multipotent stem cells

Summary

Summary: Specialized stem cells that are committed to give rise to cells that have a particular function; examples are MYOBLASTS; MYELOID PROGENITOR CELLS; and skin stem cells. (Stem Cells: A Primer [Internet]. Bethesda (MD): National Institutes of Health (US); 2000 May [cited 2002 Apr 5]. Available from: http://www.nih.gov/news/stemcell/primer.htm)

Top Publications

  1. Cao J, Ng E, McNaughton D, Stanley E, Elefanty A, Tobin M, et al. The characterisation of pluripotent and multipotent stem cells using Fourier transform infrared microspectroscopy. Int J Mol Sci. 2013;14:17453-76 pubmed publisher
    ..FTIR) microspectroscopy shows potential as a benign, objective and rapid tool to screen pluripotent and multipotent stem cells for clinical use...
  2. Ebert A, Shelley B, Hurley A, Onorati M, Castiglioni V, Patitucci T, et al. EZ spheres: a stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs. Stem Cell Res. 2013;10:417-427 pubmed publisher
    ..As such, they will be useful for the rapidly expanding field of neurological development and disease modeling, high-content screening, and regenerative therapies based on pluripotent stem cell technology...
  3. Kauts M, Pihelgas S, Orro K, Neuman T, Piirsoo A. CCL5/CCR1 axis regulates multipotency of human adipose tissue derived stromal cells. Stem Cell Res. 2013;10:166-78 pubmed publisher
    ..Our data suggest that chemokine signaling via CCR1 may be involved in regulation of stemness of ADSCs...
  4. Park S, Seo M, Kim H, Kang K. Isolation and characterization of canine amniotic membrane-derived multipotent stem cells. PLoS ONE. 2012;7:e44693 pubmed
    ..Here, we successfully isolated and identified multipotent stem cells (MSCs) from canine amniotic membrane tissue...
  5. Zhao Y, Jiang Z, Guo C. New hope for type 2 diabetics: targeting insulin resistance through the immune modulation of stem cells. Autoimmun Rev. 2011;11:137-42 pubmed publisher
    ..This review focuses on recent progress in the use of immune modulation in T2D and discusses the potential for future therapies. New insights are provided on the use of cord blood-derived multipotent stem cells (CB-SC) in T2D.
  6. Salero E, Blenkinsop T, Corneo B, Harris A, Rabin D, Stern J, et al. Adult human RPE can be activated into a multipotent stem cell that produces mesenchymal derivatives. Cell Stem Cell. 2012;10:88-95 pubmed publisher
    ..This study establishes the RPESC as an accessible, human CNS-derived multipotent stem cell, useful for the study of fate choice, replacement therapy, and disease modeling...
  7. Zhao Y, Jiang Z, Zhao T, Ye M, Hu C, Yin Z, et al. Reversal of type 1 diabetes via islet ? cell regeneration following immune modulation by cord blood-derived multipotent stem cells. BMC Med. 2012;10:3 pubmed publisher
    ..Evidence that human cord blood-derived multipotent stem cells (CB-SCs) can control autoimmune responses by altering regulatory T cells (Tregs) and human islet ? cell-..
  8. Cavaliere F, Urra O, Alberdi E, Matute C. Oligodendrocyte differentiation from adult multipotent stem cells is modulated by glutamate. Cell Death Dis. 2012;3:e268 pubmed publisher
    We used multipotent stem cells (MSCs) derived from the young rat subventricular zone (SVZ) to study the effects of glutamate in oligodendrocyte maturation...
  9. Li X, Li H, Bi J, Chen Y, Jain S, Zhao Y. Human cord blood-derived multipotent stem cells (CB-SCs) treated with all-trans-retinoic acid (ATRA) give rise to dopamine neurons. Biochem Biophys Res Commun. 2012;419:110-6 pubmed publisher
    ..Human cord blood-derived multipotent stem cells (CB-SCs) display embryonic stem cell characteristics, including multi-potential differentiation...
  10. Rodriguez R, Rubio R, Menendez P. Modeling sarcomagenesis using multipotent mesenchymal stem cells. Cell Res. 2012;22:62-77 pubmed publisher
    ..Here, we comprehensively review the existing MSC-based models of sarcoma and discuss the most common mechanisms leading to tumoral transformation of MSCs and sarcomagenesis...

