hep g2 cells


Summary: A human liver tumor cell line used to study a variety of liver-specific metabolic functions.

Top Publications

  1. Ho L, Titus A, Banerjee K, George S, Lin W, Deota S, et al. SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK. Aging (Albany NY). 2013;5:835-49 pubmed
    ..This study highlights the ability of Sirt4 to regulate ATP levels via ANT2 and a feedback loop involving AMPK. ..
  2. Zhang B, Yang X, Wang Y, Zhai G. Heparin modified graphene oxide for pH-sensitive sustained release of doxorubicin hydrochloride. Mater Sci Eng C Mater Biol Appl. 2017;75:198-206 pubmed publisher
    ..Based on the in vitro and in vivo investigations, the fabricated GO-ADH-Hep could be a promising candidate as an ideal nano-carrier for drug delivery and anti-cancer therapy. ..
  3. Wu G, Wang N, Luo Y, Zhang Y, Wang P, Zhu Z, et al. Metabolic perturbation of epigenome by inhibiting S-adenosylhomocysteine hydrolase elicits senescence through DNA damage response in hepatoma cells. Tumour Biol. 2017;39:1010428317699117 pubmed publisher
    ..In conclusion, our study demonstrated that metabolic perturbation of chromatin status in oncogene-activated cancers could be an optional intervention to sensitize DNA damage response signaling. ..
  4. Yi H, Gu C, Li M, Zhang Z, Li Q, Feng J, et al. PERK/eIF2? contributes to changes of insulin signaling in HepG2 cell induced by intermittent hypoxia. Life Sci. 2017;181:17-22 pubmed publisher
    ..p-PERK and p-eIF2? expression in HepG2 cells in IH groups with 4-PBA preculture were inhibited while levels of p-JNK and p-IRE1 remained unchanged. IH, the hallmarker of OSAHS, could disturb insulin signaling via activating PERK/eIF2?. ..
  5. Tian K, Xu F, Gao X, Han T, Li J, Pan H, et al. Nitric oxide-releasing derivatives of brefeldin A as potent and highly selective anticancer agents. Eur J Med Chem. 2017;136:131-143 pubmed publisher
    ..Furthermore, in western blot assay, 13b increased the expression of Bax, Cyt c and caspase 3, and reduced the relative levels of Bcl-2, Bcl-xl and pro-caspase 3 in HepG-2 cells. ..
  6. Zhang X, Liu Z, Liu J, Zeng Y, Guo G, Sun Q. Antitumor activity of a Rhodococcus sp. Lut0910 isolated from polluted soil. Tumour Biol. 2017;39:1010428317711661 pubmed publisher
    ..Our result would provide a new way and potent source for development of new anticancer agent from the polluted environment. ..
  7. Su C, Liu Z, Wang Y, Wang Y, Song E, Song Y. The electrophilic character of quinones is essential for the suppression of Bach1. Toxicology. 2017;387:17-26 pubmed publisher
    ..Taking together, our investigation illustrated that the electrophilic character of quinones ensure their conjugation with Bach1, which is important for the downregulation of Bach1 and the upregulation of Nrf2 signaling. ..
  8. Kishimoto S, Yasuda M, Fukushima S. Changes in the Expression of Various Transporters as Influencing Factors of Resistance to Cisplatin. Anticancer Res. 2017;37:5477-5484 pubmed
    ..This study was designed to clarify whether CDDP-resistant strains isolated from a cell line had the same characteristics, and whether these characteristics could be therapeutic targets...
  9. Elizalde M, Urtasun R, Azkona M, Latasa M, Goñi S, Garcia Irigoyen O, et al. Splicing regulator SLU7 is essential for maintaining liver homeostasis. J Clin Invest. 2014;124:2909-20 pubmed publisher
    ..Together, out data indicate that SLU7 is central regulator of hepatocyte identity and quiescence. ..

More Information

Publications113 found, 100 shown here

  1. Kośmider A, Czepielewska E, Kuraś M, Gulewicz K, Pietrzak W, Nowak R, et al. Uncaria tomentosa Leaves Decoction Modulates Differently ROS Production in Cancer and Normal Cells, and Effects Cisplatin Cytotoxicity. Molecules. 2017;22: pubmed publisher
    ..Further studies are needed to confirm our observations and to describe underlying molecular mechanism, and the potential usefulness of Uncaria tomentosa decoction in adjuvant therapy for cancer. ..
