adult germline stem cells


Summary: Progenitor stem cells found in the testicles.

Top Publications

  1. Hertz D, Henry N, Rae J. Germline genetic predictors of aromatase inhibitor concentrations, estrogen suppression and drug efficacy and toxicity in breast cancer patients. Pharmacogenomics. 2017;18:481-499 pubmed publisher
  2. Bedford Guaus S, Kim S, Mulero L, Vaquero J, Morera C, Adan Milanès R, et al. Molecular markers of putative spermatogonial stem cells in the domestic cat. Reprod Domest Anim. 2017;52 Suppl 2:177-186 pubmed publisher
    ..Future studies should identify additional surface markers that alone or in combination can be used to further enrich SSCs from cat germ cells. ..
  3. Chassot A, Le Rolle M, Jourden M, Taketo M, Ghyselinck N, Chaboissier M. Constitutive WNT/CTNNB1 activation triggers spermatogonial stem cell proliferation and germ cell depletion. Dev Biol. 2017;426:17-27 pubmed publisher
    ..These findings demonstrate that a finely tuned timing in WNT/CTNNB1 signalling activity is required for spermatogenesis. ..
  4. Xu L, Guo Q, Chang G, Qiu L, Liu X, Bi Y, et al. Discovery of microRNAs during early spermatogenesis in chicken. PLoS ONE. 2017;12:e0177098 pubmed publisher
  5. Elkouby Y, Mullins M. Coordination of cellular differentiation, polarity, mitosis and meiosis - New findings from early vertebrate oogenesis. Dev Biol. 2017;430:275-287 pubmed publisher
    ..Here, we review these advances mostly from the zebrafish and mouse. We discuss oogenesis concepts across established model organisms, and construct an inclusive paradigm for early oocyte differentiation in vertebrates. ..
  6. Eun S, Feng L, Cedeno Rosario L, Gan Q, Wei G, Cui K, et al. Polycomb Group Gene E(z) Is Required for Spermatogonial Dedifferentiation in Drosophila Adult Testis. J Mol Biol. 2017;429:2030-2041 pubmed publisher
    ..Taken together, our data suggest that E(z) acts intrinsically in germ cells to activate dedifferentiation and thus replenish lost GSCs during both aging and tissue regeneration. ..
  7. Wei Y, Cai S, Ma F, Zhang Y, Zhou Z, Xu S, et al. Double sex and mab-3 related transcription factor 1 regulates differentiation and proliferation in dairy goat male germline stem cells. J Cell Physiol. 2017;: pubmed publisher
    ..These findings identify a central role for Dmrt1 in controlling population stability and injury restoring of SSCs. ..
  8. Tyc K, Nabih A, Wu M, Wedeles C, Sobotka J, Claycomb J. The Conserved Intron Binding Protein EMB-4 Plays Differential Roles in Germline Small RNA Pathways of C. elegans. Dev Cell. 2017;42:256-270.e6 pubmed publisher
    ..These data suggest that EMB-4 could contribute to a molecular signature that distinguishes the targets of these two germline small RNA pathways. ..