skeletal muscle satellite cells

Summary

Summary: Elongated, spindle-shaped, quiescent myoblasts lying in close contact with adult skeletal muscle. They are thought to play a role in muscle repair and regeneration.

Top Publications

  1. Dezawa M, Ishikawa H, Itokazu Y, Yoshihara T, Hoshino M, Takeda S, et al. Bone marrow stromal cells generate muscle cells and repair muscle degeneration. Science. 2005;309:314-7 pubmed
    ..These MSCs represent a more ready supply of myogenic cells than do the rare myogenic stem cells normally found in muscle and bone marrow...
  2. Ustanina S, Carvajal J, Rigby P, Braun T. The myogenic factor Myf5 supports efficient skeletal muscle regeneration by enabling transient myoblast amplification. Stem Cells. 2007;25:2006-16 pubmed
    ..We reason that Myf5 supports efficient skeletal muscle regeneration by enabling transient myoblast amplification. Disclosure of potential conflicts of interest is found at the end of this article...
  3. Shefer G, Van de Mark D, Richardson J, Yablonka Reuveni Z. Satellite-cell pool size does matter: defining the myogenic potency of aging skeletal muscle. Dev Biol. 2006;294:50-66 pubmed
    ..This study suggests that the population of satellite cells that participate in myofiber maintenance during routine muscle utilization is not fully replenished throughout life...
  4. Frock R, Kudlow B, Evans A, Jameson S, Hauschka S, Kennedy B. Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation. Genes Dev. 2006;20:486-500 pubmed
    ..The delayed differentiation kinetics and decreased differentiation potential of lamin A/C-deficient and emerin-deficient myoblasts may in part underlie the dystrophic phenotypes observed in patients with EDMD...
  5. Kawano F, Takeno Y, Nakai N, Higo Y, Terada M, Ohira T, et al. Essential role of satellite cells in the growth of rat soleus muscle fibers. Am J Physiol Cell Physiol. 2008;295:C458-67 pubmed publisher
    ..It is suggested that the satellite cell-related stimulation in response to gravitational loading plays an essential role in the cross-sectional growth of soleus muscle fibers...
  6. Gayraud Morel B, Chretien F, Flamant P, Gomès D, Zammit P, Tajbakhsh S. A role for the myogenic determination gene Myf5 in adult regenerative myogenesis. Dev Biol. 2007;312:13-28 pubmed
    ..Therefore, we show that Myf5 is a regulator of regenerative myogenesis and homeostasis, with functions distinct from those of Myod and Mrf4...
  7. Fukada S, Uezumi A, Ikemoto M, Masuda S, Segawa M, Tanimura N, et al. Molecular signature of quiescent satellite cells in adult skeletal muscle. Stem Cells. 2007;25:2448-59 pubmed
    b>Skeletal muscle satellite cells play key roles in postnatal muscle growth and regeneration...
  8. Shinin V, Gayraud Morel B, Tajbakhsh S. Template DNA-strand co-segregation and asymmetric cell division in skeletal muscle stem cells. Methods Mol Biol. 2009;482:295-317 pubmed publisher
    ..In addition, asymmetric segregation of template DNA and the cytoplasmic protein Numb provides a landmark to define cell behaviour as self-renewal and differentiation decisions are being executed...
  9. Zammit P, Partridge T, Yablonka Reuveni Z. The skeletal muscle satellite cell: the stem cell that came in from the cold. J Histochem Cytochem. 2006;54:1177-91 pubmed
    ..This is a fast-moving and dynamic field, however, and in this review we discuss the evidence that we think puts this enigmatic cell firmly back at the center of adult myogenesis...

More Information

Publications62

  1. Collins C, Olsen I, Zammit P, Heslop L, Petrie A, Partridge T, et al. Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche. Cell. 2005;122:289-301 pubmed
    ..Thus, within a normally stable tissue, the satellite cell exhibits archetypal stem cell properties and is competent to form the basal origin of adult muscle regeneration...
  2. Singh N, Chae H, Hwang I, Yoo Y, Ahn C, Lee S, et al. Transdifferentiation of porcine satellite cells to adipoblasts with ciglitizone. J Anim Sci. 2007;85:1126-35 pubmed
    ..2 and approximately 60.4 kDa, respectively), and real-time PCR. Ciglitizone appeared to convert the differentiation pathway of satellite cells into that of adipoblasts...
