stem cells

Summary

Summary: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.

Top Publications

  1. Yang P, Huang X, Wang C, Dang X, Wang K. Repair of bone defects using a new biomimetic construction fabricated by adipose-derived stem cells, collagen I, and porous beta-tricalcium phosphate scaffolds. Exp Biol Med (Maywood). 2013;238:1331-43 pubmed publisher
    Adipose derived stem cells (ASCs) with multilineage differentiation capacities have been demonstrated as an alternative cell candidate for in vitro and in vivo bone regeneration...
  2. Chang J, Wang C, Jin C, Yang C, Huang Y, Liu J, et al. Self-renewal and multilineage differentiation of mouse dental epithelial stem cells. Stem Cell Res. 2013;11:990-1002 pubmed publisher
    ..the cellular and molecular mechanisms underlying the self-renewal and differentiation of dental epithelial stem cells (DESCs) that support the unlimited growth potential of mouse incisors is critical for developing novel tooth ..
  3. Stange D, Koo B, Huch M, Sibbel G, Basak O, Lyubimova A, et al. Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell. 2013;155:357-68 pubmed publisher
    ..in that they are capable of replenishing entire gastric units, essentially serving as quiescent "reserve" stem cells. These observations challenge the notion that stem cell hierarchies represent a "one-way street."
  4. Sheng L, Yang M, Liang Y, Li Q. Adipose tissue-derived stem cells (ADSCs) transplantation promotes regeneration of expanded skin using a tissue expansion model. Wound Repair Regen. 2013;21:746-54 pubmed publisher
    Transplantation of adipose tissue-derived stem cells (ADSCs) is a promising method that has been used in regenerative medicine because it has shown the capacity to accelerate wound healing...
  5. Morad G, Kheiri L, Khojasteh A. Dental pulp stem cells for in vivo bone regeneration: a systematic review of literature. Arch Oral Biol. 2013;58:1818-27 pubmed publisher
    This review of literature was aimed to assess in vivo experiments which have evaluated the efficacy of dental pulp stem cells (DPSCs) for bone regeneration.
  6. Reyes R, Pec M, Sanchez E, Del Rosario C, Delgado A, Evora C. Comparative, osteochondral defect repair: stem cells versus chondrocytes versus bone morphogenetic protein-2, solely or in combination. Eur Cell Mater. 2013;25:351-65; discussion 365 pubmed
    ..Studies with growth factors, implantation of autologous chondrocytes and mesenchymal stem cells have led to variable, to some extent inconsistent, results...
  7. Sugitani S, Tsuruma K, Ohno Y, Kuse Y, Yamauchi M, Egashira Y, et al. The potential neuroprotective effect of human adipose stem cells conditioned medium against light-induced retinal damage. Exp Eye Res. 2013;116:254-64 pubmed publisher
    Human adipose-derived stem cells (hASCs) are present in adult adipose tissue and have been reported to secrete various factors that have neuroprotective effects...
  8. Luesma M, Gherghiceanu M, Popescu L. Telocytes and stem cells in limbus and uvea of mouse eye. J Cell Mol Med. 2013;17:1016-24 pubmed publisher
    ..The ultrastructural nanocontacts of TCs with SCs and the TCs paracrine influence via exosomes in the epithelial and stromal SC niches suggest an important participation of TCs in eye regeneration. ..
  9. Tata P, Mou H, Pardo Saganta A, Zhao R, Prabhu M, Law B, et al. Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature. 2013;503:218-23 pubmed publisher
    ..differentiated cells are known to revert into replicating progenitors, but these cells do not persist as stable stem cells. Here we present evidence that differentiated airway epithelial cells can revert into stable and functional stem ..
  10. Song D, Li Y, Cao J, Han Z, Gao L, Xu Z, et al. Effect of iron deficiency on c-kit? cardiac stem cells in vitro. PLoS ONE. 2013;8:e65721 pubmed publisher
    ..The c-kit? cardiac stem cells (CSCs) play a vital role in cardiac function repair...

