oxyphil cells

Summary

Summary: Large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askenazy cells.

Top Publications

  1. Montone K, Baloch Z, LiVolsi V. The thyroid Hürthle (oncocytic) cell and its associated pathologic conditions: a surgical pathology and cytopathology review. Arch Pathol Lab Med. 2008;132:1241-50 pubmed publisher
    ..Hürthle cells are eosinophilic, follicular-derived cells that are associated with a variety of nonneoplastic and neoplastic thyroid lesions. The differential diagnosis of Hürthle cell lesions is quite broad...
  2. Gasparre G, Porcelli A, Bonora E, Pennisi L, Toller M, Iommarini L, et al. Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors. Proc Natl Acad Sci U S A. 2007;104:9001-6 pubmed
    ..We conclude that disruptive mutations in complex I subunits are markers of thyroid oncocytic tumors...
  3. Dettori T, Frau D, Lai M, Mariotti S, Uccheddu A, Daniele G, et al. Aneuploidy in oncocytic lesions of the thyroid gland: diffuse accumulation of mitochondria within the cell is associated with trisomy 7 and progressive numerical chromosomal alterations. Genes Chromosomes Cancer. 2003;38:22-31 pubmed
    ..Our data support the contention that follicular tumors composed of oncocytes should be regarded as a distinct subset...
  4. Guaraldi F, Zang G, Dackiw A, Caturegli P. Oncocytic mania: a review of oncocytic lesions throughout the body. J Endocrinol Invest. 2011;34:383-94 pubmed publisher
    ..The causes and mechanisms that transform a normal cell into an oncocyte remain to be elucidated. Aim of this article is to review the most common oncocytic lesions, highlighting their key pathological features and clinical significance...
  5. Kasper K, Stewart J, Das K. Fine-needle aspiration cytology of thyroid nodules with Hürthle cells: cytomorphologic predictors for neoplasms, improving diagnostic accuracy and overcoming pitfalls. Acta Cytol. 2014;58:145-52 pubmed publisher
  6. Fujimaki M, Fukumura Y, Saito T, Mitani K, Uchida S, Yokoyama J, et al. Oncocytic mucoepidermoid carcinoma of the parotid gland with CRTC1-MAML2 fusion transcript: report of a case with review of literature. Hum Pathol. 2011;42:2052-5 pubmed publisher
    ..Identification of this fusion gene may help in distinguishing oncocytic mucoepidermoid carcinoma from its mimics...
  7. Shi Y, Hogue J, Dixit D, Koh J, Olson J. Functional and genetic studies of isolated cells from parathyroid tumors reveal the complex pathogenesis of parathyroid neoplasia. Proc Natl Acad Sci U S A. 2014;111:3092-7 pubmed publisher
    ..analysis of resected adenomatous parathyroid glands, we have isolated and characterized chief cells, oxyphil cells, and tumor-infiltrating lymphocytes...
  8. Ritter C, Haughey B, Miller B, Brown A. Differential gene expression by oxyphil and chief cells of human parathyroid glands. J Clin Endocrinol Metab. 2012;97:E1499-505 pubmed publisher
    Parathyroid oxyphil cells, whose function is unknown, are thought to be derived from chief cells...
  9. Mai K, Thomas J, Yazdi H, Commons A, Lamba M, Stinson A. Pathologic study and clinical significance of Hürthle cell papillary thyroid carcinoma. Appl Immunohistochem Mol Morphol. 2004;12:329-37 pubmed

More Information

Publications62

  1. Nixon I, Ganly I, Hann L, Lin O, Yu C, Brandt S, et al. Nomogram for predicting malignancy in thyroid nodules using clinical, biochemical, ultrasonographic, and cytologic features. Surgery. 2010;148:1120-7; discussion 1127-8 pubmed publisher
    ..Our aim was to create a nomogram to predict accurately the chance of malignancy within a thyroid nodule...
