endothelial cells

Summary

Summary: Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.

Top Publications

  1. Coleman P, Chang G, Hutas G, Grimshaw M, Vadas M, Gamble J. Age-associated stresses induce an anti-inflammatory senescent phenotype in endothelial cells. Aging (Albany NY). 2013;5:913-24 pubmed
    ..However, we have previously shown that senescence induced by overexpression ofSENEX (or ARHGAP18), in endothelial cells results in an anti-inflammatory phenotype...
  2. Poulos M, Guo P, Kofler N, Pinho S, Gutkin M, Tikhonova A, et al. Endothelial Jagged-1 is necessary for homeostatic and regenerative hematopoiesis. Cell Rep. 2013;4:1022-34 pubmed publisher
    ..We have previously demonstrated that endothelial cells support the proper regeneration of the hematopoietic system following myeloablation (Butler et al...
  3. Rosas Hernández H, Cuevas E, Lantz S, Ali S, Gonzalez C. Prolactin protects against the methamphetamine-induced cerebral vascular toxicity. Curr Neurovasc Res. 2013;10:346-55 pubmed
    ..substances in the blood, keeping a low permeability through the presence of tight junctions (TJs) between endothelial cells. Meth increases BBB permeability by decreasing the TJs proteins claudin-5 and occludin and by decreasing the ..
  4. Raynaud C, Butler J, Halabi N, Ahmad F, Ahmed B, Rafii S, et al. Endothelial cells provide a niche for placental hematopoietic stem/progenitor cell expansion through broad transcriptomic modification. Stem Cell Res. 2013;11:1074-90 pubmed publisher
    ..We investigated the ability of different feeder layers, mesenchymal progenitors (MPs) and endothelial cells (ECs), to amplify hematopoietic stem/progenitor cells...
  5. Jansen F, Yang X, Hoelscher M, Cattelan A, Schmitz T, Proebsting S, et al. Endothelial microparticle-mediated transfer of MicroRNA-126 promotes vascular endothelial cell repair via SPRED1 and is abrogated in glucose-damaged endothelial microparticles. Circulation. 2013;128:2026-38 pubmed publisher
    ..The underlying mechanisms of endothelial cell repair are largely unknown. We sought to investigate whether endothelial microparticles (EMPs), released from apoptotic endothelial cells (ECs), influence EC repair.
  6. Afolayan A, Teng R, Eis A, Rana U, Broniowska K, Corbett J, et al. Inducible HSP70 regulates superoxide dismutase-2 and mitochondrial oxidative stress in the endothelial cells from developing lungs. Am J Physiol Lung Cell Mol Physiol. 2014;306:L351-60 pubmed publisher
    ..SOD-2 activity, and decreased the mitochondrial superoxide (O2(·-)) levels in PPHN pulmonary artery endothelial cells (PAEC) by promoting iHSP70-SOD-2 dissociation at the outer mitochondrial membrane...
  7. Bret n Romero R, Lamas S. Hydrogen peroxide signaling mediator in the activation of p38 MAPK in vascular endothelial cells. Methods Enzymol. 2013;528:49-59 pubmed publisher
    ..We describe p38 MAPK as an early redox sensor in LSS. Our studies show that it is essential for the activation of endothelial nitric oxide synthase, the subsequent nitric oxide generation, and the protection of endothelial function...
  8. Targosz Korecka M, Brzezinka G, Malek K, Stepien E, Szymonski M. Stiffness memory of EA.hy926 endothelial cells in response to chronic hyperglycemia. Cardiovasc Diabetol. 2013;12:96 pubmed publisher
    Glycemic memory of endothelial cells is an effect of long-lasting hyperglycemia and is a cause of various diabetics complications, that arises despite of the treatment targeted towards returning low glucose level in blood system...
