smooth muscle myoblasts

Summary

Summary: Precursor cells destined to differentiate into smooth muscle myocytes (MYOCYTES, SMOOTH MUSCLE).

Top Publications

  1. Montes G, Zugaib M, Joazeiro P, Varayoud J, Ramos J, Munoz De Toro M, et al. Phenotypic modulation of fibroblastic cells in the mucous layer of the human uterine cervix at term. Reproduction. 2002;124:783-90 pubmed
    ..The implications of the plasticity of fibroblastic-myofibroblastic cells in the physiological changes displayed in the uterine cervix during pregnancy, labour and postpartum involution require further investigation...
  2. Iwanaga K, Murata T, Hori M, Ozaki H. Isolation and characterization of bovine intestinal subepithelial myofibroblasts. J Pharmacol Sci. 2010;112:98-104 pubmed
    ..Thus, bovine ISMFs might be a novel useful tool with long life span and good cellular responses to investigate physiological/pathophysiological roles of ISMFs...
  3. von Wantoch Rekowski M, Pyriochou A, Papapetropoulos N, Stössel A, Papapetropoulos A, Giannis A. Synthesis and biological evaluation of oxadiazole derivatives as inhibitors of soluble guanylyl cyclase. Bioorg Med Chem. 2010;18:1288-96 pubmed publisher
    ..Our experiments underline the major importance of the oxadiazole ring in ODQ and NS 2028 for the efficiency of this class of inhibitors...
  4. Rodriguez Gil Y, González M, Carcavilla C, Santamaría J. Lines of cell differentiation in solitary fibrous tumor: an ultrastructural and immunohistochemical study of 10 cases. Ultrastruct Pathol. 2009;33:274-85 pubmed publisher
    ..Since their initial description as arising from the pleura, SFTs have been reported in many extraserosal sites. It is now accepted that this neoplasm is derived from mesenchymal cells but its histogenesis is still not known...
  5. Pullens R, Stekelenburg M, Baaijens F, Post M. The influence of endothelial cells on the ECM composition of 3D engineered cardiovascular constructs. J Tissue Eng Regen Med. 2009;3:11-8 pubmed publisher
    ..The layer was co-cultured for 1 and 2 weeks. Although, the collagen production of the MFs was slightly lowered, co-culturing ECs for 1 week results in constructs with good mechanical properties and a confluent EC layer...
  6. Blau H. Cell therapies for muscular dystrophy. N Engl J Med. 2008;359:1403-5 pubmed publisher
  7. Mawaki A, Nakatani T, Sugama J, Konya C. Relationship between the distribution of myofibroblasts, and stellar and circular scar formation due to the contraction of square and circular wound healing. Anat Sci Int. 2007;82:147-55 pubmed
    ..Thus, the earlier disappearance of myofibroblasts in the angles is very important for the formation of stellar scars...
  8. Liu J, Swartz D, Peng H, Gugino S, Russell J, Andreadis S. Functional tissue-engineered blood vessels from bone marrow progenitor cells. Cardiovasc Res. 2007;75:618-28 pubmed
    ..Stem cells have significant potential for development of cell-based therapeutics for cardiovascular tissue regeneration...
  9. Majesky M. Developmental basis of vascular smooth muscle diversity. Arterioscler Thromb Vasc Biol. 2007;27:1248-58 pubmed

More Information

Publications53

  1. Andoh A, Ogawa A, Bamba S, Fujiyama Y. Interaction between interleukin-17-producing CD4+ T cells and colonic subepithelial myofibroblasts: what are they doing in mucosal inflammation?. J Gastroenterol. 2007;42 Suppl 17:29-33 pubmed
    ..Furthermore, based on the data from our laboratory, interaction between Th-17 cells and colonic subepithelial myofibroblasts may play an important role in the pathophysiology of IBS and IBD...
  2. Saada J, Pinchuk I, Barrera C, Adegboyega P, Suarez G, Mifflin R, et al. Subepithelial myofibroblasts are novel nonprofessional APCs in the human colonic mucosa. J Immunol. 2006;177:5968-79 pubmed
    ..Thus, human CMFs may be important in regulating local immunity in the colon...