  2. Treiber T, Treiber N, Plessmann U, Harlander S, Daiß J, Eichner N, et al. A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. Mol Cell. 2017;66:270-284.e13 pubmed publisher
    ..We provide an extended database of RBPs that interact with pre-miRNAs in extracts of different cell types, highlighting a widespread layer of co- and posttranscriptional regulation of miRNA biogenesis. ..
  3. Ma J, Li T, Han X, Yuan H, Liang H, Wang Y, et al. Discovery and mechanism of action of Novel Baicalein modified derivatives as potent antihepatitis agent. Virology. 2017;507:199-205 pubmed publisher
    ..Compound 4k also showed excellent pharmacokinetic profile in experimental animal and thus, provide a novel class of potent anti-HBV agents. ..
  4. Lou S, Zhang X, Zhang M, Ji S, Wang W, Zhang J, et al. Preparation of a dual cored hepatoma-specific star glycopolymer nanogel via arm-first ATRP approach. Int J Nanomedicine. 2017;12:3653-3664 pubmed publisher
    ..Our data indicate that the lactose-decorated star-shaped nanogels are dual responsive and hepatoma targeted, and could be employed as hepatoma-specific anti-cancer drug delivery vehicle for cancer chemotherapy...
  5. Friães S, Silva A, Boto R, Ferreira D, Fernandes J, Souto E, et al. Synthesis, spectroscopic characterization and biological evaluation of unsymmetrical aminosquarylium cyanine dyes. Bioorg Med Chem. 2017;25:3803-3814 pubmed publisher
    ..Although in different extents, these dyes show promising in vitro results as photosensitizers. ..
  6. Zhang P, Xu L, Guan H, Liu L, Liu J, Huang Z, et al. Beraprost sodium, a prostacyclin analogue, reduces fructose-induced hepatocellular steatosis in mice and in vitro via the microRNA-200a and SIRT1 signaling pathway. Metabolism. 2017;73:9-21 pubmed publisher
    ..Our findings suggested that SIRT1 might be a therapeutic target of fructose-related metabolism disorders. ..
  7. Chen L, Tang Z, Wang X, Ma H, Shan D, Cui S. PKM2 aggravates palmitate-induced insulin resistance in HepG2 cells via STAT3 pathway. Biochem Biophys Res Commun. 2017;492:109-115 pubmed publisher
    ..Taken together, these studies demonstrate that PKM2 may promote hepatic IR via STAT3 pathway and would provide a new insight into dissecting the molecular pathogenesis of hepatic insulin resistance. ..
  8. Domracheva I, Kanepe Lapsa I, Jackevica L, Vasiljeva J, Arsenyan P. Selenopheno quinolinones and coumarins promote cancer cell apoptosis by ROS depletion and caspase-7 activation. Life Sci. 2017;186:92-101 pubmed publisher
    ..This present study provides scientific evidence that selenopheno quinolinones and coumarins promote cancer cell apoptosis by ROS depletion and caspase-7 activation in malignant cells. ..
  9. Guo X, Wang L, Wang S, Li Y, Cao L, Cai R, et al. Synergistic antiproliferative effect of chemo-phototherapy: Synthesis and photodynamic activity evaluation of novel Chlorin e6-artesunate conjugates as antiproliferative agents. Bioorg Med Chem Lett. 2017;27:4548-4551 pubmed publisher
    ..The results demonstrated that the conjugation of Chlorin e6 and artesunate could accomplish synergistic effects of chemo-phototherapy, and finally enhanced their antiproliferative effects. ..
  10. Ren Z, Chen S, Qing T, Xuan J, Couch L, Yu D, et al. Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017;392:11-21 pubmed publisher
    ..In summary, our data indicate that both ER stress and the activation of JNK and ERK1/2 contribute to leflunomide-induced cytotoxicity. ..