Detail Information

Publications62

  1. Yang P, Huang X, Wang C, Dang X, Wang K. Repair of bone defects using a new biomimetic construction fabricated by adipose-derived stem cells, collagen I, and porous beta-tricalcium phosphate scaffolds. Exp Biol Med (Maywood). 2013;238:1331-43 pubmed publisher
    Adipose derived stem cells (ASCs) with multilineage differentiation capacities have been demonstrated as an alternative cell candidate for in vitro and in vivo bone regeneration...
  2. Chang J, Wang C, Jin C, Yang C, Huang Y, Liu J, et al. Self-renewal and multilineage differentiation of mouse dental epithelial stem cells. Stem Cell Res. 2013;11:990-1002 pubmed publisher
    ..the cellular and molecular mechanisms underlying the self-renewal and differentiation of dental epithelial stem cells (DESCs) that support the unlimited growth potential of mouse incisors is critical for developing novel tooth ..
  3. Stange D, Koo B, Huch M, Sibbel G, Basak O, Lyubimova A, et al. Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell. 2013;155:357-68 pubmed publisher
    ..in that they are capable of replenishing entire gastric units, essentially serving as quiescent "reserve" stem cells. These observations challenge the notion that stem cell hierarchies represent a "one-way street."
  4. Sheng L, Yang M, Liang Y, Li Q. Adipose tissue-derived stem cells (ADSCs) transplantation promotes regeneration of expanded skin using a tissue expansion model. Wound Repair Regen. 2013;21:746-54 pubmed publisher
    Transplantation of adipose tissue-derived stem cells (ADSCs) is a promising method that has been used in regenerative medicine because it has shown the capacity to accelerate wound healing...
  5. Morad G, Kheiri L, Khojasteh A. Dental pulp stem cells for in vivo bone regeneration: a systematic review of literature. Arch Oral Biol. 2013;58:1818-27 pubmed publisher
    This review of literature was aimed to assess in vivo experiments which have evaluated the efficacy of dental pulp stem cells (DPSCs) for bone regeneration.
  6. Reyes R, Pec M, Sanchez E, Del Rosario C, Delgado A, Evora C. Comparative, osteochondral defect repair: stem cells versus chondrocytes versus bone morphogenetic protein-2, solely or in combination. Eur Cell Mater. 2013;25:351-65; discussion 365 pubmed
    ..Studies with growth factors, implantation of autologous chondrocytes and mesenchymal stem cells have led to variable, to some extent inconsistent, results...
  7. Sugitani S, Tsuruma K, Ohno Y, Kuse Y, Yamauchi M, Egashira Y, et al. The potential neuroprotective effect of human adipose stem cells conditioned medium against light-induced retinal damage. Exp Eye Res. 2013;116:254-64 pubmed publisher
    Human adipose-derived stem cells (hASCs) are present in adult adipose tissue and have been reported to secrete various factors that have neuroprotective effects...
  8. Luesma M, Gherghiceanu M, Popescu L. Telocytes and stem cells in limbus and uvea of mouse eye. J Cell Mol Med. 2013;17:1016-24 pubmed publisher
    ..The ultrastructural nanocontacts of TCs with SCs and the TCs paracrine influence via exosomes in the epithelial and stromal SC niches suggest an important participation of TCs in eye regeneration. ..
  9. Tata P, Mou H, Pardo Saganta A, Zhao R, Prabhu M, Law B, et al. Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature. 2013;503:218-23 pubmed publisher
    ..differentiated cells are known to revert into replicating progenitors, but these cells do not persist as stable stem cells. Here we present evidence that differentiated airway epithelial cells can revert into stable and functional stem ..
  10. Song D, Li Y, Cao J, Han Z, Gao L, Xu Z, et al. Effect of iron deficiency on c-kit? cardiac stem cells in vitro. PLoS ONE. 2013;8:e65721 pubmed publisher
    ..The c-kit? cardiac stem cells (CSCs) play a vital role in cardiac function repair...
  11. Euler de Souza Lucena E, Guzen F, Lopes de Paiva Cavalcanti J, Galvão Barboza C, Silva do Nascimento Júnior E, Cavalcante J. Experimental considerations concerning the use of stem cells and tissue engineering for facial nerve regeneration: a systematic review. J Oral Maxillofac Surg. 2014;72:1001-12 pubmed publisher
    ..The authors investigated the source and delivery method of stem cells in experimental outcomes, seeking to clarify whether stem cells must be differentiated in the injured facial ..
