erythroid cells

Summary

Summary: The series of cells in the red blood cell lineage at various stages of differentiation.

Top Publications

  1. Gambari R, Fabbri E, Borgatti M, Lampronti I, Finotti A, Brognara E, et al. Targeting microRNAs involved in human diseases: a novel approach for modification of gene expression and drug development. Biochem Pharmacol. 2011;82:1416-29 pubmed publisher
    ..PNAs targeting miR-122, miR-155 and miR-210 have already been developed and their biological effects studied both in vitro and in vivo...
  2. Gregory G, Miccio A, Bersenev A, Wang Y, Hong W, Zhang Z, et al. FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment. Blood. 2010;115:2156-66 pubmed publisher
    ..Normal FOG1 function in late-stage erythroid cells and MK requires interaction with the chromatin remodeling complex NuRD...
  3. Hu W, Yuan B, Flygare J, Lodish H. Long noncoding RNA-mediated anti-apoptotic activity in murine erythroid terminal differentiation. Genes Dev. 2011;25:2573-8 pubmed publisher
    ..Conversely, ectopic expression of this lncRNA can inhibit apoptosis in mouse erythroid cells. This lncRNA represses expression of Pycard, a proapoptotic gene, explaining in part the inhibition of ..
  4. Chen M, Li Y, De Obaldia M, Yang Q, Yzaguirre A, Yamada Inagawa T, et al. Erythroid/myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells. Cell Stem Cell. 2011;9:541-52 pubmed publisher
    ..The data indicate that EMPs and HSCs differentiate from distinct populations of hemogenic endothelial cells, with Ly6a expression specifically marking the HSC-generating hemogenic endothelium...
  5. Felli N, Pedini F, Romania P, Biffoni M, Morsilli O, Castelli G, et al. MicroRNA 223-dependent expression of LMO2 regulates normal erythropoiesis. Haematologica. 2009;94:479-86 pubmed publisher
    ..This study focused on the functional role of microRNA-223 (miR-223) on erythroid differentiation...
  6. Chen W, Gu P, Jiang X, Ruan H, Li C, Gao X. Protein phosphatase 2A catalytic subunit ? (PP2Ac?) maintains survival of committed erythroid cells in fetal liver erythropoiesis through the STAT5 pathway. Am J Pathol. 2011;178:2333-43 pubmed publisher
    ..However, whether PP2A plays a role in preventing erythroid cells from undergoing apoptosis remains to be elucidated...
  7. Accetta A, Corradini R, Sforza S, Tedeschi T, Brognara E, Borgatti M, et al. New uracil dimers showing erythroid differentiation inducing activities. J Med Chem. 2009;52:87-94 pubmed publisher
  8. Macari E, Lowrey C. Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway. Blood. 2011;117:5987-97 pubmed publisher
    ..siRNA knockdown of NRF2 inhibited ?-globin induction by tBHQ. When tested in human primary erythroid cells, tBHQ induced NRF2 binding to the ?-globin promoter, increased ?-globin mRNA and HbF, and suppressed ?-globin ..
  9. Xu J, Peng C, Sankaran V, Shao Z, Esrick E, Chong B, et al. Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. Science. 2011;334:993-6 pubmed publisher
    ..Thus, interference with HbF silencing by manipulation of a single target protein is sufficient to reverse SCD...

More Information

Publications62

  1. van Zalen S, Jeschke G, Hexner E, Russell J. AUF-1 and YB-1 are critical determinants of ?-globin mRNA expression in erythroid cells. Blood. 2012;119:1045-53 pubmed publisher
    The normal accumulation of ?-globin protein in terminally differentiating erythroid cells is critically dependent on the high stability of its encoding mRNA. The molecular basis for this property, though, is incompletely understood...
  2. Snow J, Trowbridge J, Fujiwara T, Emambokus N, Grass J, Orkin S, et al. A single cis element maintains repression of the key developmental regulator Gata2. PLoS Genet. 2010;6:e1001103 pubmed publisher
    ..These studies reveal how an individual cis element establishes a normal developmental program via regulating specific steps in the mechanism by which a critical transcription factor is repressed...
