fast twitch muscle fibers

Summary

Summary: Skeletal muscle fibers characterized by their expression of the Type II MYOSIN HEAVY CHAIN isoforms which have high ATPase activity and effect several other functional properties - shortening velocity, power output, rate of tension redevelopment. Several fast types have been identified.

Top Publications

  1. Pedersen T, de Paoli F, de Paoli F, Flatman J, Nielsen O. Regulation of ClC-1 and KATP channels in action potential-firing fast-twitch muscle fibers. J Gen Physiol. 2009;134:309-22 pubmed publisher
    ..In conclusion, G(Cl) and G(K) are acutely regulated in AP-firing fast-twitch muscle fibers. Such regulation may contribute to the physiological control of excitability in active muscle...
  2. Roots H, Offer G, Ranatunga K. Comparison of the tension responses to ramp shortening and lengthening in intact mammalian muscle fibres: crossbridge and non-crossbridge contributions. J Muscle Res Cell Motil. 2007;28:123-39 pubmed
  3. Moore C, Parkin C, Bidet Y, Ingham P. A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion. Development. 2007;134:3145-53 pubmed
    ..In addition, we show that the adaptor proteins Crk and Crk-like (Crkl), with which Dock proteins are known to interact physically, are also required for myoblast fusion...
  4. Stuart C, Howell M, Baker J, Dykes R, Duffourc M, Ramsey M, et al. Cycle training increased GLUT4 and activation of mammalian target of rapamycin in fast twitch muscle fibers. Med Sci Sports Exerc. 2010;42:96-106 pubmed publisher
    ..To determine whether cycle training of sedentary subjects would increase the expression of the principle muscle glucose transporters, six volunteers completed 6 wk of progressively increasing intensity stationary cycle cycling...
  5. Zancanaro C, Mariotti R, Perdoni F, Nicolato E, Malatesta M. Physical training is associated with changes in nuclear magnetic resonance and morphometrical parameters of the skeletal muscle in senescent mice. Eur J Histochem. 2007;51:305-10 pubmed
    ..These data show that training can prevent sarcopenia in senescent mice by affecting muscle status and inducing myofibre hypertrophy in the absence of significant muscle damage...
  6. Murphy R, Larkins N, Mollica J, Beard N, Lamb G. Calsequestrin content and SERCA determine normal and maximal Ca2+ storage levels in sarcoplasmic reticulum of fast- and slow-twitch fibres of rat. J Physiol. 2009;587:443-60 pubmed publisher
  7. Von Hofsten J, Elworthy S, Gilchrist M, Smith J, Wardle F, Ingham P. Prdm1- and Sox6-mediated transcriptional repression specifies muscle fibre type in the zebrafish embryo. EMBO Rep. 2008;9:683-9 pubmed publisher
    ..Thus, Prdm1 promotes slow-twitch fibre differentiation by acting as a global repressor of fast-fibre-specific genes, as well as by abrogating the repression of slow-fibre-specific genes...
  8. Pedersen T, Macdonald W, de Paoli F, de Paoli F, Gurung I, Nielsen O. Comparison of regulated passive membrane conductance in action potential-firing fast- and slow-twitch muscle. J Gen Physiol. 2009;134:323-37 pubmed publisher
    ..It is concluded that regulation of G(m) is a general phenomenon in AP-firing muscle, and that differences in G(m) regulation may contribute to the different phenotypes of fast- and slow-twitch muscle...
  9. Lynch G, Faulkner J, Brooks S. Force deficits and breakage rates after single lengthening contractions of single fast fibers from unconditioned and conditioned muscles of young and old rats. Am J Physiol Cell Physiol. 2008;295:C249-56 pubmed publisher

More Information

Publications93

  1. Li P, Akimoto T, Zhang M, Williams R, Yan Z. Resident stem cells are not required for exercise-induced fiber-type switching and angiogenesis but are necessary for activity-dependent muscle growth. Am J Physiol Cell Physiol. 2006;290:C1461-8 pubmed
    ..The origin of the angiogenic cells in this physiological exercise model remains to be determined...
