cardiac myoblasts

Summary

Summary: Precursor cells destined to differentiate into cardiac myocytes (MYOCYTES, CARDIAC).

Top Publications

  1. Bonavita F, Stefanelli C, Giordano E, Columbaro M, Facchini A, Bonafe F, et al. H9c2 cardiac myoblasts undergo apoptosis in a model of ischemia consisting of serum deprivation and hypoxia: inhibition by PMA. FEBS Lett. 2003;536:85-91 pubmed
    ..Phorbol-12-myristate-13-acetate significantly reduced the induction of apoptosis, inhibiting caspase 3 cleavage, Bax accumulation, Bcl-xL down-regulation as well as restoring cell viability...
  2. Madonna R, Di Napoli P, Massaro M, Grilli A, Felaco M, De Caterina A, et al. Simvastatin attenuates expression of cytokine-inducible nitric-oxide synthase in embryonic cardiac myoblasts. J Biol Chem. 2005;280:13503-11 pubmed
    ..reductase with simvastatin on the expression of inducible nitric-oxide synthase (iNOS) in embryonic cardiac myoblasts stimulated with the proinflammatory cytokines, interleukin-1 or tumor necrosis factor...
  3. Agnetti G, Maraldi T, Fiorentini D, Giordano E, Prata C, Hakim G, et al. Activation of glucose transport during simulated ischemia in H9c2 cardiac myoblasts is mediated by protein kinase C isoforms. Life Sci. 2005;78:264-70 pubmed
  4. Bidez P, Li S, Macdiarmid A, Venancio E, Wei Y, Lelkes P. Polyaniline, an electroactive polymer, supports adhesion and proliferation of cardiac myoblasts. J Biomater Sci Polym Ed. 2006;17:199-212 pubmed
    ..We have investigated the adhesion and proliferation properties of H9c2 cardiac myoblasts on a conductive polyaniline substrate...
  5. Fujita T, Otsu K, Oshikawa J, Hori H, Kitamura H, Ito T, et al. Caveolin-3 inhibits growth signal in cardiac myoblasts in a Ca2+-dependent manner. J Cell Mol Med. 2006;10:216-24 pubmed
    ..Our findings suggest that caveolin exhibits growth inhibition in a Ca2+-dependent manner, most likely through PKC, in cardiac myoblasts.
  6. Gupta M, Neelakantan T, Sanghamitra M, Tyagi R, Dinda A, Maulik S, et al. An assessment of the role of reactive oxygen species and redox signaling in norepinephrine-induced apoptosis and hypertrophy of H9c2 cardiac myoblasts. Antioxid Redox Signal. 2006;8:1081-93 pubmed
    ..H9c2 cardiac myoblasts upon treatment with hypertrophic and apoptotic doses of NE (2 and 100 microM, respectively) transiently ..
  7. Tantini B, Fiumana E, Cetrullo S, Pignatti C, Bonavita F, Shantz L, et al. Involvement of polyamines in apoptosis of cardiac myoblasts in a model of simulated ischemia. J Mol Cell Cardiol. 2006;40:775-82 pubmed
    ..In conclusion, this finding may suggest novel pharmacological approaches for the protection of cardiomyocytes injury caused by ischemia...
  8. Canepa M, Coviello D, Chiarella F. [Cardiac cell therapy: the puzzle is waiting to be solved]. G Ital Cardiol (Rome). 2006;7:252-65 pubmed
    ..5) Who might be the suitable patient? Further multicenter randomized trials with adequate patient selection are needed to answer this crucial question...
  9. McMullen N, Zhang F, Hotchkiss A, Bretzner F, Wilson J, Ma H, et al. Functional characterization of cardiac progenitor cells and their derivatives in the embryonic heart post-chamber formation. Dev Dyn. 2009;238:2787-99 pubmed publisher
    ..Our data suggest that these inhibitory pathways may delay functional specification in a subset of developing ventricular cells...