  3. Salvador A, Dalĺ Acqua S, Sardo M, Caffieri S, Vedaldi D, Dall Acqua F, et al. Erythroid induction of chronic myelogenous leukemia K562 cells following treatment with a photoproduct derived from the UV-A irradiation of 5-methoxypsoralen. ChemMedChem. 2010;5:1506-12 pubmed publisher
    ..The major photoproduct was characterized and analyzed, and it was found to induce erythroid differentiation of K562 cells and inhibit NF-kappaB/DNA interactions...
  4. Redmond L, Dumur C, Archer K, Grayson D, Haar J, Lloyd J. Krüppel-like factor 2 regulated gene expression in mouse embryonic yolk sac erythroid cells. Blood Cells Mol Dis. 2011;47:1-11 pubmed publisher
    ..In KLF2-/- embryos, ?-like globin gene expression is reduced, and E10.5 erythroid cells exhibit abnormal morphology. In this study, other genes regulated by KLF2 were identified by comparing E9...
  5. Chen W, Dailey H, Paw B. Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis. Blood. 2010;116:628-30 pubmed publisher
    In erythroid cells, ferrous iron is imported into the mitochondrion by mitoferrin-1 (Mfrn1). Previously, we showed that Mfrn1 interacts with Abcb10 to enhance mitochondrial iron importation...
  6. Xu J, Sankaran V, Ni M, Menne T, Puram R, Kim W, et al. Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes Dev. 2010;24:783-98 pubmed publisher
    ..Our findings provide insight into the mechanism of BCL11A action and new clues for the developmental gene regulatory programs that function at the beta-globin locus...
  7. Marini M, Porcu L, Asunis I, Loi M, Ristaldi M, Porcu S, et al. Regulation of the human HBA genes by KLF4 in erythroid cell lines. Br J Haematol. 2010;149:748-58 pubmed publisher
    ..All experiments combined support a regulatory role of KLF4 in the control of HBA gene expression...
  8. Gabbianelli M, Testa U, Morsilli O, Pelosi E, Saulle E, Petrucci E, et al. Mechanism of human Hb switching: a possible role of the kit receptor/miR 221-222 complex. Haematologica. 2010;95:1253-60 pubmed publisher
    ..MicroRNAs (miRs) play a pivotal role in normal hematopoiesis: downmodulation of miR-221/222 stimulates human erythropoietic proliferation through upmodulation of the kit receptor...
  9. Kaneko H, Shimizu R, Yamamoto M. GATA factor switching during erythroid differentiation. Curr Opin Hematol. 2010;17:163-8 pubmed publisher
    ..clarified that lineage-specific transcription factor networks are essential for proper differentiation of erythroid cells. The transcription factors GATA1 and GATA2 are involved in such networks that regulate erythroid gene ..
  10. Will B, Siddiqi T, Jorda M, Shimamura T, Luptakova K, Staber P, et al. Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells. Blood. 2010;115:2901-9 pubmed publisher
    ..These data suggest that Bim is a key effector molecule in JAK2 inhibition-induced apoptosis and that targeting this apoptotic pathway could be a novel therapeutic strategy for patients with activating JAK2 mutations...
  11. Cui S, Kolodziej K, Obara N, Amaral Psarris A, Demmers J, Shi L, et al. Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic ?-type globin promoters in differentiated adult erythroid cells. Mol Cell Biol. 2011;31:3298-311 pubmed publisher
    ..By chromatin immunoprecipitation (ChIP) we show that, in adult erythroid cells, TR2/TR4 bind to the embryonic ?-type globin promoters but not to the adult ?-globin promoter...
  12. Elahi S, Ertelt J, Kinder J, Jiang T, Zhang X, Xin L, et al. Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection. Nature. 2013;504:158-62 pubmed publisher
    ..Here we show that physiologically enriched CD71(+) erythroid cells in neonatal mice and human cord blood have distinctive immunosuppressive properties...