  11. Qiu D, Chen J, Liu J, Luo Z, Jiang W, Huang J, et al. Expression of microRNA let-7a positively correlates with hepatitis B virus replication in hepatocellular carcinoma tissues. Exp Biol Med (Maywood). 2017;242:939-944 pubmed publisher
    ..Our finding might be the base for a new approach to improve HBV infection treatments in the future. ..
  12. Ma Q, Yu P, Zhang F, Li Y, Yang S, Mo X, et al. [Mechanism of heat shock protein 90 for regulating 26S proteasome in hyperthermia]. Nan Fang Yi Ke Da Xue Xue Bao. 2016;37:537-541 pubmed
    ..The accumulation of denatured protein causes unfolded protein reaction in the cells to eventually result in cell death. ..
  13. Chi H, Chen S, Lin S, Tsai C, Chuang W, Lin Y, et al. Thyroid hormone protects hepatocytes from HBx-induced carcinogenesis by enhancing mitochondrial turnover. Oncogene. 2017;36:5274-5284 pubmed publisher
    ..Thus, the utilization of the agonists of TRs could be the meaningful strategy in liver relative diseases, ranging from simple hepatic steatosis to HCC. ..
  14. Hsieh J, Huang R, Lin J, Sedykh A, Zhao J, Tice R, et al. Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage. PLoS ONE. 2017;12:e0177902 pubmed publisher
  15. Yasumoto J, Kasai H, Yoshimura K, Otoguro T, Watashi K, Wakita T, et al. Hepatitis B virus prevents excessive viral production via reduction of cell death-inducing DFF45-like effectors. J Gen Virol. 2017;98:1762-1773 pubmed publisher
    ..These results suggest that HBV regulates its own viral replication via CIDEB and CIDEC. ..
  16. Reddy E, Remya C, Mantosh K, Sajith A, Omkumar R, Sadasivan C, et al. Novel tacrine derivatives exhibiting improved acetylcholinesterase inhibition: Design, synthesis and biological evaluation. Eur J Med Chem. 2017;139:367-377 pubmed publisher
    ..However, further pharmacokinetic studies are necessary to comment on the efficacy of the compound as a drug for AD. ..
  17. Chen M, Lei X, Shi C, Huang M, Li X, Wu B, et al. Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents. J Clin Invest. 2017;127:3689-3701 pubmed publisher
    ..This study demonstrates that targeting tumor pericytes with an FAP?-activated VDA prodrug represents a potential vascular disruption strategy in overcoming tumor resistance to VDA treatments. ..
  18. Subban K, Singh S, Subramani R, Johnpaul M, Chelliah J. Fungal 7-epi-10-deacetyltaxol produced by an endophytic Pestalotiopsis microspora induces apoptosis in human hepatocellular carcinoma cell line (HepG2). BMC Complement Altern Med. 2017;17:504 pubmed publisher
    ..This is the first report for 7-epi-10-deacetyltaxol (EDT) isolated from a microbial source. ..
  19. Goi C, Little P, Xie C. Cell-type and transcription factor specific enrichment of transcriptional cofactor motifs in ENCODE ChIP-seq data. BMC Genomics. 2013;14 Suppl 5:S2 pubmed publisher
    ..Novel cofactor binding site enrichments observed provides valuable insight into TF and cell type specific interactions driving TF interactions. ..
  20. Silva I, Polaquini C, Regasini L, Ferreira H, Pavan F. Evaluation of cytotoxic, apoptotic, mutagenic, and chemopreventive activities of semi-synthetic esters of gallic acid. Food Chem Toxicol. 2017;105:300-307 pubmed publisher
    ..In conclusion, our results suggest that alkyl gallates are non-genotoxic, non-mutagenic, and pro-apoptotic agents, which may serve as suitable and promising candidates for preventing chemically-induced chromosomal damage. ..
  21. Xiang L, Ou H, Liu X, Chen Z, Li X, Huang Y, et al. Loss of tumor suppressor miR-126 contributes to the development of hepatitis B virus-related hepatocellular carcinoma metastasis through the upregulation of ADAM9. Tumour Biol. 2017;39:1010428317709128 pubmed publisher
    ..MiR-126-ADAM9 pathway-based therapeutic targeting may represent a novel approach for the inhibition of hepatitis B virus-related hepatocellular carcinoma metastases. ..
