embryoid bodies


Summary: Spontaneous aggregations of human embryonic stem cells that occur in vitro after culturing in a medium that lacks LEUKEMIC INHIBITORY FACTOR. The embryoid bodies can further differentiate into cells that represent different lineages.

Top Publications

  1. Lim W, Inoue Yokoo T, Tan K, Lai M, Sugiyama D. Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells. Stem Cell Res Ther. 2013;4:71 pubmed publisher
    ..We hereby review the current progress of hematopoietic cell induction from embryonic stem/induced pluripotent stem cells. ..
  2. Toustrup L, Zhou Y, Kvistgaard H, Gregersen N, Rittig S, Aagaard L, et al. Induced pluripotent stem cells derived from a patient with autosomal dominant familial neurohypophyseal diabetes insipidus caused by a variant in the AVP gene. Stem Cell Res. 2017;19:37-42 pubmed publisher
    ..This iPSC line is useful in future studies focusing on the pathogenesis of adFNDI. ..
  3. Muller M, Stockmann M, Malan D, Wolheim A, Tischendorf M, Linta L, et al. Ca2+ activated K channels-new tools to induce cardiac commitment from pluripotent stem cells in mice and men. Stem Cell Rev. 2012;8:720-40 pubmed publisher
  4. Simunovic M, Brivanlou A. Embryoids, organoids and gastruloids: new approaches to understanding embryogenesis. Development. 2017;144:976-985 pubmed publisher
  5. Saito M, Ishida A, Nakagawa S. In vitro production of insulin-responsive skeletal muscle tissue from mouse embryonic stem cells by spermine-induced differentiation method. Hum Cell. 2017;30:162-168 pubmed publisher
    ..6 times higher than the control without insulin, and this insulin responsiveness was maintained for 5 days. The advantages of the 3-dimensional structure of MMTS are discussed in the contexts of its potential in vivo and in vitro uses. ..
  6. Danziger S, Miller L, Singh K, Whitney G, Peskind E, Li G, et al. An indicator cell assay for blood-based diagnostics. PLoS ONE. 2017;12:e0178608 pubmed publisher
    ..10E-3). For both assays, iCAP features were enriched for disease-related genes, supporting the assay's relevance for disease research. ..
  7. Ikeda M, Imaizumi M, Yoshie S, Nakamura R, Otsuki K, Murono S, et al. Implantation of Induced Pluripotent Stem Cell-Derived Tracheal Epithelial Cells. Ann Otol Rhinol Laryngol. 2017;126:517-524 pubmed publisher
    ..Red fluorescent tdTomato protein was electroporated into mouse iPSCs to produce tdTomato-labeled iPSCs. Embryoid bodies derived from these iPSCs were then cultured in differentiation medium supplemented with growth factors, ..
  8. Kobayashi T, Zhang H, Tang W, Irie N, Withey S, Klisch D, et al. Principles of early human development and germ cell program from conserved model systems. Nature. 2017;546:416-420 pubmed publisher
    ..Our combinatorial approach using human, porcine and monkey in vivo and in vitro models provides synthetic insights into early human development. ..
  9. Park S, Sung Y, Jeong J, Choi M, Lee J, Kwon W, et al. Critical roles of hMAGEA2 in induced pluripotent stem cell pluripotency, proliferation, and differentiation. Cell Biochem Funct. 2017;35:392-400 pubmed publisher
    ..Therefore, our findings prove that hMAGEA2 plays key roles in iPS cells. ..

More Information


  1. Cinghu S, Yang P, Kosak J, Conway A, Kumar D, Oldfield A, et al. Intragenic Enhancers Attenuate Host Gene Expression. Mol Cell. 2017;68:104-117.e6 pubmed publisher