  9. Hussmann K, Fredericksen B. Differential induction of CCL5 by pathogenic and non-pathogenic strains of West Nile virus in brain endothelial cells and astrocytes. J Gen Virol. 2014;95:862-7 pubmed publisher
    ..Here, we assessed chemokine expression in brain microvascular endothelial cells and astrocytes, which comprise the major components of the blood-brain barrier (BBB), in response to a non-..
  10. Dallaglio K, Bruno A, Cantelmo A, Esposito A, Ruggiero L, Orecchioni S, et al. Paradoxic effects of metformin on endothelial cells and angiogenesis. Carcinogenesis. 2014;35:1055-66 pubmed publisher
    ..Here, we clarify some of the contradictory effects of metformin on endothelial cells and angiogenesis, using in vitro and in vivo assays combined with transcriptomic and protein array ..

Detail Information

Publications62

  1. Coleman P, Chang G, Hutas G, Grimshaw M, Vadas M, Gamble J. Age-associated stresses induce an anti-inflammatory senescent phenotype in endothelial cells. Aging (Albany NY). 2013;5:913-24 pubmed
    ..However, we have previously shown that senescence induced by overexpression ofSENEX (or ARHGAP18), in endothelial cells results in an anti-inflammatory phenotype...
  2. Poulos M, Guo P, Kofler N, Pinho S, Gutkin M, Tikhonova A, et al. Endothelial Jagged-1 is necessary for homeostatic and regenerative hematopoiesis. Cell Rep. 2013;4:1022-34 pubmed publisher
    ..We have previously demonstrated that endothelial cells support the proper regeneration of the hematopoietic system following myeloablation (Butler et al...
  3. Rosas Hernández H, Cuevas E, Lantz S, Ali S, Gonzalez C. Prolactin protects against the methamphetamine-induced cerebral vascular toxicity. Curr Neurovasc Res. 2013;10:346-55 pubmed
    ..substances in the blood, keeping a low permeability through the presence of tight junctions (TJs) between endothelial cells. Meth increases BBB permeability by decreasing the TJs proteins claudin-5 and occludin and by decreasing the ..
  4. Raynaud C, Butler J, Halabi N, Ahmad F, Ahmed B, Rafii S, et al. Endothelial cells provide a niche for placental hematopoietic stem/progenitor cell expansion through broad transcriptomic modification. Stem Cell Res. 2013;11:1074-90 pubmed publisher
    ..We investigated the ability of different feeder layers, mesenchymal progenitors (MPs) and endothelial cells (ECs), to amplify hematopoietic stem/progenitor cells...
  5. Jansen F, Yang X, Hoelscher M, Cattelan A, Schmitz T, Proebsting S, et al. Endothelial microparticle-mediated transfer of MicroRNA-126 promotes vascular endothelial cell repair via SPRED1 and is abrogated in glucose-damaged endothelial microparticles. Circulation. 2013;128:2026-38 pubmed publisher
    ..The underlying mechanisms of endothelial cell repair are largely unknown. We sought to investigate whether endothelial microparticles (EMPs), released from apoptotic endothelial cells (ECs), influence EC repair.
  6. Afolayan A, Teng R, Eis A, Rana U, Broniowska K, Corbett J, et al. Inducible HSP70 regulates superoxide dismutase-2 and mitochondrial oxidative stress in the endothelial cells from developing lungs. Am J Physiol Lung Cell Mol Physiol. 2014;306:L351-60 pubmed publisher
    ..SOD-2 activity, and decreased the mitochondrial superoxide (O2(·-)) levels in PPHN pulmonary artery endothelial cells (PAEC) by promoting iHSP70-SOD-2 dissociation at the outer mitochondrial membrane...
  7. Bret n Romero R, Lamas S. Hydrogen peroxide signaling mediator in the activation of p38 MAPK in vascular endothelial cells. Methods Enzymol. 2013;528:49-59 pubmed publisher
    ..We describe p38 MAPK as an early redox sensor in LSS. Our studies show that it is essential for the activation of endothelial nitric oxide synthase, the subsequent nitric oxide generation, and the protection of endothelial function...