  22. Abdel Fattah W, Eid M, Abd El Moez S, Mohamed E, Ali G. Synthesis of biogenic Ag@Pd Core-shell nanoparticles having anti-cancer/anti-microbial functions. Life Sci. 2017;183:28-36 pubmed publisher
    ..The obtained BCSnp are proposed for cancer therapy and bactericidal applications with improved efficiency applying the nanomedicine approach. Tailorable properties can be obtained by tuning the individual structures. ..
  23. Cheng S, Wang L, Deng C, Du S, Han Z. ARID1A represses hepatocellular carcinoma cell proliferation and migration through lncRNA MVIH. Biochem Biophys Res Commun. 2017;491:178-182 pubmed publisher
    ..Our data suggests that deficiency or loss of functional mutations of ARID1A in HCC cells might contribute to the increased activity of certain cancer-promoting lncRNAs. ..
  24. Marczak M, Yan B. Circadian rhythmicity: A functional connection between differentiated embryonic chondrocyte-1 (DEC1) and small heterodimer partner (SHP). Arch Biochem Biophys. 2017;631:11-18 pubmed publisher
    ..Our findings collectively establish that DEC1 participates in the negative loop of SHP oscillating expression with potential implications in metabolic homeostasis. ..
  25. Łazewska D, Kaleta M, Schwed J, Karcz T, Mogilski S, Latacz G, et al. Biphenyloxy-alkyl-piperidine and azepane derivatives as histamine H3 receptor ligands. Bioorg Med Chem. 2017;25:5341-5354 pubmed publisher
    ..Metabolites produced were analyzed and tentatively identified by UPLC-MS techniques. The results demonstrated easy hydroxylation of the biphenyl ring. ..
  26. Jung Y, Lee H, Jo A, Hiroo I, Cha H, Kim H. Activity analysis of LTR12C as an effective regulatory element of the RAE1 gene. Gene. 2017;634:22-28 pubmed publisher
  27. Fuchs C, Claudel T, Scharnagl H, Stojakovic T, Trauner M. FXR controls CHOP expression in steatohepatitis. FEBS Lett. 2017;591:3360-3368 pubmed publisher
    ..Our study shows that FXR/RXR regulates Chop expression in a mouse model of steatohepatitis, providing novel insights into pathogenesis of this disorder. ..
  28. Endougou Effa A, Gantier E, Hennebelle T, Roumy V, Rivière C, Dimo T, et al. Neoboutonia melleri var velutina Prain: in vitro and in vivo hepatoprotective effects of the aqueous stem bark extract on acute hepatitis models. BMC Complement Altern Med. 2018;18:24 pubmed publisher
    ..Taking into account underlying mechanisms in both hepatitis models, we demonstrate the extract's radical scavenging capacity. Neoboutonia velutina displays a potent hepatoprotective effect mediated through radical scavenging properties. ..
  29. Zhao J, Liu L, Shen A, Lin W, Cao Z, Zhuang Q, et al. [Effect of bear bile powder on STAT3 pathway in hepatocellular carcinoma xenograft]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014;34:976-81 pubmed
    ..BBP could induce the apoptosis of hepatoma carcinoma cells and inhibit their proliferation by regulating STAT3 pathway. ..
  30. Wu Y, Liu Z, Shi M, Yu H, Jiang X, Yang A, et al. Identification of ACTG2 functions as a promoter gene in hepatocellular carcinoma cells migration and tumor metastasis. Biochem Biophys Res Commun. 2017;491:537-544 pubmed publisher
    ..Collectively, our study reveals a critical role of ACTG2 in HCC tumor metastasis, and renders it a novel target for the treatment of HCC. ..
  31. Basu S, Barawkar D, Ramdas V, Patel M, Waman Y, Panmand A, et al. Design and synthesis of novel xanthine derivatives as potent and selective A2B adenosine receptor antagonists for the treatment of chronic inflammatory airway diseases. Eur J Med Chem. 2017;134:218-229 pubmed publisher
    ..8 nM in cAMP assay and good aqueous solubility of 529 ?M at neutral pH. Compound 46 was further tested for in vivo efficacy and found to be efficacious in ovalbumin-induced allergic asthma model in mice. ..