  3. Gros J, Manceau M, Thomé V, Marcelle C. A common somitic origin for embryonic muscle progenitors and satellite cells. Nature. 2005;435:954-8 pubmed
    ..We conclude that embryonic muscle progenitors and satellite cells share a common origin that can be traced back to the dermomyotome...
  4. Morrison J, Borg P, Simon A. Plasticity and recovery of skeletal muscle satellite cells during limb regeneration. FASEB J. 2010;24:750-6 pubmed publisher
    ..The results demonstrate that except for a transient and subsequently blunted increase, skeletal muscle satellite cells constitute a stable pool of reserve cells for multiple limb regeneration events.-Morrison, J. I...
  5. Schafer R, Zweyer M, Knauf U, Mundegar R, Wernig A. The ontogeny of soleus muscles in mdx and wild type mice. Neuromuscul Disord. 2005;15:57-64 pubmed
    ..Satellite cell numbers showed some considerable variation between individual animals, although with a markedly smaller variability between results of the same animal, pointing to the satellite cell pool being an individual variant...
  6. Shefer G, Yablonka Reuveni Z. Reflections on lineage potential of skeletal muscle satellite cells: do they sometimes go MAD?. Crit Rev Eukaryot Gene Expr. 2007;17:13-29 pubmed
    ..Last, we highlight evidence in favor of satellite cell plasticity and emerging hurdles restraining this hypothesis...
  7. Olguin H, Yang Z, Tapscott S, Olwin B. Reciprocal inhibition between Pax7 and muscle regulatory factors modulates myogenic cell fate determination. J Cell Biol. 2007;177:769-79 pubmed
    ..This could represent an additional mechanism for the control of satellite cell fate decisions resulting in proliferation, differentiation, and self-renewal, necessary for skeletal muscle maintenance and repair...
  8. Carlson M, Conboy I. Loss of stem cell regenerative capacity within aged niches. Aging Cell. 2007;6:371-82 pubmed
    ..Comprehensively, this work points toward novel venues for in situ restoration of tissue repair in the old and identifies critical determinants of successful cell-replacement therapies for aged degenerating organs...
  9. Brack A, Conboy M, Roy S, Lee M, Kuo C, Keller C, et al. Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science. 2007;317:807-10 pubmed
    ..These results indicate that the Wnt signaling pathway may play a critical role in tissue-specific stem cell aging and an increase in tissue fibrosis with age...
  10. Shefer G, Benayahu D. SVEP1 is a novel marker of activated pre-determined skeletal muscle satellite cells. Stem Cell Rev. 2010;6:42-9 pubmed publisher
    ..The impact of this finding is that it may allow scrutinizing signals that affect differentiation commitment. Thus, holds a therapeutic potential for maladies that involve deregulated stem cell fate-decision...
  11. Cerletti M, Jurga S, Witczak C, Hirshman M, Shadrach J, Goodyear L, et al. Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles. Cell. 2008;134:37-47 pubmed publisher
    ..Together, these studies indicate the presence in adult skeletal muscle of prospectively isolatable muscle-forming stem cells and directly demonstrate the efficacy of myogenic stem cell transplant for treating muscle degenerative disease...
  12. Sacco A, Doyonnas R, Kraft P, Vitorovic S, Blau H. Self-renewal and expansion of single transplanted muscle stem cells. Nature. 2008;456:502-6 pubmed publisher
  13. Blau H. Cell therapies for muscular dystrophy. N Engl J Med. 2008;359:1403-5 pubmed publisher
  14. Gnocchi V, White R, Ono Y, Ellis J, Zammit P. Further characterisation of the molecular signature of quiescent and activated mouse muscle satellite cells. PLoS ONE. 2009;4:e5205 pubmed publisher
    ..Conversely, Jagged-1, a Notch ligand, was not expressed in quiescent satellite cells but was induced upon activation. These findings further contribute to defining the molecular signature of muscle satellite cells. ..
  15. Amthor H, Otto A, Vulin A, Rochat A, Dumonceaux J, Garcia L, et al. Muscle hypertrophy driven by myostatin blockade does not require stem/precursor-cell activity. Proc Natl Acad Sci U S A. 2009;106:7479-84 pubmed publisher
    ..It predicts too that any benefits of myostatin blockade in chronic myopathies are unlikely to impose any extra stress on the satellite cells...
  16. Snijders T, Verdijk L, van Loon L. The impact of sarcopenia and exercise training on skeletal muscle satellite cells. Ageing Res Rev. 2009;8:328-38 pubmed publisher
    ..b>Skeletal muscle satellite cells (SC), as precursors of new myonuclei, have been suggested to be involved in the development of ..