  10. Maeda S, Sakamoto K, Matsuoka I, Iwamoto T, Kimura J. Lysophosphatidylcholine increases Na+/Ca2+ exchanger expression via RhoB-geranylgeranylation in H9c2 cells. J Pharmacol Sci. 2009;109:565-72 pubmed
    ..We conclude that geranylgeranylation, but not farnesylation, of RhoB mediates LPC-induced NCX1 mRNA increase in H9c2 cells...

Detail Information

Publications62

  1. Bonavita F, Stefanelli C, Giordano E, Columbaro M, Facchini A, Bonafe F, et al. H9c2 cardiac myoblasts undergo apoptosis in a model of ischemia consisting of serum deprivation and hypoxia: inhibition by PMA. FEBS Lett. 2003;536:85-91 pubmed
    ..Phorbol-12-myristate-13-acetate significantly reduced the induction of apoptosis, inhibiting caspase 3 cleavage, Bax accumulation, Bcl-xL down-regulation as well as restoring cell viability...
  2. Madonna R, Di Napoli P, Massaro M, Grilli A, Felaco M, De Caterina A, et al. Simvastatin attenuates expression of cytokine-inducible nitric-oxide synthase in embryonic cardiac myoblasts. J Biol Chem. 2005;280:13503-11 pubmed
    ..reductase with simvastatin on the expression of inducible nitric-oxide synthase (iNOS) in embryonic cardiac myoblasts stimulated with the proinflammatory cytokines, interleukin-1 or tumor necrosis factor...
  3. Agnetti G, Maraldi T, Fiorentini D, Giordano E, Prata C, Hakim G, et al. Activation of glucose transport during simulated ischemia in H9c2 cardiac myoblasts is mediated by protein kinase C isoforms. Life Sci. 2005;78:264-70 pubmed
  4. Bidez P, Li S, Macdiarmid A, Venancio E, Wei Y, Lelkes P. Polyaniline, an electroactive polymer, supports adhesion and proliferation of cardiac myoblasts. J Biomater Sci Polym Ed. 2006;17:199-212 pubmed
    ..We have investigated the adhesion and proliferation properties of H9c2 cardiac myoblasts on a conductive polyaniline substrate...
  5. Fujita T, Otsu K, Oshikawa J, Hori H, Kitamura H, Ito T, et al. Caveolin-3 inhibits growth signal in cardiac myoblasts in a Ca2+-dependent manner. J Cell Mol Med. 2006;10:216-24 pubmed
    ..Our findings suggest that caveolin exhibits growth inhibition in a Ca2+-dependent manner, most likely through PKC, in cardiac myoblasts.
  6. Gupta M, Neelakantan T, Sanghamitra M, Tyagi R, Dinda A, Maulik S, et al. An assessment of the role of reactive oxygen species and redox signaling in norepinephrine-induced apoptosis and hypertrophy of H9c2 cardiac myoblasts. Antioxid Redox Signal. 2006;8:1081-93 pubmed
    ..H9c2 cardiac myoblasts upon treatment with hypertrophic and apoptotic doses of NE (2 and 100 microM, respectively) transiently ..
  7. Tantini B, Fiumana E, Cetrullo S, Pignatti C, Bonavita F, Shantz L, et al. Involvement of polyamines in apoptosis of cardiac myoblasts in a model of simulated ischemia. J Mol Cell Cardiol. 2006;40:775-82 pubmed
    ..In conclusion, this finding may suggest novel pharmacological approaches for the protection of cardiomyocytes injury caused by ischemia...
  8. Canepa M, Coviello D, Chiarella F. [Cardiac cell therapy: the puzzle is waiting to be solved]. G Ital Cardiol (Rome). 2006;7:252-65 pubmed
    ..5) Who might be the suitable patient? Further multicenter randomized trials with adequate patient selection are needed to answer this crucial question...
