endothelial progenitor cells


Summary: Cells derived from BONE MARROW that circulate in the adult bloodstream and possess the potential to proliferate and differentiate into mature ENDOTHELIAL CELLS.

Top Publications

  1. Tsukada S, Kwon S, Matsuda T, Jung S, Lee J, Lee S, et al. Identification of mouse colony-forming endothelial progenitor cells for postnatal neovascularization: a novel insight highlighted by new mouse colony-forming assay. Stem Cell Res Ther. 2013;4:20 pubmed publisher
    b>Endothelial progenitor cells (EPCs) play a critical role in restoration of ischemic diseases. However, the actual status of EPC development and the mechanisms of EPC dysfunctions in patients with various ischemic diseases remain unknown...
  2. Gao S, Zheng G, Wang L, Liang Y, Zhang S, Lao X, et al. Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB. PLoS ONE. 2017;12:e0179248 pubmed publisher
    ..exposed to zoledronate, conditioned medium (CM) from the cells significantly induced less migration of endothelial progenitor cells (EPCs) and mesenchymal stem cells (MSCs) compared to CM from unexposed preosteoclasts...
  3. Dopheide J, Geissler P, Rubrech J, Trumpp A, Zeller G, Bock K, et al. Inflammation is associated with a reduced number of pro-angiogenic Tie-2 monocytes and endothelial progenitor cells in patients with critical limb ischemia. Angiogenesis. 2016;19:67-78 pubmed
    ..Here, pro-angiogenic Tie-2-expressing monocytes (TEM) and endothelial progenitor cells (EPC) play a crucial role...
  4. Cui X, Zhang X, Bu H, Liu N, Li H, Guan X, et al. Shear stress-mediated changes in the expression of complement regulatory protein CD59 on human endothelial progenitor cells by ECM-integrin?V?3-F-actin pathway in vitro. Biochem Biophys Res Commun. 2017;494:416-421 pubmed publisher
    ..Previous investigations confirmed that shear stress in the physiological range was more favorable for endothelial progenitor cells (EPCs) to repair injured vascular endothelial cells and operates mainly in atheroprotective actions...
  5. Madonna R, Renna F, Lanuti P, Perfetti M, Marchisio M, Briguori C, et al. The acute impact of high-dose lipid-lowering treatment on endothelial progenitor cells in patients with coronary artery disease-The REMEDY-EPC early substudy. PLoS ONE. 2017;12:e0172800 pubmed publisher
    b>Endothelial progenitor cells (EPCs) play a role in vascular repair, while circulating endothelial cells (CECs) are biomarkers of vascular damage and regeneration. Statins may promote EPC/CEC mobilization in the peripheral blood...
  6. Vinci G, Buffat C, Simoncini S, Boubred F, Ligi I, Dumont F, et al. Gestational age-related patterns of AMOT methylation are revealed in preterm infant endothelial progenitors. PLoS ONE. 2017;12:e0186321 pubmed publisher
    ..We previously demonstrated that in preterm newborns circulating cord blood endothelial progenitor cells (ECFC), responsible for angio/vasculogenesis, are reduced in number and display altered angiogenic ..
  7. Chen W, Zeng W, Sun J, Yang M, Li L, Zhou J, et al. Construction of an Aptamer-SiRNA Chimera-Modified Tissue-Engineered Blood Vessel for Cell-Type-Specific Capture and Delivery. ACS Nano. 2015;9:6069-76 pubmed publisher
    ..Due to few and/or dysfunctional endothelial progenitor cells (EPCs), it is difficult to successfully construct EPC capture TEBVs in diabetes...
  8. Wang C, Li Y, Chen H, Zhang J, Zhang J, Qin T, et al. Inhibition of CYP4A by a novel flavonoid FLA-16 prolongs survival and normalizes tumor vasculature in glioma. Cancer Lett. 2017;402:131-141 pubmed publisher
    ..with the decreased secretion of 20-HETE, VEGF and TGF-β in tumor-associated macrophages (TAMs) and endothelial progenitor cells (EPCs) in C6 and U87 gliomas...