Detail Information

Publications62

  1. Cao J, Ng E, McNaughton D, Stanley E, Elefanty A, Tobin M, et al. The characterisation of pluripotent and multipotent stem cells using Fourier transform infrared microspectroscopy. Int J Mol Sci. 2013;14:17453-76 pubmed publisher
    ..FTIR) microspectroscopy shows potential as a benign, objective and rapid tool to screen pluripotent and multipotent stem cells for clinical use...
  2. Ebert A, Shelley B, Hurley A, Onorati M, Castiglioni V, Patitucci T, et al. EZ spheres: a stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs. Stem Cell Res. 2013;10:417-427 pubmed publisher
    ..As such, they will be useful for the rapidly expanding field of neurological development and disease modeling, high-content screening, and regenerative therapies based on pluripotent stem cell technology...
  3. Kauts M, Pihelgas S, Orro K, Neuman T, Piirsoo A. CCL5/CCR1 axis regulates multipotency of human adipose tissue derived stromal cells. Stem Cell Res. 2013;10:166-78 pubmed publisher
    ..Our data suggest that chemokine signaling via CCR1 may be involved in regulation of stemness of ADSCs...
  4. Park S, Seo M, Kim H, Kang K. Isolation and characterization of canine amniotic membrane-derived multipotent stem cells. PLoS ONE. 2012;7:e44693 pubmed
    ..Here, we successfully isolated and identified multipotent stem cells (MSCs) from canine amniotic membrane tissue...
  5. Zhao Y, Jiang Z, Guo C. New hope for type 2 diabetics: targeting insulin resistance through the immune modulation of stem cells. Autoimmun Rev. 2011;11:137-42 pubmed publisher
    ..This review focuses on recent progress in the use of immune modulation in T2D and discusses the potential for future therapies. New insights are provided on the use of cord blood-derived multipotent stem cells (CB-SC) in T2D.
  6. Salero E, Blenkinsop T, Corneo B, Harris A, Rabin D, Stern J, et al. Adult human RPE can be activated into a multipotent stem cell that produces mesenchymal derivatives. Cell Stem Cell. 2012;10:88-95 pubmed publisher
    ..This study establishes the RPESC as an accessible, human CNS-derived multipotent stem cell, useful for the study of fate choice, replacement therapy, and disease modeling...
  7. Zhao Y, Jiang Z, Zhao T, Ye M, Hu C, Yin Z, et al. Reversal of type 1 diabetes via islet ? cell regeneration following immune modulation by cord blood-derived multipotent stem cells. BMC Med. 2012;10:3 pubmed publisher
    ..Evidence that human cord blood-derived multipotent stem cells (CB-SCs) can control autoimmune responses by altering regulatory T cells (Tregs) and human islet ? cell-..
  8. Cavaliere F, Urra O, Alberdi E, Matute C. Oligodendrocyte differentiation from adult multipotent stem cells is modulated by glutamate. Cell Death Dis. 2012;3:e268 pubmed publisher
    We used multipotent stem cells (MSCs) derived from the young rat subventricular zone (SVZ) to study the effects of glutamate in oligodendrocyte maturation...
  9. Li X, Li H, Bi J, Chen Y, Jain S, Zhao Y. Human cord blood-derived multipotent stem cells (CB-SCs) treated with all-trans-retinoic acid (ATRA) give rise to dopamine neurons. Biochem Biophys Res Commun. 2012;419:110-6 pubmed publisher
    ..Human cord blood-derived multipotent stem cells (CB-SCs) display embryonic stem cell characteristics, including multi-potential differentiation...
  10. Rodriguez R, Rubio R, Menendez P. Modeling sarcomagenesis using multipotent mesenchymal stem cells. Cell Res. 2012;22:62-77 pubmed publisher
    ..Here, we comprehensively review the existing MSC-based models of sarcoma and discuss the most common mechanisms leading to tumoral transformation of MSCs and sarcomagenesis...
  11. Van Keymeulen A, Rocha A, Ousset M, Beck B, Bouvencourt G, Rock J, et al. Distinct stem cells contribute to mammary gland development and maintenance. Nature. 2011;479:189-93 pubmed publisher
  12. Dar A, Domev H, Ben Yosef O, Tzukerman M, Zeevi Levin N, Novak A, et al. Multipotent vasculogenic pericytes from human pluripotent stem cells promote recovery of murine ischemic limb. Circulation. 2012;125:87-99 pubmed publisher
  13. Psaltis P, Harbuzariu A, Delacroix S, Witt T, Holroyd E, Spoon D, et al. Identification of a monocyte-predisposed hierarchy of hematopoietic progenitor cells in the adventitia of postnatal murine aorta. Circulation. 2012;125:592-603 pubmed publisher
    ..Here, we hypothesized that the arterial wall is a source of hematopoietic progenitor and stem cells in postnatal life...