  32. Sathish Kumar P, Viswanathan M, Venkatesan M, Balakrishna K. Bauerenol, a triterpenoid from Indian Suregada angustifolia: Induces reactive oxygen species-mediated P38MAPK activation and apoptosis in human hepatocellular carcinoma (HepG2) cells. Tumour Biol. 2017;39:1010428317698387 pubmed publisher
    ..This study clearly states that bauerenol induces cell cycle arrest and apoptosis through the reactive oxygen species-dependent p38MAPK activation in HepG2 cancer cells. ..
  33. Zor M, Aydin S, Güner N, Basaran N, Başaran A. Antigenotoxic properties of Paliurus spina-christi Mill fruits and their active compounds. BMC Complement Altern Med. 2017;17:229 pubmed publisher
    ..It has been suggested that PS fruits and their compounds catechins, gallocatechin and rutin may have beneficial effects in oxidative DNA damage. It seems that PS fruits may be used in protection of the disorders related to DNA damage. ..
  34. Willy J, Young S, Mosley A, Gawrieh S, Stevens J, Masuoka H, et al. Function of inhibitor of Bruton's tyrosine kinase isoform ? (IBTK?) in nonalcoholic steatohepatitis links autophagy and the unfolded protein response. J Biol Chem. 2017;292:14050-14065 pubmed publisher
    ..These results indicate a function for IBTK? in NASH that links autophagy with activation of the UPR. ..
  35. Flesch D, Cheung S, Schmidt J, Gabler M, Heitel P, Kramer J, et al. Nonacidic Farnesoid X Receptor Modulators. J Med Chem. 2017;60:7199-7205 pubmed publisher
    ..Here we report the development and characterization of a high-affinity FXR modulator not comprising an acidic residue...
  36. Zhang N, Wu Y, Lyu X, Li B, Yan X, Xiong H, et al. HSF1 upregulates ATG4B expression and enhances epirubicin-induced protective autophagy in hepatocellular carcinoma cells. Cancer Lett. 2017;409:81-90 pubmed publisher
  37. Chen R, Liu Y, Zhuang H, Yang B, Hei K, Xiao M, et al. Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation. Nucleic Acids Res. 2017;45:9947-9959 pubmed publisher
    ..Our results uncover a novel mechanism by which MALAT1 regulates the activity of p53 through the lncRNA-protein interaction. ..
  38. Fischer J, Dalhoff C, Schrey A, Graebner O, Michaelis S, Andrich K, et al. Dasatinib, imatinib and staurosporine capture compounds - Complementary tools for the profiling of kinases by Capture Compound Mass Spectrometry (CCMS). J Proteomics. 2011;75:160-8 pubmed publisher
    ..Besides sets of expected kinases we identified additional specific interactors; these off-targets may be of relevance in the view of the pharmacological profile of dasatinib and imatinib. ..
  39. Kuang D, Xiao X, Zhao Q, Chen M, Li X, Liu R, et al. B7-H1-expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets. J Clin Invest. 2014;124:4657-67 pubmed publisher
    ..Our results provide insight into the selective modulation of Th22 subsets and suggest that strategies to influence functional activities of inflammatory cells may benefit anticancer therapy. ..
  40. Wang L, Huang H, Wu Q. The diversity of DNA fragment editing by CRISPR/Cas9 in highly homologous or repetitive sequences. Yi Chuan. 2017;39:313-325 pubmed publisher
    ..Our results have demonstrated the potential issues with important implications for using CRISPR/Cas9 to edit duplicated genes or repetitive sequences in diploid or polyploid species or cell lines. ..
  41. Tsai T, Yu C, Chang Y, Lin Y, Huang C, Kuo Y, et al. Protective Effect of Caffeic Acid Derivatives on tert-Butyl Hydroperoxide-Induced Oxidative Hepato-Toxicity and Mitochondrial Dysfunction in HepG2 Cells. Molecules. 2017;22: pubmed publisher
    ..Our results suggest that CA derivatives might be a hepatoprotective agent against oxidative stress. ..