  2. Shavlakadze T, White J, Hoh J, Rosenthal N, Grounds M. Targeted expression of insulin-like growth factor-I reduces early myofiber necrosis in dystrophic mdx mice. Mol Ther. 2004;10:829-43 pubmed
    ..This mechanism of action can account for the long-term reduced severity of the dystropathology in mdx mice that overexpress mIGF-1 and provides promising opportunities for therapeutic strategies...
  3. Henry C, Amacher S. Zebrafish slow muscle cell migration induces a wave of fast muscle morphogenesis. Dev Cell. 2004;7:917-23 pubmed
    The specification and morphogenesis of slow and fast twitch muscle fibers are crucial for muscle development. In zebrafish, Hedgehog is required for slow muscle fiber specification...
  4. McCullagh K, Calabria E, Pallafacchina G, Ciciliot S, Serrano A, Argentini C, et al. NFAT is a nerve activity sensor in skeletal muscle and controls activity-dependent myosin switching. Proc Natl Acad Sci U S A. 2004;101:10590-5 pubmed
    ..These results support the notion that Cn-NFAT signaling acts as a nerve activity sensor in skeletal muscle in vivo and controls nerve activity-dependent myosin switching...
  5. Grifone R, Laclef C, Spitz F, Lopez S, Demignon J, Guidotti J, et al. Six1 and Eya1 expression can reprogram adult muscle from the slow-twitch phenotype into the fast-twitch phenotype. Mol Cell Biol. 2004;24:6253-67 pubmed
    ..Collectively, these data identify Six1 and Eya1 as the first transcriptional complex that is able to reprogram adult slow-twitch oxidative fibers toward a fast-twitch glycolytic phenotype...
  6. Macdonald W, Pedersen T, Clausen T, Nielsen O. N-Benzyl-p-toluene sulphonamide allows the recording of trains of intracellular action potentials from nerve-stimulated intact fast-twitch skeletal muscle of the rat. Exp Physiol. 2005;90:815-25 pubmed
  7. Parsons S, Millay D, Wilkins B, Bueno O, Tsika G, Neilson J, et al. Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy. J Biol Chem. 2004;279:26192-200 pubmed
    ..We conclude that calcineurin expression is important during myogenesis and fiber-type switching, but not for muscle growth in response to hypertrophic stimuli...
  8. Bruusgaard J, Liestøl K, Gundersen K. Distribution of myonuclei and microtubules in live muscle fibers of young, middle-aged, and old mice. J Appl Physiol (1985). 2006;100:2024-30 pubmed
    ..Thus changes in myonuclear number and distribution, perhaps related to alterations in the microtubular network, may underlie some of the adverse consequences of aging on skeletal muscle size and function...
  9. Andruchov O, Wang Y, Andruchova O, Galler S. Functional properties of skinned rabbit skeletal and cardiac muscle preparations containing alpha-cardiac myosin heavy chain. Pflugers Arch. 2004;448:44-53 pubmed
    ..We conclude that type alpha fibres have characteristic kinetic properties that fill the gap between the fast type II and the slow type I fibres, and the following order of velocity can be established: IIB>IID(X)>IIA>alpha>I...
  10. Moran A, Warren G, Lowe D. Soleus and EDL muscle contractility across the lifespan of female C57BL/6 mice. Exp Gerontol. 2005;40:966-75 pubmed
    ..Thus this study provides essential, comprehensive baseline data for future studies on age-related muscle dysfunction in the female mouse...
  11. Mogensen M, Sahlin K. Mitochondrial efficiency in rat skeletal muscle: influence of respiration rate, substrate and muscle type. Acta Physiol Scand. 2005;185:229-36 pubmed
    ..To investigate the hypothesis that mitochondrial efficiency (i.e. P/O ratio) is higher in type I than in type II fibres during submaximal rates of respiration...
  12. Donoghue P, Ribaric S, Moran B, Cebasek V, Erzen I, Ohlendieck K. Early effects of denervation on Ca(2+)-handling proteins in skeletal muscle. Int J Mol Med. 2004;13:767-72 pubmed
    ..Hence, changes in muscle activity appear to have a profound effect on the abundance and isoform expression pattern of Ca(2+)-handling elements...
  13. Trappe S, Trappe T, Gallagher P, Harber M, Alkner B, Tesch P. Human single muscle fibre function with 84 day bed-rest and resistance exercise. J Physiol. 2004;557:501-13 pubmed
    ..the maintenance of MHC IIa power and (2). the shift from slow to fast (MHC I --> MHC I/IIa) in single fibre MHC isoform composition...