  9. McMullen N, Zhang F, Hotchkiss A, Bretzner F, Wilson J, Ma H, et al. Functional characterization of cardiac progenitor cells and their derivatives in the embryonic heart post-chamber formation. Dev Dyn. 2009;238:2787-99 pubmed publisher
    ..Our data suggest that these inhibitory pathways may delay functional specification in a subset of developing ventricular cells...
  10. Maeda S, Sakamoto K, Matsuoka I, Iwamoto T, Kimura J. Lysophosphatidylcholine increases Na+/Ca2+ exchanger expression via RhoB-geranylgeranylation in H9c2 cells. J Pharmacol Sci. 2009;109:565-72 pubmed
    ..We conclude that geranylgeranylation, but not farnesylation, of RhoB mediates LPC-induced NCX1 mRNA increase in H9c2 cells...
  11. Patel A, Genovese J. Stem cell therapy for the treatment of heart failure. Curr Opin Cardiol. 2007;22:464-70 pubmed
    ..A number of issues remain as to the type of cells, delivery, timing, and mechanisms involved, however...
  12. Tateishi K, Ashihara E, Takehara N, Nomura T, Honsho S, Nakagami T, et al. Clonally amplified cardiac stem cells are regulated by Sca-1 signaling for efficient cardiovascular regeneration. J Cell Sci. 2007;120:1791-800 pubmed
    ..Thus, Sca-1 might be an essential component to promote CSC proliferation and survival to directly facilitate early engraftment, and might indirectly exert the effects on late cardiovascular differentiation after CSC transplantation...
  13. Menasche P. [Perspectives in cardiac cell therapy]. Presse Med. 2007;36:1007-11 pubmed
    ..Three challenges remain to obtain optimal therapeutic benefits: prevent the migration of these cells, increase their survival, and improve their integration into the recipient myocardium...
  14. Yuan W, Zhang Y, Tang W, Wang J, Li Y, Wang Y, et al. Role of svp in Drosophila pericardial cell growth. Yi Chuan Xue Bao. 2006;33:32-40 pubmed
  15. Siepe M, Giraud M, Pavlovic M, Receputo C, Beyersdorf F, Menasche P, et al. Myoblast-seeded biodegradable scaffolds to prevent post-myocardial infarction evolution toward heart failure. J Thorac Cardiovasc Surg. 2006;132:124-31 pubmed
    ..We previously reported on the bioengineering of myoblast-based constructs. We investigate here the functional outcome of infarcted hearts treated by implantation of myoblast-seeded scaffolds...
  16. Martinez E, Wang J, Gan S, Singh R, Lee C, Kofidis T. Ascorbic acid improves embryonic cardiomyoblast cell survival and promotes vascularization in potential myocardial grafts in vivo. Tissue Eng Part A. 2010;16:1349-61 pubmed publisher
    ..In this study, we identified AA as a potent supplement that improves cardiomyoblast survival and promotes neovascularization in bioartificial grafts...
  17. Kandasamy A, Schulz R. Glycogen synthase kinase-3beta is activated by matrix metalloproteinase-2 mediated proteolysis in cardiomyoblasts. Cardiovasc Res. 2009;83:698-706 pubmed publisher
    ..Glycogen synthase kinase (GSK)-3beta is dysregulated during oxidative stress and is susceptible to proteolytic cleavage. Here we determined whether GSK-3beta is a MMP-2 substrate as a result of oxidative stress...
  18. Khryapenkova T, Plotnikov E, Korotetskaya M, Sukhikh G, Zorov D. Heterogeneity of mitochondrial potential as a marker for isolation of pure cardiomyoblast population. Bull Exp Biol Med. 2008;146:506-11 pubmed
    ..These results open possibilities for the development of a new specific method for isolation of cardiomyocyte culture from fetal and embryonic sources for their further use in clinical practice...