  8. Targosz Korecka M, Brzezinka G, Malek K, Stepien E, Szymonski M. Stiffness memory of EA.hy926 endothelial cells in response to chronic hyperglycemia. Cardiovasc Diabetol. 2013;12:96 pubmed publisher
    Glycemic memory of endothelial cells is an effect of long-lasting hyperglycemia and is a cause of various diabetics complications, that arises despite of the treatment targeted towards returning low glucose level in blood system...
  9. Hussmann K, Fredericksen B. Differential induction of CCL5 by pathogenic and non-pathogenic strains of West Nile virus in brain endothelial cells and astrocytes. J Gen Virol. 2014;95:862-7 pubmed publisher
    ..Here, we assessed chemokine expression in brain microvascular endothelial cells and astrocytes, which comprise the major components of the blood-brain barrier (BBB), in response to a non-..
  10. Dallaglio K, Bruno A, Cantelmo A, Esposito A, Ruggiero L, Orecchioni S, et al. Paradoxic effects of metformin on endothelial cells and angiogenesis. Carcinogenesis. 2014;35:1055-66 pubmed publisher
    ..Here, we clarify some of the contradictory effects of metformin on endothelial cells and angiogenesis, using in vitro and in vivo assays combined with transcriptomic and protein array ..
  11. Lee J, Bhang D, Beede A, Huang T, Stripp B, Bloch K, et al. Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis. Cell. 2014;156:440-55 pubmed publisher
    ..We used clonal 3D cocultures of endothelial cells and distal lung stem cells, bronchioalveolar stem cells (BASCs), to probe the instructive mechanisms...
  12. Pereira C, Chang B, Qiu J, Niu X, Papatsenko D, Hendry C, et al. Induction of a hemogenic program in mouse fibroblasts. Cell Stem Cell. 2013;13:205-18 pubmed publisher
    ..These findings provide insights into the specification of definitive hemogenesis and a platform for future development of patient-specific stem and progenitor cells, as well as more-differentiated blood products. ..
  13. Eirin A, Zhu X, Woollard J, Herrmann S, Gloviczki M, Saad A, et al. Increased circulating inflammatory endothelial cells in blacks with essential hypertension. Hypertension. 2013;62:585-91 pubmed publisher
    ..Although circulating endothelial progenitor cells (EPCs) preserve endothelial integrity, inflammatory endothelial cells (IECs) detach from sites of injury and represent markers of vascular damage...
  14. van den Biggelaar M, Hernández Fernaud J, van den Eshof B, Neilson L, Meijer A, Mertens K, et al. Quantitative phosphoproteomics unveils temporal dynamics of thrombin signaling in human endothelial cells. Blood. 2014;123:e22-36 pubmed publisher
    ..Because of its complexity, thrombin-induced signaling in endothelial cells has remained incompletely understood...
  15. Abdullah H, Brankin B, Brady C, Cosby S. Wild-type measles virus infection upregulates poliovirus receptor-related 4 and causes apoptosis in brain endothelial cells by induction of tumor necrosis factor-related apoptosis-inducing ligand. J Neuropathol Exp Neurol. 2013;72:681-96 pubmed publisher
    Small numbers of brain endothelial cells (BECs) are infected in children with neurologic complications of measles virus (MV) infection...
  16. Paolinelli R, Corada M, Ferrarini L, Devraj K, Artus C, Czupalla C, et al. Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro. PLoS ONE. 2013;8:e70233 pubmed publisher
    ..This model may be thus suitable to test the BBB permeability to chemicals or large molecular weight proteins, transmigration of inflammatory cells, treatments with cytokines, and genetic manipulation. ..
