Rogers I. Induced pluripotent stem cells from human kidney. J Am Soc Nephrol. 2011;22:1179-80 pubmed publisher
Zanon A, Kalvakuri S, Rakovic A, Foco L, Guida M, Schwienbacher C, et al
. SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila. Hum Mol Genet. 2017;26:2412-2425 pubmed publisher
..This finding places further emphasis on the significance of Parkin for the maintenance of mitochondrial function in neurons and provides a novel target for therapeutic strategies...
Zhang S, Lv Z, Zhang S, Liu L, Li Q, Gong W, et al
. Characterization of human induced pluripotent stem cell (iPSC) line from a 72year old male patient with later onset Alzheimer's disease. Stem Cell Res. 2017;19:34-36 pubmed publisher
..The iPSC line also showed normal karyotype. This in vitro cellular model will be useful for studying the pathological mechanism of Alzheimer's disease. ..
Minnerop M, Kurzwelly D, Wagner H, Soehn A, Reichbauer J, Tao F, et al
. Hypomorphic mutations in POLR3A are a frequent cause of sporadic and recessive spastic ataxia. Brain. 2017;140:1561-1578 pubmed publisher
..Furthermore, our results demonstrate that substantial progress in revealing the causes of Mendelian diseases can be made by exploring the non-coding sequences of the human genome. ..
Velasquez Mao A, Tsao C, Monroe M, Legras X, Bissig Choisat B, Bissig K, et al
. Differentiation of spontaneously contracting cardiomyocytes from non-virally reprogrammed human amniotic fluid stem cells. PLoS ONE. 2017;12:e0177824 pubmed publisher
..the potential of amniotic fluid-derived stem cells (AFSC) to undergo non-viral reprogramming into induced pluripotent stem cells (iPSC) followed by growth-factor-free differentiation into functional cardiomyocytes...
Suchorska W, Augustyniak E, Richter M, Łukjanow M, Filas V, Kaczmarczyk J, et al
. Modified methods for efficiently differentiating human embryonic stem cells into chondrocyte-like cells. Postepy Hig Med Dosw (Online). 2017;71:500-509 pubmed
..The most useful GFs are TGF-?1, -3 and BMP-2 that possess the most chondrogenic potential. These methods can also be used to obtain chondrocyte-like cells from differentiating induced pluripotent stem cells (iPSCs).
Sirenko O, Grimm F, Ryan K, Iwata Y, Chiu W, Parham F, et al
. In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model. Toxicol Appl Pharmacol. 2017;322:60-74 pubmed publisher
Aberdam E, Petit I, Sangari L, Aberdam D. Induced pluripotent stem cell-derived limbal epithelial cells (LiPSC) as a cellular alternative for in vitro ocular toxicity testing. PLoS ONE. 2017;12:e0179913 pubmed publisher
b>Induced pluripotent stem cells hold great potential to produce unlimited amount of differentiated cells as cellular source for regenerative medicine but also for in vitro drug screening and cytotoxicity tests...
Barefield D, Puckelwartz M, Kim E, Wilsbacher L, Vo A, Waters E, et al
. Experimental Modeling Supports a Role for MyBP-HL as a Novel Myofilament Component in Arrhythmia and Dilated Cardiomyopathy. Circulation. 2017;136:1477-1491 pubmed publisher
..Whole-genome sequencing and induced pluripotent stem cells were used to examine a family with dilated cardiomyopathy and atrial and ventricular arrhythmias...
Yuan T, Liao W, Feng N, Lou Y, Niu X, Zhang A, et al
. Human induced pluripotent stem cell-derived neural stem cells survive, migrate, differentiate, and improve neurologic function in a rat model of middle cerebral artery occlusion. Stem Cell Res Ther. 2013;4:73 pubmed publisher
..b>Induced pluripotent stem cells (iPSCs) have the potential to generate all cell types in vitro and can be generated from a stroke ..
Vallier L. Putting induced pluripotent stem cells to the test. Nat Biotechnol. 2015;33:1145-6 pubmed publisher
Pournasr B, Duncan S. Modeling Inborn Errors of Hepatic Metabolism Using Induced Pluripotent Stem Cells. Arterioscler Thromb Vasc Biol. 2017;37:1994-1999 pubmed publisher
..Recently, investigators have exploited molecular techniques to generate induced pluripotent stem cells from patients' somatic cells...