  3. Terada N, Ohno N, Murata S, Katoh R, Stallcup W, Ohno S. Immunohistochemical study of NG2 chondroitin sulfate proteoglycan expression in the small and large intestines. Histochem Cell Biol. 2006;126:483-90 pubmed
    ..This first report of NG2 proteoglycan expression by ISEMF provides insights into the nature of the interaction of these cells with extracellular matrix and/or intestinal epithelial cells...
  4. Van Lieshout M, Peters G, Rutten M, Baaijens F. A knitted, fibrin-covered polycaprolactone scaffold for tissue engineering of the aortic valve. Tissue Eng. 2006;12:481-7 pubmed
    ..A tissue engineering process that includes cell culture will have to show whether this scaffold, besides mechanically reliable and biocompatible, is suitable to lead to a functional, nonregurgitant, durable aortic valve...
  5. Zhang C, Zhu Z, Liu J, Yang X, Deng A. [Role of connective tissue growth factor in human renal tubular epithelial cell transdifferentiation in vitro]. Zhonghua Yi Xue Za Zhi. 2005;85:2920-5 pubmed
  6. Marlow S, Blennerhassett M. Deficient innervation characterizes intestinal strictures in a rat model of colitis. Exp Mol Pathol. 2006;80:54-66 pubmed
  7. Fang Y, Svoboda K. Nicotine inhibits myofibroblast differentiation in human gingival fibroblasts. J Cell Biochem. 2005;95:1108-19 pubmed
  8. Dai Q, Thompson M, Pippen A, Cherwek H, Taylor D, Annex B. Alterations in endothelial cell proliferation and apoptosis contribute to vascular remodeling following hind-limb ischemia in rabbits. Vasc Med. 2002;7:87-91 pubmed
    ..Modulating apoptosis in ischemic skeletal muscle may present a novel therapeutic target in peripheral arterial disease...
  9. Ball S, Shuttleworth A, Kielty C. Direct cell contact influences bone marrow mesenchymal stem cell fate. Int J Biochem Cell Biol. 2004;36:714-27 pubmed
    ..Thus, direct contact with distinct differentiated cells may be a critical determinant of mesenchymal stem cell fate in blood vessels and other connective tissues...
  10. van der Bas J, Quax P, van den Berg A, Visser M, van der Linden E, van Bockel J. Ingrowth of aorta wall into stent grafts impregnated with basic fibroblast growth factor: a porcine in vivo study of blood vessel prosthesis healing. J Vasc Surg. 2004;39:850-8 pubmed
    ..In this study we evaluated healing with bFGF-heparin-collagen-coated stent grafts in vivo...
  11. Hewitson T, Ho W, Samuel C. Antifibrotic properties of relaxin: in vivo mechanism of action in experimental renal tubulointerstitial fibrosis. Endocrinology. 2010;151:4938-48 pubmed publisher
    ..Not all of these effects paralleled changes to TGF-?-Smad signaling...
  12. Baouz S, Giron Michel J, Azzarone B, Giuliani M, Cagnoni F, Olsson S, et al. Lung myofibroblasts as targets of salmeterol and fluticasone propionate: inhibition of alpha-SMA and NF-kappaB. Int Immunol. 2005;17:1473-81 pubmed
  13. Shin D, Minn K. The effect of myofibroblast on contracture of hypertrophic scar. Plast Reconstr Surg. 2004;113:633-40 pubmed
    ..By utilizing an in vitro model, the authors have demonstrated that myofibroblasts play a more important role in the contracture of the hypertrophic scar...
  14. Roy Chaudhury P, Wang Y, Krishnamoorthy M, Zhang J, Banerjee R, Munda R, et al. Cellular phenotypes in human stenotic lesions from haemodialysis vascular access. Nephrol Dial Transplant. 2009;24:2786-91 pubmed publisher
    ..The aim of the current study was to identify the specific cell types present within stenotic tissue samples from patients with AV fistula and graft failure...