  2. Stelow E, Woon C, Atkins K, Bardales R, Cathro H, Frierson H, et al. Interobserver variability with the interpretation of thyroid FNA specimens showing predominantly Hürthle cells. Am J Clin Pathol. 2006;126:580-3 pubmed
  3. Petersson F, Sima R, Grossmann P, Michal M, Kuroda N, Hora M, et al. Renal small cell oncocytoma with pseudorosettes A histomorphologic, immunohistochemical, and molecular genetic study of 10 cases. Hum Pathol. 2011;42:1751-60 pubmed publisher
    ..All tumors behaved in a benign fashion during follow-up (mean, 3.1 years; median, 1 year)...
  4. Rouzbahman M, Serra S, Chetty R. Rectal adenocarcinoma with oncocytic features: possible relationship with preoperative chemoradiotherapy. J Clin Pathol. 2006;59:1039-43 pubmed
    ..The constellation of histopathological changes is varied and well documented...
  5. Ugur O, Bozkurt M, Hamaloglu E, Sokmensuer C, Etikan I, Ugur Y, et al. Clinicopathologic and radiopharmacokinetic factors affecting gamma probe-guided parathyroidectomy. Arch Surg. 2004;139:1175-9 pubmed
    ..The success of gamma probe-guided parathyroidectomy is closely related to the parathyroid-to-thyroid activity ratio at the time of surgery. Preoperative determination of maximum uptake ratio may improve the surgical outcome...
  6. Kao C, Grignon D, Ulbright T, Idrees M. A case report of adrenocortical carcinosarcoma with oncocytic and primitive neuroectodermal-like features. Hum Pathol. 2013;44:1947-55 pubmed publisher
    ..Adrenal carcinosarcoma is a rare highly aggressive malignancy with a wide morphologic spectrum. Recognition of variant morphology and applying correct immunohistochemical studies will aid in reaching an accurate diagnosis. ..
  7. Moreira A, Waisman J, Cangiarella J. Aspiration cytology of the oncocytic variant of papillary adenocarcinoma of the thyroid gland. Acta Cytol. 2004;48:137-41 pubmed
    ..To study the cytologic features of the oncocytic variant of papillary adenocarcinoma of the thyroid gland to distinguish this subtype from other oncocytic lesions of the thyroid...
  8. Lomonte C, Martino R, Selvaggiolo M, Bona R, Cazzato F, Milano R, et al. Calcitriol pulse therapy and histology of parathyroid glands in hemodialysis patients. J Nephrol. 2003;16:716-20 pubmed
    ..However, not much is known about the effect of such therapy on parathyroid morphology...
  9. Chang S, Wei C, Tseng C. The cytology of a thyroid granular cell tumor. Endocr Pathol. 2009;20:137-40 pubmed publisher
    ..A differential diagnosis of thyroid GCT with more frequent thyroid lesions containing cytoplasmic granules, including Hurthle cells, macrophages, follicular cells, and cells of black thyroid syndrome, was also performed...
  10. Wischerath H, Brehmer D, Hesse G, Laubert A. [Oncocytic adenocarcinoma of the submandibular gland]. HNO. 2002;50:565-9 pubmed
    ..The tumors show no capsule and an infiltrative local growth with perineural and vascular expansions...
  11. Mai K, Bokhary R, Yazdi H, Thomas J, Commons A. Reduced HBME-1 immunoreactivity of papillary thyroid carcinoma and papillary thyroid carcinoma-related neoplastic lesions with Hürthle cell and/or apocrine-like changes. Histopathology. 2002;40:133-42 pubmed
    ..The purpose of this study is to correlate papillary thyroid carcinoma with positive and negative immunoreactivity for HBME with the histopathological features...
  12. Hofauer B, Strenger T, Knopf A. [Solid as a rock]. HNO. 2011;59:1026-9 pubmed publisher
    ..Physical examination and a magnetic resonance imaging (MRI) scan did not identify the nature of the tumor. A resection of the mass was performed and the surgical specimen was revealed to be a mature teratoma by histology...