  12. Sánchez Aragó M, Garcia Bermudez J, Martínez Reyes I, Santacatterina F, Cuezva J. Degradation of IF1 controls energy metabolism during osteogenic differentiation of stem cells. EMBO Rep. 2013;14:638-44 pubmed publisher
    Differentiation of human mesenchymal stem cells (hMSCs) requires the rewiring of energy metabolism...
  13. Gazave E, Béhague J, Laplane L, Guillou A, Préau L, Demilly A, et al. Posterior elongation in the annelid Platynereis dumerilii involves stem cells molecularly related to primordial germ cells. Dev Biol. 2013;382:246-67 pubmed publisher
    ..elongation in Platynereis, in particular to test the hypothesis that the SAZ contains a specific set of stem cells dedicated to posterior elongation...
  14. Zhao X, Chen Y, Zhao X, Liu D, Xu L, Wang Y, et al. Improved outcomes using G-CSF-mobilized blood and bone marrow grafts as the source of stem cells compared with G-PB after HLA-identical sibling transplantation in patients with acute leukemia. Clin Transplant. 2013;27:844-51 pubmed publisher
    ..Our results suggest that HLA-identical transplantation with G-BM&PB results in superior clinical outcomes compared with G-PB for patients with acute leukemia...
  15. Doma E, Rupp C, Baccarini M. EGFR-ras-raf signaling in epidermal stem cells: roles in hair follicle development, regeneration, tissue remodeling and epidermal cancers. Int J Mol Sci. 2013;14:19361-84 pubmed publisher
    ..its role in cutaneous tumor initiation and maintenance, much less is known about Ras signaling in the epidermal stem cells, which are the main targets of skin carcinogenesis...
  16. Murakami M, Horibe H, Iohara K, Hayashi Y, Osako Y, Takei Y, et al. The use of granulocyte-colony stimulating factor induced mobilization for isolation of dental pulp stem cells with high regenerative potential. Biomaterials. 2013;34:9036-47 pubmed publisher
    Human dental pulp stem cells (DPSCs) contain subsets of progenitor/stem cells with high angiogenic, neurogenic and regenerative potential useful for cell therapy...
  17. Kim H, Yi B, Hwang K, Kim S, Choi K. Anticancer effects of the engineered stem cells transduced with therapeutic genes via a selective tumor tropism caused by vascular endothelial growth factor toward HeLa cervical cancer cells. Mol Cells. 2013;36:347-54 pubmed publisher
    The aim of the present study was to investigate the therapeutic efficacy of genetically engineered stem cells (GESTECs) expressing bacterial cytosine deaminase (CD) and/or human interferon-beta (IFN-?) gene against HeLa cervical cancer ..
  18. Wang D, Zhang Z, O Loughlin E, Wang L, Fan X, Lai E, et al. MicroRNA-205 controls neonatal expansion of skin stem cells by modulating the PI(3)K pathway. Nat Cell Biol. 2013;15:1153-63 pubmed publisher
    Skin stem cells (SCs) are specified and rapidly expanded to fuel body growth during early development. However, the molecular mechanisms that govern the amplification of skin SCs remain unclear...
  19. Xia J, Luo M, Ni N, Chen J, Hu Y, Deng Y, et al. Bone marrow mesenchymal stem cells stimulate proliferation and neuronal differentiation of retinal progenitor cells. PLoS ONE. 2013;8:e76157 pubmed publisher
    ..Bone marrow mesenchymal stem cells (BMSCs) are reported to express a variety of cytokines and neurotrophic factors, which have powerful trophic and ..
  20. Huang Z, Shen Y, Pei N, Sun A, Xu J, Song Y, et al. The effect of nonuniform magnetic targeting of intracoronary-delivering mesenchymal stem cells on coronary embolisation. Biomaterials. 2013;34:9905-16 pubmed publisher
    ..In the in vitro experiments, iron-labelled mesenchymal stem cells (MSCs) were accumulated in layers predominantly at the edge of the magnet...