  17. Le Grand F, Jones A, Seale V, Scime A, Rudnicki M. Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells. Cell Stem Cell. 2009;4:535-47 pubmed publisher
    ..Therefore, Wnt7a signaling through the planar cell polarity pathway controls the homeostatic level of satellite stem cells and hence regulates the regenerative potential of muscle...
  18. Abou Khalil R, Le Grand F, Pallafacchina G, Valable S, Authier F, Rudnicki M, et al. Autocrine and paracrine angiopoietin 1/Tie-2 signaling promotes muscle satellite cell self-renewal. Cell Stem Cell. 2009;5:298-309 pubmed publisher
    ..We propose that Ang1/Tie-2 signaling regulates mpc self-renewal by controlling the return to quiescence of a subset of satellite cells...
  19. Cosgrove B, Sacco A, Gilbert P, Blau H. A home away from home: challenges and opportunities in engineering in vitro muscle satellite cell niches. Differentiation. 2009;78:185-94 pubmed publisher
  20. Christov C, Chretien F, Abou Khalil R, Bassez G, Vallet G, Authier F, et al. Muscle satellite cells and endothelial cells: close neighbors and privileged partners. Mol Biol Cell. 2007;18:1397-409 pubmed
    ..Thus, SCs are largely juxtavascular and reciprocally interact with ECs during differentiation to support angio-myogenesis...
  21. Schienda J, Engleka K, Jun S, Hansen M, Epstein J, Tabin C, et al. Somitic origin of limb muscle satellite and side population cells. Proc Natl Acad Sci U S A. 2006;103:945-50 pubmed
    ..Thus, we show that the somites, which supply embryonic and fetal myoblasts, are also an important source of highly myogenic adult muscle progenitors...
  22. Jejurikar S, Henkelman E, Cederna P, Marcelo C, Urbanchek M, Kuzon W. Aging increases the susceptibility of skeletal muscle derived satellite cells to apoptosis. Exp Gerontol. 2006;41:828-36 pubmed
    ..These data support the hypothesis that aging increases satellite cell susceptibility to apoptosis. In old muscle, apoptosis may play a causative role in the depletion of satellite cells, impairing the regenerative response to injury...
  23. Conboy I, Rando T. Aging, stem cells and tissue regeneration: lessons from muscle. Cell Cycle. 2005;4:407-10 pubmed
    ..Therefore, it may be that even very old stem cells may be capable of maintaining and repairing aged tissues if provided with optimal environmental cues...
  24. Nagata Y, Partridge T, Matsuda R, Zammit P. Entry of muscle satellite cells into the cell cycle requires sphingolipid signaling. J Cell Biol. 2006;174:245-53 pubmed
    ..Together, our observations show that sphingolipid signaling is involved in the induction of proliferation in an adult stem cell and a key component of muscle regeneration...
  25. Tatsumi R, Liu X, Pulido A, Morales M, Sakata T, Dial S, et al. Satellite cell activation in stretched skeletal muscle and the role of nitric oxide and hepatocyte growth factor. Am J Physiol Cell Physiol. 2006;290:C1487-94 pubmed
    ..The results of these experiments demonstrate that stretching muscle liberates HGF in a NO-dependent manner, which can activate satellite cells...
  26. Montarras D, Morgan J, Collins C, Relaix F, Zaffran S, Cumano A, et al. Direct isolation of satellite cells for skeletal muscle regeneration. Science. 2005;309:2064-7 pubmed
    ..Such cells, grafted into muscles of mdx nu/nu mice, contributed both to fiber repair and to the muscle satellite cell compartment. Expansion of these cells in culture before engraftment reduced their regenerative capacity...
  27. Zammit P. All muscle satellite cells are equal, but are some more equal than others?. J Cell Sci. 2008;121:2975-82 pubmed publisher
    ..This Commentary seeks to integrate these interesting new findings into the wider context of satellite-cell biology, and to highlight some of the many outstanding questions...
  28. Relaix F, Montarras D, Zaffran S, Gayraud Morel B, Rocancourt D, Tajbakhsh S, et al. Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells. J Cell Biol. 2006;172:91-102 pubmed
    ..These findings underline the importance of cell survival in controlling the stem cell populations of adult tissues and demonstrate a role for upstream factors in this context...