  9. Wang S, Miao J, Qu M, Yang G, Shen L. Adiponectin modulates the function of endothelial progenitor cells via AMPK/eNOS signaling pathway. Biochem Biophys Res Commun. 2017;493:64-70 pubmed publisher
    b>Endothelial progenitor cells have been shown to differentiate into endothelial cells and to play a pivotal role in vascular homeostasis...

More Information


  1. Guo Y, Li P, Gao L, Zhang J, Yang Z, Bledsoe G, et al. Kallistatin reduces vascular senescence and aging by regulating microRNA-34a-SIRT1 pathway. Aging Cell. 2017;16:837-846 pubmed publisher
    ..oxidative stress and inflammation in hypertensive rats and enhancing the mobility and function of endothelial progenitor cells (EPCs)...
  2. Xie W, Ren M, Li L, Zhu Y, Chu Z, Zhu Z, et al. Perinatal testosterone exposure potentiates vascular dysfunction by ER? suppression in endothelial progenitor cells. PLoS ONE. 2017;12:e0182945 pubmed publisher
    ..showed that perinatal testosterone exposure in mice induces estrogen receptor ? (ER?) suppression in endothelial progenitor cells (EPCs) in offspring but not mothers, while estradiol (E2) had no effect...
  3. Cao W, Cui J, Li S, Zhang D, Guo Y, Li Q, et al. Crocetin restores diabetic endothelial progenitor cell dysfunction by enhancing NO bioavailability via regulation of PI3K/AKT-eNOS and ROS pathways. Life Sci. 2017;181:9-16 pubmed publisher
    ..Therefore, this research supports a potential promising therapeutic aspect for diabetic patients. ..
  4. Chang S, Li Y, Yuan F, Qu M, Song Y, Zhang Z, et al. Monomeric CXCL12 outperforms its dimeric and wild type variants in the promotion of human endothelial progenitor cells' function. Biochem Biophys Res Commun. 2017;488:303-310 pubmed publisher
    ..neurobehavioral recovery during post-ischemic stroke through multiple mechanisms including promoting endothelial progenitor cells function in animal models...
  5. Hammer Y, Soudry A, Levi A, Talmor Barkan Y, Leshem Lev D, Singer J, et al. Effect of vitamin D on endothelial progenitor cells function. PLoS ONE. 2017;12:e0178057 pubmed publisher
    b>Endothelial progenitor cells (EPCs) are a population of bone marrow-derived cells, which have an important role in the process of endothelialization and vascular repair following injury...
  6. Bittencourt C, Izar M, França C, Schwerz V, Póvoa R, Fonseca F. Effects of Chronic Exercise on Endothelial Progenitor Cells and Microparticles in Professional Runners. Arq Bras Cardiol. 2017;108:212-216 pubmed publisher
    ..Our study aimed to compare the amounts of endothelial progenitor cells (EPCs), and endothelial (EMP) and platelet (PMP) microparticles between professional runners and ..
  7. Ye M, Li D, Yang J, Xie J, Yu F, Ma Y, et al. MicroRNA-130a Targets MAP3K12 to Modulate Diabetic Endothelial Progenitor Cell Function. Cell Physiol Biochem. 2015;36:712-26 pubmed
    ..of microRNA (miR)-130a dysregulation on the JNK signal pathway through its target MAP3K12 in diabetic endothelial progenitor cells (EPCs). The expression of miR-130a was compared between diabetic and normal EPCs...
  8. Li H, Liu J, Wang Y, Fu Z, Huttemann M, Monks T, et al. MiR-27b augments bone marrow progenitor cell survival via suppressing the mitochondrial apoptotic pathway in Type 2 diabetes. Am J Physiol Endocrinol Metab. 2017;313:E391-E401 pubmed publisher
    ..These findings may provide a mechanistic basis for rescuing BMPC dysfunction in diabetes for successful autologous cell therapy. ..