  14. Groves J, Hammond C, Hughes S. Fgf8 drives myogenic progression of a novel lateral fast muscle fibre population in zebrafish. Development. 2005;132:4211-22 pubmed
    ..We conclude that Fgf8 drives terminal differentiation of a specific population of lateral muscle precursor cells within the early somite...
  15. Stocksley M, Chakkalakal J, Bradford A, Miura P, De Repentigny Y, Kothary R, et al. A 1.3 kb promoter fragment confers spatial and temporal expression of utrophin A mRNA in mouse skeletal muscle fibers. Neuromuscul Disord. 2005;15:437-49 pubmed
    ..This transgenic mouse will be valuable as an in vivo model for developing and testing molecules aimed at increasing utrophin A expression...
  16. Michel R, Dunn S, Chin E. Calcineurin and skeletal muscle growth. Proc Nutr Soc. 2004;63:341-9 pubmed
    ..Increased understanding of these mediators of muscle growth may provide strategies for the development of effective therapeutics to counter muscle weakness and muscular dystrophy...
  17. Minnaard R, Drost M, Wagenmakers A, van Kranenburg G, Kuipers H, Hesselink M. Skeletal Muscle wasting and contractile performance in septic rats. Muscle Nerve. 2005;31:339-48 pubmed
    ..These findings suggest that both the inherent function of a muscle and the muscle fiber-type distribution affect the responsiveness to catabolic signals...
  18. Debold E, Romatowski J, Fitts R. The depressive effect of Pi on the force-pCa relationship in skinned single muscle fibers is temperature dependent. Am J Physiol Cell Physiol. 2006;290:C1041-50 pubmed
    ..Consequently, the combined changes in these ions likely account for a greater portion of fatigue than previously predicted based on studies at lower temperatures or high temperatures at saturating Ca(2+) levels...
  19. Frías J, Cadefau J, Prats C, Moran M, Megias A, Cusso R. Disturbances of the sarcoplasmic reticulum and transverse tubular system in 24-h electrostimulated fast-twitch skeletal muscle. Biochim Biophys Acta. 2005;1668:64-74 pubmed
    ..Since this process is reversible, we suggest that it may be part of a physiological response to fatigue...
  20. Hernelahti M, Tikkanen H, Karjalainen J, Kujala U. Muscle fiber-type distribution as a predictor of blood pressure: a 19-year follow-up study. Hypertension. 2005;45:1019-23 pubmed
    ..A high proportion of type I fibers in skeletal muscle is an independent predictor of low blood pressure and explains part of the known association between high levels of physical activity and low blood pressure...
  21. Hagiwara N, Ma B, Ly A. Slow and fast fiber isoform gene expression is systematically altered in skeletal muscle of the Sox6 mutant, p100H. Dev Dyn. 2005;234:301-11 pubmed
    ..Together with our earlier report, demonstrating early postnatal muscle defects in the Sox6 null-p100H mutant, the present results suggest that Sox6 likely plays an important role in muscle development...
  22. Zhang S, Andersson D, Sandstrom M, Westerblad H, Katz A. Cross bridges account for only 20% of total ATP consumption during submaximal isometric contraction in mouse fast-twitch skeletal muscle. Am J Physiol Cell Physiol. 2006;291:C147-54 pubmed
  23. Pogrzebna M, Celichowski J. Changes in the contractile properties of motor units in the rat medial gastrocnemius muscle after one month of treadmill training. Acta Physiol (Oxf). 2008;193:367-79 pubmed publisher
    ..The significant change in the proportions of fast MUs following training indicates FF to FR transformation. The various effects of training seen in the different MU types help explain the rationale behind mixed training. ..
  24. Serrano R, Barreda M, Blanes M. Investigating the presence of organochlorine pesticides and polychlorinated biphenyls in wild and farmed gilthead sea bream (Sparus aurata) from the Western Mediterranean sea. Mar Pollut Bull. 2008;56:963-72 pubmed publisher
    ..The diet is highlighted as an important factor in understanding differences observed in organochlorine pollutants levels of fish tissues. ..