  17. Jane Wit D, Manes T, Yi T, Qin L, Clark P, Kirkiles Smith N, et al. Alloantibody and complement promote T cell-mediated cardiac allograft vasculopathy through noncanonical nuclear factor-?B signaling in endothelial cells. Circulation. 2013;128:2504-16 pubmed publisher
    ..Pathological interactions between these immune effectors, representing cellular and humoral immunity, respectively, remain largely unexplored...
  18. Dos Santos M, Da Costa A, Ferreira B, Souza S, da Silva Lannes P, Santos G, et al. A phosphoramidon-sensitive metalloprotease induces apoptosis of human endothelial cells by Group B Streptococcus. Antonie Van Leeuwenhoek. 2013;104:1125-33 pubmed publisher
    We explored Group B Streptococcus (GBS)-induced apoptosis in human umbilical vein endothelial cells (HUVEC) and the role of phosphoramidon, a zinc metalloprotease inhibitor, in this process...
  19. Mabeta P. Decreased secretion of vascular endothelial growth factor is associated with increased apoptosis in vascular tumor derived endothelial cells. J Physiol Pharmacol. 2013;64:473-7 pubmed
    ..accelerating haemangioma regression, we have investigated the effects of the drug on vascular tumor inducing endothelial cells (sEnd.2 cells)...
  20. Tian P, Ge H, Liu H, Kern T, Du L, Guan L, et al. Leukocytes from diabetic patients kill retinal endothelial cells: effects of berberine. Mol Vis. 2013;19:2092-105 pubmed
    ..The present study was designed to investigate whether leukocytes from diabetic patients could kill retinal endothelial cells and whether that cytotoxicity could be inhibited in vivo by administration of berberine.
  21. Thangjam G, Dimitropoulou C, Joshi A, Barabutis N, Shaw M, Kovalenkov Y, et al. Novel mechanism of attenuation of LPS-induced NF-?B activation by the heat shock protein 90 inhibitor, 17-N-allylamino-17-demethoxygeldanamycin, in human lung microvascular endothelial cells. Am J Respir Cell Mol Biol. 2014;50:942-52 pubmed publisher
    ..17-AAG) on NF-?B activation by LPS in primary human lung microvascular endothelial cells. Transcriptional activation of NF-?B was measured by luciferase reporter assay, gene expression by real-time ..
  22. Singh V, Dutta D, Ansari M, Dutta S, Chandran B. Kaposi's sarcoma-associated herpesvirus induces the ATM and H2AX DNA damage response early during de novo infection of primary endothelial cells, which play roles in latency establishment. J Virol. 2014;88:2821-34 pubmed publisher
    ..Here, we investigated the modulation of DDR signaling during de novo infection of primary endothelial cells by Kaposi's sarcoma-associated herpesvirus (KSHV)...
  23. Nolan D, Ginsberg M, Israely E, Palikuqi B, Poulos M, James D, et al. Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration. Dev Cell. 2013;26:204-19 pubmed publisher
    Microvascular endothelial cells (ECs) within different tissues are endowed with distinct but as yet unrecognized structural, phenotypic, and functional attributes...
  24. Li W, Liu J, He P, Ni Z, Hu Y, Xu H, et al. Hydroxysafflor yellow A protects methylglyoxal-induced injury in the cultured human brain microvascular endothelial cells. Neurosci Lett. 2013;549:146-50 pubmed publisher
    ..It is not known whether HSYA can protect against MGO-induced injury in cultured human brain microvascular endothelial cells (HBMEC)...
  25. Fomin M, Zhou Y, Beyer A, Publicover J, Baron J, Muench M. Production of factor VIII by human liver sinusoidal endothelial cells transplanted in immunodeficient uPA mice. PLoS ONE. 2013;8:e77255 pubmed publisher
    Liver sinusoidal endothelial cells (LSECs) form a semi-permeable barrier between parenchymal hepatocytes and the blood...