  21. Uchida N, Tasaka M. Regulation of plant vascular stem cells by endodermis-derived EPFL-family peptide hormones and phloem-expressed ERECTA-family receptor kinases. J Exp Bot. 2013;64:5335-43 pubmed publisher
    ..The (pro)cambium serves as vascular stem cells that produce all vascular cells...
  22. Adachi K, Nikaido I, Ohta H, Ohtsuka S, Ura H, Kadota M, et al. Context-dependent wiring of Sox2 regulatory networks for self-renewal of embryonic and trophoblast stem cells. Mol Cell. 2013;52:380-92 pubmed publisher
    ..It also plays an essential role in different types of multipotent stem cells, raising the possibility that Sox2 governs the common stemness phenotype...
  23. Wang Y, Zheng Y, Li J, Wang Z, Zhang G, Yu J. 10(-7)  m 17?-oestradiol enhances odonto/osteogenic potency of human dental pulp stem cells by activation of the NF-?B pathway. Cell Prolif. 2013;46:677-84 pubmed publisher
    ..potency, while oestrogen deficiency usually leads to impaired osteogenic differentiation of mesenchymal stem cells. However, little is known concerning direct effects of oestrogen on differentiation of human dental pulp stem ..
  24. Ordonez P, Chow S, Wakefield D, Di Girolamo N. Human limbal epithelial progenitor cells express ?v?5-integrin and the interferon-inducible chemokine CXCL10/IP-10. Stem Cell Res. 2013;11:888-901 pubmed publisher
    ..If limbal epithelial stem cells (LESC) can be more readily identified, isolated and maintained ex vivo, patients could be treated with better ..
  25. Tantin D. Oct transcription factors in development and stem cells: insights and mechanisms. Development. 2013;140:2857-66 pubmed publisher
  26. Lim X, Tan S, Koh W, Chau R, Yan K, Kuo C, et al. Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling. Science. 2013;342:1226-30 pubmed publisher
    The skin is a classical example of a tissue maintained by stem cells. However, the identity of the stem cells that maintain the interfollicular epidermis and the source of the signals that control their activity remain unclear...
  27. Liu G, Sun X, Bian J, Wu R, Guan X, Ouyang B, et al. Correction of diabetic erectile dysfunction with adipose derived stem cells modified with the vascular endothelial growth factor gene in a rodent diabetic model. PLoS ONE. 2013;8:e72790 pubmed publisher
    The aim of this study was to determine whether adipose derived stem cells (ADSCs) expressing vascular endothelial growth factor (VEGF) gene can improve endothelial function, recover the impaired VEGF signaling pathway and enhance smooth ..
  28. Lerit D, Rusan N. PLP inhibits the activity of interphase centrosomes to ensure their proper segregation in stem cells. J Cell Biol. 2013;202:1013-22 pubmed publisher
    Centrosomes determine the mitotic axis of asymmetrically dividing stem cells. Several studies have shown that the centrosomes of the Drosophila melanogaster central brain neural stem cells are themselves asymmetric, organizing varying ..
  29. Patil R, Kumar B, Lee W, Jeon R, Jang S, Lee Y, et al. Multilineage potential and proteomic profiling of human dental stem cells derived from a single donor. Exp Cell Res. 2014;320:92-107 pubmed publisher
    Dental tissues provide an alternative autologous source of mesenchymal stem cells (MSCs) for regenerative medicine...
  30. Chavez Munoz C, Nguyen K, Xu W, Hong S, Mustoe T, Galiano R. Transdifferentiation of adipose-derived stem cells into keratinocyte-like cells: engineering a stratified epidermis. PLoS ONE. 2013;8:e80587 pubmed publisher
    ..Human adipose-derived stem cells (ASC) have been shown to differentiate in-vitro into both mesenchymal lineages and non-mesenchymal lineages, ..
  31. Minakhina S, Changela N, Steward R. Zfrp8/PDCD2 is required in ovarian stem cells and interacts with the piRNA pathway machinery. Development. 2014;141:259-68 pubmed publisher
    The maintenance of stem cells is central to generating diverse cell populations in many tissues throughout the life of an animal...