  13. Noh S, Miller S, Lee Y, Goh S, Marincola F, Stroncek D, et al. Let-7 microRNAs are developmentally regulated in circulating human erythroid cells. J Transl Med. 2009;7:98 pubmed publisher
  14. Miccio A, Wang Y, Hong W, Gregory G, Wang H, Yu X, et al. NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development. EMBO J. 2010;29:442-56 pubmed publisher
    ..Gene expression analysis in primary mutant erythroid cells and megakaryocytes (MKs) revealed an essential function for NuRD during both the repression and activation of ..
  15. Cheng Y, Wu W, Kumar S, Yu D, Deng W, Tripic T, et al. Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression. Genome Res. 2009;19:2172-84 pubmed publisher
    ..More broadly, these studies illustrate how a "master regulator" transcription factor coordinates tissue differentiation through a panoply of DNA and protein interactions...
  16. Dore L, Chlon T, Brown C, White K, Crispino J. Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis. Blood. 2012;119:3724-33 pubmed publisher
    ..Finally, by comparing GATA1 occupancy in erythroid cells and megakaryocytes, we find that the presence of ETS factor motifs is a major discriminator of megakaryocyte ..
  17. Sripichai O, Kiefer C, Bhanu N, Tanno T, Noh S, Goh S, et al. Cytokine-mediated increases in fetal hemoglobin are associated with globin gene histone modification and transcription factor reprogramming. Blood. 2009;114:2299-306 pubmed publisher
    ..Thus, cytokine-mediated signal transduction in adult erythroid cells causes significant changes in the pattern of globin gene and protein expression that are associated with ..
  18. Kowalczyk M, Hughes J, Garrick D, Lynch M, Sharpe J, Sloane Stanley J, et al. Intragenic enhancers act as alternative promoters. Mol Cell. 2012;45:447-58 pubmed publisher
    ..Distinguishing between meRNAs and mRNAs will transform our interpretation of dynamic changes in transcription both at the level of individual genes and of the genome as a whole. ..
  19. Skorokhod O, Caione L, Marrocco T, Migliardi G, Barrera V, Arese P, et al. Inhibition of erythropoiesis in malaria anemia: role of hemozoin and hemozoin-generated 4-hydroxynonenal. Blood. 2010;116:4328-37 pubmed publisher
    ..HZ-laden human monocytes inhibited growth of cocultivated human erythroid cells and produced HNE that diffused to adjacent cells generating HNE-protein adducts...
  20. Liu P, Barb J, Woodhouse K, Taylor J, Munson P, Raghavachari N. Transcriptome profiling and sequencing of differentiated human hematopoietic stem cells reveal lineage-specific expression and alternative splicing of genes. Physiol Genomics. 2011;43:1117-34 pubmed publisher
    ..Knowledge of molecular processes by which the cells acquire their cell-specific fate would be beneficial in developing cell-based therapies for human diseases...
  21. Gallagher P, Nilson D, Steiner L, Maksimova Y, Lin J, Bodine D. An insulator with barrier-element activity promotes alpha-spectrin gene expression in erythroid cells. Blood. 2009;113:1547-54 pubmed publisher
    ..1' to the alpha-spectrin promoter conferred tissue-specific expression of a linked (A)gamma-globin gene in erythroid cells at all developmental stages...
  22. Lulli V, Romania P, Morsilli O, Cianciulli P, Gabbianelli M, Testa U, et al. MicroRNA-486-3p regulates ?-globin expression in human erythroid cells by directly modulating BCL11A. PLoS ONE. 2013;8:e60436 pubmed publisher
    ..Overexpression of miR-486-3p in erythroid cells resulted in reduced BCL11A protein levels, associated to increased expression of ?-globin gene, whereas ..
  23. Du T, Fu Y, Dong M, Wang L, Fan H, Chen Y, et al. Experimental validation and complexity of miRNA-mRNA target interaction during zebrafish primitive erythropoiesis. Biochem Biophys Res Commun. 2009;381:688-93 pubmed publisher
    ..The results address the importance of using multiple approaches combined with Western blot analysis to validate the physiological target of a given miRNA...
