard L, Torbati M, Graulet B, Leroux C, Chilliard Y. Long-chain fatty acids differentially alter lipogenesis in bovine and caprine mammary slices. J Dairy Res. 2013;80:89-95 pubmed publisher
    ..Our objective was to investigate the effects on lipogenesis of 18-carbon LCFA differing in the degree of unsaturation and/or double bond conformation using cultured slices ..
  40. Pandey P, Xing F, Sharma S, Watabe M, Pai S, Iiizumi Gairani M, et al. Elevated lipogenesis in epithelial stem-like cell confers survival advantage in ductal carcinoma in situ of breast cancer. Oncogene. 2013;32:5111-22 pubmed publisher
    Upregulation of lipogenesis is a hallmark of cancer and blocking the lipogenic pathway is known to cause tumor cell death by apoptosis. However, the exact role of lipogenesis in tumor initiation is as yet poorly understood...
  41. Jung C, Jang S, Ahn J, Gwon S, Jeon T, Kim T, et al. Alpinia officinarum inhibits adipocyte differentiation and high-fat diet-induced obesity in mice through regulation of adipogenesis and lipogenesis. J Med Food. 2012;15:959-67 pubmed publisher
    ..Collectively, these results suggest that AOE prevents obesity by suppressing adipogenic and lipogenic genes. AOE has potential for use as an antiobesity therapeutic agent that can function by regulating lipid metabolism...
  42. Lee J, Gang G, Kim D, Kim Y, Koo S, Lee C, et al. Ursodeoxycholic acid inhibits liver X receptor ?-mediated hepatic lipogenesis via induction of the nuclear corepressor SMILE. J Biol Chem. 2014;289:1079-91 pubmed publisher
    ..Collectively, these results demonstrate that UDCA activates SMILE gene expression through adenosine monophosphate-activated kinase phosphorylation, which leads to repression of LXR-mediated hepatic lipogenic enzyme gene expression. ..
  43. Wu C, Luan H, Wang S, Zhang X, Wang R, Jin L, et al. Modulation of lipogenesis and glucose consumption in HepG2 cells and C2C12 myotubes by sophoricoside. Molecules. 2013;18:15624-35 pubmed publisher
    ..In this study, the effects of sophoricoside on lipogenesis and glucose consumption in HepG2 cells and C2C12 myotubes were investigated...
  44. Yuan M, Pino E, Wu L, Kacergis M, Soukas A. Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2. J Biol Chem. 2012;287:29579-88 pubmed publisher
    ..However, in the absence of mTORC2, forced Akt2 activation was unable to drive hepatic lipogenesis. Thus, we have identified an Akt-independent relay from mTORC2 to hepatic lipogenesis that separates the ..
  45. Zhao X, Feng D, Wang Q, Abdulla A, Xie X, Zhou J, et al. Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. J Clin Invest. 2012;122:2417-27 pubmed publisher
    ..Insulin is the primary stimulator of hepatic lipogenesis through activation of the SREBP-1c transcription factor...
  46. Zaidi N, Lupien L, Kuemmerle N, Kinlaw W, Swinnen J, Smans K. Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids. Prog Lipid Res. 2013;52:585-9 pubmed publisher
    One of the most important metabolic hallmarks of cancer cells is enhanced lipogenesis. Depending on the tumor type, tumor cells synthesize up to 95% of saturated and mono-unsaturated fatty acids (FA) de novo in spite of sufficient ..
  47. Garcia Mediavilla M, Pisonero Vaquero S, Lima Cabello E, Benedicto I, Majano P, Jorquera F, et al. Liver X receptor ?-mediated regulation of lipogenesis by core and NS5A proteins contributes to HCV-induced liver steatosis and HCV replication. Lab Invest. 2012;92:1191-202 pubmed publisher
    ..The effects of LXR? siRNA or agonist GW3965 treatment on lipogenesis and HCV replication capacity in our HCV replicon system were also examined...
  48. Lin V, Tsai Y, Lin J, Fan L, Pan M, Ho C, et al. Activation of AMPK by pterostilbene suppresses lipogenesis and cell-cycle progression in p53 positive and negative human prostate cancer cells. J Agric Food Chem. 2012;60:6399-407 pubmed publisher
    ..Our results suggest that pterostilbene may be a functional chemopreventive agent and that dietary exposure to pterostilbene would be helpful for antiprostate cancer activity. ..
  49. Iverson S, Eriksson S, Xu J, Prigge J, Talago E, Meade T, et al. A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification. Free Radic Biol Med. 2013;63:369-80 pubmed publisher
    ..Following APAP challenge, this effectively sustained the GSH system and attenuated damage. ..
  50. Haas J, Miao J, Chanda D, Wang Y, Zhao E, Haas M, et al. Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. Cell Metab. 2012;15:873-84 pubmed publisher
    ..Thus, insulin-independent signaling pathways can partially compensate for insulin in the induction of SREBP-1c by feeding but the further induction by obesity/Type 2 diabetes is entirely dependent upon insulin. ..