  25. Brunner F, Schmid A, Sheikhzadeh A, Nordin M, Yoon J, Frankel V. Effects of aging on Type II muscle fibers: a systematic review of the literature. J Aging Phys Act. 2007;15:336-48 pubmed
    ..Because the process of aging involves various complex phenomena such as fiber-type coexpression, however, it seems difficult to assign those changes solely to a specific fiber type. ..
  26. Caputo C, Bolaños P. Effect of mitochondria poisoning by FCCP on Ca2+ signaling in mouse skeletal muscle fibers. Pflugers Arch. 2008;455:733-43 pubmed
    ..This suggests an important role for Ca(2+) in the FCCP effect on transient amplitude. ..
  27. Baguet A, Reyngoudt H, Pottier A, Everaert I, Callens S, Achten E, et al. Carnosine loading and washout in human skeletal muscles. J Appl Physiol (1985). 2009;106:837-42 pubmed publisher
    ..The present study shows that washout periods for crossover designs in supplementation studies for muscle metabolites may sometimes require months rather than weeks. ..
  28. Guigas B. No lack of contraction-induced AMPK activation and glucose uptake in fast-twitch muscles from adenylate kinase-1 knockout mice. Acta Physiol (Oxf). 2008;192:337 pubmed publisher
  29. Dutka T, Mollica J, Lamboley C, Weerakkody V, Greening D, Posterino G, et al. S-nitrosylation and S-glutathionylation of Cys134 on troponin I have opposing competitive actions on Ca2+ sensitivity in rat fast-twitch muscle fibers. Am J Physiol Cell Physiol. 2017;312:C316-C327 pubmed publisher
    ..These findings demonstrate that S-nitrosylation and S-glutathionylation exert opposing effects on Ca2+ sensitivity in mammalian FT muscle fibers, mediated by competitive actions on Cys134 of TnIf. ..
  30. Morozov V, Tsyplenkov P, Golberg N, Kalinski M. The effects of high-intensity exercise on skeletal muscle neutrophil myeloperoxidase in untrained and trained rats. Eur J Appl Physiol. 2006;97:716-22 pubmed
    ..A smaller neutrophil infiltration in muscles of trained animals after exhaustive exercise suggests a protective effect of previous training to muscle injury. ..
  31. Du S, Rotllant J, Tan X. Muscle-specific expression of the smyd1 gene is controlled by its 5.3-kb promoter and 5'-flanking sequence in zebrafish embryos. Dev Dyn. 2006;235:3306-15 pubmed
    ..Together, these data indicate that smyd1 is specifically expressed in most, if not all, striated muscles, and the muscle specificity is controlled by the 5.3-kb promoter and flanking sequences. ..
  32. Migita T, Hirakoba K. Effect of different pedal rates on oxygen uptake slow component during constant-load cycling exercise. J Sports Med Phys Fitness. 2006;46:189-96 pubmed
  33. MacLean H, Chiu W, Notini A, Axell A, Davey R, McManus J, et al. Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice. FASEB J. 2008;22:2676-89 pubmed publisher
    ..In conclusion, androgens are not required for peak muscle mass in females. In males, androgens act through the AR to regulate multiple gene pathways that control muscle mass, strength, and fatigue resistance. ..
  34. Donoghue P, Doran P, Wynne K, Pedersen K, Dunn M, Ohlendieck K. Proteomic profiling of chronic low-frequency stimulated fast muscle. Proteomics. 2007;7:3417-30 pubmed
  35. Zhang S, Sandström M, Aydin J, Westerblad H, Wieringa B, Katz A. Activation of glucose transport and AMP-activated protein kinase during muscle contraction in adenylate kinase-1 knockout mice. Acta Physiol (Oxf). 2008;192:413-20 pubmed
    ..In conclusion, AK(-/-) mice have a normal capacity for contraction-mediated glucose uptake. This appears to occur via increases in AMP and reactive oxygen species that result in the activation of AMPK. ..
  36. De Bock K, Derave W, Ramaekers M, Richter E, Hespel P. Fiber type-specific muscle glycogen sparing due to carbohydrate intake before and during exercise. J Appl Physiol (1985). 2007;102:183-8 pubmed
    ..We conclude that the combination of carbohydrate intake both before and during moderate- to high-intensity endurance exercise results in glycogen sparing in type IIa muscle fibers. ..