  15. Il inskaia O, Kudriashova E, Antropova I, Kalinina N, Solomatina M, Bobik A, et al. [The origin of neointimal cells in the rat carotid artery after balloon angioplasty]. Tsitologiia. 2003;45:678-89 pubmed
    ..Probably, early smooth muscle and endothelial precursor cells penetrate into injured area with blood stream, where they proliferative and differentiate into mature cells...
  16. Neuhaus J, Scholler U, Freick K, Schwalenberg T, Heinrich M, Horn L, et al. [Myofibroblasts and afferent signalling in the urinary bladder. A concept]. Urologe A. 2008;47:1085-6, 1088-90 pubmed publisher
    ..They possess all features required to take part in the complex interactions with urothelial cells and sensory nerves. Modulation of their function by cytokines may provide a pathomechanism for bladder dysfunction...
  17. Préfontaine A, Calderone A, Dupuis J. Role of endothelin receptors on basal and endothelin-1-stimulated lung myofibroblast proliferation. Can J Physiol Pharmacol. 2008;86:337-42 pubmed publisher
    ..ET-1 levels were not affected by the antagonists. Our findings indicate that both the ETA-R and the ETB-R regulate basal and stimulated lung MYF proliferation and suggest possible interactions between the receptors...
  18. Fu K, Corbley M, Sun L, Friedman J, Shan F, Papadatos J, et al. SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model. Arterioscler Thromb Vasc Biol. 2008;28:665-71 pubmed publisher
    ..TGF-beta plays a significant role in vascular injury-induced stenosis. This study evaluates the efficacy of a novel, small molecule inhibitor of ALK5/ALK4 kinase, in the rat carotid injury model of vascular fibrosis...
  19. Ghajar C, Chen X, Harris J, Suresh V, Hughes C, Jeon N, et al. The effect of matrix density on the regulation of 3-D capillary morphogenesis. Biophys J. 2008;94:1930-41 pubmed
    ..Although roles for matrix stiffness and ligand binding density have previously been identified, our results emphasize the importance of diffusion restrictions in limiting capillary morphogenesis...
  20. Martinez E, Araújo V, Sousa S, Arana Chavez V. TGF-beta1 enhances the expression of alpha-smooth muscle actin in cultured human pulpal fibroblasts: immunochemical and ultrastructural analyses. J Endod. 2007;33:1313-8 pubmed
    ..Both fibroblast types were positive for vimentin. The present findings showed that TGF-beta1 up-regulated the expression of alpha-SMA, thus inducing pulpal fibroblasts to acquire the myofibroblast phenotype...
  21. Oommen K, Newman A. Co-regulation by Notch and Fos is required for cell fate specification of intermediate precursors during C. elegans uterine development. Development. 2007;134:3999-4009 pubmed
    ..We show that FOS-1 is expressed at pi cell specification and can bind in vitro to egl-13 upstream regulatory sequence (URS) as a heterodimer with C. elegans Jun...
  22. Jiang Y, Dai A, Li Q, Hu R. Transforming growth factor-beta1 induces transdifferentiation of fibroblasts into myofibroblasts in hypoxic pulmonary vascular remodeling. Acta Biochim Biophys Sin (Shanghai). 2006;38:29-36 pubmed
    ..Taken together, our results suggested that TGF-beta1 induces transdifferentiation of fibroblasts into myofibroblasts, which is important in hypoxic pulmonary vascular remodeling...
  23. Murray G, Garcia Arraras J. Myogenesis during holothurian intestinal regeneration. Cell Tissue Res. 2004;318:515-24 pubmed
    ..We also provide a comparative view of muscle regeneration in an echinoderm, a topic of interest in view of the many recent studies of muscle regeneration in vertebrate species...
  24. Guyot C, Combe C, Desmouliere A. The common bile duct ligation in rat: A relevant in vivo model to study the role of mechanical stress on cell and matrix behaviour. Histochem Cell Biol. 2006;126:517-23 pubmed
    ..We show here that common bile duct ligation represents an invaluable model to study myofibroblastic differentiation and extracellular matrix adaptation produced by an acute mechanical stress...
