neuroepithelial bodies

Summary

Summary: Innervated clusters of NEUROEPITHELIAL CELLS found in the LUNGS. They act as airway OXYGEN sensors, releasing regulatory PEPTIDES and SEROTONIN in response to HYPOXIA.

Top Publications

  1. Yu J, Lin S, Zhang J, Walker J. Pulmonary nociceptors are potentially connected with neuroepithelial bodies. Adv Exp Med Biol. 2006;580:301-6; discussion 351-9 pubmed
  2. Cutz E, Perrin D, Pan J, Haas E, Krous H. Pulmonary neuroendocrine cells and neuroepithelial bodies in sudden infant death syndrome: potential markers of airway chemoreceptor dysfunction. Pediatr Dev Pathol. 2007;10:106-16 pubmed
    Pulmonary neuroendocrine cells (PNEC), including neuroepithelial bodies (NEB), are amine- and peptide (for example, bombesin)-producing cells that function as hypoxia/hypercapnia-sensitive chemoreceptors that could be involved in the ..
  3. Domnik N, Cutz E. Pulmonary neuroepithelial bodies as airway sensors: putative role in the generation of dyspnea. Curr Opin Pharmacol. 2011;11:211-7 pubmed publisher
    The neuroepithelial bodies (NEB) of the intrapulmonary airways (AW) are multimodal AW sensors responding to a variety of stimuli including hypoxia, hypercarbia, and mechanical stretch...
  4. Pan J, Yeger H, Ratcliffe P, Bishop T, Cutz E. Hyperplasia of pulmonary neuroepithelial bodies (NEB) in lungs of prolyl hydroxylase -1(PHD-1) deficient mice. Adv Exp Med Biol. 2012;758:149-55 pubmed publisher
    ..Since the PHD-1 deficient mouse appears to be the first animal model showing NEB cell hyperplasia it may be useful for studies of NEB physiology and pathobiology. ..
  5. Lembrechts R, Brouns I, Schnorbusch K, Pintelon I, Timmermans J, Adriaensen D. Neuroepithelial bodies as mechanotransducers in the intrapulmonary airway epithelium: involvement of TRPC5. Am J Respir Cell Mol Biol. 2012;47:315-23 pubmed publisher
    In rodent lungs, a major part of the myelinated vagal airway afferents selectively contacts pulmonary neuroepithelial bodies (NEBs)...
  6. Guha A, Vasconcelos M, Cai Y, Yoneda M, Hinds A, Qian J, et al. Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways. Proc Natl Acad Sci U S A. 2012;109:12592-7 pubmed publisher
    ..Furthermore, we identified a subpopulation of secretory precursors juxtaposed to presumptive neuroepithelial bodies (NEBs), distinguished by their strong Scgb3a2 and uroplakin 3a (Upk3a) signals and reduced Ccsp (Scgb1a1) ..
  7. Fukuda K. Novel hypothesis for the cause of panic disorder via the neuroepithelial bodies in the lung. Med Hypotheses. 2005;64:1192-7 pubmed
    ..The pulmonary neuroepithelial bodies (NEBs), which are situated at the bifurcation point of the small bronchi, act as storage cells for 5-..
  8. Pan J, Luk C, Kent G, Cutz E, Yeger H. Pulmonary neuroendocrine cells, airway innervation, and smooth muscle are altered in Cftr null mice. Am J Respir Cell Mol Biol. 2006;35:320-6 pubmed
    ..widely distributed within the airway mucosa of mammalian lung as solitary cells and innervated clusters, neuroepithelial bodies (NEB), which function as airway O2 sensors...
  9. Fu X, Spindel E. Recruitment of GABA(A) receptors in chemoreceptor pulmonary neuroepithelial bodies by prenatal nicotine exposure in monkey lung. Adv Exp Med Biol. 2009;648:439-45 pubmed publisher
    Pulmonary neuroepithelial bodies (NEB) act as airway oxygen sensors and produce serotonin, a variety of neuropeptides and are involved in autonomic nervous system control of breathing, especially during the neonatal period...