  37. Vukova T, Dimitrov V, Radicheva N. Three methods for estimation of changes in frequency characteristics of potentials elicited by long-lasting (fatiguing) activity of isolated muscle fibres. Gen Physiol Biophys. 2010;29:243-54 pubmed
    ..All methods are applicable but DWT is a preferable for study of muscle fibre fatigue in clinical and experimental neurophysiology. ..
  38. Radak Z, Kumagai S, Nakamoto H, Goto S. 8-Oxoguanosine and uracil repair of nuclear and mitochondrial DNA in red and white skeletal muscle of exercise-trained old rats. J Appl Physiol (1985). 2007;102:1696-701 pubmed
    ..These data provide evidence for differential regulation of UDG and OGG1 in maintaining fidelity of DNA in oxidatively stressed cells. ..
  39. Kimber E, Tajsharghi H, Kroksmark A, Oldfors A, Tulinius M. A mutation in the fast skeletal muscle troponin I gene causes myopathy and distal arthrogryposis. Neurology. 2006;67:597-601 pubmed
    ..To describe a three-generation family with distal arthrogryposis associated with myopathy and caused by a mutation in the gene encoding for sarcomeric thin filament protein troponin I, TNNI2...
  40. Gosker H, Zeegers M, Wouters E, Schols A. Muscle fibre type shifting in the vastus lateralis of patients with COPD is associated with disease severity: a systematic review and meta-analysis. Thorax. 2007;62:944-9 pubmed
    ..A study was conducted to determine whether vastus lateralis muscle fibre type proportions are associated with COPD disease severity and to provide reference values for the proportions of fibre types in the vastus lateralis in COPD...
  41. Jensen J, Grønning Wang L, Jebens E, Whitehead J, Zorec R, Shepherd P. Adrenaline potentiates insulin-stimulated PKB activation in the rat fast-twitch epitrochlearis muscle without affecting IRS-1-associated PI 3-kinase activity. Pflugers Arch. 2008;456:969-78 pubmed publisher
    ..These results indicate that the combination of adrenaline and insulin may activate novel signalling molecules rather than just summing up their effects on linear pathways. ..
  42. Huerta M, Ortiz Mesina M, Trujillo X, Sanchez Pastor E, Vasquez C, Castro E, et al. Effects of cannabinoids on caffeine contractures in slow and fast skeletal muscle fibers of the frog. J Membr Biol. 2009;229:91-9 pubmed publisher
    ..In conclusion, our results suggest that in the slow and fast muscle fibers of the frog cannabinoids diminish caffeine-evoked tension through a receptor-mediated mechanism. ..
  43. Nieto Gonzalez J, Carrascal L, Nunez Abades P, Torres B. Phasic and tonic firing properties in rat oculomotor nucleus motoneurons, studied in vitro. Eur J Neurosci. 2007;25:2682-96 pubmed
  44. Spencer T, Posterino G. Sequential effects of GSNO and H2O2 on the Ca2+ sensitivity of the contractile apparatus of fast- and slow-twitch skeletal muscle fibers from the rat. Am J Physiol Cell Physiol. 2009;296:C1015-23 pubmed publisher
    ..Furthermore, the absence of effects in slow-twitch muscle may further explain why this fiber type is relatively insensitive to fatigue. ..
  45. Bombardier E, Vigna C, Iqbal S, Tiidus P, Tupling A. Effects of ovarian sex hormones and downhill running on fiber-type-specific HSP70 expression in rat soleus. J Appl Physiol (1985). 2009;106:2009-15 pubmed publisher
  46. Royer L, Sztretye M, Manno C, Pouvreau S, Zhou J, Knollmann B, et al. Paradoxical buffering of calcium by calsequestrin demonstrated for the calcium store of skeletal muscle. J Gen Physiol. 2010;136:325-38 pubmed publisher
    ..The study revealed a surprisingly modest loss of Ca(2+) storage capacity in null cells, which may reflect concurrent changes, rather than detract from the physiological importance of calsequestrin...
  47. Peters M, Adams M, Froehner S. Differential association of syntrophin pairs with the dystrophin complex. J Cell Biol. 1997;138:81-93 pubmed
    ..Since individual syntrophins do not have intrinsic binding specificity for dystrophin, dystrobrevin, or utrophin, the observed preferential pairing of syntrophins must depend on extrinsic regulatory mechanisms. ..