  9. Ammendola M, Leporini C, Luposella M, Sacco R, Sammarco G, Russo E, et al. Targeting endothelial progenitor cells in cancer as a novel biomarker and anti-angiogenic therapy. Curr Stem Cell Res Ther. 2015;10:181-7 pubmed
    ..In particular, vasculogenesis is mediated by endothelial progenitor cells (EPCs), which include cellular subpopulations with different functional capacities...
  10. Giusti L, Gabriele M, Penno G, Garofolo M, Longo V, Del Prato S, et al. A Fermented Whole Grain Prevents Lipopolysaccharides-Induced Dysfunction in Human Endothelial Progenitor Cells. Oxid Med Cell Longev. 2017;2017:1026268 pubmed publisher
    ..b>Endothelial progenitor cells (EPCs), bone marrow derived stem cells, promote recovery of damaged endothelium playing a pivotal role ..
  11. Huizer K, Mustafa D, Spelt J, Kros J, Sacchetti A. Improving the characterization of endothelial progenitor cell subsets by an optimized FACS protocol. PLoS ONE. 2017;12:e0184895 pubmed publisher
    The characterization of circulating endothelial progenitor cells (EPCs) is fundamental to any study related to angiogenesis...
  12. Laganà A, Giordano D, Loddo S, Zoccali G, Vitale S, Santamaria A, et al. Decreased Endothelial Progenitor Cells (EPCs) and increased Natural Killer (NK) cells in peripheral blood as possible early markers of preeclampsia: a case-control analysis. Arch Gynecol Obstet. 2017;295:867-872 pubmed publisher
    b>Endothelial Progenitor Cells (EPCs) and Natural Killer (NK) cells were recently advocates in the pathogenesis of preeclampsia (PE), since they can be mobilized into the bloodstream and may orchestrate vascular endothelium function...
  13. Varda Bloom N, Treves A, Kroupnik T, Spiegelstein D, Raanani E, Nagler A. Enriching hematopoietic, endothelial and mesenchymal functional progenitors by short-term culture of steady-state peripheral blood mononuclear cells obtained from healthy donors and ischemic patients. Isr Med Assoc J. 2014;16:774-82 pubmed
    ..Moreover, we found that each of the two enriched subpopulations (adherent and non-adherent) has a different differentiation potential (mesenchymal, endothelial and hematopoietic). ..
  14. Patschan S, Nemirovsky K, Henze E, Scholze J, Muller G, Patschan D. Tocilizumab increases EPC regeneration in rheumatoid arthritis. Scand J Rheumatol. 2014;43:528-30 pubmed publisher
  15. King T, McDermott J. Endothelial progenitor cells and cardiovascular disease. J Stem Cells. 2014;9:93-106 pubmed publisher
    b>Endothelial Progenitor Cells (EPCs) are bone-marrow derived stem cells that are postulated to contribute to post-natal vasculogenesis and to repair of damaged endothelium by incorporation into the vessel wall, secretion of paracrine ..
  16. Malerba M, Nardin M, Radaeli A, Montuschi P, Carpagnano G, Clini E. The potential role of endothelial dysfunction and platelet activation in the development of thrombotic risk in COPD patients. Expert Rev Hematol. 2017;10:821-832 pubmed publisher
    ..Endothelium dysfunction and platelet activation are potential targets of therapy in patients with COPD aiming to reduce their risk of cardiovascular events. ..
  17. Li F, Chen J, Leng F, Lu Z, Ling Y. Effect of Saxagliptin on Circulating Endothelial Progenitor Cells and Endothelial Function in Newly Diagnosed Type 2 Diabetic Patients. Exp Clin Endocrinol Diabetes. 2017;125:400-407 pubmed publisher
    ..Endothelial dysfunction is associated with the risk of cardiovascular complications in diabetic patients. Endothelial progenitor cells (EPCs) and flow-mediated dilation (FMD) are common markers of endothelial function...