  13. Zeppa P, Benincasa G, Troncone G, Zabatta A, Fulciniti F, Vetrani A, et al. Quantitative assessment of oxyphilic cell lesions of the thyroid gland on fine needle aspiration samples. Anal Quant Cytol Histol. 2001;23:178-84 pubmed
    ..To assess the possible contribution by a multiparametric quantitative approach to the cytologic diagnosis of oxyphilic cell (OC) thyroid lesions...
  14. Wakely P. Oncocytic and oncocyte-like lesions of the head and neck. Ann Diagn Pathol. 2008;12:222-30 pubmed publisher
    ..Correlating the fine-needle aspiration cytology and histology of both oncocytic and oncocyte-like neoplasms can assist in avoiding interpretive pitfalls among these lesions...
  15. Sumida K, Nakamura M, Ubara Y, Marui Y, Tanaka K, Takaichi K, et al. Histopathological alterations of the parathyroid glands in haemodialysis patients with secondary hyperparathyroidism refractory to cinacalcet hydrochloride. J Clin Pathol. 2011;64:756-60 pubmed publisher
    ..The aim of this study was to elucidate the effects of cinacalcet for histopathological alterations on the parathyroid glands...
  16. Kang D, Kim K, Kim J, Kim S, Kim J, Baik H, et al. High prevalence of RET, RAS, and ERK expression in Hashimoto's thyroiditis and in papillary thyroid carcinoma in the Korean population. Thyroid. 2007;17:1031-8 pubmed
    ..The RET/PTC-RAS-BRAF cascade is associated with papillary thyroid carcinoma (PTC)...
  17. Pathak K, Klonisch T, Nason R, Leslie W. FDG-PET characteristics of Hürthle cell and follicular adenomas. Ann Nucl Med. 2016;30:506-9 pubmed publisher
    ..The overall accuracy was 87 %. HCA shows significantly higher focal FDG uptake as compared to FA and should always be considered in the differential diagnosis of FDG-PET positive thyroid nodules. ..
  18. Garcia J, Hunt J, Weinreb I, McHugh J, Barnes E, Cieply K, et al. Fluorescence in situ hybridization for detection of MAML2 rearrangements in oncocytic mucoepidermoid carcinomas: utility as a diagnostic test. Hum Pathol. 2011;42:2001-9 pubmed publisher
    ..However, we demonstrate that the presence of MAML2 rearrangement can be used as supportive evidence to distinguish oncocytic mucoepidermoid carcinoma from other oncocytic lesions...
  19. Rossi E, Zannoni G, Lombardi C, Vellone V, Moncelsi S, Papi G, et al. Morphological and immunocytochemical diagnosis of thyroiditis: Comparison between conventional and liquid-based cytology. Diagn Cytopathol. 2012;40:404-9 pubmed publisher
    ..5%. Among these cases, 10 had a benign histology and a concordant negative ICC. LBC can be used as a valid method for HT, especially for the possible application of ICC to HN, and it allows a correct preoperative selection of lesions..
  20. Hotárková S, Hermanova M, Povysilova V, Dvorak K, Feit J, Lukas Z, et al. Demonstration of MyoD1 expression in oncocytic cardiomyopathy: report of two cases and review of the literature. Pathol Res Pract. 2004;200:59-65 pubmed
    ..To confirm this hypothesis, it is necessary to further investigate myogenic transcription factor program in human cardiac conduction system cells...
  21. Tsurumi K, Kamiya H, Yokoi M, Kameyama Y. Papillary oncocytic cystadenoma of palatal minor salivary gland: a case report. J Oral Maxillofac Surg. 2003;61:631-3 pubmed
  22. Wong Y, Md Isa N, Md Zin R, Noor Akmal S. Hurthle cells in fine needle aspiration cytology of the thyroid: a potential diagnostic dilemma?. Malays J Pathol. 2015;37:49-52 pubmed
    ..However, accurate diagnosis can still be made with careful observation of the predominant cell population, nuclear features and whether there is abundant colloid or lymphocytes in the background. ..