  32. Visvader J, Stingl J. Mammary stem cells and the differentiation hierarchy: current status and perspectives. Genes Dev. 2014;28:1143-58 pubmed publisher
    ..Lineage tracing has highlighted the existence of bipotent mammary stem cells (MaSCs) in situ as well as long-lived unipotent cells that drive morphogenesis and homeostasis of the ductal ..
  33. Berry S, Andruszkiewicz P, Chun J, Hong J. Nestin expression in end-stage disease in dystrophin-deficient heart: implications for regeneration from endogenous cardiac stem cells. Stem Cells Transl Med. 2013;2:848-61 pubmed publisher
    Nestin(+) cardiac stem cells differentiate into striated cells following myocardial infarct...
  34. Kim S, Kim H, Huang W, Okada M, Welge J, Wang Y, et al. Cardiac stem cells with electrical stimulation improve ischaemic heart function through regulation of connective tissue growth factor and miR-378. Cardiovasc Res. 2013;100:241-51 pubmed publisher
    In this study, we investigated whether pre-conditioning (PC) by electrical stimulation (EleS) induces cytoprotective effect on cardiac stem cells (CSCs) and determined its underlying molecular mechanisms.
  35. Blanpain C, Fuchs E. Stem cell plasticity. Plasticity of epithelial stem cells in tissue regeneration. Science. 2014;344:1242281 pubmed publisher
    Tissues rely upon stem cells for homeostasis and repair...
  36. Ahn J, Lee H, Seo K, Kang S, Ra J, Youn H. Anti-tumor effect of adipose tissue derived-mesenchymal stem cells expressing interferon-? and treatment with cisplatin in a xenograft mouse model for canine melanoma. PLoS ONE. 2013;8:e74897 pubmed publisher
    Adipose tissue-derived mesenchymal stem cells (AT-MSCs) are attractive cell-therapy vehicles for the delivery of anti-tumor molecules into the tumor microenvironment...
  37. Ju S, Mu J, Dokland T, Zhuang X, Wang Q, Jiang H, et al. Grape exosome-like nanoparticles induce intestinal stem cells and protect mice from DSS-induced colitis. Mol Ther. 2013;21:1345-57 pubmed publisher
    ..a proof of concept, we show that the cells targeted by grape exosome-like nanoparticles (GELNs) are intestinal stem cells whose responses underlie the GELN-mediated intestinal tissue remodeling and protection against dextran sulfate ..
  38. Chou W, Takeo M, Rabbani P, Hu H, Lee W, Chung Y, et al. Direct migration of follicular melanocyte stem cells to the epidermis after wounding or UVB irradiation is dependent on Mc1r signaling. Nat Med. 2013;19:924-9 pubmed publisher
    During wound healing, stem cells provide functional mature cells to meet acute demands for tissue regeneration. Simultaneously, the tissue must maintain a pool of stem cells to sustain its future regeneration capability...
  39. Deng Y, Zhou H, Zou D, Xie Q, Bi X, Gu P, et al. The role of miR-31-modified adipose tissue-derived stem cells in repairing rat critical-sized calvarial defects. Biomaterials. 2013;34:6717-28 pubmed publisher
    ..Recent studies have proven that miRNAs are involved in the osteogenic differentiation of stem cells. However, few studies have reported the use of miRNA-modified adult stem cells to repair critical-sized defects (..
  40. Xiao L, Tsutsui T. Characterization of human dental pulp cells-derived spheroids in serum-free medium: stem cells in the core. J Cell Biochem. 2013;114:2624-36 pubmed publisher
    ..Whole mount immunofluorescence staining and histological analysis showed a distribution of stem cells in the central/intermediate zones of spheroids...
  41. Wansleeben C, Barkauskas C, Rock J, Hogan B. Stem cells of the adult lung: their development and role in homeostasis, regeneration, and disease. Wiley Interdiscip Rev Dev Biol. 2013;2:131-48 pubmed publisher
    ..The identification of the long-term stem cells in the alveolar region is still under debate, and little is known about resident stem and progenitor cells for ..