  19. Zelarayan L, Noack C, Sekkali B, Kmecova J, Gehrke C, Renger A, et al. Beta-Catenin downregulation attenuates ischemic cardiac remodeling through enhanced resident precursor cell differentiation. Proc Natl Acad Sci U S A. 2008;105:19762-7 pubmed publisher
    ..9 +/- 2.4% alpha-actin(pos), P < 0.001). We conclude that beta-catenin depletion attenuates postinfarct LV remodeling in part through increased differentiation of GATA4(pos)/Sca-1(pos) resident cardiac progenitor cells...
  20. Itoh K, Minakawa M, Ono Y, Tsushima T, Fukui K, Fukuda I. Role of oxidative stress in hypertrophied myoblasts stimulated by isoproterenol. Gen Thorac Cardiovasc Surg. 2008;56:170-6 pubmed publisher
    ..As a mechanism contributing to progression of hypertrophy, we hypothesized that the formation of H(2)O(2) to improve glucose uptake could be an oxidative stress resulting in apoptotic cell death...
  21. Puceat M, Jaconi M. Ca2+ signalling in cardiogenesis. Cell Calcium. 2005;38:383-9 pubmed
    ..Evidence is accumulating to foresee Ca2+ as a major second messenger in directing the fate of stem cells and patterning the heart in the embryo...
  22. Tillmanns J, Rota M, Hosoda T, Misao Y, Esposito G, Gonzalez A, et al. Formation of large coronary arteries by cardiac progenitor cells. Proc Natl Acad Sci U S A. 2008;105:1668-73 pubmed publisher
    ..In conclusion, locally delivered activated CPCs generate de novo coronary vasculature and may be implemented clinically for restoration of blood supply to the ischemic myocardium...
  23. Smart N, Risebro C, Melville A, Moses K, Schwartz R, Chien K, et al. Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature. 2007;445:177-82 pubmed
  24. Abuarqoub H, Green C, Foresti R, Motterlini R. Curcumin reduces cold storage-induced damage in human cardiac myoblasts. Exp Mol Med. 2007;39:139-48 pubmed
    ..Thus, curcumin added to Celsior preservation solution effectively prevents the damage caused by cold-storage; this effect involves the protective enzyme HO-1 but also other not yet identified mechanisms...
  25. McKneally M. Controversies in cardiothoracic surgery: should therapeutic cloning be supported to provide stem cells for cardiothoracic surgery research and treatment?. J Thorac Cardiovasc Surg. 2006;131:937-40 pubmed
  26. Scott I, Masri B, D Amico L, Jin S, Jungblut B, Wehman A, et al. The g protein-coupled receptor agtrl1b regulates early development of myocardial progenitors. Dev Cell. 2007;12:403-13 pubmed
    ..These results support a model in which agtrl1b regulates the migration of cells fated to form myocardial progenitors...
  27. Turakhia S, Venkatakrishnan C, Dunsmore K, Wong H, Kuppusamy P, Zweier J, et al. Doxorubicin-induced cardiotoxicity: direct correlation of cardiac fibroblast and H9c2 cell survival and aconitase activity with heat shock protein 27. Am J Physiol Heart Circ Physiol. 2007;293:H3111-21 pubmed
    ..Such a protection of aconitase by HSP27 eliminates the catalytic recycling of aconitase released Fe(II) and its deleterious effects in cardiac cells...
  28. Quertermous T. Apelin and its g protein-coupled receptor regulate cardiac development as well as cardiac function. Dev Cell. 2007;12:319-20 pubmed
    ..In this issue of Developmental Cell, experiments in zebrafish convincingly show a critical role for this pathway in myocardial cell specification and heart development...
  29. Porter K, Turner N, O Regan D, Ball S. Tumor necrosis factor alpha induces human atrial myofibroblast proliferation, invasion and MMP-9 secretion: inhibition by simvastatin. Cardiovasc Res. 2004;64:507-15 pubmed
    ..This study investigated the effect of TNFalpha on human cardiac myofibroblast proliferation, invasion and MMP-9 secretion, and determined whether these properties were modulated by simvastatin...