  14. Pina C, Fugazza C, Tipping A, Brown J, Soneji S, Teles J, et al. Inferring rules of lineage commitment in haematopoiesis. Nat Cell Biol. 2012;14:287-94 pubmed publisher
  15. Ratajczak M, Zuba Surma E, Kucia M, Poniewierska A, Suszynska M, Ratajczak J. Pluripotent and multipotent stem cells in adult tissues. Adv Med Sci. 2012;57:1-17 pubmed publisher
    ..These different populations of stem cells will be reviewed in this paper...
  16. Hwang S, Kim S, Park S, Choi M, Kang H, Seol Y, et al. Human inferior turbinate: an alternative tissue source of multipotent mesenchymal stromal cells. Otolaryngol Head Neck Surg. 2012;147:568-74 pubmed publisher
    ..This study aimed to explore potential new sources of multipotent MSCs for use in tissue regeneration and the functional restoration of organs...
  17. Karpiuk O, Najafova Z, Kramer F, Hennion M, Galonska C, König A, et al. The histone H2B monoubiquitination regulatory pathway is required for differentiation of multipotent stem cells. Mol Cell. 2012;46:705-13 pubmed publisher
    ..Thus, these data indicate that H2Bub1 is required for maintaining multipotency of hMSCs and plays a central role in controlling stem cell differentiation...
  18. Wang W, Zhao Y, Lin B, Yang J, Ge L. Identification of multipotent stem cells from adult dog periodontal ligament. Eur J Oral Sci. 2012;120:303-10 pubmed publisher
  19. Zhao Y. Stem cell educator therapy and induction of immune balance. Curr Diab Rep. 2012;12:517-23 pubmed publisher
    ..We established the Stem Cell Educator therapy by using cord blood-derived multipotent stem cells (CB-SCs)...
  20. Pan F, Bankaitis E, Boyer D, Xu X, Van De Casteele M, Magnuson M, et al. Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development. 2013;140:751-64 pubmed publisher
    ..Thus, we show that acinar cells, without exogenously introduced factors, can regain aspects of embryonic multipotentiality under injury, and convert into mature ?-cells...
  21. Hauser S, Widera D, Qunneis F, Müller J, Zander C, Greiner J, et al. Isolation of novel multipotent neural crest-derived stem cells from adult human inferior turbinate. Stem Cells Dev. 2012;21:742-56 pubmed publisher
    ..Taken together our study describes a novel, readily accessible source of multipotent human NCSCs for potential cell-replacement therapy...
  22. Lopez M, Daigle P. Adult multipotent stromal cell technology for bone regeneration: a review. Vet Surg. 2013;42:1-11 pubmed publisher
    ..Though MSC bone tissue engineering has advanced over the last few decades, limitations to clinical translation remain. A current review of this promising field is presented with a specific focus on equine investigations...
  23. Hill R, Gledhill K, Gardner A, Higgins C, Crawford H, Lawrence C, et al. Generation and characterization of multipotent stem cells from established dermal cultures. PLoS ONE. 2012;7:e50742 pubmed publisher
  24. Seta N, Okazaki Y, Izumi K, Miyazaki H, Kato T, Kuwana M. Fibronectin binding is required for acquisition of mesenchymal/endothelial differentiation potential in human circulating monocytes. Clin Dev Immunol. 2012;2012:820827 pubmed publisher
    ..These results indicate that acquisition of the multidifferentiation potential by circulating monocytes depends on their binding to the RGD domain of fibronectin via cell-surface ?(5)?(1) integrin...
  25. Duong J, Mii S, Uchugonova A, Liu F, Moossa A, Hoffman R. Real-time confocal imaging of trafficking of nestin-expressing multipotent stem cells in mouse whiskers in long-term 3-D histoculture. In Vitro Cell Dev Biol Anim. 2012;48:301-5 pubmed publisher
    ..This new method of long-term histoculture of whiskers from ND-GFP mice will enable the extensive study of the behavior of nestin-expressing multipotent stem cells of the hair follicle.