  26. Tecedor L, Stein C, Schultz M, Farwanah H, Sandhoff K, Davidson B. CLN3 loss disturbs membrane microdomain properties and protein transport in brain endothelial cells. J Neurosci. 2013;33:18065-79 pubmed publisher
    ..microdomain-associated proteins caveolin-1, syntaxin-6, and multidrug resistance protein 1 (MDR1) in brain endothelial cells. Correspondingly, CLN3-null cells have reduced caveolae, and impaired caveolae- and MDR1-related functions ..
  27. Jiao H, Zhang Y, Yan Z, Wang Z, Liu G, Minshall R, et al. Caveolin-1 Tyr14 phosphorylation induces interaction with TLR4 in endothelial cells and mediates MyD88-dependent signaling and sepsis-induced lung inflammation. J Immunol. 2013;191:6191-9 pubmed publisher
    ..In this study, we investigated the role of caveolin-1 in regulating TLR4 signaling in endothelial cells. We observed that LPS interaction with CD14 in endothelial cells induced Src-dependent caveolin-1 ..
  28. Marcelo K, SILLS T, Coskun S, Vasavada H, Sanglikar S, Goldie L, et al. Hemogenic endothelial cell specification requires c-Kit, Notch signaling, and p27-mediated cell-cycle control. Dev Cell. 2013;27:504-15 pubmed publisher
    Delineating the mechanism or mechanisms that regulate the specification of hemogenic endothelial cells from primordial endothelium is critical for optimizing their derivation from human stem cells for clinical therapies...
  29. Deissler H, Deissler H, Lang G, Lang G. Ranibizumab efficiently blocks migration but not proliferation induced by growth factor combinations including VEGF in retinal endothelial cells. Graefes Arch Clin Exp Ophthalmol. 2013;251:2345-53 pubmed publisher
    Proliferation and migration of retinal endothelial cells (REC) are associated with the development of proliferative diabetic retinopathy. REC proliferation is stimulated by isoforms of vascular endothelial growth factor-A (i.e...
  30. Vaheri A, Strandin T, Hepojoki J, Sironen T, Henttonen H, Makela S, et al. Uncovering the mysteries of hantavirus infections. Nat Rev Microbiol. 2013;11:539-50 pubmed
    ..In this Review, we discuss the basic molecular properties and cell biology of hantaviruses and offer an overview of virus-induced pathology, in particular vascular leakage and immunopathology...
  31. Liu X, Zhang G, Hou C, Wang H, Yang Y, Guan G, et al. Vascularized bone tissue formation induced by fiber-reinforced scaffolds cultured with osteoblasts and endothelial cells. Biomed Res Int. 2013;2013:854917 pubmed publisher
    ..composite scaffold which was reinforced by chitosan fibers and cultured with osteoblasts and endothelial cells was fabricated...
  32. Totonchy J, Osborn J, Botto S, Clepper L, Moses A. Aberrant proliferation in CXCR7+ endothelial cells via degradation of the retinoblastoma protein. PLoS ONE. 2013;8:e69828 pubmed publisher
    ..These findings identify a heretofore unappreciated role for CXCR7 in vascular dysfunction and confirm this receptor as a plausible target for anti-tumor therapy. ..
  33. Lakota K, Mrak Poljsak K, Bozic B, Tomsic M, Sodin Semrl S. Serum amyloid A activation of human coronary artery endothelial cells exhibits a neutrophil promoting molecular profile. Microvasc Res. 2013;90:55-63 pubmed publisher
    ..SAA-stimulated human coronary artery endothelial cells (HCAEC) were reported to release pro-inflammatory cytokines, chemokines and adhesion molecules; however it ..
  34. Reinert R, Brissova M, Shostak A, Pan F, Poffenberger G, Cai Q, et al. Vascular endothelial growth factor-a and islet vascularization are necessary in developing, but not adult, pancreatic islets. Diabetes. 2013;62:4154-64 pubmed publisher
    ..To investigate the role of VEGF-A and endothelial cells (ECs) in adult islets, we used complementary genetic approaches to temporally inactivate VEGF-A in ..