  42. Pénzes A, Mahmud Abdelwahab E, Rapp J, Péteri Z, Bovári Biri J, Fekete C, et al. Toxicology studies of primycin-sulphate using a three-dimensional (3D) in vitro human liver aggregate model. Toxicol Lett. 2017;281:44-52 pubmed publisher
  43. Weiler S, Pinna F, Wolf T, Lutz T, Geldiyev A, Sticht C, et al. Induction of Chromosome Instability by Activation of Yes-Associated Protein and Forkhead Box M1 in Liver Cancer. Gastroenterology. 2017;152:2037-2051.e22 pubmed publisher
    ..Agents that disrupt this pathway might be developed as treatments for liver cancer. Transcriptome data are available in the Gene Expression Omnibus public database (accession numbers: GSE32597 and GSE73396). ..
  44. Zhang J, Wang X, Hao L, Wang H, Zhang X, Muhammad I, et al. Nrf2 is crucial for the down-regulation of Cyp7a1 induced by arachidonic acid in Hepg2 cells. Environ Toxicol Pharmacol. 2017;52:21-26 pubmed publisher
    ..In conclusion, Nrf2 plays a significant role in the down-regulation of CYP7A1 induced by AA in HepG2 cells. ..
  45. Abdel Rahman L, Abu Dief A, Aboelez M, Hassan Abdel Mawgoud A. DNA interaction, antimicrobial, anticancer activities and molecular docking study of some new VO(II), Cr(III), Mn(II) and Ni(II) mononuclear chelates encompassing quaridentate imine ligand. J Photochem Photobiol B. 2017;170:271-285 pubmed publisher
    ..Furthermore, the molecular docking into TRK (PDB: 1t46) was done for the optimization of the investigated compounds as potential TRK inhibitors. ..
  46. Endo Umeda K, Aoyama A, Shimizu M, Ishikawa M, Hashimoto Y, Yamada S, et al. 1?-Hydroxy derivatives of 7-dehydrocholesterol are selective liver X receptor modulators. J Steroid Biochem Mol Biol. 2017;172:136-148 pubmed publisher
    ..These oxysterols have potential as LXR-targeted therapeutics for inflammatory disease. ..
  47. Chen Y, Chen G, Fu X, Liu R. Phytochemical profiles and antioxidant activity of different varieties of Adinandra Tea (Adinandra Jack). J Agric Food Chem. 2015;63:169-76 pubmed
    ..05 to 6.44 mg/mL and from 2.26 to 8.02 mg/mL, respectively. Among the four varieties compared, Nitida and Millettii had a higher CAA value and antiproliferation activity, while Latifolia contained considerable bound phenolics. ..
  48. Zhang S, Tang D, Zang W, Yin G, Dai J, Sun Y, et al. Synergistic Inhibitory Effect of Traditional Chinese Medicine Astragaloside IV and Curcumin on Tumor Growth and Angiogenesis in an Orthotopic Nude-Mouse Model of Human Hepatocellular Carcinoma. Anticancer Res. 2017;37:465-473 pubmed
    ..The present study indicates future clinical potential of combination therapy with AS-IV and curcumin for HCC. ..
  49. You W, Fan Y, Xu Y, Wu K, Tan X. Molecular characterization and functional analysis of PPAR? promoter in yellow catfish Pelteobagrus fulvidraco. Gene. 2017;627:106-113 pubmed publisher
    ..Overall, the present study provided new insights into the mechanisms for transcriptional regulation of PPAR? in fish. ..
  50. Wang Q, Liu S, Yang F, Gan L, Yang X, Yang Y. Magnetic alginate microspheres detected by MRI fabricated using microfluidic technique and release behavior of encapsulated dual drugs. Int J Nanomedicine. 2017;12:4335-4347 pubmed publisher
    ..As a novel embolic agent, such microspheres in blood vessels can be tracked by magnetic resonance scanner. Thus, the integration of embolotherapy, chemotherapy, and postoperative diagnosis can be realized. ..
  51. Saha B, Parks R. Human adenovirus type 5 vectors deleted of early region 1 (E1) undergo limited expression of early replicative E2 proteins and DNA replication in non-permissive cells. PLoS ONE. 2017;12:e0181012 pubmed publisher
    ..These data show that E1-deleted Ad gives rise to limited expression of the E2-encoded genes and replication in infected cells, but highlight the importance of considering viral dose-dependent effects in gene therapy studies. ..