  26. Cardinale V, Wang Y, Carpino G, Mendel G, Alpini G, Gaudio E, et al. The biliary tree--a reservoir of multipotent stem cells. Nat Rev Gastroenterol Hepatol. 2012;9:231-40 pubmed publisher
    ..Peribiliary glands contain multipotent stem cells, which self-replicate and can differentiate into hepatocytes, cholangiocytes or pancreatic islets, ..
  27. Du Y, Roh D, Mann M, Funderburgh M, Funderburgh J, Schuman J. Multipotent stem cells from trabecular meshwork become phagocytic TM cells. Invest Ophthalmol Vis Sci. 2012;53:1566-75 pubmed publisher
    ..To isolate and characterize stem cells from human trabecular meshwork (TM) and to investigate the potential of these stem cells to differentiate into TM cells...
  28. Huch M, Dorrell C, Boj S, van Es J, Li V, van de Wetering M, et al. In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature. 2013;494:247-50 pubmed publisher
    ..These findings indicate that previous observations concerning Lgr5(+) stem cells in actively self-renewing tissues can also be extended to damage-induced stem cells in a tissue with a low rate of spontaneous proliferation...
  29. Hattori H, Suzuki S, Okazaki Y, Suzuki N, Kuwana M. Intracranial transplantation of monocyte-derived multipotential cells enhances recovery after ischemic stroke in rats. J Neurosci Res. 2012;90:479-88 pubmed publisher
    ..These findings provide evidence that the intracranial delivery of MOMCs enhances functional recovery by promoting neovascularization in a rat model for ischemic stroke...
  30. Murrell W, Palmero E, Bianco J, Stangeland B, Joel M, Paulson L, et al. Expansion of multipotent stem cells from the adult human brain. PLoS ONE. 2013;8:e71334 pubmed publisher
    ..Whilst clarification of these cells' behavior is ongoing, results so far portend well for the future repair of tissues by transplantation of an adult patient's own-derived stem cells. ..
  31. Zhao Y, Jiang Z, Zhao T, Ye M, Hu C, Zhou H, et al. Targeting insulin resistance in type 2 diabetes via immune modulation of cord blood-derived multipotent stem cells (CB-SCs) in stem cell educator therapy: phase I/II clinical trial. BMC Med. 2013;11:160 pubmed publisher
    ..It suggests that immune modulation may be a useful tool in treating the disease...
  32. Humphries A, Cereser B, Gay L, Miller D, Das B, Gutteridge A, et al. Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution. Proc Natl Acad Sci U S A. 2013;110:E2490-9 pubmed publisher
    ..Relative stasis and occasional rapid subclone growth may characterize colorectal tumorigenesis. ..
  33. Li T, Lewallen M, Chen S, Yu W, Zhang N, Xie T. Multipotent stem cells isolated from the adult mouse retina are capable of producing functional photoreceptor cells. Cell Res. 2013;23:788-802 pubmed publisher
    ..Therefore, this study has demonstrated that RSCs isolated from the adult retina have the potential of producing functional photoreceptor cells that can potentially restore lost vision caused by loss of photoreceptor cells in RP and AMD...
  34. Montgomery R, Carlone D, Richmond C, Farilla L, Kranendonk M, Henderson D, et al. Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proc Natl Acad Sci U S A. 2011;108:179-84 pubmed publisher
    ..Consistent with other highly regenerative tissues, our results demonstrate that a slowly cycling stem cell population exists within the intestine...
  35. Richie Ehrlich L, Serwold T, Weissman I. In vitro assays misrepresent in vivo lineage potentials of murine lymphoid progenitors. Blood. 2011;117:2618-24 pubmed publisher
  36. Tallone T, Realini C, Böhmler A, Kornfeld C, Vassalli G, Moccetti T, et al. Adult human adipose tissue contains several types of multipotent cells. J Cardiovasc Transl Res. 2011;4:200-10 pubmed publisher
    ..In the light of the discussed data, particularly the identification of new markers, and advances in the understanding of fundamental MSC biology, we also suggest a revision of the 2006 ISCT criteria...
  37. Delcroix G, Curtis K, Schiller P, Montero Menei C. EGF and bFGF pre-treatment enhances neural specification and the response to neuronal commitment of MIAMI cells. Differentiation. 2010;80:213-27 pubmed publisher
    ..In this study, we thoroughly assessed for the first time the capacity of these factors to enhance the neuronal differentiation of MSCs...
  38. Zhang P, Moudgill N, Hager E, Tarola N, DiMatteo C, McIlhenny S, et al. Endothelial differentiation of adipose-derived stem cells from elderly patients with cardiovascular disease. Stem Cells Dev. 2011;20:977-88 pubmed publisher
    ..As such, adipose tissue is a practical source of autologous stem cells for vascular tissue engineering...