  30. Zimmermann W, Eschenhagen T. Tissue engineering of aortic heart valves. Cardiovasc Res. 2003;60:460-2 pubmed
  31. Nasim M, Chernova T, Chowdhury H, Yue B, Eperon I. HnRNP G and Tra2beta: opposite effects on splicing matched by antagonism in RNA binding. Hum Mol Genet. 2003;12:1337-48 pubmed
    ..It is included to a higher level after transfection of a mini-gene into rodent cardiac myoblasts than into skeletal muscle myoblasts...
  32. Grego Bessa J, Luna Zurita L, del Monte G, Bolós V, Melgar P, Arandilla A, et al. Notch signaling is essential for ventricular chamber development. Dev Cell. 2007;12:415-29 pubmed
    ..We suggest that during trabeculation Notch independently regulates cardiomyocyte proliferation and differentiation, two exquisitely balanced processes whose perturbation may result in congenital heart disease...
  33. Kondo Nakamura M, Shintani Ishida K, Uemura K, Yoshida K. Brief exposure to carbon monoxide preconditions cardiomyogenic cells against apoptosis in ischemia-reperfusion. Biochem Biophys Res Commun. 2010;393:449-54 pubmed publisher
    ..These results suggest that CO pretreatment induces mitochondrial generation of O2(-), which is then converted by SOD to H2O2, and subsequent Akt activation by H2O2 attenuates apoptosis in ischemia-reperfusion...
  34. Nishikimi T. [Urotensin II and cardiac disease]. Nihon Rinsho. 2004;62 Suppl 9:722-6 pubmed
  35. Maeda S, Matsuoka I, Iwamoto T, Kurose H, Kimura J. Down-regulation of Na+/Ca2+ exchanger by fluvastatin in rat cardiomyoblast H9c2 cells: involvement of RhoB in Na+/Ca2+ exchanger mRNA stability. Mol Pharmacol. 2005;68:414-20 pubmed
    ..Long-term treatment of rat with Flv in vivo also down-regulated the cardiac NCX1 mRNA. These results suggest that a RhoB-mediated signaling pathway regulates cardiac NCX1 levels by controlling the NCX1 mRNA stability...
  36. Pagano M, Naviglio S, Spina A, Chiosi E, Castoria G, Romano M, et al. Differentiation of H9c2 cardiomyoblasts: The role of adenylate cyclase system. J Cell Physiol. 2004;198:408-16 pubmed
    ..The functional relationship between intracellular cAMP content and protein levels of AC system is discussed...
  37. Wang J, Tao Y, Reim I, Gajewski K, Frasch M, Schulz R. Expression, regulation, and requirement of the toll transmembrane protein during dorsal vessel formation in Drosophila melanogaster. Mol Cell Biol. 2005;25:4200-10 pubmed
    ..Such findings implicate Toll as a critical cell adhesion molecule in the alignment and migration of cardioblasts during dorsal vessel morphogenesis...
  38. Kato J, Kitamura K, Eto T. [Adrenomedullin in heart failure]. Nihon Rinsho. 2004;62 Suppl 9:269-72 pubmed
  39. Memon I, Sawa Y, Fukushima N, Matsumiya G, Miyagawa S, Taketani S, et al. Repair of impaired myocardium by means of implantation of engineered autologous myoblast sheets. J Thorac Cardiovasc Surg. 2005;130:1333-41 pubmed
  40. Sathishkumar K, Haque M, Perumal T, Francis J, Uppu R. A major ozonation product of cholesterol, 3beta-hydroxy-5-oxo-5,6-secocholestan-6-al, induces apoptosis in H9c2 cardiomyoblasts. FEBS Lett. 2005;579:6444-50 pubmed
    ..This study, for the first time, demonstrates the induction of apoptotic cell death in cardiomyocytes by a cholesterol ozonation product, implying a role for ozone in myocardial injury...