  23. Tan S, Ouyang Y, Li X, Wen M, Li S. [Connection of magnetic antisense probe with SK-Br-3 oncocyte mRNA nucleotide detected by high resolution atomic force microscope]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2011;28:442-5 pubmed
    ..05). These experiments demonstrated that the high resolution AFM could be used to show the binding of magnetic antisense probe and SK-Br-3 mRNA of tumor cell nuclear...
  24. Bellevicine C, Malapelle U, Docimo G, Ciancia G, Mossetti G, Pettinato G, et al. Multicentric encapsulated papillary oncocytic neoplasm of the thyroid: A case diagnosed by a combined cytological, histological, immunohistochemical, and molecular approach. Diagn Cytopathol. 2012;40:450-4 pubmed publisher
    ..Here, we first report on FNA, its cytological features together with histological, immunohistochemical, and molecular correlates...
  25. Dugonjić S, Cerovic S, Janković Z, Ajdinovic B. Correlation of subtraction parathyroid scintigraphy with weight, pathohistologic finding and oxyphil cell content of parathyroid glands in parathyroid hyperplasia. Vojnosanit Pregl. 2012;69:345-52 pubmed
  26. Wen M, Li B, Ouyang Y, Luo Y, Li S. Preparation and quality test of superparamagnetic iron oxide labeled antisense oligodeoxynucleotide probe: a preliminary study. Ann Biomed Eng. 2009;37:1240-50 pubmed publisher
    ..These results indicate that the SPIO-labeled ASODN probe is potentially useful as a MR targeting contrast enhancing agent to specifically diagnose tumors which had over-expression of the c-erbB2 oncogene at an early stage...
  27. Ragazzi M, de Biase D, Betts C, Farnedi A, Ramadan S, Tallini G, et al. Oncocytic carcinoma of the breast: frequency, morphology and follow-up. Hum Pathol. 2011;42:166-75 pubmed publisher
    ..Clinical features and overall survival of oncocytic carcinomas are not distinctive because they are similar to those of the other cases when matched for grade and stage...
  28. Sav A, Scheithauer B, Mazzola C, Ketterling S, Thompson S, Reilly M. Oncocytic choroid plexus carcinoma: case report. Clin Neuropathol. 2010;29:14-20 pubmed
    ..Choroid plexus carcinoma with oncocytic transformation has not been previously reported. The remarkable extent of this alteration and its clinical significance remains to be determined...
  29. Pusiol T, Franceschetti I, Scialpi M, Piscioli I. Oncocytic sialolipoma of the submandibular gland with sebaceous differentiation: a new pathological entity. Indian J Pathol Microbiol. 2009;52:379-82 pubmed publisher
    ..The tumor was composed of mature adipose tissue surrounded by a thin fibrous capsule, multiple nodules of oncocytes, normal ductal-acinar units with focal ductal sebaceous differentiation...
  30. Wen M, Li B, Ouyang Y, Jiang M, Luo Y, Li S. [Application of superparamagnetic iron oxide labeled antisense oligodeoxynucleotide probe in cellular magnetic resonance imaging]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2008;30:554-8 pubmed
    ..To prepare the superparamagnetic iron oxide (SPIO)-labeled antisense oligodeoxynucleotide (ASODN) probe and evaluate the application of this probe in cellular magnetic resonance imaging (MRI)...
  31. Szende B, Farid P, Végso G, Perner F, Kopper L. Apoptosis and P53, Bcl-2 and Bax gene expression in parathyroid glands of patients with hyperparathyroidism. Pathol Oncol Res. 2004;10:98-103 pubmed
    ..b>Oxyphil cells were more frequently positive than chief cells or clear cells...