  24. Walker A, Steward S, Howard T, Mortier N, Smeltzer M, Wang Y, et al. Epigenetic and molecular profiles of erythroid cells after hydroxyurea treatment in sickle cell anemia. Blood. 2011;118:5664-70 pubmed publisher
    ..This study was registered at ClinicalTrials.gov (NCT00305175)...
  25. Migliaccio A, Whitsett C, Migliaccio G. Erythroid cells in vitro: from developmental biology to blood transfusion products. Curr Opin Hematol. 2009;16:259-68 pubmed publisher
    ..These considerations highlight the importance of developing alternative blood products...
  26. Augoff K, Kolondra A, Chorzalska A, Lach A, Grabowski K, Sikorski A. Expression, purification and functional characterization of recombinant human acyl-CoA-binding protein (ACBP) from erythroid cells. Acta Biochim Pol. 2010;57:533-40 pubmed
    ..In this study, a recombinant form of ACBP derived from human erythroid cells was expressed in E. coli, purified, and functionally characterized...
  27. Zeigler B, Vajdos J, Qin W, Loverro L, Niss K. A mouse model for an erythropoietin-deficiency anemia. Dis Model Mech. 2010;3:763-72 pubmed publisher
    ..Taken together, these results demonstrate that this model can serve as a valuable preclinical model for the anemia of EPO deficiency, as well as a tool for the study of stress-induced erythropoiesis during limiting conditions of EPO...
  28. Yao X, Kodeboyina S, Liu L, Dzandu J, Sangerman J, Ofori Acquah S, et al. Role of STAT3 and GATA-1 interactions in gamma-globin gene expression. Exp Hematol. 2009;37:889-900 pubmed publisher
    ..for signal transducers and activators of transcription 3 (STAT3) in gamma-globin gene regulation in primary erythroid cells. Recently, GATA-1, a key transcription factor involved in hematopoietic cell development, was shown to ..
  29. Patrick D, Zhang C, Tao Y, Yao H, Qi X, Schwartz R, et al. Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3zeta. Genes Dev. 2010;24:1614-9 pubmed publisher
    ..These findings reveal an essential role of 14-3-3zeta as a mediator of the proerythroid differentiation actions of miR-451, and highlight the therapeutic potential of miR-451 inhibitors...
  30. Pase L, Layton J, Kloosterman W, Carradice D, Waterhouse P, Lieschke G. miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2. Blood. 2009;113:1794-804 pubmed publisher
    ..These studies define a new genetic pathway promoting erythroid maturation (mnr/miR-451/gata2) and provide a rare example of partial rescue of a mutant phenotype solely by miRNA overexpression...
  31. Fukumoto T, Kubota Y, Kitanaka A, Yamaoka G, Ohara Waki F, Imataki O, et al. Gab1 transduces PI3K-mediated erythropoietin signals to the Erk pathway and regulates erythropoietin-dependent proliferation and survival of erythroid cells. Cell Signal. 2009;21:1775-83 pubmed publisher
    ..EPO-induced tyrosine phosphorylation of Gab1 and its association with Grb2 in human primary EPO-sensitive erythroid cells. The co-immunoprecipitation experiments using the Jak inhibitor AG490 or siRNA duplexes targeting Jak2 and in ..
  32. Rincón Arano H, Guerrero G, Valdes Quezada C, Recillas Targa F. Chicken alpha-globin switching depends on autonomous silencing of the embryonic pi globin gene by epigenetics mechanisms. J Cell Biochem. 2009;108:675-87 pubmed publisher
    ..We propose that epigenetic mechanisms are necessary for in vivo chicken alpha-globin gene switching through differential gene silencing of the embryonic alpha-globin gene in order to allow proper activation of adult alpha-globin genes...