  18. Zhang L, Li X, Yu X, Li Y, Sun A, Huang C, et al. Construction of vascularized pacemaker tissues by seeding cardiac progenitor cells and endothelial progenitor cells into Matrigel. Life Sci. 2017;179:139-146 pubmed publisher
    ..pacemaking cells and vascularization of TECP fabricated from CPCs-derived pacemaking cells and endothelial progenitor cells (EPCs) in vitro and in vivo implantation...
  19. Haase N, Rüder C, Haase H, Kamann S, Kouno M, Morano I, et al. Protective Function of Ahnak1 in Vascular Healing after Wire Injury. J Vasc Res. 2017;54:131-142 pubmed publisher
    ..The large scaffold and adaptor proteins Ahnak1 and Ahnak2 exhibit differential expression patterns and functions in naïve and injured arteries. Ahnak1 plays a nonredundant protective role in vascular healing. ..
  20. Zhao B, Zhao Z, Sun X, Zhang Y, Guo Y, Tian P, et al. Effect of micro strain stress on proliferation of endothelial progenitor cells in vitro by the MAPK-ERK1/2 signaling pathway. Biochem Biophys Res Commun. 2017;492:206-211 pubmed publisher
    The aim of this study was to analyze the effect of micro strain stress on the proliferation of endothelial progenitor cells in vitro by the MAPK-ERK1/2 signaling pathway...
  21. Obi S, Yamamoto K, Ando J. Effects of shear stress on endothelial progenitor cells. J Biomed Nanotechnol. 2014;10:2586-97 pubmed
    b>Endothelial progenitor cells (EPCs) are adult stem cells that play a central role in neovascularization...
  22. Avouac J, Guignabert C, Hoffmann Vold A, Ruiz B, Dorfmuller P, Pezet S, et al. Role of Stromelysin 2 (Matrix Metalloproteinase 10) as a Novel Mediator of Vascular Remodeling Underlying Pulmonary Hypertension Associated With Systemic Sclerosis. Arthritis Rheumatol. 2017;69:2209-2221 pubmed publisher
    ..MMP10 is overexpressed in the serum and pulmonary arteries of patients with SSc-associated PH, and its blockade alleviates PH in the Fra-2-Tg mouse model. MMP10 appears to be a prospective treatment target for this devastating disorder. ..
  23. Dai T, Hu Y, Zheng H. Hypoxia increases expression of CXC chemokine receptor 4 via activation of PI3K/Akt leading to enhanced migration of endothelial progenitor cells. Eur Rev Med Pharmacol Sci. 2017;21:1820-1827 pubmed
    Recruitment of endothelial progenitor cells (EPCs) to the ischemia has recently been suggested as an important mechanism of neovascularization...
  24. Yu P, Li S, Zhang Z, Wen X, Quan W, Tian Q, et al. Progesterone-mediated angiogenic activity of endothelial progenitor cell and angiogenesis in traumatic brain injury rats were antagonized by progesterone receptor antagonist. Cell Prolif. 2017;50: pubmed publisher
    ..It may suggest that P4-mediated angiogenic activity of EPC and angiogenesis in TBI rats were antagonized by PR antagonist. ..
  25. Mukherjee E, Maringer K, Papke E, Bushnell D, Schaefer C, Kramann R, et al. Endothelial marker-expressing stromal cells are critical for kidney formation. Am J Physiol Renal Physiol. 2017;313:F611-F620 pubmed publisher
    ..Also, loss of Flk1 in the renal stroma leads to nonautonomous-patterning defects in ureteric lineages. ..