  39. Gieseke F, Böhringer J, Bussolari R, Dominici M, Handgretinger R, Müller I. Human multipotent mesenchymal stromal cells use galectin-1 to inhibit immune effector cells. Blood. 2010;116:3770-9 pubmed publisher
    ..These results identify galectin-1 as the first lectin mediating the immunomodulatory effect of MSCs on allogeneic T cells...
  40. Khromov T, Pantakani D, Nolte J, Wolf M, Dressel R, Engel W, et al. Global and gene-specific histone modification profiles of mouse multipotent adult germline stem cells. Mol Hum Reprod. 2011;17:166-74 pubmed publisher
    ..Collectively, our results demonstrate that maGSCs also closely resemble ESCs with regard to their chromatin state and further evidence their pluripotent nature...
  41. Pijanka J, Kumar D, Dale T, Yousef I, Parkes G, Untereiner V, et al. Vibrational spectroscopy differentiates between multipotent and pluripotent stem cells. Analyst. 2010;135:3126-32 pubmed publisher
    ..While vibrational spectroscopy could therefore be of potential use in identifying different populations of stem cells further work is required to better understand these differences...
  42. Cardinale V, Wang Y, Carpino G, Alvaro D, Reid L, Gaudio E. Multipotent stem cells in the biliary tree. Ital J Anat Embryol. 2010;115:85-90 pubmed
    ..The biliary tree stem/progenitors represent a new source of cells that can be used as tools for regenerative medicine of liver, bile duct and pancreas...
  43. Zhong J, Hu N, Xiong X, Lei Q, Li L. A novel promising therapy for skin aging: dermal multipotent stem cells against photoaged skin by activation of TGF-?/Smad and p38 MAPK signaling pathway. Med Hypotheses. 2011;76:343-6 pubmed publisher
    ..Dermal multipotent stem cells (dMSCs) are a population of adult stem cells derived from dermis in recent years...
  44. Delgado O, Kaisani A, Spinola M, Xie X, Batten K, Minna J, et al. Multipotent capacity of immortalized human bronchial epithelial cells. PLoS ONE. 2011;6:e22023 pubmed publisher
    ..Here we show that human bronchial epithelial cells (HBECs) display characteristics of multipotent stem cells of the lung...
  45. McMurray R, Gadegaard N, Tsimbouri P, Burgess K, McNamara L, Tare R, et al. Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency. Nat Mater. 2011;10:637-44 pubmed publisher
    ..Furthermore, the study implicates a role for small RNAs in repressing key cell signalling and metabolomic pathways, demonstrating the potential of surfaces as non-invasive tools with which to address the stem cell niche...
  46. Roelandt P, Sancho Bru P, Pauwelyn K, Verfaillie C. Differentiation of rat multipotent adult progenitor cells to functional hepatocyte-like cells by mimicking embryonic liver development. Nat Protoc. 2010;5:1324-36 pubmed publisher
  47. Mendez Ferrer S, Michurina T, Ferraro F, Mazloom A, MacArthur B, Lira S, et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature. 2010;466:829-34 pubmed publisher
    ..These results uncover an unprecedented partnership between two distinct somatic stem-cell types and are indicative of a unique niche in the bone marrow made of heterotypic stem-cell pairs...
  48. Kopp J, Dubois C, Schaffer A, Hao E, Shih H, Seymour P, et al. Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development. 2011;138:653-65 pubmed publisher
  49. Meyer S, Nolte J, Opitz L, Salinas Riester G, Engel W. Pluripotent embryonic stem cells and multipotent adult germline stem cells reveal similar transcriptomes including pluripotency-related genes. Mol Hum Reprod. 2010;16:846-55 pubmed publisher
    ..This is the first study, at transcriptome level, to compare ESCs and a pluripotent cell line derived from an adult organism (maGSCs)...
  50. Roelandt P, Pauwelyn K, Sancho Bru P, Subramanian K, Bose B, Ordovas L, et al. Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS ONE. 2010;5:e12101 pubmed publisher
    ..This differentiation protocol will be useful for generating hepatocyte-like cells from rodent and human stem cells, and to gain insight into the early stages of liver development...