More Information

Publications41

  1. Cutz E, Pan J, Yeger H, Domnik N, Fisher J. Recent advances and contraversies on the role of pulmonary neuroepithelial bodies as airway sensors. Semin Cell Dev Biol. 2013;24:40-50 pubmed publisher
    Pulmonary neuroepithelial bodies are polymodal sensors widely distributed within the airway mucosa of mammals and other species. Neuroepithelial body cells store and most likely release serotonin and peptides as transmitters...
  2. De Proost I, Pintelon I, Brouns I, Kroese A, Riccardi D, Kemp P, et al. Functional live cell imaging of the pulmonary neuroepithelial body microenvironment. Am J Respir Cell Mol Biol. 2008;39:180-9 pubmed publisher
    Pulmonary neuroepithelial bodies (NEBs) are densely innervated groups of neuroendocrine cells invariably accompanied by Clara-like cells...
  3. Oztay F, Brouns I, Pintelon I, Raab M, Neuhuber W, Timmermans J, et al. Neurotrophin-4 dependency of intraepithelial vagal sensory nerve terminals that selectively contact pulmonary NEBs in mice. Histol Histopathol. 2010;25:975-84 pubmed publisher
    ..that selectively contact complex morphologically well-characterized receptor end-organs, called neuroepithelial bodies (NEBs)...
  4. Brouns I, Pintelon I, De Proost I, Alewaters R, Timmermans J, Adriaensen D. Neurochemical characterisation of sensory receptors in airway smooth muscle: comparison with pulmonary neuroepithelial bodies. Histochem Cell Biol. 2006;125:351-67 pubmed
    ..The results were compared with those obtained for pulmonary neuroepithelial bodies (NEBs), which are complex intraepithelial sensory airway receptors...
  5. Brouns I, De Proost I, Pintelon I, Timmermans J, Adriaensen D. Sensory receptors in the airways: neurochemical coding of smooth muscle-associated airway receptors and pulmonary neuroepithelial body innervation. Auton Neurosci. 2006;126-127:307-19 pubmed
    ..Secondly, we further explored the sensory innervation of pulmonary neuroepithelial bodies (NEBs)...
  6. Dunham Snary K, Hong Z, Xiong P, Del Paggio J, Herr J, Johri A, et al. A mitochondrial redox oxygen sensor in the pulmonary vasculature and ductus arteriosus. Pflugers Arch. 2016;468:43-58 pubmed publisher
    ..The HOSS includes carotid body type 1 cells, adrenomedullary cells, neuroepithelial bodies, and smooth muscle cells (SMCs) in pulmonary arteries (PAs), ductus arteriosus (DA), and fetoplacental ..
  7. De Proost I, Pintelon I, Wilkinson W, Goethals S, Brouns I, Van Nassauw L, et al. Purinergic signaling in the pulmonary neuroepithelial body microenvironment unraveled by live cell imaging. FASEB J. 2009;23:1153-60 pubmed publisher
    Pulmonary neuroepithelial bodies (NEBs) are densely innervated groups of complex sensory airway receptors involved in the regulation of breathing...
  8. Noguchi M, Sumiyama K, Morimoto M. Directed Migration of Pulmonary Neuroendocrine Cells toward Airway Branches Organizes the Stereotypic Location of Neuroepithelial Bodies. Cell Rep. 2015;13:2679-86 pubmed publisher
    ..NE cells often localize at bifurcation points of airway tubes, forming small clusters called neuroepithelial bodies (NEBs)...
  9. Schnorbusch K, Lembrechts R, Brouns I, Pintelon I, Timmermans J, Adriaensen D. Precision-cut vibratome slices allow functional live cell imaging of the pulmonary neuroepithelial body microenvironment in fetal mice. Adv Exp Med Biol. 2012;758:157-66 pubmed publisher
    We recently developed an ex vivo lung slice model that allows for confocal live cell imaging (LCI) of neuroepithelial bodies (NEBs) in postnatal mouse lungs (postnatal days 1-21 and adult)...
  10. Lembrechts R, Brouns I, Schnorbusch K, Pintelon I, Kemp P, Timmermans J, et al. Functional expression of the multimodal extracellular calcium-sensing receptor in pulmonary neuroendocrine cells. J Cell Sci. 2013;126:4490-501 pubmed publisher
    ..Here, we show that neuroepithelial bodies (NEBs) of the postnatal mouse lung express a functional CaSR...
  11. Cutz E. Hyperplasia of pulmonary neuroendocrine cells in infancy and childhood. Semin Diagn Pathol. 2015;32:420-37 pubmed publisher