  52. Kah J, Koh S, Volz T, Ceccarello E, Allweiss L, Lutgehetmann M, et al. Lymphocytes transiently expressing virus-specific T cell receptors reduce hepatitis B virus infection. J Clin Invest. 2017;127:3177-3188 pubmed publisher
    ..T cell transfer did not trigger inflammation in uninfected mice. These data support the feasibility of using mRNA electroporation to engineer HBV TCR-redirected T cells in patients with chronic HBV infection. ..
  53. Liang R, Zhang Z, Lin S. Effects of pulsed electric field on intracellular antioxidant activity and antioxidant enzyme regulating capacities of pine nut (Pinus koraiensis) peptide QDHCH in HepG2 cells. Food Chem. 2017;237:793-802 pubmed publisher
    ..53%; the basic structure was not changed by PEF, while the influenced secondary structures may induce the antioxidant activity improvement in HepG2 cells. ..
  54. Liu Z, Huo X, Zhao S, Yang J, Shi W, Jing L, et al. Low density lipoprotein receptor class A domain containing 4 (LDLRAD4) promotes tumorigenesis of hepatic cancer cells. Exp Cell Res. 2017;360:189-198 pubmed publisher
    ..In addition, depletion of LDLRAD4 in HepG2 liver cancer cells inhibited tumorigenesis in nude mice. These results reveal an oncogenic role of LDLRAD4 in tumorigenesis through its association with Nedd4. ..
  55. Wei Y, Wang Y, Zang A, Shang Y, Song Z, Wang Z, et al. Inducible T-cell co-stimulators regulate the proliferation and invasion of human hepatocellular carcinoma HepG2 cells. Biol Res. 2018;51:2 pubmed publisher
    ..01). Down-regulating ICOS expression in HepG2 cells suppressed cell proliferation and invasion. The underlying mechanism may be related to the expression of the downstream factor, PI3K/AKT. ..
  56. Sun J, Yu X, Wang C, Yu C, Li Z, Nie W, et al. RIP-1/c-FLIPL Induce Hepatic Cancer Cell Apoptosis Through Regulating Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL). Med Sci Monit. 2017;23:1190-1199 pubmed
    ..TRAIL mediates apoptosis resistance through upregulating RIP-1 expression, enhancing NF-kB transcriptional activity, and weakening caspase activity. ..
  57. Chen L, Niu S, Li L, Ding G, Yu M, Zhang G, et al. Trichoderpyrone, a Unique Polyketide Hybrid with a Cyclopentenone-Pyrone Skeleton from the Plant Endophytic Fungus Trichoderma gamsii. J Nat Prod. 2017;80:1944-1947 pubmed publisher
    ..Trichoderpyrone (1) displayed weak cytotoxic activities against A549, HepG2, and HeLa cancer cell lines. 1 might originate from a hybrid biosynthetic pathway through two nonreduced (NR) polyketide megasynthetases. ..
  58. Wang Y, Dong L, Li J, Luo M, Shang B. Pentoxifylline induces apoptosis of HepG2 cells by reducing reactive oxygen species production and activating the MAPK signaling. Life Sci. 2017;183:60-68 pubmed publisher
    ..Our data demonstrate that PTX inhibits proliferation of HepG2 cells and induces HepG2 cell apoptosis by attenuating ROS production and enhancing the MAPK activation in HepG2 cells. ..
  59. Feng C, Li D, Jiang L, Liu X, Li Q, Geng C, et al. Citreoviridin induces triglyceride accumulation in hepatocytes through inhibiting PPAR-? in vivo and in vitro. Chem Biol Interact. 2017;273:212-218 pubmed publisher
    ..In summary, we reported that CIT induced PPAR-?-dependent hepatic triglyceride accumulation and dyslipidemia. Our data will provide new mechanistic insights into CIT-induced lipid alterations. ..