  51. Bhandari D, Seo K, Jung J, Kim H, Yang S, Kang K. The regulatory role of c-MYC on HDAC2 and PcG expression in human multipotent stem cells. J Cell Mol Med. 2011;15:1603-14 pubmed publisher
    ..From this finding, it can be concluded that c-MYC plays a vital role in cell proliferation and differentiation via chromosomal modification...
  52. Aranguren X, Pelacho B, Penuelas I, Abizanda G, Uriz M, Ecay M, et al. MAPC transplantation confers a more durable benefit than AC133+ cell transplantation in severe hind limb ischemia. Cell Transplant. 2011;20:259-69 pubmed publisher
    ..This, in turn, conferred tissue protection and regeneration with longer term functional improvement...
  53. Bonfanti P, Claudinot S, Amici A, Farley A, Blackburn C, Barrandon Y. Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells. Nature. 2010;466:978-82 pubmed publisher
    ..These cells can irreversibly adopt the fate of hair follicle multipotent stem cells when exposed to an inductive skin microenvironment; this change in fate is correlated with robust changes ..
  54. Park S, Seo M, Kang J, Chae J, Kang K. Isolation and characterization of equine amniotic fluid-derived multipotent stem cells. Cytotherapy. 2011;13:341-9 pubmed publisher
    ..However, there have been no reports regarding equine AF stem cells. We have isolated equine AF-derived multipotent stem cells (MSC) (eAF-MSC) and show that these cells exhibit self-renewal ability and multilineage differentiation.
  55. Pierantozzi E, Gava B, Manini I, Roviello F, Marotta G, Chiavarelli M, et al. Pluripotency regulators in human mesenchymal stem cells: expression of NANOG but not of OCT-4 and SOX-2. Stem Cells Dev. 2011;20:915-23 pubmed publisher
    ..Accordingly, we propose that activation of NANOG expression in MSCs is associated with, although cannot directly regulate, the transition from in vivo quiescence to adaptation to in vitro growth conditions...
  56. Sato T, van Es J, Snippert H, Stange D, Vries R, van den Born M, et al. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature. 2011;469:415-8 pubmed publisher
    ..In colon crypts, CD24(+) cells residing between Lgr5 stem cells may represent the Paneth cell equivalents. We conclude that Lgr5 stem cells compete for essential niche signals provided by a specialized daughter cell, the Paneth cell...
  57. Tapia N, Arauzo Bravo M, Ko K, Scholer H. Concise review: challenging the pluripotency of human testis-derived ESC-like cells. Stem Cells. 2011;29:1165-9 pubmed publisher
    ..Here, we critically review these reports and provide insight to guide future studies on the derivation of human pluripotent cells from testicular tissue...
  58. Chen J, Lu Z, Cheng D, Peng S, Wang H. Isolation and characterization of porcine amniotic fluid-derived multipotent stem cells. PLoS ONE. 2011;6:e19964 pubmed publisher
    The aim of this study was to isolate and characterize porcine amniotic fluid-derived multipotent stem cells (pAF-MSC)...
  59. Smukler S, Arntfield M, Razavi R, Bikopoulos G, Karpowicz P, Seaberg R, et al. The adult mouse and human pancreas contain rare multipotent stem cells that express insulin. Cell Stem Cell. 2011;8:281-93 pubmed publisher
    ..These findings demonstrate that the adult mammalian pancreas contains a population of insulin(+) multipotent stem cells and suggest that these cells may provide a promising line of investigation toward potential therapeutic ..
  60. Cavazzana Calvo M, Fischer A, Bushman F, Payen E, Hacein Bey Abina S, Leboulch P. Is normal hematopoiesis maintained solely by long-term multipotent stem cells?. Blood. 2011;117:4420-4 pubmed publisher
    ..The distribution of integration sites observed tends to support the validity of the revised model...
  61. Medici D, Shore E, Lounev V, Kaplan F, Kalluri R, Olsen B. Conversion of vascular endothelial cells into multipotent stem-like cells. Nat Med. 2010;16:1400-6 pubmed publisher
    ..These stem-like cells could be triggered to differentiate into osteoblasts, chondrocytes or adipocytes. We suggest that conversion of endothelial cells to stem-like cells may provide a new approach to tissue engineering...
  62. Dimomeletis I, Deindl E, Zaruba M, Groebner M, Zahler S, Laslo S, et al. Assessment of human MAPCs for stem cell transplantation and cardiac regeneration after myocardial infarction in SCID mice. Exp Hematol. 2010;38:1105-14 pubmed publisher
    ..We analyzed the cardioregenerative potential of human MAPCs in a murine model of myocardial infarction...