    ..throughout the airway mucosa of mammalian lung as solitary cells and as distinctive innervated clusters, neuroepithelial bodies (NEB)...
  12. Yu J. An overview of vagal airway receptors. Sheng Li Xue Bao. 2002;54:451-9 pubmed
    ..After more than a century investigation, our knowledge accumulates immensely, however, our understanding of the nature of these sensory receptors is still far from complete. This brief review provides an overview on this topic. ..
  13. Min K. Two different types of carcinoid tumors of the lung: immunohistochemical and ultrastructural investigation and their histogenetic consideration. Ultrastruct Pathol. 2013;37:23-35 pubmed publisher
    ..cells) similar to enteric counterparts, and, secondly, they are found in aggregates known as "neuroepithelial bodies" (NEB) usually found in the branching point of bronchi...
  14. Wang Y, Yu J. Na(+)/K(+) -ATPase as a marker for detecting pulmonary sensory receptors. Sheng Li Xue Bao. 2002;54:390-4 pubmed
    ..This technique permits examining pulmonary receptor structures in detail, and should assist in identifying the morphology of the receptors and the mechanisms of receptor activation. ..
  15. Morimoto M, Nishinakamura R, Saga Y, Kopan R. Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells. Development. 2012;139:4365-73 pubmed publisher
    ..These results suggest that two different assemblies of Notch receptors coordinate the numbers and distribution of the major epithelial cell types in the conducting airway during lung organogenesis. ..
  16. Hennel M, Harsanyiova J, Ru F, Zatko T, Brozmanova M, Trancikova A, et al. Structure of vagal afferent nerve terminal fibers in the mouse trachea. Respir Physiol Neurobiol. 2018;249:35-46 pubmed publisher
    ..While the complex vagal airway nerve terminals (stretch receptors, cough receptors and neuroepithelial bodies) were thoroughly characterized, much less is known about the structure of airway nerves that do not form ..
  17. Caravagna C, Seaborn T. Oxygen Sensing in Early Life. Lung. 2016;194:715-22 pubmed publisher
    ..However, pulmonary neuroendocrine cells, which are mainly gathered in neuroepithelial bodies, also present the capability to exert chemosensitivity...
  18. Zaccone D, Dabrowski K, Lauriano E, de Pasquale A, Macrì D, Satora L, et al. The simultaneous presence of neuroepithelial cells and neuroepithelial bodies in the respiratory gas bladder of the longnose gar, Lepisosteus osseus, and the spotted gar, L. oculatus. Acta Histochem. 2012;114:370-8 pubmed publisher
    ..of Polypterus, these cells are scattered as solitary cells in the glottal epithelium, and grouped to form neuroepithelial bodies (NEBs) in the mucociliated epithelium investing the main trabeculae in the air-bladder of Lepisosteus ..
  19. Pintelon I, De Proost I, Brouns I, van Herck H, Van Genechten J, van Meir F, et al. Selective visualisation of neuroepithelial bodies in vibratome slices of living lung by 4-Di-2-ASP in various animal species. Cell Tissue Res. 2005;321:21-33 pubmed
    Pulmonary neuroepithelial bodies (NEBs) are extensively innervated organoid groups of neuroendocrine cells that lie in the epithelium of intrapulmonary airways...
  20. Brouns I, Pintelon I, Timmermans J, Adriaensen D. Novel insights in the neurochemistry and function of pulmonary sensory receptors. Adv Anat Embryol Cell Biol. 2012;211:1-115, vii pubmed
    ..are currently morphologically well characterised: smooth muscle-associated airway receptors (SMARs), neuroepithelial bodies (NEBs) and visceral pleura receptors (VPRs)...
  21. Brouns I, Oztay F, Pintelon I, De Proost I, Lembrechts R, Timmermans J, et al. Neurochemical pattern of the complex innervation of neuroepithelial bodies in mouse lungs. Histochem Cell Biol. 2009;131:55-74 pubmed publisher
    As best characterized for rats, it is clear that pulmonary neuroepithelial bodies (NEBs) are contacted by a plethora of nerve fiber populations, suggesting that they represent an extensive group of multifunctional intraepithelial airway ..