  42. Hu Y, de Rooij D, Page D. Tumor suppressor gene Rb is required for self-renewal of spermatogonial stem cells in mice. Proc Natl Acad Sci U S A. 2013;110:12685-90 pubmed publisher
    ..suppressor gene Rb is essential for maintaining the quiescence and for regulating the differentiation of somatic stem cells. Inactivation of Rb in somatic stem cells typically leads to their overexpansion, often followed by increased ..
  43. Wu T, Tzeng Y, Chang W, Cheng C, Kuo Y, Chien C, et al. Tracking the engraftment and regenerative capabilities of transplanted lung stem cells using fluorescent nanodiamonds. Nat Nanotechnol. 2013;8:682-9 pubmed publisher
    ..Several optical imaging methods and probes have been used to track how stem cells incorporate and regenerate themselves in vivo over time...
  44. Biazar E, Keshel S. The healing effect of stem cells loaded in nanofibrous scaffolds on full thickness skin defects. J Biomed Nanotechnol. 2013;9:1471-82 pubmed
    In this study, we have evaluated the wound-healing effects of unrestricted somatic stem cells loaded in chitosan-cross linked PHBV nanofibrous scaffold, implanted into the full thickness skin defects of rats...
  45. Chang Y, Pi H, Hsieh C, Fuller M. Smurf-mediated differential proteolysis generates dynamic BMP signaling in germline stem cells during Drosophila testis development. Dev Biol. 2013;383:106-20 pubmed publisher
    Germline stem cells (GSCs) produce gametes throughout the reproductive life of many animals, and intensive studies have revealed critical roles of BMP signaling to maintain GSC self-renewal in Drospophila adult gonads...
  46. Guo Z, Driver I, Ohlstein B. Injury-induced BMP signaling negatively regulates Drosophila midgut homeostasis. J Cell Biol. 2013;201:945-61 pubmed publisher
    ..Our data establish a new link between injury and hyperplasia and may provide insight into how BMP signaling mutations drive formation of human intestinal cancers...
  47. Niederreiter L, Fritz T, Adolph T, Krismer A, Offner F, Tschurtschenthaler M, et al. ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells. J Exp Med. 2013;210:2041-56 pubmed publisher
    ..As such, Xbp1 in the intestinal epithelium not only regulates local inflammation but at the same time also determines the propensity of the epithelium to develop tumors. ..
  48. Bui H, Van Thuan N, Kwon D, Choi Y, Kang M, Han J, et al. Identification and characterization of putative stem cells in the adult pig ovary. Development. 2014;141:2235-44 pubmed publisher
    ..to isolate, identify and characterize, including their proliferation and differentiation capabilities, putative stem cells (PSCs) from the ovary...
  49. Ito K, Suda T. Metabolic requirements for the maintenance of self-renewing stem cells. Nat Rev Mol Cell Biol. 2014;15:243-56 pubmed publisher
    A distinctive feature of stem cells is their capacity to self-renew to maintain pluripotency...
  50. Sun B, Looi L, Guo S, He Z, Gan E, Huang J, et al. Timing mechanism dependent on cell division is invoked by Polycomb eviction in plant stem cells. Science. 2014;343:1248559 pubmed publisher
    Plant floral stem cells divide a limited number of times before they stop and terminally differentiate, but the mechanisms that control this timing remain unclear...
  51. Wang R, Li Z, Zhang H, Zheng P, Li Q, Shi J, et al. Invasive cancers are not necessarily from preformed in situ tumours - an alternative way of carcinogenesis from misplaced stem cells. J Cell Mol Med. 2013;17:921-6 pubmed publisher
    ..that majority of invasive cancers arise in the connective tissue stroma de novo, from the misplaced epithelial stem cells which come to the wrong land of connective tissue stroma by accident...
  52. Chen Y, Wong M, Campagnolo P, Simpson R, Winkler B, Margariti A, et al. Adventitial stem cells in vein grafts display multilineage potential that contributes to neointimal formation. Arterioscler Thromb Vasc Biol. 2013;33:1844-51 pubmed publisher
    This study was designed to carry out the characterization of stem cells within the adventitia and to elucidate their functional role in the pathogenesis of vein graft atherosclerosis.