  35. Hulsmans M, Holvoet P. MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease. Cardiovasc Res. 2013;100:7-18 pubmed publisher
    ..Hereby, we focused on cell-specific microvesicles derived from platelets, endothelial cells and monocyte and monocyte-derived cells...
  36. Kuang L, Feng J, He G, Jing T. Knockdown of Nrf2 inhibits the angiogenesis of rat cardiac micro-vascular endothelial cells under hypoxic conditions. Int J Biol Sci. 2013;9:656-65 pubmed publisher
    ..Cardiac micro-vascular endothelial cells (CMECs) are important participants in myocardial angiogenesis processes...
  37. Jeffery H, Wheat R, Blackbourn D, Nash G, Butler L. Infection and transmission dynamics of rKSHV.219 in primary endothelial cells. J Virol Methods. 2013;193:251-9 pubmed publisher
    ..This study provides methodological guidance for the use of rKSHV.21. In addition, it highlights potential problems associated with the use of fluorescent proteins as markers of viral infection. ..
  38. Guerrero J, Catros S, Derkaoui S, Lalande C, Siadous R, Bareille R, et al. Cell interactions between human progenitor-derived endothelial cells and human mesenchymal stem cells in a three-dimensional macroporous polysaccharide-based scaffold promote osteogenesis. Acta Biomater. 2013;9:8200-13 pubmed publisher
    ..prevascularization of the three-dimensional (3-D) constructs using co-cultures of human progenitor-derived endothelial cells (PDECs) with human bone marrow mesenchymal stem cells (HBMSCs) appeared as a potential strategy...
  39. Chen C, Khismatullin D. Lipopolysaccharide induces the interactions of breast cancer and endothelial cells via activated monocytes. Cancer Lett. 2014;345:75-84 pubmed publisher
    ..of monocytes, bacterial lipopolysaccharide (LPS), and histamine in breast cancer cell adhesion to vascular endothelial cells. Tumor necrosis factor-? (TNF-?) released from LPS-treated monocytes triggered the expression of ..
  40. Punsawad C, Maneerat Y, Chaisri U, Nantavisai K, Viriyavejakul P. Nuclear factor kappa B modulates apoptosis in the brain endothelial cells and intravascular leukocytes of fatal cerebral malaria. Malar J. 2013;12:260 pubmed publisher
    ..An important signaling factor, nuclear factor kappa B (NF-?B) is known to regulate apoptosis. This work aimed to study the expression of NF-?B p65 and its correlation with apoptosis in the brain of fatal CM...
  41. Chu L, Ramakrishnan D, Silverstein R. Thrombospondin-1 modulates VEGF signaling via CD36 by recruiting SHP-1 to VEGFR2 complex in microvascular endothelial cells. Blood. 2013;122:1822-32 pubmed publisher
    Thrombospondin-1 (TSP-1) inhibits growth factor signaling at the receptor level in microvascular endothelial cells (MVEC), and CD36 has been suggested to be involved in this inhibition, but the mechanisms are not known...
  42. Valtcheva N, Primorac A, Jurisic G, Hollmen M, Detmar M. The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42. J Biol Chem. 2013;288:35736-48 pubmed publisher
    ..the GPCR expression profiles of ex vivo isolated intestinal mouse lymphatic (LECs) and blood vascular endothelial cells (BECs)...
  43. Vockel M, Vestweber D. How T cells trigger the dissociation of the endothelial receptor phosphatase VE-PTP from VE-cadherin. Blood. 2013;122:2512-22 pubmed publisher
    ..This complex is rapidly dissociated by adhesion of leukocytes to endothelial cells or by vascular endothelial growth factor...
  44. Khaw L, Ball H, Golenser J, Combes V, Grau G, Wheway J, et al. Endothelial cells potentiate interferon-? production in a novel tripartite culture model of human cerebral malaria. PLoS ONE. 2013;8:e69521 pubmed publisher
    We have established a novel in vitro co-culture system of human brain endothelial cells (HBEC), Plasmodium falciparum parasitised red blood cells (iRBC) and peripheral blood mononuclear cells (PBMC), in order to simulate the chief ..