  48. Shi H, Zeng C, Ricome A, Hannon K, Grant A, Gerrard D. Extracellular signal-regulated kinase pathway is differentially involved in beta-agonist-induced hypertrophy in slow and fast muscles. Am J Physiol Cell Physiol. 2007;292:C1681-9 pubmed
    ..These data suggest that fast myofibers are pivotal in the adaptation of muscle to environmental cues and that the mechanism underlying this change is partially mediated by the MAPK signaling cascade...
  49. Raheem O, Huovinen S, Suominen T, Haapasalo H, Udd B. Novel myosin heavy chain immunohistochemical double staining developed for the routine diagnostic separation of I, IIA and IIX fibers. Acta Neuropathol. 2010;119:495-500 pubmed publisher
    ..The method provides even more detailed information of fast fiber subtypes and highly atrophic fibers on one single slide. ..
  50. Fokina N, Tavitova M, Shenkman B. Cellular marker of myofiber activity for ankle flexor and extensor under conditions of rat hindlimb suspension. J Gravit Physiol. 2007;14:P99-100 pubmed
    ..soleus and slow-twitch fibers of m. tibialis anterior, these differences were not significant. In spite of this the obtained data do not contradict our initial hypothesis. ..
  51. Kawai N, Sano R, Korfage J, Nakamura S, Tanaka E, van Wessel T, et al. Functional characteristics of the rat jaw muscles: daily muscle activity and fiber type composition. J Anat. 2009;215:656-62 pubmed publisher
  52. Roots H, Ranatunga K. An analysis of the temperature dependence of force, during steady shortening at different velocities, in (mammalian) fast muscle fibres. J Muscle Res Cell Motil. 2008;29:9-24 pubmed publisher
    ..e. when doing external work. ..
  53. Guerrero M, Guiu Comadevall M, Cadefau J, Parra J, Balius R, Estruch A, et al. Fast and slow myosins as markers of muscle injury. Br J Sports Med. 2008;42:581-4; discussion 584 pubmed
    ..The correct diagnosis of grade I lesions can prevent progression of the injury in athletes undergoing continual training sessions and competitions, thus aiding sports physicians in their decision making. ..
  54. Tang K, Wagner P, Breen E. TNF-alpha-mediated reduction in PGC-1alpha may impair skeletal muscle function after cigarette smoke exposure. J Cell Physiol. 2010;222:320-7 pubmed publisher
  55. Bostick B, Ghosh A, Yue Y, Long C, Duan D. Systemic AAV-9 transduction in mice is influenced by animal age but not by the route of administration. Gene Ther. 2007;14:1605-9 pubmed
    ..The unique expression patterns in the aorta, liver, kidney and retina call for special attention when designing AAV-9 gene therapy applications for these organs...
  56. López Olmeda J, Bayarri M, Rol de Lama M, Madrid J, Sanchez Vazquez F. Effects of melatonin administration on oxidative stress and daily locomotor activity patterns in goldfish. J Physiol Biochem. 2006;62:17-25 pubmed
    ..In conclusion, melatonin administration provoked slight effects on lipid peroxidation and mortality resulting from oxidative stress, with reduction of locomotor activity in relation to the vehicle...
  57. Pandorf C, Haddad F, Wright C, Bodell P, Baldwin K. Differential epigenetic modifications of histones at the myosin heavy chain genes in fast and slow skeletal muscle fibers and in response to muscle unloading. Am J Physiol Cell Physiol. 2009;297:C6-16 pubmed publisher
  58. Xiong G, Yang L, Wei Y, Wang S, Tian L, Lei S, et al. Expression of the human fast-twitch skeletal muscle troponin I cDNA in a human ovarian carcinoma suppresses tumor growth. Sci China C Life Sci. 2007;50:93-100 pubmed
    ..Our data might also provide a novel useful strategy for cancer therapy by antiangiogenic gene therapy with a specific angiogenesis inhibitor Tnl-fast...
  59. Servais S, Letexier D, Favier R, Duchamp C, Desplanches D. Prevention of unloading-induced atrophy by vitamin E supplementation: links between oxidative stress and soleus muscle proteolysis?. Free Radic Biol Med. 2007;42:627-35 pubmed
    ..In conclusion, the protective effect of vitamin E might be due to modulation of muscle proteolysis-related genes rather than to its antioxidant function...