  25. Mailleux A, Kelly R, Veltmaat J, De Langhe S, Zaffran S, Thiery J, et al. Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage. Development. 2005;132:2157-66 pubmed
    ..We provide support for a role of epithelial BMP4 in mediating the formation of parabronchial smooth muscle cells...
  26. Nagayama K, Watanabe M. IP10 released by colonic subepithelial myofibroblasts: by which stimuli and for which tissue?. J Gastroenterol. 2005;40:551-2 pubmed
  27. Dai D, Ding Y, Danielson M, Kadirvel R, Hunter L, Zhan W, et al. Endovascular treatment of experimental aneurysms by use of fibroblast-coated platinum coils: an angiographic and histopathologic study. Stroke. 2007;38:170-6 pubmed
    ..Hypotheses included: (1) fibroblast-coated (FBC) platinum coils can improve angiographic results after embolization; and (2) FBC platinum coils can accelerate histological healing of embolized aneurysms...
  28. Yagi Y, Andoh A, Nishida A, Shioya M, Nishimura T, Hashimoto T, et al. Interleukin-31 stimulates production of inflammatory mediators from human colonic subepithelial myofibroblasts. Int J Mol Med. 2007;19:941-6 pubmed
    ..In conclusion, we demonstrated that IL-31 is a potent inducer of proinflammatory mediators in human colonic SEMFs. IL-31 may function as a proinflammatory cytokine derived from Th2 cells...
  29. Rönty M, Leivonen S, Hinz B, Rachlin A, Otey C, Kahari V, et al. Isoform-specific regulation of the actin-organizing protein palladin during TGF-beta1-induced myofibroblast differentiation. J Invest Dermatol. 2006;126:2387-96 pubmed
    ..They also provide for the first time information about the signaling cascades involved in the regulation of palladin expression...
  30. Bledsoe G, Shen B, Yao Y, Zhang J, Chao L, Chao J. Reversal of renal fibrosis, inflammation, and glomerular hypertrophy by kallikrein gene delivery. Hum Gene Ther. 2006;17:545-55 pubmed
    ..These results indicate that tissue kallikrein, through the kinin B2 receptor, reverses salt-induced inflammation, renal fibrosis, and glomerular hypertrophy via suppression of oxidative stress...
  31. Inatomi O, Andoh A, Yagi Y, Bamba S, Tsujikawa T, Fujiyama Y. Regulation of amphiregulin and epiregulin expression in human colonic subepithelial myofibroblasts. Int J Mol Med. 2006;18:497-503 pubmed
    ..We demonstrated expression of amphiregulin and epiregulin in SEMFs. Amphiregulin and epiregulin may play an important role in the mechanism underlying wound healing in damaged colonic mucosa...
  32. Jie K, Zaikova M, Bergevoet M, Westerweel P, Rastmanesh M, Blankestijn P, et al. Progenitor cells and vascular function are impaired in patients with chronic kidney disease. Nephrol Dial Transplant. 2010;25:1875-82 pubmed publisher
    ..Smooth muscle progenitor cells (SPC) may stimulate atherosclerosis development. We hypothesized that an imbalance in EPC and SPC occurs in CKD, which may contribute to the increased cardiovascular disease (CVD) risk...
  33. Niu W, Huang C, Nawaz Z, Levy M, Somwar R, Li D, et al. Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis. J Biol Chem. 2003;278:17953-62 pubmed
    ..Regulation of GLUT4 activity by insulin develops upon muscle cell differentiation and correlates with p38 MAPK activation by insulin...