Zhang H, Shi J, Hachet M, Xue C, Bauer R, Jiang H, et al
. CRISPR/Cas9-Mediated Gene Editing in Human iPSC-Derived Macrophage Reveals Lysosomal Acid Lipase Function in Human Macrophages-Brief Report. Arterioscler Thromb Vasc Biol. 2017;37:2156-2160 pubmed publisher
..palindromic repeats)/Cas9 (CRISPR-associated protein 9) technology to knock out LIPA in human induced pluripotent stem cells and then differentiate to macrophage (human-induced pluripotent stem cells-derived macrophage [IPSDM]) ..
Vunjak Novakovic G, Bhatia S, Chen C, Hirschi K. HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease. Stem Cell Res Ther. 2013;4 Suppl 1:S8 pubmed publisher
..In this paper, we summarize progress made over the first year of the grant. ..
Paşca S. Personalized Human Cortical Spheroids. Am J Psychiatry. 2016;173:332-3 pubmed publisher
Mzoughi S, Zhang J, Hequet D, Teo S, Fang H, Xing Q, et al
. PRDM15 safeguards naive pluripotency by transcriptionally regulating WNT and MAPK-ERK signaling. Nat Genet. 2017;49:1354-1363 pubmed publisher
..Collectively, our findings uncover an essential role for PRDM15 as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency. ..
Mangale V, Marro B, Plaisted W, Walsh C, Lane T. Neural precursor cells derived from induced pluripotent stem cells exhibit reduced susceptibility to infection with a neurotropic coronavirus. Virology. 2017;511:49-55 pubmed publisher
..The relevance of this in terms of therapeutic application of NPCs resistant to viral infection is discussed. ..
Park S, Sung Y, Jeong J, Choi M, Lee J, Kwon W, et al
. Critical roles of hMAGEA2 in induced pluripotent stem cell pluripotency, proliferation, and differentiation. Cell Biochem Funct. 2017;35:392-400 pubmed publisher
..Therefore, our findings prove that hMAGEA2 plays key roles in iPS cells. ..
Yoshida Y, Yamanaka S. Recent stem cell advances: induced pluripotent stem cells for disease modeling and stem cell-based regeneration. Circulation. 2010;122:80-7 pubmed publisher
Rodriguez M, Graham B, Pabon L, Han S, Murry C, Sniadecki N. Measuring the contractile forces of human induced pluripotent stem cell-derived cardiomyocytes with arrays of microposts. J Biomech Eng. 2014;136:051005 pubmed publisher
..This system should facilitate studies of hiPSC-CM maturation, disease modeling, and drug screens as well as fundamental studies of human cardiac contraction. ..
Warren C, Jaquish C, Cowan C. The NextGen Genetic Association Studies Consortium: A Foray into InÂ Vitro Population Genetics. Cell Stem Cell. 2017;20:431-433 pubmed publisher
..This issue of Cell Stem Cell and affiliated journals include several manuscripts describing the results of the consortium's efforts. ..
Warren C, O Sullivan J, Friesen M, Becker C, Zhang X, Liu P, et al
. Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease. Cell Stem Cell. 2017;20:547-557.e7 pubmed publisher
..Here we describe an approach to functionally validate identified variants through differentiation of induced pluripotent stem cells (iPSCs) to study cellular pathophysiology...
Artyukhov A, Dashinimaev E, Tsvetkov V, Bolshakov A, Konovalova E, Kolbaev S, et al
. New genes for accurate normalization of qRT-PCR results in study of iPS and iPS-derived cells. Gene. 2017;626:234-240 pubmed publisher
iPSC-derived cells (from induced pluripotent stem cells) are a useful source that provide a powerful and widely accepted tool for the study of various types of human cells in vitro...
Sharma A, Burridge P, McKeithan W, Serrano R, Shukla P, Sayed N, et al
. High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells. Sci Transl Med. 2017;9: pubmed publisher
..This approach provides unexpected insights, as illustrated by our finding that toxicity can be alleviated via cardioprotective insulin/IGF signaling. ..