  60. Rusu L, Călina M, Avramescu E, Păun E, Vasilescu M. Neuromuscular investigation in diabetic polyneuropathy. Rom J Morphol Embryol. 2009;50:283-90 pubmed
    ..Also, values of Dm help us to assess the muscle tonus, elasticity and response to electrostimulus. We consider that this method helps the clinicians to have a prediction of a future polyneuropathy at diabetic patients...
  61. Cairns S, Robinson D, Loiselle D. Double-sigmoid model for fitting fatigue profiles in mouse fast- and slow-twitch muscle. Exp Physiol. 2008;93:851-62 pubmed publisher
    ..We conclude that a double-sigmoid expression is a useful and accurate model to characterize fatigue in isolated muscle preparations...
  62. DiMenna F, Wilkerson D, Burnley M, Bailey S, Jones A. Influence of priming exercise on pulmonary O2 uptake kinetics during transitions to high-intensity exercise at extreme pedal rates. J Appl Physiol (1985). 2009;106:432-42 pubmed publisher
    ..These data indicate that prior high-intensity exercise at a high pedal rate can speed Vo(2) kinetics during subsequent high-intensity exercise, presumably through specific priming effects on type II muscle fibers...
  63. Wank V, Fischer M, Walter B, Bauer R. Muscle growth and fiber type composition in hind limb muscles during postnatal development in pigs. Cells Tissues Organs. 2006;182:171-81 pubmed
    ..In contrast, at birth no remarkable differences in the diameter of fast and slow fibers were found. The rapid increase in muscle mass compared to body mass reflects the high performance in meat production of the cross pig investigated...
  64. Raikova R, Pogrzebna M, Drzymała H, Celichowski J, Aladjov H. Variability of successive contractions subtracted from unfused tetanus of fast and slow motor units. J Electromyogr Kinesiol. 2008;18:741-51 pubmed
  65. Saito T, Yamane A, Kaneko S, Ogawa T, Ikawa T, Saito K, et al. Changes in the lingual muscles of obese rats induced by high-fat diet feeding. Arch Oral Biol. 2010;55:803-8 pubmed publisher
    ..To elucidate the influences of obesity on the properties and volume of lingual (genioglossus and geniohyoid) muscles in obese rats...
  66. Ravosa M, Ning J, Costley D, Daniel A, Stock S, Stack M. Masticatory biomechanics and masseter fiber-type plasticity. J Musculoskelet Neuronal Interact. 2010;10:46-55 pubmed
  67. Hesse B, Fischer M, Schilling N. Distribution pattern of muscle fiber types in the perivertebral musculature of two different sized species of mice. Anat Rec (Hoboken). 2010;293:446-63 pubmed publisher
    ..Thereby, not all muscles or muscle regions similarly reflected the expected scaling effects. However, our results clearly show that body size is a critical factor when fiber-type proportions are compared among different sized mammals...
  68. Hepple R, Howlett R, Kindig C, Stary C, Hogan M. The O2 cost of the tension-time integral in isolated single myocytes during fatigue. Am J Physiol Regul Integr Comp Physiol. 2010;298:R983-8 pubmed publisher
    ..These data show that more fatigue-resistant fibers maintain aerobic metabolism as they fatigue, resulting in an increased O(2) cost of contractions that could contribute to the Vo(2) slow component seen in whole body exercise...
  69. Biérinx A, Sebille A. The urethral striated sphincter in adult male rat. Anat Embryol (Berl). 2006;211:435-41 pubmed
    ..The predominance of fast fibres is consistent with phasic contractions playing a role not only during micturition and urinary continence but also probably during ejaculation...
  70. Tannerstedt J, Apró W, Blomstrand E. Maximal lengthening contractions induce different signaling responses in the type I and type II fibers of human skeletal muscle. J Appl Physiol (1985). 2009;106:1412-8 pubmed publisher
    ..Our findings also suggest that p70(S6k) is activated, at least in part, via pathways not involving Akt-mTOR and MAPK...
  71. Matsuura T, Li Y, Giacobino J, Fu F, Huard J. Skeletal muscle fiber type conversion during the repair of mouse soleus: potential implications for muscle healing after injury. J Orthop Res. 2007;25:1534-40 pubmed
    ..These results suggest that PGC-1alpha contributes to myofiber type conversion after muscle injury and that this phenomenon could influence the recovery of the injured muscle...