  26. Chang T, Tsai W, Huang T, Su S, Chang C, Ma H, et al. Dysregulation of endothelial colony-forming cell function by a negative feedback loop of circulating miR-146a and -146b in cardiovascular disease patients. PLoS ONE. 2017;12:e0181562 pubmed publisher
    Functional impairment of endothelial colony-forming cells (ECFCs), a specific cell lineage of endothelial progenitor cells (EPCs) is highly associated with the severity of coronary artery disease (CAD), the most common type of ..
  27. Ahmed L, Rizk S, El Maraghy S. Pinocembrin ex vivo preconditioning improves the therapeutic efficacy of endothelial progenitor cells in monocrotaline-induced pulmonary hypertension in rats. Biochem Pharmacol. 2017;138:193-204 pubmed publisher
    ..The present study was directed to investigate the possible modulatory effect of pinocembrin on endothelial progenitor cells transplanted in monocrotaline-induced pulmonary hypertension in rats...
  28. Li W, Li N, Song D, Rong J, Qian A, Li X. Metformin inhibits endothelial progenitor cell migration by decreasing matrix metalloproteinases, MMP-2 and MMP-9, via the AMPK/mTOR/autophagy pathway. Int J Mol Med. 2017;39:1262-1268 pubmed publisher
    ..In conclusion, our results showed that metformin inhibited the migration of EPCs by decreasing MMP-2 and MMP-9. The AMPK/mTOR/autophagy pathway was demonstrated to be involved in the regulatory mechanisms. ..
  29. Benyamine A, Magalon J, Cointe S, Lacroix R, Arnaud L, Bardin N, et al. Increased serum levels of fractalkine and mobilisation of CD34+CD45- endothelial progenitor cells in systemic sclerosis. Arthritis Res Ther. 2017;19:60 pubmed publisher
    ..Enhanced numbers of EMPs, CFU-ECs and non-haematopoietic CD34+CD45- endothelial progenitor cells (EPCs) were observed in patients with SSc...
  30. Sudo K, Sato K, Sakamoto S, Hasegawa Y, Asano M, Okuda Y, et al. Association Between Endothelial Progenitor Cells and Treatment Response in Non-Squamous Non-small Cell Lung Cancer Treated with Bevacizumab. Anticancer Res. 2017;37:5565-5571 pubmed
    To investigate the association between the number of circulating endothelial progenitor cells (EPCs) in non-squamous non-small cell lung cancer (NSCLC) and disease outcome, in combination chemotherapy with and without bevacizumab.
  31. Oh J, Kim G, Kim S, Lee S. Antofine, a natural phenanthroindolizidine alkaloid, suppresses angiogenesis via regulation of AKT/mTOR and AMPK pathway in endothelial cells and endothelial progenitor cells derived from mouse embryonic stem cells. Food Chem Toxicol. 2017;107:201-207 pubmed publisher
    ..The underlying mechanism of anti-angiogenic activity of antofine was, in part, associated with the modulation of AKT/mTOR and AMP-activated protein kinase (AMPK) signaling in VEGF-stimulated HUVECs. ..
  32. Fernandes S, Chong J, Paige S, Iwata M, Torok Storb B, Keller G, et al. Comparison of Human Embryonic Stem Cell-Derived Cardiomyocytes, Cardiovascular Progenitors, and Bone Marrow Mononuclear Cells for Cardiac Repair. Stem Cell Reports. 2015;5:753-62 pubmed
    ..Thus, hESC-CMs and CVPs show similar efficacy for cardiac repair, and both are more efficient than hBM-MNCs. However, hESC-CVPs do not form larger grafts or more significant numbers of human vessels in the infarcted heart. ..
  33. Lin L, Huang C, Chen J, Wu T, Leu H, Huang P, et al. Effects of pitavastatin versus atorvastatin on the peripheral endothelial progenitor cells and vascular endothelial growth factor in high-risk patients: a pilot prospective, double-blind, randomized study. Cardiovasc Diabetol. 2014;13:111 pubmed publisher
    Circulating endothelial progenitor cells (EPCs) reflect endothelial repair capacity and may be a significant marker for the clinical outcomes of cardiovascular disease...