  22. Fu X, Nurse C, Cutz E. Characterization of slowly inactivating KV{alpha} current in rabbit pulmonary neuroepithelial bodies: effects of hypoxia and nicotine. Am J Physiol Lung Cell Mol Physiol. 2007;293:L892-902 pubmed
    Pulmonary neuroepithelial bodies (NEB) form innervated cell clusters that express voltage-activated currents and function as airway O(2) sensors...
  23. Yu J, Zhang J, Wang Y, Fan F, Yu A. Neuroepithelial bodies not connected to pulmonary slowly adapting stretch receptors. Respir Physiol Neurobiol. 2004;144:1-14 pubmed
    b>Neuroepithelial bodies (NEBs) are believed to be connected with one of the known types of airway receptors. The present studies determined whether NEB afferents are pulmonary slowly adapting stretch receptors (SARs)...
  24. Lembrechts R, Pintelon I, Schnorbusch K, Timmermans J, Adriaensen D, Brouns I. Expression of mechanogated two-pore domain potassium channels in mouse lungs: special reference to mechanosensory airway receptors. Histochem Cell Biol. 2011;136:371-85 pubmed publisher
    ..well-formed airway receptor end organs, smooth muscle-associated airway receptors (SMARs) and neuroepithelial bodies (NEBs), localised in airway smooth muscle and epithelium, respectively...
  25. Fu X, Cutz E. Identification and characterization of hypoxia sensitive Kvalpha subunits in pulmonary neuroepithelial bodies. Adv Exp Med Biol. 2006;580:313-8; discussion 351-9 pubmed
  26. Linnoila R. Functional facets of the pulmonary neuroendocrine system. Lab Invest. 2006;86:425-44 pubmed
    ..Moreover, PNECs may be important for inflammatory responses, and pivotal for lung stem cell niches. These discoveries signify an exciting new era for PNECs and are likely to have therapeutic and diagnostic applications. ..
  27. Kuo C, Krasnow M. Formation of a Neurosensory Organ by Epithelial Cell Slithering. Cell. 2015;163:394-405 pubmed publisher
    ..We mapped the formation of lung neuroepithelial bodies (NEBs), innervated clusters of neuroendocrine/neurosensory cells within the bronchial epithelium, ..
  28. Yeger H, Pan J, Fu X, Bear C, Cutz E. Expression of CFTR and Cl(-) conductances in cells of pulmonary neuroepithelial bodies. Am J Physiol Lung Cell Mol Physiol. 2001;281:L713-21 pubmed
    ..neuroendocrine cell system comprises solitary neuroendocrine cells and clusters of innervated cells or neuroepithelial bodies (NEBs)...
  29. Buttigieg J, Pan J, Yeger H, Cutz E. NOX2 (gp91phox) is a predominant O2 sensor in a human airway chemoreceptor cell line: biochemical, molecular, and electrophysiological evidence. Am J Physiol Lung Cell Mol Physiol. 2012;303:L598-607 pubmed publisher
    Pulmonary neuroepithelial bodies (NEBs), composed of clusters of amine [serotonin (5-HT)] and peptide-producing cells, are widely distributed within the airway mucosa of human and animal lungs...
  30. Cutz E, Yeger H, Pan J. Pulmonary neuroendocrine cell system in pediatric lung disease-recent advances. Pediatr Dev Pathol. 2007;10:419-35 pubmed
    ..pulmonary neuroendocrine cells (PNEC), distributed as solitary cells and as innervated clusters, neuroepithelial bodies (NEB)...
  31. Guha A, Deshpande A, Jain A, Sebastiani P, Cardoso W. Uroplakin 3a+ Cells Are a Distinctive Population of Epithelial Progenitors that Contribute to Airway Maintenance and Post-injury Repair. Cell Rep. 2017;19:246-254 pubmed publisher
    There is evidence that certain club cells (CCs) in the murine airways associated with neuroepithelial bodies (NEBs) and terminal bronchioles are resistant to the xenobiotic naphthalene (Nap) and repopulate the airways after Nap injury...
  32. Cutz E, Pan J, Yeger H. The role of NOX2 and "novel oxidases" in airway chemoreceptor O(2) sensing. Adv Exp Med Biol. 2009;648:427-38 pubmed publisher
    In pulmonary neuroepithelial bodies (NEB), presumed airway chemoreceptors, classical NADPH oxidase (gp91 phox, NOX2) is co-expressed with O(2) sensitive K(+) channels (K(+)O(2)) and functions as an O(2) sensor...