  51. Basaranoglu M, Basaranoglu G, Sabuncu T, Senturk H. Fructose as a key player in the development of fatty liver disease. World J Gastroenterol. 2013;19:1166-72 pubmed publisher
    ..Hepatic de novo lipogenesis (fatty acid and triglyceride synthesis) is increased in patients with NAFLD...
  52. Dunn S, Thomas M, Nette G, Dove S. A lipidomic approach to understanding free fatty acid lipogenesis derived from dissolved inorganic carbon within cnidarian-dinoflagellate symbiosis. PLoS ONE. 2012;7:e46801 pubmed publisher
    ..The study addressed free FA lipogenesis by using a new method of enriched stable isotopic ((13)C) incorporation from dissolved inorganic carbon (DI(13)..
  53. Parlevliet E, Wang Y, Geerling J, Schröder van der Elst J, Picha K, O Neil K, et al. GLP-1 receptor activation inhibits VLDL production and reverses hepatic steatosis by decreasing hepatic lipogenesis in high-fat-fed APOE*3-Leiden mice. PLoS ONE. 2012;7:e49152 pubmed publisher
    ..23% and -36% respectively), accompanied by down-regulation of expression of genes involved in hepatic lipogenesis (Srebp-1c, Fasn, Dgat1) and apoB synthesis (Apob)...
  54. Funai K, Song H, Yin L, Lodhi I, Wei X, Yoshino J, et al. Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling. J Clin Invest. 2013;123:1229-40 pubmed publisher
    ..obesity-associated diabetes in mice, but also causes muscle weakness, which suggests that mammals have retained the capacity for lipogenesis in muscle to preserve physical performance in the setting of disrupted metabolic homeostasis.
  55. Lamaziere A, Wolf C, Barbe U, Bausero P, Visioli F. Lipidomics of hepatic lipogenesis inhibition by omega 3 fatty acids. Prostaglandins Leukot Essent Fatty Acids. 2013;88:149-54 pubmed publisher
    ..We also evaluated their effect on lipogenesis and its related enzymes. Rats were administered 100 mg/kg/d fish oil, by oral gavage, for 30 days...
  56. Musselman L, Fink J, Ramachandran P, Patterson B, Okunade A, Maier E, et al. Role of fat body lipogenesis in protection against the effects of caloric overload in Drosophila. J Biol Chem. 2013;288:8028-42 pubmed publisher
    ..We tested the role of the fat body in larval tolerance of caloric excess. Our experiments demonstrated that lipogenesis was necessary for animals to tolerate high sugar feeding as tissue-specific loss of orthologs of carbohydrate ..
  57. Guo J, Ren W, Li A, Ding Y, Guo W, Su D, et al. Fat mass and obesity-associated gene enhances oxidative stress and lipogenesis in nonalcoholic fatty liver disease. Dig Dis Sci. 2013;58:1004-9 pubmed publisher
    ..FTO overexpression in L02 cells enhanced lipogenesis and oxidative stress...
  58. Kamalam B, Médale F, Kaushik S, Polakof S, Skiba Cassy S, Panserat S. Regulation of metabolism by dietary carbohydrates in two lines of rainbow trout divergently selected for muscle fat content. J Exp Biol. 2012;215:2567-78 pubmed publisher
    ..However, the F line showed a higher gene expression of hepatic enzymes involved in lipogenesis and fatty acid bioconversion, in particular with an increased dietary carbohydrate intake...
  59. Hanse E, Mashek D, Becker J, Solmonson A, Mullany L, Mashek M, et al. Cyclin D1 inhibits hepatic lipogenesis via repression of carbohydrate response element binding protein and hepatocyte nuclear factor 4?. Cell Cycle. 2012;11:2681-90 pubmed publisher
    ..In this study, we examined the regulation of de novo lipogenesis by cyclin D1, a key mediator of hepatocyte cell cycle progression...
  60. Bederman I, Perez A, Henderson L, Freedman J, Poleman J, Guentert D, et al. Altered de novo lipogenesis contributes to low adipose stores in cystic fibrosis mice. Am J Physiol Gastrointest Liver Physiol. 2012;303:G507-18 pubmed publisher
    ..Hepatic de novo lipogenesis (DNL), determined by (2)H incorporation, was reduced in CF mice...
  61. Kirpich I, Gobejishvili L, Bon Homme M, Waigel S, Cave M, Arteel G, et al. Integrated hepatic transcriptome and proteome analysis of mice with high-fat diet-induced nonalcoholic fatty liver disease. J Nutr Biochem. 2011;22:38-45 pubmed publisher
    ..05). Multiple genes encoding proteins involved in lipogenesis were down-regulated, whereas genes involved in fatty acid oxidation were up-regulated...
  62. Ren L, Chan S, Zeng X, Laybutt D, Iseli T, Sun R, et al. Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance. PLoS ONE. 2012;7:e30816 pubmed publisher
    ..study investigated their roles in the development of hepatic steatosis and insulin resistance during de novo lipogenesis (DNL) compared to extrahepatic lipid oversupply...