  32. Arena V, Arena E, Stigliano E, Capelli A. Bile duct adenoma with oncocytic features. Histopathology. 2006;49:318-20 pubmed
  33. Arvanitis D, Arvanitis L, Panourias I, Kitsoulis P, Kanavaros P. Mitochondria-rich normal, metaplastic, and neoplastic cells show overexpression of the epitope H recognized by the monoclonal antibody H. Pathol Res Pract. 2005;201:319-24 pubmed
    ..Immunohistochemical staining for the mAbH was observed in oxyphil cells of parathyroid glands, in striated duct cells of parotid glands, in urinary tubules of kidneys, in parietal ..
  34. Elliott D, Pitman M, Bloom L, Faquin W. Fine-needle aspiration biopsy of Hurthle cell lesions of the thyroid gland: A cytomorphologic study of 139 cases with statistical analysis. Cancer. 2006;108:102-9 pubmed
  35. Gilloteaux J, Eze N, Jamison J, McGuire K, Summers J. A rare, human prostate oncocyte cell originates from the prostatic carcinoma (DU145) cell line. Ultrastruct Pathol. 2013;37:440-8 pubmed publisher
  36. Liu Y, Tang Q, Wang L, Liu Q, Fan S, Li H. Concomitant lymphocyte-rich classical Hodgkin's lymphoma and Warthin's tumor. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116:e117-20 pubmed publisher
    ..This case serves as a reminder that a careful evaluation of the histomorphological and immunohistological features of the lymphoid tissue is required for a WT biopsy. ..
  37. Petit A, Castillo M, Santos M, Mellado B, Alcover J, Mallofre C. KIT expression in chromophobe renal cell carcinoma: comparative immunohistochemical analysis of KIT expression in different renal cell neoplasms. Am J Surg Pathol. 2004;28:676-8 pubmed
  38. Agaimy A, Ihrler S, Märkl B, Lell M, Zenk J, Hartmann A, et al. Lipomatous salivary gland tumors: a series of 31 cases spanning their morphologic spectrum with emphasis on sialolipoma and oncocytic lipoadenoma. Am J Surg Pathol. 2013;37:128-37 pubmed publisher
    ..Oncocytic lipoadenoma is an epithelial-predominant tumor that is distinct from the fat-dominated nononcocytic sialolipoma, but the 2 types seem to merge in some cases...
  39. Mandel L, Carrao V. Bilateral parotid diffuse hyperplastic oncocytosis: case report. J Oral Maxillofac Surg. 2005;63:560-2 pubmed
  40. Jih D, Morgan M, Bass J, Tuthill R, Somach S. Oncocytic metaplasia occurring in melanoma. Semin Cutan Med Surg. 2004;23:73-9 pubmed
    ..We recently reviewed a spectrum of oncocytic melanocytic nevi that did not have clinical significance. We now describe similar changes in melanoma...
  41. Shah N, Tighe J, Barrett A, Kumar S, Allen J. Bilateral intraparotid and extraparotid Warthin's tumours. Br J Oral Maxillofac Surg. 2007;45:238-9 pubmed
    ..In this report, we describe a patient with simultaneous bilateral involvement of the parotid glands and neck by multiple Warthin's tumours, an occurrence not previously described...
  42. Di Palma S, Lambros M, Savage K, Jones C, Mackay A, Dexter T, et al. Oncocytic change in pleomorphic adenoma: molecular evidence in support of an origin in neoplastic cells. J Clin Pathol. 2007;60:492-9 pubmed
    ..When found within pleomorphic adenomas (PAs), cells with OC may be perceived as evidence of malignancy, and lead to a misdiagnosis of carcinoma ex pleomorphic adenoma (CaExPa)...
  43. Fellegara G, Rosai J. Signet ring cells in a poorly differentiated Hurthle cell carcinoma of the thyroid combined with two papillary microcarcinomas. Int J Surg Pathol. 2007;15:388-90 pubmed
  44. Rother P, Wohlgemuth B, Wolff W, Rebentrost I. Morphometrically observable aging changes in the human tongue. Ann Anat. 2002;184:159-64 pubmed
    ..We have demonstrated the process of adipose tissue formation in muscles and serous glands. Gender differences in the aging process could be clearly shown. Numerous oncocytes were visible in ducts from elder persons...