Mandai M, Watanabe A, Kurimoto Y, Hirami Y, Morinaga C, Daimon T, et al
. Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration. N Engl J Med. 2017;376:1038-1046 pubmed publisher
..the feasibility of transplanting a sheet of retinal pigment epithelial (RPE) cells differentiated from induced pluripotent stem cells (iPSCs) in a patient with neovascular age-related macular degeneration...
Takayama K, Igai K, Hagihara Y, Hashimoto R, Hanawa M, Sakuma T, et al
. Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN system. Nucleic Acids Res. 2017;45:5198-5207 pubmed publisher
..Importantly, RAD51 overexpression and valproic acid treatment synergistically increased the biallelic homologous recombination efficiency. Our findings would facilitate genome editing study using human ES/iPS cells. ..
Lonfat N, Cepko C. Epigenomics of Retinal Development in Mice and Humans. Neuron. 2017;94:420-423 pubmed publisher
..In this issue of Neuron, Aldiri et al. (2017) present an analysis of epigenetic changes during retinal development, and use these data to probe reprogramming of retinal iPSC cells, as well as the origin of retinoblastoma cells. ..
Sloma I, Mitjavila Garcia M, Feraud O, Griscelli F, Oudrhiri N, El Marsafy S, et al
. Whole-genome analysis reveals unexpected dynamics of mutant subclone development in a patient with JAK2-V617F-positive chronic myeloid leukemia. Exp Hematol. 2017;53:48-58 pubmed publisher
..Surprisingly, WGS of induced pluripotent stem cells (iPSCs) derived from the AP cells revealed only six additional coding somatic mutations, despite ..
Korsgren O. Islet Encapsulation: Physiological Possibilities and Limitations. Diabetes. 2017;66:1748-1754 pubmed publisher
..Generation of transplantable insulin-producing cells from human embryonic stem cells or induced pluripotent stem cells is at present close to reality, and we are currently awaiting the first clinical studies...
Au E, Fernandez Godino R, Kaczynksi T, Sousa M, Farkas M. Characterization of lincRNA expression in the human retinal pigment epithelium and differentiated induced pluripotent stem cells. PLoS ONE. 2017;12:e0183939 pubmed publisher
..lincRNA transcriptome using RNA-Seq data generated from human fetal RPE (fRPE), RPE derived from human induced pluripotent stem cells (iPS-RPE), and undifferentiated iPS (iPS)...
Topol A, Zhu S, Tran N, Simone A, Fang G, Brennand K. Altered WNT Signaling in Human Induced Pluripotent Stem Cell Neural Progenitor Cells Derived from Four Schizophrenia Patients. Biol Psychiatry. 2015;78:e29-34 pubmed publisher
Lee J, Dykstra B, Spencer J, Kenney L, Greiner D, Shultz L, et al
. mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors. J Clin Invest. 2017;127:2433-2437 pubmed publisher
..Our results suggest that strategies toward increasing E-selectin ligand expression could be applicable as part of a multifaceted approach to optimize the production of HSPCs from human PSCs. ..
Chadwick A, Wang X, Musunuru K. In Vivo Base Editing of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) as a Therapeutic Alternative to Genome Editing. Arterioscler Thromb Vasc Biol. 2017;37:1741-1747 pubmed publisher
..We screened base editors for activity in cultured cells, including human-induced pluripotent stem cells. We then delivered a base editor into the livers of adult mice to assess whether it could introduce ..
Henzler C, Li Z, Dang J, Arcila M, Zhou H, Liu J, et al
. Staged miRNA re-regulation patterns during reprogramming. Genome Biol. 2013;14:R149 pubmed publisher
..stem cells from mouse fibroblasts and isolate FACS-sorted Thy1- and SSEA1+ intermediates and Oct4-GFP+?induced pluripotent stem cells (iPSCs)...