  72. Takata H, Terada K, Oka H, Sunada Y, Moriguchi T, Nohno T. Involvement of Wnt4 signaling during myogenic proliferation and differentiation of skeletal muscle. Dev Dyn. 2007;236:2800-7 pubmed
    ..The present results are identical to those of myostatin knockout, suggesting that Wnt4 is acting against myostatin as an antagonizing signal for myostatin...
  73. Rader E, Cederna P, McClellan W, Caterson S, Panter K, Yu D, et al. Effect of cleft palate repair on the susceptibility to contraction-induced injury of single permeabilized muscle fibers from congenitally-clefted goat palates. Cleft Palate Craniofac J. 2008;45:113-20 pubmed publisher
    ..As an initial step to determining the validity of this theory, we tested the hypothesis that, in most cases, repair induces the transformation to type 1 fibers, thus diminishing susceptibility to injury...
  74. Calderón J, Bolaños P, Caputo C. Myosin heavy chain isoform composition and Ca(2+) transients in fibres from enzymatically dissociated murine soleus and extensor digitorum longus muscles. J Physiol. 2010;588:267-79 pubmed publisher
    ..In conclusion, we show for the first time the diversity of Ca(2+) transients for the whole continuum of fibre types and correlate this functional diversity with the structural and biochemical diversity of the skeletal muscle fibres...
  75. Stevens Lapsley J, Ye F, Liu M, Borst S, Conover C, Yarasheski K, et al. Impact of viral-mediated IGF-I gene transfer on skeletal muscle following cast immobilization. Am J Physiol Endocrinol Metab. 2010;299:E730-40 pubmed publisher
    ..Changes in IGFBP-5 mRNA expression during cast immobilization and reambulation paralleled those of IGF-I, whereas IGFBP-3 expression changed inversely to IGFBP-5...
  76. Jin T, Wernig A, Witzemann V. Changes in acetylcholine receptor function induce shifts in muscle fiber type composition. FEBS J. 2008;275:2042-54 pubmed publisher
    ..Muscle thus represents a self-matching system that adjusts contractile properties and synaptic function to variable functional demands...
  77. Muthny T, Kovarik M, Sispera L, Tilser I, Holecek M. Protein metabolism in slow- and fast-twitch skeletal muscle during turpentine-induced inflammation. Int J Exp Pathol. 2008;89:64-71 pubmed publisher
    ..Release of leucine was inhibited significantly more in SOL. We conclude that turpentine-induced inflammation affects more CHTLA, protein synthesis and leucine release in EDL compared to SOL...
  78. Macqueen D, Johnston I. A novel salmonid myoD gene is distinctly regulated during development and probably arose by duplication after the genome tetraploidization. FEBS Lett. 2006;580:4996-5002 pubmed publisher
    ..Another myoD paralogue (myoD2) is present in at least some teleosts, reflecting a more ancient genome duplication. To accommodate these findings we propose a simplified teleost-myoD nomenclature...
  79. Tee J, van Rooijen C, Boonen R, Zivkovic D. Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling. PLoS ONE. 2009;4:e5880 pubmed publisher
    ..Epistatic analyses suggest a possible genetic interaction between Wnt/beta-catenin and Myostatin in regulation of slow and fast twitch muscle myofibrillogenesis...
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    ..Our current studies show the potential of AAV8 to achieve widespread muscle transduction in utero and suggest its therapeutic potential for primary muscle disorders...
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    ..To investigate the frequency of structural changes in the vastus medialis muscle in patients with osteoarthritis (OA) of the knee...
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    ..The aim of this study was to investigate whether the PGC-1beta Ala203Pro polymorphism influences the age-related decline in skeletal muscle PGC-1beta expression, in vivo metabolism and markers for muscle fibre type composition...
  83. Iwamoto H. On the ability of 8-bromoadenosine triphosphate to support contractility of vertebrate skeletal muscle fibers. J Muscle Res Cell Motil. 2008;29:45-55 pubmed publisher
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    ..Motor neuron diseases (amyotrophic lateral sclerosis [ALS] and spinal muscular atrophy [SMA]) have been rarely associated with mitochondrial respiratory chain defects...