  33. Andolfo I, De Falco L, Asci R, Russo R, Colucci S, Gorrese M, et al. Regulation of divalent metal transporter 1 (DMT1) non-IRE isoform by the microRNA Let-7d in erythroid cells. Haematologica. 2010;95:1244-52 pubmed publisher
    ..DMT1-IRE might be the major DMT1 isoform expressed in erythroid cells, although its regulation pathways are still unknown.
  34. Breig O, Théoleyre O, Douablin A, Baklouti F. Subtle distinct regulations of late erythroid molecular events by PI3K/AKT-mediated activation of Spi-1/PU.1 oncogene autoregulation loop. Oncogene. 2010;29:2807-16 pubmed publisher
    ..1 inhibits 4.1R erythroid splicing through two different pathways, and bring new insights into the extracellular signal impact triggered by erythropoietin on late erythroid regulatory program, including pre-mRNA splicing...
  35. Su M, Steiner L, Bogardus H, Mishra T, Schulz V, Hardison R, et al. Identification of biologically relevant enhancers in human erythroid cells. J Biol Chem. 2013;288:8433-44 pubmed publisher
    ..We hypothesized that a unique set of enhancers regulates gene expression in human erythroid cells, a highly specialized cell type evolved to provide adequate amounts of oxygen throughout the body...
  36. Zhu Y, Wang D, Wang F, Li T, Dong L, Liu H, et al. A comprehensive analysis of GATA-1-regulated miRNAs reveals miR-23a to be a positive modulator of erythropoiesis. Nucleic Acids Res. 2013;41:4129-43 pubmed publisher
    ..in mice or zebrafish demonstrated that it was essential for normal morphology in terminally differentiated erythroid cells. Furthermore, a protein tyrosine phosphatase, SHP2, was identified as a downstream target of miR-23a that ..
  37. Pina C, Fugazza C, Tipping A, Brown J, Soneji S, Teles J, et al. Inferring rules of lineage commitment in haematopoiesis. Nat Cell Biol. 2012;14:287-94 pubmed publisher
  38. Kassouf M, Hughes J, Taylor S, McGowan S, Soneji S, Green A, et al. Genome-wide identification of TAL1's functional targets: insights into its mechanisms of action in primary erythroid cells. Genome Res. 2010;20:1064-83 pubmed publisher
    ..action in erythropoiesis, we performed ChIP-sequencing and gene expression analyses from primary fetal liver erythroid cells. We show that TAL1 coordinates expression of genes in most known red cell-specific processes...
  39. McGrath K, Frame J, Fromm G, Koniski A, Kingsley P, Little J, et al. A transient definitive erythroid lineage with unique regulation of the ?-globin locus in the mammalian embryo. Blood. 2011;117:4600-8 pubmed publisher
    ..We conclude that yolk sac-derived EMPs, the first of 2 origins of definitive erythropoiesis, express a unique pattern of globin genes as they generate the first definitive erythrocytes in the liver of the mammalian embryo...
  40. Martin F, Xu X, von Löhneysen K, Gilmartin T, Friedman J. SOD2 deficient erythroid cells up-regulate transferrin receptor and down-regulate mitochondrial biogenesis and metabolism. PLoS ONE. 2011;6:e16894 pubmed publisher
    ..SA is primarily an acquired, clonal marrow disorder occurring in individuals over 60 years of age with uncertain etiology...
  41. Tallack M, Whitington T, Yuen W, Wainwright E, Keys J, Gardiner B, et al. A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells. Genome Res. 2010;20:1052-63 pubmed publisher
    ..We found at least 945 sites in the genome of E14.5 fetal liver erythroid cells which are occupied by endogenous KLF1...
  42. Mortensen M, Ferguson D, Edelmann M, Kessler B, Morten K, Komatsu M, et al. Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo. Proc Natl Acad Sci U S A. 2010;107:832-7 pubmed publisher
    ..In summary, we show that the selective removal of mitochondria by autophagy, but not other organelles, during erythropoeisis is essential and that this is a necessary developmental step in erythroid cells.