Ding Z, Sui L, Ren R, Liu Y, Xu X, Fu L, et al
. A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells. Protein Cell. 2015;6:386-9 pubmed publisher
Paillusson S, Gomez Suaga P, Stoica R, LITTLE D, Gissen P, Devine M, et al
. α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production. Acta Neuropathol. 2017;134:129-149 pubmed publisher
..This disruption to the VAPB-PTPIP51 tethers is also seen in neurons derived from induced pluripotent stem cells from familial Parkinson's disease patients harbouring pathogenic triplication of the α-synuclein gene...
Saarimäki Vire J, Balboa D, Russell M, Saarikettu J, Kinnunen M, Keskitalo S, et al
. An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation. Cell Rep. 2017;19:281-294 pubmed publisher
..the effect of an activating mutation, STAT3K392R, on pancreatic development using induced pluripotent stem cells (iPSCs) derived from a patient with neonatal diabetes and pancreatic hypoplasia...
Zhang S, Lv Z, Liu Y, Li Q, Gong W, Liu L, et al
. Development of human induced pluripotent stem cell (iPSC) line from a 60year old female patient with multiple schwannoma. Stem Cell Res. 2017;19:31-33 pubmed publisher
..The iPSC line also showed normal karyotype. This in vitro cellular model will be useful for further pathological studies of multiple schwannoma. ..
Millman J, Pagliuca F. Autologous Pluripotent Stem Cell-Derived ?-Like Cells for Diabetes Cellular Therapy. Diabetes. 2017;66:1111-1120 pubmed publisher
..to generate functional ?-like cells from human pluripotent stem cells in vitro, including from human induced pluripotent stem cells (hiPSCs)...
Meskus M, de Miguel Beriain I. Embryo-like features of induced pluripotent stem cells defy legal and ethical boundaries. Croat Med J. 2013;54:589-91 pubmed
Grima J, Daigle J, Arbez N, Cunningham K, Zhang K, Ochaba J, et al
. Mutant Huntingtin Disrupts the Nuclear Pore Complex. Neuron. 2017;94:93-107.e6 pubmed publisher
..Additionally, overexpression of NUPs and treatment with drugs that prevent aberrant NUP biology also mitigated this transport defect and neurotoxicity, providing future novel therapy targets. ..
Lee J, Kim Y, Yi H, Diecke S, Kim J, Jung H, et al
. Generation of disease-specific induced pluripotent stem cells from patients with rheumatoid arthritis and osteoarthritis. Arthritis Res Ther. 2014;16:R41 pubmed publisher
Since the concept of reprogramming mature somatic cells to generate induced pluripotent stem cells (iPSCs) was demonstrated in 2006, iPSCs have become a potential substitute for embryonic stem cells (ESCs) given their pluripotency and &..
Stockmann M, Linta L, Fohr K, Boeckers A, Ludolph A, Kuh G, et al
. Developmental and functional nature of human iPSC derived motoneurons. Stem Cell Rev. 2013;9:475-92 pubmed publisher
Ghaedi M, Calle E, Mendez J, Gard A, Balestrini J, Booth A, et al
. Human iPS cell-derived alveolar epithelium repopulates lung extracellular matrix. J Clin Invest. 2013;123:4950-62 pubmed publisher
The use of induced pluripotent stem cells (iPSCs) has been postulated to be the most effective strategy for developing patient-specific respiratory epithelial cells, which may be valuable for lung-related cell therapy and lung tissue ..
Kadari A, Lu M, Li M, Sekaran T, Thummer R, Guyette N, et al
. Excision of viral reprogramming cassettes by Cre protein transduction enables rapid, robust and efficient derivation of transgene-free human induced pluripotent stem cells. Stem Cell Res Ther. 2014;5:47 pubmed publisher
..represent robust tools for cellular reprogramming; however, the presence of viral transgenes in induced pluripotent stem cells (iPSCs) is deleterious because it holds the risk of insertional mutagenesis leading to malignant ..