  29. Collins C, Partridge T. Self-renewal of the adult skeletal muscle satellite cell. Cell Cycle. 2005;4:1338-41 pubmed
    ..The satellite cell may thus serve as a prototype for stem cell function in stable adult tissues: a tissue-specific progenitor which is normally quiescent but which has self-renewal properties similar to those of better known stem cells...
  30. Gnocchi V, Ellis J, Zammit P. Does satellite cell dysfunction contribute to disease progression in Emery-Dreifuss muscular dystrophy?. Biochem Soc Trans. 2008;36:1344-9 pubmed publisher
  31. Wagers A, Conboy I. Cellular and molecular signatures of muscle regeneration: current concepts and controversies in adult myogenesis. Cell. 2005;122:659-67 pubmed
  32. Kuang S, Chargé S, Seale P, Huh M, Rudnicki M. Distinct roles for Pax7 and Pax3 in adult regenerative myogenesis. J Cell Biol. 2006;172:103-13 pubmed
  33. Rhoads R, Johnson R, Rathbone C, Liu X, Temm Grove C, Sheehan S, et al. Satellite cell-mediated angiogenesis in vitro coincides with a functional hypoxia-inducible factor pathway. Am J Physiol Cell Physiol. 2009;296:C1321-8 pubmed publisher
    ..Collectively, these initial observations suggest that a heretofore unexplored aspect of satellite cell physiology is the initiation of a proangiogenic program...
  34. Brooks N, Schuenke M, Hikida R. No change in skeletal muscle satellite cells in young and aging rat soleus muscle. J Physiol Sci. 2009;59:465-71 pubmed publisher
    ..We conclude that satellite cell number does not decrease with age and postulate that satellite cell functionality may be responsible for age-related sarcopenia...
  35. Fulle S, Di Donna S, Puglielli C, Pietrangelo T, Beccafico S, Bellomo R, et al. Age-dependent imbalance of the antioxidative system in human satellite cells. Exp Gerontol. 2005;40:189-97 pubmed
    ..This status is derived from a decrease in the antioxidative capacity, and may negatively affect the ageing satellite cells ability to repair muscle...
  36. Yamada M, Tatsumi R, Yamanouchi K, Hosoyama T, Shiratsuchi S, Sato A, et al. High concentrations of HGF inhibit skeletal muscle satellite cell proliferation in vitro by inducing expression of myostatin: a possible mechanism for reestablishing satellite cell quiescence in vivo. Am J Physiol Cell Physiol. 2010;298:C465-76 pubmed publisher
    ..This time lag may delay action of the quiescence signaling program in proliferating satellite cells during initial phases of muscle regeneration followed by induction of quiescence in a subset of cells during later phases...
  37. Sherwood R, Christensen J, Conboy I, Conboy M, Rando T, Weissman I, et al. Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle. Cell. 2004;119:543-54 pubmed
    ..Together, these studies describe the clonal isolation of functional adult myogenic progenitors and demonstrate that these cells do not arise from hematopoietic or other bone marrow or circulating precursors...
  38. Holterman C, Le Grand F, Kuang S, Seale P, Rudnicki M. Megf10 regulates the progression of the satellite cell myogenic program. J Cell Biol. 2007;179:911-22 pubmed
    ..We conclude that Megf10 represents a novel transmembrane protein that impinges on Notch signaling to regulate the satellite cell population balance between proliferation and differentiation...
  39. Liu Y, Yan X, Sun Z, Chen B, Han Q, Li J, et al. Flk-1+ adipose-derived mesenchymal stem cells differentiate into skeletal muscle satellite cells and ameliorate muscular dystrophy in mdx mice. Stem Cells Dev. 2007;16:695-706 pubmed
    ..These cells also differentiated into endothelial cells, thereby possibly improving fiber regeneration as a result of the induced angiogenesis. Therefore, Flk-1(+) AD-MSC transplants may repair muscular dystrophy...
  40. Kuang S, Rudnicki M. The emerging biology of satellite cells and their therapeutic potential. Trends Mol Med. 2008;14:82-91 pubmed publisher
    ..Here, we review the latest advances in our current understanding of the quiescence, activation, proliferation and self-renewal of satellite cells and the challenges in the development of satellite cell-based regenerative medicine...
  41. Vasyutina E, Lenhard D, Wende H, Erdmann B, Epstein J, Birchmeier C. RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells. Proc Natl Acad Sci U S A. 2007;104:4443-8 pubmed
    ..In addition, satellite cells are not formed late in fetal development in conditional RBP-J mutant mice. We conclude that RBP-J is required in the developing muscle to set aside proliferating progenitors and satellite cells...