  41. Ott H, Berjukow S, Marksteiner R, Margreiter E, Bock G, Laufer G, et al. On the fate of skeletal myoblasts in a cardiac environment: down-regulation of voltage-gated ion channels. J Physiol. 2004;558:793-805 pubmed
    ..The down-regulation of ion channels and changes in potassium current kinetics suggest that the environment provided by infarcted myocardium affects expression of voltage-gated ion channels of skeletal myoblasts...
  42. Parmacek M, Epstein J. Pursuing cardiac progenitors: regeneration redux. Cell. 2005;120:295-8 pubmed
    ..Despite this progress, the physiologic role and therapeutic potential of cardiac resident progenitor cells remain unclear...
  43. Leri A, Kajstura J, Nadal Ginard B, Anversa P. Some like it plastic. Circ Res. 2004;94:132-4 pubmed
  44. Gilleron M, Marechal X, Montaigne D, Franczak J, Neviere R, Lancel S. NADPH oxidases participate to doxorubicin-induced cardiac myocyte apoptosis. Biochem Biophys Res Commun. 2009;388:727-31 pubmed publisher
    ..In conclusion, NADPH oxidases participate to doxorubicin-induced cardiac apoptosis...
  45. Lee S, Chanoit G, McIntosh R, Zvara D, Xu Z. Molecular mechanism underlying Akt activation in zinc-induced cardioprotection. Am J Physiol Heart Circ Physiol. 2009;297:H569-75 pubmed publisher
    ..Taken together, these findings demonstrate that exogenous zinc activates Akt via IGF-1RTK and prevents the mPTP opening in cardiac cells. Inactivation of Ser/Thr protein phosphatases may also contribute to zinc-induced Akt activation...
  46. Radisic M, Euloth M, Yang L, Langer R, Freed L, Vunjak Novakovic G. High-density seeding of myocyte cells for cardiac tissue engineering. Biotechnol Bioeng. 2003;82:403-14 pubmed
    ..Direct perfusion can thus enable seeding of hypoxia-sensitive cells at physiologically high and spatially uniform initial densities and maintain cell viability and function...
  47. Kuehn B. Discovery boosts hope for heart repair. JAMA. 2005;293:1434-5 pubmed
  48. Vindis C, D Angelo R, Mucher E, Negre Salvayre A, Parini A, Mialet Perez J. Essential role of TRPC1 channels in cardiomyoblasts hypertrophy mediated by 5-HT2A serotonin receptors. Biochem Biophys Res Commun. 2010;391:979-83 pubmed publisher
    ..These findings provide new insights about a mechanistic basis for the activation of the calcineurin/NFAT pathway by 5-HT(2A) receptors and highlight the critical role of TRPC1 in the development of cardiac hypertrophy...
  49. Lee J, Tan C, Lee S, Kim Y, Lee K. Controlled delivery of heat shock protein using an injectable microsphere/hydrogel combination system for the treatment of myocardial infarction. J Control Release. 2009;137:196-202 pubmed publisher
    ..This approach to controlling the release behavior of TAT-HSP27 using microsphere/hydrogel combination delivery systems may be useful for treating myocardial infarction in a minimally invasive manner...
  50. Tsuchikane E, Taketani S, Shimogami M, Sawa Y, Katoh O. A novel catheter system for percutaneous intracoronary artery cardiomyoplasty. J Invasive Cardiol. 2008;20:357-60 pubmed
    ..Cell and tissue therapies are a promising treatment alternative for patients with severe ischemic heart disease...
  51. Fijnvandraat A, Lekanne Deprez R, Moorman A. Development of heart muscle-cell diversity: a help or a hindrance for phenotyping embryonic stem cell-derived cardiomyocytes. Cardiovasc Res. 2003;58:303-12 pubmed
    ..Although for the phenotyping of ESDCs a comparison should be made with the phenotypes of the developing heart, so far none of the currently available markers allow unequivocal assignment of subtypes...