  60. Luethi D, Liechti M, Krahenbuhl S. Mechanisms of hepatocellular toxicity associated with new psychoactive synthetic cathinones. Toxicology. 2017;387:57-66 pubmed publisher
    ..Since liver injury is rare in users of these drugs, affected persons must have susceptibility factors rendering them more sensitive for these drugs. ..
  61. Loregger A, Raaben M, Tan J, Scheij S, Moeton M, van den Berg M, et al. Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis. Arterioscler Thromb Vasc Biol. 2017;37:2064-2074 pubmed publisher
  62. Jin Y, Wang J, Han J, Luo D, Sun Z. MiR-122 inhibits epithelial-mesenchymal transition in hepatocellular carcinoma by targeting Snail1 and Snail2 and suppressing WNT/?-cadherin signaling pathway. Exp Cell Res. 2017;360:210-217 pubmed publisher
    ..Taken together, our results indicated that miR-122 may be a biomarker for predicting prognosis of HCC and therapeutic target for HCC patients. ..
  63. Xu C, Han X, Jiang Y, Yuan S, Wu Z, Wu Z, et al. Microenvironmental Control of MUC1 Aptamer-Guided Acid-Labile Nanoconjugate within Injectable Microporous Hydrogels. Bioconjug Chem. 2017;28:2530-2537 pubmed publisher
  64. Yang G, Bai Y, Wu X, Sun X, Sun M, Liu X, et al. Patulin induced ROS-dependent autophagic cell death in Human Hepatoma G2 cells. Chem Biol Interact. 2018;288:24-31 pubmed publisher
    ..These findings suggested that PAT-induced autophagic cell death was ROS-dependent in HepG2 cells. In conclusion, it is possible that PAT elicited autophagy through ROS-Akt1-MTOR pathway in the HepG2 cells. ..
  65. Qu K, Wang Z, Fan H, Li J, Liu J, Li P, et al. MCM7 promotes cancer progression through cyclin D1-dependent signaling and serves as a prognostic marker for patients with hepatocellular carcinoma. Cell Death Dis. 2017;8:e2603 pubmed publisher
    ..Taken together, our results suggest that MCM7-cyclin D1 pathway may participate in cancer progression and serve as a biomarker for prognosis in HCC. ..
  66. Wijayakumara D, Mackenzie P, McKinnon R, Hu D, Meech R. Regulation of UDP-Glucuronosyltransferases UGT2B4 and UGT2B7 by MicroRNAs in Liver Cancer Cells. J Pharmacol Exp Ther. 2017;361:386-397 pubmed publisher
    ..Together, these data suggest that miR-135a and miR-410 control UGT2B4 and that miR-3664 controls UGT2B7 expression in liver cancer and/or normal liver cells. ..
  67. Wang Y, Yu D, Tolleson W, Yu L, Green B, Zeng L, et al. A systematic evaluation of microRNAs in regulating human hepatic CYP2E1. Biochem Pharmacol. 2017;138:174-184 pubmed publisher
    ..These results substantiate the suppressing effect of hsa-miR-214-3p on CYP2E1 expression. ..
  68. YAO Y, Wang Z, Wu S, Li Q, Yu C, Liang X, et al. Identification of novel 1-indolyl acetate-5-nitroimidazole derivatives of combretastatin A-4 as potential tubulin polymerization inhibitors. Biochem Pharmacol. 2017;137:10-28 pubmed publisher
    ..Collectively, these in vitro and in vivo results indicated that compound 3 might be a promising lead compound for further development as a potential anti-cancer drug. ..
  69. Allen K, Coughlan K, Mahmood F, Valentine R, Ruderman N, Saha A. The effects of troglitazone on AMPK in HepG2 cells. Arch Biochem Biophys. 2017;623-624:49-57 pubmed publisher
    ..Phosphorylation at sites of both activation and inhibition can occur in tandem, although the mechanism by which this occurs has not yet been elucidated. ..
  70. Mahara A, Harada Shiba M, Yamaoka T. A Novel Strategy for Etiologic Factor Removal: Drug-Navigated Clearance System (DNCS). Chem Pharm Bull (Tokyo). 2017;65:649-652 pubmed publisher
    ..Therefore, this process demonstrates our attempt to navigate the etiologic factor to an alternate target pathway such as the LDL salvage. ..
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