Neofytou E, O Brien C, Couture L, Wu J. Hurdles to clinical translation of human induced pluripotent stem cells. J Clin Invest. 2015;125:2551-7 pubmed publisher
Koike H, Zhang R, Ueno Y, Sekine K, Zheng Y, Takebe T, et al
. Nutritional modulation of mouse and human liver bud growth through a branched-chain amino acid metabolism. Development. 2017;144:1018-1024 pubmed publisher
Deboever C, Li H, Jakubosky D, Benaglio P, Reyna J, Olson K, et al
. Large-Scale Profiling Reveals the Influence of Genetic Variation on Gene Expression in Human Induced Pluripotent Stem Cells. Cell Stem Cell. 2017;20:533-546.e7 pubmed publisher
..Our work highlights the value of iPSCs for genetic association analyses and provides a unique resource for investigating the genetic regulation of gene expression in pluripotent cells. ..
Susaimanickam P, Maddileti S, Pulimamidi V, Boyinpally S, Naik R, Naik M, et al
. Generating minicorneal organoids from human induced pluripotent stem cells. Development. 2017;144:2338-2351 pubmed publisher
..They offer an alternative tissue source for regenerating different layers of the cornea and eliminate the need for complicated cell enrichment procedures. ..
Yoshida Y, Yamanaka S. Induced Pluripotent Stem Cells 10 Years Later: For Cardiac Applications. Circ Res. 2017;120:1958-1968 pubmed publisher
b>Induced pluripotent stem cells (iPSCs) are reprogrammed cells that have features similar to embryonic stem cells, such as the capacity of self-renewal and differentiation into many types of cells, including cardiac myocytes...
Megaw R, Abu Arafeh H, JUNGNICKEL M, Mellough C, Gurniak C, Witke W, et al
. Gelsolin dysfunction causes photoreceptor loss in induced pluripotent cell and animal retinitis pigmentosa models. Nat Commun. 2017;8:271 pubmed publisher
..Here, the authors show in induced pluripotent stem cells and mouse knockouts that RPGR mediates actin dynamics in photoreceptors via the actin-severing protein,..
Pera M. Stem cells: The dark side of induced pluripotency. Nature. 2011;471:46-7 pubmed publisher
Mascetti V, Pedersen R. Naiveté of the human pluripotent stem cell. Nat Biotechnol. 2014;32:68-70 pubmed publisher
Simon C, Lin Gibson S, Elliott J, Sarkar S, Plant A. Strategies for Achieving Measurement Assurance for Cell Therapy Products. Stem Cells Transl Med. 2016;5:705-8 pubmed
..Application of these strategies to cell measurements will help to establish qualified assays for cell characterization, which may help streamline regulatory approval and enable more efficient development of cell therapy products. ..
Pashos E, Park Y, Wang X, Raghavan A, Yang W, Abbey D, et al
. Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci. Cell Stem Cell. 2017;20:558-570.e10 pubmed publisher
..We recruited a multi-ethnic cohort of healthy volunteers (nÂ = 91) and used their tissue to generate induced pluripotent stem cells (iPSCs) and hepatocyte-like cells (HLCs) for genome-wide mapping of expression quantitative trait loci ..
Zhao J, Davis M, Martens Y, Shinohara M, Graff Radford N, Younkin S, et al
. APOE ?4/?4 diminishes neurotrophic function of human iPSC-derived astrocytes. Hum Mol Genet. 2017;26:2690-2700 pubmed publisher
..Human induced pluripotent stem cells (iPSCs) derived from individuals carrying specific gene variants or mutations provide an alternative ..
Breckwoldt K, Letuffe Brenière D, Mannhardt I, Schulze T, Ulmer B, Werner T, et al
. Differentiation of cardiomyocytes and generation of human engineered heart tissue. Nat Protoc. 2017;12:1177-1197 pubmed publisher
Since the advent of the generation of human induced pluripotent stem cells (hiPSCs), numerous protocols have been developed to differentiate hiPSCs into cardiomyocytes and then subsequently assess their ability to recapitulate the ..
Chauveau S, Anyukhovsky E, Ben Ari M, Naor S, Jiang Y, Danilo P, et al
. Induced Pluripotent Stem Cell-Derived Cardiomyocytes Provide In Vivo Biological Pacemaker Function. Circ Arrhythm Electrophysiol. 2017;10:e004508 pubmed publisher
..iPSC-CMs can integrate into host myocardium and create a biological pacemaker. Although this is a promising development, rate and rhythm of the iPSC-CMs pacemakers remain to be optimized. ..