  52. Uetani T, Nakayama H, Okayama H, Okura T, Higaki J, Inoue H, et al. Insufficiency of pro-heparin-binding epidermal growth factor-like growth factor shedding enhances hypoxic cell death in H9c2 cardiomyoblasts via the activation of caspase-3 and c-Jun N-terminal kinase. J Biol Chem. 2009;284:12399-409 pubmed publisher
    ..These data indicate that insufficiency of proHB-EGF shedding under hypoxic stress leads to cardiomyocyte apoptosis via Caspase-3- and JNK-dependent pathways...
  53. Zhang X, Ma Y, Wen Y, Xu X. [Erythropoietin suppresses the expressions of TGF-beta1 and collagen in rat cardiac fibroblasts induced by angiotensin II]. Zhonghua Xin Xue Guan Bing Za Zhi. 2008;36:636-40 pubmed
  54. Kumar S, Yong S, Dheen S, Bay B, Tay S. Cardiac malformations are associated with altered expression of vascular endothelial growth factor and endothelial nitric oxide synthase genes in embryos of diabetic mice. Exp Biol Med (Maywood). 2008;233:1421-32 pubmed publisher
    ..It is suggested that hyperglycemia alters the expression of eNOS and VEGF genes that are involved in the regulation of cell growth and vasculogenesis, thereby contributing to the cardiac malformations seen in embryos from diabetic mice...
  55. Nakanishi C, Yamagishi M, Yamahara K, Hagino I, Mori H, Sawa Y, et al. Activation of cardiac progenitor cells through paracrine effects of mesenchymal stem cells. Biochem Biophys Res Commun. 2008;374:11-6 pubmed publisher
    ..In conclusion, MSC-derived conditioned medium had protective effects on CPC and enhanced their migration and differentiation...
  56. Koller A, Haid C. Is restoring regenerative potential a way to prevent anthracycline cardiotoxicity? A hypothesis. Med Sci Monit. 2005;11:HY21-23 pubmed
    ..g. by dexrazoxane)...
  57. Planat Benard V, Menard C, Andre M, Puceat M, Perez A, Garcia Verdugo J, et al. Spontaneous cardiomyocyte differentiation from adipose tissue stroma cells. Circ Res. 2004;94:223-9 pubmed
    ..According to the large amount of this tissue in adult mammal, it could represent a useful source of cardiomyocyte progenitors...
  58. Fernandes S, Amirault J, Lande G, Nguyen J, Forest V, Bignolais O, et al. Autologous myoblast transplantation after myocardial infarction increases the inducibility of ventricular arrhythmias. Cardiovasc Res. 2006;69:348-58 pubmed
    ..However, these trials were hampered by unexpected episodes of life-threatening ventricular tachyarrhythmias (VT). We investigated cardiac electrical stability after myoblast transplantation to the myocardium...
  59. Tsuruda T, Kato J, Eto T. [Effect of adrenomedullin on cardiac myocytes and fibroblasts]. Nihon Rinsho. 2004;62 Suppl 9:233-6 pubmed
  60. Massie B. 2003: The year in heart failure. J Card Fail. 2004;10:1-3 pubmed
  61. van der Putten H, Joosten B, Klaren P, Everts M. Uptake of tri-iodothyronine and thyroxine in myoblasts and myotubes of the embryonic heart cell line H9c2(2-1). J Endocrinol. 2002;175:587-96 pubmed
    ..In conclusion, T(3) and T(4) share a common energy-dependent transport system in H9c2(2-1) cells, that may be important for the availability of thyroid hormone during differentiation...
  62. Saha M, Ferro A. Cardiac stem cell therapy: present and future. Br J Clin Pharmacol. 2006;61:727-9 pubmed
    ..Here we briefly review the current state of cardiac stem cell therapy and consider its future...