  53. Beckman S, Chen W, Tang Y, Proto J, Mlakar L, Wang B, et al. Beneficial effect of mechanical stimulation on the regenerative potential of muscle-derived stem cells is lost by inhibiting vascular endothelial growth factor. Arterioscler Thromb Vasc Biol. 2013;33:2004-12 pubmed publisher
    We previously reported that mechanical stimulation increased the effectiveness of muscle-derived stem cells (MDSCs) for tissue repair...
  54. Elsen M, Raschke S, Tennagels N, Schwahn U, Jelenik T, Roden M, et al. BMP4 and BMP7 induce the white-to-brown transition of primary human adipose stem cells. Am J Physiol Cell Physiol. 2014;306:C431-40 pubmed publisher
    ..Therefore, we compared the effect of BMP4 and BMP7 on white-to-brown transition in primary human adipose stem cells (hASCs) from subcutaneous AT...
  55. Arens J, Duong T, Dehmelt L. A morphometric screen identifies specific roles for microtubule-regulating genes in neuronal development of P19 stem cells. PLoS ONE. 2013;8:e79796 pubmed publisher
    ..Here we performed a siRNA-based morphometric screen in P19 stem cells to evaluate the role of 408 microtubule-regulating genes during this early neuromorphogenesis step...
  56. Villani V, Milanesi A, Sedrakyan S, DA Sacco S, Angelow S, Conconi M, et al. Amniotic fluid stem cells prevent ?-cell injury. Cytotherapy. 2014;16:41-55 pubmed publisher
    The contribution of amniotic fluid stem cells (AFSC) to tissue protection and regeneration in models of acute and chronic kidney injuries and lung failure has been shown in recent years...
  57. de Laval B, Pawlikowska P, Barbieri D, Besnard Guerin C, Cico A, Kumar R, et al. Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-?B pathways and their target, IEX-1. Blood. 2014;123:509-19 pubmed publisher
    ..Iex-1 forms a complex with pERK and the catalytic subunit of DNA-PK, which is necessary and sufficient to promote TPO-increased DNA-PK activation and NHEJ DSB repair in both mouse and human HSPCs. ..
  58. Mead B, Logan A, Berry M, Leadbeater W, Scheven B. Intravitreally transplanted dental pulp stem cells promote neuroprotection and axon regeneration of retinal ganglion cells after optic nerve injury. Invest Ophthalmol Vis Sci. 2013;54:7544-56 pubmed publisher
    To investigate the potential therapeutic benefit of intravitreally implanted dental pulp stem cells (DPSCs) on axotomized adult rat retinal ganglion cells (RGCs) using in vitro and in vivo neural injury models.
  59. Edgar R, Mazor Y, Rinon A, Blumenthal J, Golan Y, Buzhor E, et al. LifeMap Discovery™: the embryonic development, stem cells, and regenerative medicine research portal. PLoS ONE. 2013;8:e66629 pubmed publisher
    ..LifeMap Discovery is freely available to academic nonprofit institutions at http://discovery.lifemapsc.com. ..
  60. Wright B, Hopkinson A, Leyland M, Connon C. The secretome of alginate-encapsulated limbal epithelial stem cells modulates corneal epithelial cell proliferation. PLoS ONE. 2013;8:e70860 pubmed publisher
    Limbal epithelial stem cells may ameliorate limbal stem cell deficiency through secretion of therapeutic proteins, delivered to the cornea in a controlled manner using hydrogels...
  61. Chen L, Bai Y, Liao G, Peng E, Wu B, Wang Y, et al. Electrospun poly(L-lactide)/poly(?-caprolactone) blend nanofibrous scaffold: characterization and biocompatibility with human adipose-derived stem cells. PLoS ONE. 2013;8:e71265 pubmed publisher
    The essence of tissue engineering is the fabrication of autologous cells or induced stem cells in naturally derived or synthetic scaffolds to form specific tissues...
  62. Buttler K, Badar M, Seiffart V, Laggies S, Gross G, Wilting J, et al. De novo hem- and lymphangiogenesis by endothelial progenitor and mesenchymal stem cells in immunocompetent mice. Cell Mol Life Sci. 2014;71:1513-27 pubmed publisher
    ..Interactions between mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) may provide such a treatment option...