  43. Choe K, Ujhelly O, Wontakal S, Skoultchi A. PU.1 directly regulates cdk6 gene expression, linking the cell proliferation and differentiation programs in erythroid cells. J Biol Chem. 2010;285:3044-52 pubmed publisher
    ..PU.1 also may be involved in controlling proliferation of erythroid cells. We reported previously that the G(1) phase-specific cyclin-dependent kinase 6 (CDK6) also blocks erythroid ..
  44. Chaturvedi C, Hosey A, Palii C, Perez Iratxeta C, Nakatani Y, Ranish J, et al. Dual role for the methyltransferase G9a in the maintenance of beta-globin gene transcription in adult erythroid cells. Proc Natl Acad Sci U S A. 2009;106:18303-8 pubmed publisher
    ..While G9a is often regarded as a corepressor, knocking down this protein in differentiating adult erythroid cells leads to repression of the adult beta(maj) globin gene and aberrant reactivation of the embryonic beta-like ..
  45. Peller S, Tabach Y, Rotschild M, Garach Joshua O, Cohen Y, Goldfinger N, et al. Identification of gene networks associated with erythroid differentiation. Blood Cells Mol Dis. 2009;43:74-80 pubmed publisher
    ..involving a large number of genes, which balance between proliferation, differentiation and survival of the erythroid cells. To understand the molecular mechanisms of erythropoiesis and related pathological aberrations, we analyzed ..
  46. Sankaran V, Menne T, Xu J, Akie T, Lettre G, Van Handel B, et al. Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science. 2008;322:1839-42 pubmed publisher
    ..Moreover, abundant expression of full-length forms of BCL11A is developmentally restricted to adult erythroid cells. Down-regulation of BCL11A expression in primary adult erythroid cells leads to robust HbF expression...
  47. Guillemin C, Maleszewska M, Guais A, Maës J, Rouyez M, Yacia A, et al. Chromatin modifications in hematopoietic multipotent and committed progenitors are independent of gene subnuclear positioning relative to repressive compartments. Stem Cells. 2009;27:108-15 pubmed publisher
  48. Brognara E, Lampronti I, Breveglieri G, Accetta A, Corradini R, Manicardi A, et al. C(5) modified uracil derivatives showing antiproliferative and erythroid differentiation inducing activities on human chronic myelogenous leukemia K562 cells. Eur J Pharmacol. 2011;672:30-7 pubmed publisher
  49. Kiefer C, Lee J, Hou C, Dale R, Lee Y, Meier E, et al. Distinct Ldb1/NLI complexes orchestrate ?-globin repression and reactivation through ETO2 in human adult erythroid cells. Blood. 2011;118:6200-8 pubmed publisher
    ..mediates long-range interaction between the ?-globin locus control region (LCR) and gene in adult mouse erythroid cells, but whether this complex mediates chromatin interactions at other developmental stages or in human cells is ..
  50. Walkley C. Erythropoiesis, anemia and the bone marrow microenvironment. Int J Hematol. 2011;93:10-3 pubmed publisher
  51. Hatzistavrou T, Micallef S, Ng E, Vadolas J, Stanley E, Elefanty A. ErythRED, a hESC line enabling identification of erythroid cells. Nat Methods. 2009;6:659-62 pubmed publisher
    ..facilitate optimization of erythroid differentiation in vitro and aid in the identification of hESC-derived erythroid cells in transplanted animals...
  52. Zhang S, Mercado Uribe I, Liu J. Generation of erythroid cells from fibroblasts and cancer cells in vitro and in vivo. Cancer Lett. 2013;333:205-12 pubmed publisher
    Bone marrow is generally considered the main source of erythroid cells. Here we report that a single hypoxia-mimic chemical, CoCl2, can increase the size of fibroblasts and cancer cells and lead to formation of polyploidy giant cells (..
  53. Abutin R, Chen J, Lung T, Lloyd J, Sawyer S, Harada H. Erythropoietin-induced phosphorylation/degradation of BIM contributes to survival of erythroid cells. Exp Hematol. 2009;37:151-8 pubmed publisher
    ..We investigated here the role of BIM in erythropoietin (EPO)-mediated survival in erythroid cells.