Kuang Y, Miki K, Parr C, Hayashi K, Takei I, Li J, et al
. Efficient, Selective Removal of Human Pluripotent Stem Cells via Ecto-Alkaline Phosphatase-Mediated Aggregation of Synthetic Peptides. Cell Chem Biol. 2017;24:685-694.e4 pubmed publisher
The incomplete differentiation of human induced pluripotent stem cells (iPSCs) poses a serious safety risk owing to their potential tumorigenicity, hindering their clinical application...
Skamagki M, Correia C, Yeung P, Baslan T, Beck S, Zhang C, et al
. ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors. Nat Cell Biol. 2017;19:1037-1048 pubmed publisher
b>Induced pluripotent stem cells (iPSCs), which are used to produce transplantable tissues, may particularly benefit older patients, who are more likely to suffer from degenerative diseases...
Watson D, Hunziker R, Wikswo J. Fitting tissue chips and microphysiological systems into the grand scheme of medicine, biology, pharmacology, and toxicology. Exp Biol Med (Maywood). 2017;242:1559-1572 pubmed publisher
..issue, there have been significant advances in cell sourcing, with increased reliance on human-induced pluripotent stem cells, and in characterization of the genetic and functional cell state in MPS bioreactors...
Kim K, Heo D, Lee J, Seo C, Chung S. High-efficiency generation of induced pluripotent stem cells from human foreskin fibroblast cells using the Sagunja-tang herbal formula. BMC Complement Altern Med. 2017;17:529 pubmed publisher
..In this study, we evaluated the effects of SGT-4 on the formation efficiency of induced pluripotent stem cells (iPSCs) from human foreskin fibroblasts (HFFs) by four reprogramming transcription factors: Oct4, Sox2,..
Lin Y, Murayama Y, Hashimoto K, Nakamura Y, Lin C, Yokoyama K, et al
. Role of tumor suppressor genes in the cancer-associated reprogramming of human induced pluripotent stem cells. Stem Cell Res Ther. 2014;5:58 pubmed
Because of their pluripotent characteristics, human induced pluripotent stem cells (iPSCs) possess great potential for therapeutic application and for the study of degenerative disorders...
Carpentier A, Tesfaye A, Chu V, Nimgaonkar I, Zhang F, Lee S, et al
. Engrafted human stem cell-derived hepatocytes establish an infectious HCV murine model. J Clin Invest. 2014;124:4953-64 pubmed publisher
The demonstrated ability to differentiate both human embryonic stem cells (hESCs) and patient-derived induced pluripotent stem cells (hiPSCs) into hepatocyte-like cells (HLCs) holds great promise for both regenerative medicine and liver ..
Kane C, Du D, Hellen N, Terracciano C. The Fallacy of Assigning Chamber Specificity to iPSC Cardiac Myocytes from Action Potential Morphology. Biophys J. 2016;110:281-3 pubmed publisher
Yuan X, Li Z, Baines A, Gavriilaki E, Ye Z, Wen Z, et al
. A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model. PLoS ONE. 2017;12:e0174074 pubmed publisher
..1234C>T hiPSCs demonstrate increased susceptibility to complement-mediated cytotoxicity, suggesting that defective complement regulation may contribute to neurodevelopmental disorders. ..
Rojas S, Kensah G, Rotaermel A, Baraki H, Kutschka I, Zweigerdt R, et al
. Transplantation of purified iPSC-derived cardiomyocytes in myocardial infarction. PLoS ONE. 2017;12:e0173222 pubmed publisher
b>Induced pluripotent stem cells (iPSC) can be differentiated into cardiomyocytes and represent a possible autologous cell source for myocardial repair...
Qiang L, Rao A, Mostoslavsky G, James M, Comfort N, Sullivan K, et al
. Reprogramming cells from Gulf War veterans into neurons to study Gulf War illness. Neurology. 2017;88:1968-1975 pubmed publisher
..Such cell lines are immortal and will be a resource for GWI researchers to pursue mechanistic hypotheses and therapeutics. ..