  42. Peault B, Rudnicki M, Torrente Y, Cossu G, Tremblay J, Partridge T, et al. Stem and progenitor cells in skeletal muscle development, maintenance, and therapy. Mol Ther. 2007;15:867-77 pubmed
    ..As an alternative to myoblast transplantation, stem cells such as mesoangioblasts and CD133+ progenitors administered through blood circulation have recently shown great potential to regenerate dystrophic muscle...
  43. Sun H, Li L, Vercherat C, Gulbagci N, Acharjee S, Li J, et al. Stra13 regulates satellite cell activation by antagonizing Notch signaling. J Cell Biol. 2007;177:647-57 pubmed
    ..Thus, Stra13 plays an important role in postnatal myogenesis by attenuating Notch signaling to reduce myoblast proliferation and promote myogenic differentiation...
  44. Day K, Shefer G, Richardson J, Enikolopov G, Yablonka Reuveni Z. Nestin-GFP reporter expression defines the quiescent state of skeletal muscle satellite cells. Dev Biol. 2007;304:246-59 pubmed
    ..The NES-GFP model reveals unique transcriptional activity within quiescent satellite cells and permits novel insight into the heterogeneity of their molecular signatures...
  45. Scicchitano B, Spath L, Musaro A, Molinaro M, Rosenthal N, Nervi C, et al. Vasopressin-dependent myogenic cell differentiation is mediated by both Ca2+/calmodulin-dependent kinase and calcineurin pathways. Mol Biol Cell. 2005;16:3632-41 pubmed
    ..Although MEF2-NFATc1 complexes appear to regulate the expression of an early muscle-specific gene product (myogenin), the activation of late muscle-specific gene expression (MCK) involves the formation of complexes including GATA2. ..
  46. Kuang S, Kuroda K, Le Grand F, Rudnicki M. Asymmetric self-renewal and commitment of satellite stem cells in muscle. Cell. 2007;129:999-1010 pubmed
    ..These results provide critical insights into satellite cell biology and open new avenues for therapeutic treatment of neuromuscular diseases...
  47. Luo D, Renault V, Rando T. The regulation of Notch signaling in muscle stem cell activation and postnatal myogenesis. Semin Cell Dev Biol. 2005;16:612-22 pubmed
  48. Machida S, Narusawa M. The roles of satellite cells and hematopoietic stem cells in impaired regeneration of skeletal muscle in old rats. Ann N Y Acad Sci. 2006;1067:349-53 pubmed
    ..To understand the cellular mechanisms of sarcopenia, we examined the expression of satellite cells and hematopoietic stem cells in old regenerating muscles based on the expression profiles of several markers related to those cells...
  49. Holterman C, Rudnicki M. Molecular regulation of satellite cell function. Semin Cell Dev Biol. 2005;16:575-84 pubmed
    ..Furthermore, the ability of non-muscle derived stem cells and the potential multipotency of satellite cells have altered the traditional views of skeletal muscle regeneration...
  50. Shinin V, Gayraud Morel B, Gomès D, Tajbakhsh S. Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells. Nat Cell Biol. 2006;8:677-87 pubmed
    ..The cosegregation of 'immortal' template DNA strands and their link with the asymmetry apparatus has important implications for stem cell biology and cancer...
  51. Collins C, Zammit P. Isolation and grafting of single muscle fibres. Methods Mol Biol. 2009;482:319-30 pubmed publisher
    ..Here, we describe methods for the isolation of viable muscle fibres and for grafting of muscle fibres and their associated satellite cells into mouse muscles to assess the contribution of satellite cells to muscle regeneration...
  52. Tatsumi R, Yamada M, Katsuki Y, Okamoto S, Ishizaki J, Mizunoya W, et al. Low-pH preparation of skeletal muscle satellite cells can be used to study activation in vitro. Int J Biochem Cell Biol. 2006;38:1678-85 pubmed
    ..Cell yield and myogenic purity were not affected by the modifications. The low-pH procedure could provide an improved satellite cell model for in vitro activation experiments...
  53. Zhang X, Liu C, Nestor K, McFarland D, Velleman S. The effect of glypican-1 glycosaminoglycan chains on turkey myogenic satellite cell proliferation, differentiation, and fibroblast growth factor 2 responsiveness. Poult Sci. 2007;86:2020-8 pubmed
    ..These data indicate that glypican-1 function requires the GAG chain attachment sites for myogenic satellite cell FGF2 responsiveness during proliferation and to affect the process of differentiation...