  34. Kumar A, Metharom P, Schmeckpeper J, Weiss S, Martin K, Caplice N. Bone marrow-derived CX3CR1 progenitors contribute to neointimal smooth muscle cells via fractalkine CX3CR1 interaction. FASEB J. 2010;24:81-92 pubmed publisher
  35. Mattoli S, Bellini A, Schmidt M. The role of a human hematopoietic mesenchymal progenitor in wound healing and fibrotic diseases and implications for therapy. Curr Stem Cell Res Ther. 2009;4:266-80 pubmed
    ..In-vitro expanded fibrocytes may be used to improve ineffective tissue repair or may be engineered for the delivery of gene constructs in anti-cancer therapy...
  36. Hu B, Wu Y, Wu Z, Phan S. Nkx2.5/Csx represses myofibroblast differentiation. Am J Respir Cell Mol Biol. 2010;42:218-26 pubmed publisher
    ..5 as a repressor of alpha-SMA gene transcription, which may be of homeostatic significance as a means of suppressing myofibroblast differentiation in the absence of tissue injury...
  37. Li Q, Fan J, Pu L, Li Z, Qin W, Su B. [Effects of interferon-gamma on tubular epithelial-myofibroblast transdifferentiation in vitro]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008;39:895-9, 943 pubmed
    ..To investigate the effects of interferon-gamma (IFN-gamma) on tubular epithelial-myofibroblast transdifferentiation (TEMT) induced by transforming growth factor (TGF-beta1)...
  38. Inatomi O, Andoh A, Kitamura K, Yasui H, Zhang Z, Fujiyama Y. Butyrate blocks interferon-gamma-inducible protein-10 release in human intestinal subepithelial myofibroblasts. J Gastroenterol. 2005;40:483-9 pubmed
    ..However, the local secretion of IP-10 in the intestine remains unclear. In this study, we investigated IP-10 secretion in human colonic subepithelial myofibroblasts (SEMFs)...
  39. Junker J, Kratz C, Tollbäck A, Kratz G. Mechanical tension stimulates the transdifferentiation of fibroblasts into myofibroblasts in human burn scars. Burns. 2008;34:942-6 pubmed publisher
    ..This indicates that mechanical stimulation using stretching induces fibroblast to myofibroblast transdifferentiation, thus underlining the importance of further investigations of optimal methods of this regime for treating burn scars...
  40. Croons V, Martinet W, Herman A, Timmermans J, De Meyer G. Selective clearance of macrophages in atherosclerotic plaques by the protein synthesis inhibitor cycloheximide. J Pharmacol Exp Ther. 2007;320:986-93 pubmed
    ..All together, these findings demonstrate that cycloheximide decreases the macrophage load in atherosclerotic plaques by induction of apoptosis without changing SMC content or contractility...
  41. Wipff P, Rifkin D, Meister J, Hinz B. Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix. J Cell Biol. 2007;179:1311-23 pubmed
    ..We propose activation of TGF-beta1 via integrin-mediated myofibroblast contraction as a potential checkpoint in the progression of fibrosis, restricting autocrine generation of myofibroblasts to a stiffened ECM...
  42. Serrière Lanneau V, Teixeira Clerc F, Li L, Schippers M, de Wries W, Julien B, et al. The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing. FASEB J. 2007;21:2005-13 pubmed
    ..These results unravel a novel major role of S1P2 in the wound healing response to acute liver injury by a mechanism involving enhanced proliferation of hMF...
  43. Jong Hesse Y, Lang G, Kampmeier J, Lang G. [Effect of growth factors on the differentiation of porcine lens epithelial cells]. Klin Monbl Augenheilkd. 2004;221:175-9 pubmed
    ..This process is characterized by increased expression of alpha-smooth muscle actin (alpha-SMA). This study investigated the influence of bFGF, TGF-beta2, EGF and IGF-1 on the expression of alpha-SMA in porcine LECs...
  44. Neuhaus J, Heinrich M, Schlichting N, Oberbach A, Fitzl G, Schwalenberg T, et al. [Structure and function of suburothelial myofibroblasts in the human urinary bladder under normal and pathological conditions]. Urologe A. 2007;46:1197-202 pubmed
    ..Clarification of the structure and function and of the cellular plasticity of this cell type in the bladder may lead to new insights into the pathogenesis of lower urinary tract disorders...