Crespo M, Vilar E, Tsai S, Chang K, Amin S, Srinivasan T, et al
. Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing. Nat Med. 2017;23:878-884 pubmed publisher
..for deriving colonic organoids (COs) from differentiated human embryonic stem cells (hESCs) or induced pluripotent stem cells (iPSCs)...
Jeong H, Cha H. Helping Induced hPSCs Clean Up Their Act. Cell Chem Biol. 2017;24:651-652 pubmed publisher
..In this issue of Cell Chemical Biology, Kuang et al. (2017) reveal that the phospho-D-peptide D-3 efficiently induces death of residual hPSCs, but not of differentiated progenies, through high alkaline phosphatase activity in hPSCs. ..
Zhou R, Xu A, Gingold J, Strong L, Zhao R, Lee D. Li-Fraumeni Syndrome Disease Model: A Platform to Develop Precision Cancer Therapy Targeting Oncogenic p53. Trends Pharmacol Sci. 2017;38:908-927 pubmed publisher
..Finally, we discuss how recently developed methodologies can be integrated into the LFS induced pluripotent stem cell (iPSC) platform to develop precision cancer therapy. ..
Taniguchi J, Pandian G, Hidaka T, Hashiya K, Bando T, Kim K, et al
. A synthetic DNA-binding inhibitor of SOX2 guides human induced pluripotent stem cells to differentiate into mesoderm. Nucleic Acids Res. 2017;45:9219-9228 pubmed publisher
Targeted differentiation of human induced pluripotent stem cells (hiPSCs) using only chemicals would have value-added clinical potential in the regeneration of complex cell types including cardiomyocytes...
Sassone Corsi P. Physiology. When metabolism and epigenetics converge. Science. 2013;339:148-50 pubmed publisher
Moya M, Tran D, George S. An integrated in vitro model of perfused tumor and cardiac tissue. Stem Cell Res Ther. 2013;4 Suppl 1:S15 pubmed publisher
Karagiannis P, Yamanaka S. The fate of cell reprogramming. Nat Methods. 2014;11:1006-8 pubmed publisher
Bhattacharya S, Burridge P, Kropp E, Chuppa S, Kwok W, Wu J, et al
. High efficiency differentiation of human pluripotent stem cells to cardiomyocytes and characterization by flow cytometry. J Vis Exp. 2014;:52010 pubmed publisher
..Accordingly, optimized staining protocols for the analysis of IRX4, MLC2v, MLC2a, TNNI3, and TNNT2 by flow cytometry are described. ..
Chakradhar S. An eye to the future: Researchers debate best path for stem cell-derived therapies. Nat Med. 2016;22:116-9 pubmed publisher
Suzuki H, Ahuja C, Salewski R, Li L, Satkunendrarajah K, Nagoshi N, et al
. Neural stem cell mediated recovery is enhanced by Chondroitinase ABC pretreatment in chronic cervical spinal cord injury. PLoS ONE. 2017;12:e0182339 pubmed publisher
..This represents important proof-of-concept data that the chronically injured spinal cord can be 'unlocked' by ChABC pretreatment to produce a microenvironment conducive to regenerative iPS-NSC therapy. ..
DeStefano J, Xu Z, Williams A, Yimam N, Searson P. Effect of shear stress on iPSC-derived human brain microvascular endothelial cells (dhBMECs). Fluids Barriers CNS. 2017;14:20 pubmed publisher
..gene expression, of confluent monolayers of human brain microvascular endothelial cells derived from induced pluripotent stem cells. To assess the response of derived human brain microvascular endothelial cells (dhBMECs) to shear ..
Hirota T, Ohta H, Powell B, Mahadevaiah S, Ojarikre O, Saitou M, et al
. Fertile offspring from sterile sex chromosome trisomic mice. Science. 2017;357:932-935 pubmed publisher
..1% of the human population and is associated with infertility. We show that during reprogramming to induced pluripotent stem cells (iPSCs), fibroblasts from sterile trisomic XXY and XYY mice lose the extra sex chromosome through a ..
