interstitial cells of cajal


Summary: c-Kit positive cells related to SMOOTH MUSCLE CELLS that are intercalated between the autonomic nerves and the effector smooth muscle cells of the GASTROINTESTINAL TRACT. Different phenotypic classes play roles as pacemakers, mediators of neural inputs, and mechanosensors.

Top Publications

  1. Popescu L, Faussone Pellegrini M. TELOCYTES - a case of serendipity: the winding way from Interstitial Cells of Cajal (ICC), via Interstitial Cajal-Like Cells (ICLC) to TELOCYTES. J Cell Mol Med. 2010;14:729-40 pubmed publisher
    ..Consequently, they were renamed 'interstitial cells of Cajal' (ICC) and considered to be pace-makers for gut motility...
  2. Cole W. ANO1-ther brick in the wall--role of Ca2+-activated Cl- channels of interstitial cells of Cajal in cholinergic motor control of gastrointestinal smooth muscle. J Physiol. 2011;589:4641-2 pubmed publisher
  3. Rusu M, Poalelungi C, Vrapciu A, Păduraru L, Didilescu A, Stan C. Anoctamin 1 positive esophageal interstitial Cajal cells in late stage human embryos. Anat Rec (Hoboken). 2014;297:301-7 pubmed
    b>Interstitial cells of Cajal (ICCs) are located in various smooth muscle organs and act as pacemaker cells, or ensure neuromodulation or mechanosensory roles...
  4. Fry C. Interstitial cells in the urinary tract, where are they and what do they do?. BJU Int. 2014;114:434-5 pubmed publisher
  5. Strege P, Gibbons S, Mazzone A, Bernard C, Beyder A, Farrugia G. EAVK segment "c" sequence confers Ca2+-dependent changes to the kinetics of full-length human Ano1. Am J Physiol Gastrointest Liver Physiol. 2017;312:G572-G579 pubmed publisher
    Anoctamin1 (Ano1 and TMEM16A) is a calcium-activated chloride channel specifically expressed in the interstitial cells of Cajal (ICC) of the gastrointestinal tract muscularis propria...
  6. Lee M, Ha S, Park C, Park P, Fuchs R, Wei L, et al. Transcriptome of interstitial cells of Cajal reveals unique and selective gene signatures. PLoS ONE. 2017;12:e0176031 pubmed publisher
    ..The transcriptomic profile of interstitial cells of Cajal (ICC), which serve as slow-wave electrical pacemakers for gastrointestinal (GI) smooth muscle, has yet ..
  7. Hayashi Y, Toyomasu Y, Saravanaperumal S, Bardsley M, Smestad J, Lorincz A, et al. Hyperglycemia Increases Interstitial Cells of Cajal via MAPK1 and MAPK3 Signaling to ETV1 and KIT, Leading to Rapid Gastric Emptying. Gastroenterology. 2017;153:521-535.e20 pubmed publisher
    Depletion of interstitial cells of Cajal (ICCs) is common in diabetic gastroparesis. However, in approximately 20% of patients with diabetes, gastric emptying (GE) is accelerated...
  8. Deng J, Yang S, Yuan Q, Chen Y, Li D, Sun H, et al. Acupuncture Ameliorates Postoperative Ileus via IL-6-miR-19a-KIT Axis to Protect Interstitial Cells of Cajal. Am J Chin Med. 2017;45:737-755 pubmed publisher
    ..MicroRNAs (miRNAs) participate in inflammation and injury to the interstitial cells of Cajal (ICCs), both of which are considered to be contributors to POI...
  9. Bashashati M, Moraveji S, Torabi A, Sarosiek I, Davis B, Diaz J, et al. Pathological Findings of the Antral and Pyloric Smooth Muscle in Patients with Gastroparesis-Like Syndrome Compared to Gastroparesis: Similarities and Differences. Dig Dis Sci. 2017;62:2828-2833 pubmed publisher
    ..The tissues were stained with H&E, C-Kit, and trichrome. Based on previous control data, an interstitial cells of Cajal (ICC) count of <10 per high power field in the antrum and/or pylorus was considered depletion...