  45. Roh M, Jo V, Stelow E, Faquin W, Zou K, Alexander E, et al. The predictive value of the fine-needle aspiration diagnosis "suspicious for a follicular neoplasm, hurthle cell type" in patients with hashimoto thyroiditis. Am J Clin Pathol. 2011;135:139-45 pubmed publisher
    ..quot; For this reason, it might be appropriate for Hürthle cell-only aspirates from patients with HT to be categorized as either atypia of undetermined significance or SFNHCT...
  46. Colella G, Apicella A, Bove P, Rossiello L, Trodella M, Rossiello R. Oncocytic carcinoma of the accessory lobe of the parotid gland. J Craniofac Surg. 2010;21:1987-90 pubmed publisher
    ..The clinical and histologic difficulties in relationship to the diagnosis of a midcheek mass consisting of an unusual tumor are emphasized...
  47. Erickson L, Jin L, Papotti M, Lloyd R. Oxyphil parathyroid carcinomas: a clinicopathologic and immunohistochemical study of 10 cases. Am J Surg Pathol. 2002;26:344-9 pubmed
    ..These findings also indicate that the same histopathologic features should be used to diagnose oxyphil and chief cell parathyroid carcinomas...
  48. Yutan E, Clark O. Hürthle cell carcinoma. Curr Treat Options Oncol. 2001;2:331-5 pubmed
    ..All patients with HCC should be given thyroid hormone because most of these tumors have thyrotropin receptors. External beam radiation may be considered for patients with unresectable disease, but this is considered palliative...
  49. Pradella L, Zuntini R, Magini P, Ceccarelli C, Neri I, Cerasoli S, et al. Two distinct thyroid tumours in a patient with Cowden syndrome carrying both a 10q23 and a mitochondrial DNA germline deletion. J Med Genet. 2011;48:779-82 pubmed publisher
    ..Cowden syndrome (CS) is an autosomal dominant disorder characterised by macrocephaly, specific mucocutaneous features and predisposition to benign and malignant tumours. Detectable mutations in the PTEN gene account for 80-85% of cases...
  50. Albores Saavedra J, Wu J, Crook T, Amirkhan R, Jones L, Hruban R. Intestinal and oncocytic variants of pancreatic intraepithelial neoplasia. A morphological and immunohistochemical study. Ann Diagn Pathol. 2005;9:69-76 pubmed
    ..Although their significance is unknown, the possibility that these PanIN variants represent cancer precursors should be considered...
  51. Zhou C, Shi D, Ma D, Zhang J, Yu G, Gao Y. Primary oncocytic carcinoma of the salivary glands: a clinicopathologic and immunohistochemical study of 12 cases. Oral Oncol. 2010;46:773-8 pubmed publisher
    ..Complete surgical excision is the treatment of choice while the role of radiotherapy or chemotherapy is controversial, and careful follow-up is necessary...
  52. Agarwal S, Agarwal K. Rare pediatric adrenocortical carcinoma with oncocytic change: a cytologic dilemma. Endocr Pathol. 2011;22:40-3 pubmed publisher
    ..It is difficult to distinguish adrenocortical neoplasm, RCC, and pheochromocytoma on cytology because of overlapping features; hence, important cytological features which help in distinguishing between the three are discussed...
  53. Gakiopoulou H, Litsiou E, Valaris K, Balafoutas D, Patsouris E, Tseleni Balafouta S. Possible association of CEA expression with oxyphilic change but not with C-cell hyperplasia in Hashimoto's thyroiditis. Endocr J. 2010;57:693-9 pubmed
    ..In conclusion, C-cell hyperplasia and CEA expression may be encountered in the setting of Hashimoto's thyroiditis and Graves' disease...