Liu J, Li Y, Lin B, Sheng Y, Yang L. HBL1 Is a Human Long Noncoding RNA that Modulates Cardiomyocyte Development from Pluripotent Stem Cells by Counteracting MIR1. Dev Cell. 2017;42:333-348.e5 pubmed publisher
..long noncoding RNA, Heart Brake LncRNA 1 (HBL1), which regulates cardiomyocyte development from human induced pluripotent stem cells (hiPSCs)...
Yamamoto Y, Gotoh S, Korogi Y, Seki M, Konishi S, Ikeo S, et al
. Long-term expansion of alveolar stem cells derived from human iPS cells in organoids. Nat Methods. 2017;14:1097-1106 pubmed publisher
..of alveolar organoids (AOs) harboring SFTPC+ alveolar stem cells derived from human induced pluripotent stem cells (hiPSCs)...
Soldner F, Jaenisch R. Medicine. iPSC disease modeling. Science. 2012;338:1155-6 pubmed publisher
Fox I, Duncan S. Engineering liver tissue from induced pluripotent stem cells: a first step in generating new organs for transplantation?. Hepatology. 2013;58:2198-201 pubmed publisher
Bhartiya D. Stem cells, progenitors & regenerative medicine: A retrospection. Indian J Med Res. 2015;141:154-61 pubmed
Pan X, Zhou J, Yao X, Shu J, Liu J, Yang J, et al
. Transplantation of induced mesenchymal stem cells for treating chronic renal insufficiency. PLoS ONE. 2017;12:e0176273 pubmed publisher
..The ultimate goal was to explore the effects of iMSC transplantation on the treatment of chronic renal insufficiency, with the aim of providing a new therapeutic modality for this disease. ..
Konze S, Cajic S, Oberbeck A, Hennig R, Pich A, Rapp E, et al
. Quantitative Assessment of Sialo-Glycoproteins and N-Glycans during Cardiomyogenic Differentiation of Human Induced Pluripotent Stem Cells. Chembiochem. 2017;18:1317-1331 pubmed publisher
..Bisecting GlcNAc structures strongly increased during differentiation, and we propose that they are characteristic of early, immature CMs. ..
Kimura T, Uesugi M, Takase K, Miyamoto N, Sawada K. Hsp90 inhibitor geldanamycin attenuates the cytotoxicity of sunitinib in cardiomyocytes via inhibition of the autophagy pathway. Toxicol Appl Pharmacol. 2017;329:282-292 pubmed publisher
Arber C, Angelova P, Wiethoff S, Tsuchiya Y, Mazzacuva F, Preza E, et al
. iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease. PLoS ONE. 2017;12:e0184104 pubmed publisher
..In this study, atypical patient-derived fibroblasts were reprogrammed into induced pluripotent stem cells (iPSCs) and subsequently differentiated into cortical neuronal cells for studying disease mechanisms ..
Haraguchi Y, Hasegawa A, Matsuura K, Kobayashi M, Iwana S, Kabetani Y, et al
. Three-Dimensional Human Cardiac Tissue Engineered by Centrifugation of Stacked Cell Sheets and Cross-Sectional Observation of Its Synchronous Beatings by Optical Coherence Tomography. Biomed Res Int. 2017;2017:5341702 pubmed publisher
..The rapid tissue-fabrication technique and OCT technology will show a powerful potential in cardiac tissue engineering, regenerative medicine, and drug discovery research. ..
Cayo M, Mallanna S, Di Furio F, Jing R, Tolliver L, Bures M, et al
. A Drug Screen using Human iPSC-Derived Hepatocyte-like Cells Reveals Cardiac Glycosides as a Potential Treatment for Hypercholesterolemia. Cell Stem Cell. 2017;20:478-489.e5 pubmed publisher
..However, cells with hepatocyte characteristics can be produced from induced pluripotent stem cells (iPSCs)...
Toustrup L, Zhou Y, Kvistgaard H, Gregersen N, Rittig S, Aagaard L, et al
. Induced pluripotent stem cells derived from a patient with autosomal dominant familial neurohypophyseal diabetes insipidus caused by a variant in the AVP gene. Stem Cell Res. 2017;19:37-42 pubmed publisher
..Here we report the generation of induced pluripotent stem cells (iPSCs) from a 42-year-old man carrying an adFNDI causing variant in exon 1 of the AVP gene using ..