  45. Luo Y, Li S, Yang J, Qiu Y, Chen F. HMGB1 induces an inflammatory response in endothelial cells via the RAGE-dependent endoplasmic reticulum stress pathway. Biochem Biophys Res Commun. 2013;438:732-8 pubmed publisher
    The high mobility group 1B protein (HMGB1) mediates chronic inflammatory responses in endothelial cells, which play a critical role in atherosclerosis. However, the underlying mechanism is unknown...
  46. Kusumbe A, Ramasamy S, Adams R. Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature. 2014;507:323-328 pubmed publisher
    ..The abundance of these vessels and associated osteoprogenitors was strongly reduced in bone from aged animals, and pharmacological reversal of this decline allowed the restoration of bone mass. ..
  47. Lupo G, Motta C, Giurdanella G, Anfuso C, Alberghina M, Drago F, et al. Role of phospholipases A2 in diabetic retinopathy: in vitro and in vivo studies. Biochem Pharmacol. 2013;86:1603-13 pubmed publisher
    ..Mono- and co-cultures of endothelial cells (EC) and pericytes (PC), treated with high or fluctuating concentrations of glucose, to mimic the diabetic ..
  48. El Assaad F, Wheway J, Mitchell A, Lou J, Hunt N, Combes V, et al. Cytoadherence of Plasmodium berghei-infected red blood cells to murine brain and lung microvascular endothelial cells in vitro. Infect Immun. 2013;81:3984-91 pubmed publisher
    ..the first direct in vitro evidence for the binding of PbA-iRBC to murine brain and lung microvascular endothelial cells (MVEC)...
  49. Bateman H, Liang Q, Fan D, Rodriguez V, Lessner S. Sparstolonin B inhibits pro-angiogenic functions and blocks cell cycle progression in endothelial cells. PLoS ONE. 2013;8:e70500 pubmed publisher
    ..Microarray experiments with human umbilical vein endothelial cells (HUVECs) and human coronary artery endothelial cells (HCAECs) demonstrated differential expression of ..
  50. Zhang J, Friedman M. Adaptive response of vascular endothelial cells to an acute increase in shear stress frequency. Am J Physiol Heart Circ Physiol. 2013;305:H894-902 pubmed publisher
    Local shear stress sensed by arterial endothelial cells is occasionally altered by changes in global hemodynamic parameters, e.g., heart rate and blood flow rate, as a result of normal physiological events, such as exercise...
  51. Joo Y, Eun S, Park S, Lee J, Chang K, Kim H. Honokiol inhibits U87MG human glioblastoma cell invasion through endothelial cells by regulating membrane permeability and the epithelial-mesenchymal transition. Int J Oncol. 2014;44:187-94 pubmed publisher
    ..of honokiol on the cell invasion process of U87MG human glioblastoma cells through brain microvascular endothelial cells (BMECs) and its possible mechanisms...
  52. Patella F, Leucci E, Evangelista M, Parker B, Wen J, Mercatanti A, et al. MiR-492 impairs the angiogenic potential of endothelial cells. J Cell Mol Med. 2013;17:1006-15 pubmed publisher
    b>Endothelial cells growing in high glucose-containing medium show reduced cell proliferation and in vitro angiogenesis...
  53. Schober A, Nazari Jahantigh M, Wei Y, Bidzhekov K, Gremse F, Grommes J, et al. MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1. Nat Med. 2014;20:368-76 pubmed publisher
    ..At nonpredilection sites, high miR-126-5p levels in endothelial cells confer a proliferative reserve that compensates for the antiproliferative effects of hyperlipidemia, such ..
  54. Everett L, Cleuren A, Khoriaty R, Ginsburg D. Murine coagulation factor VIII is synthesized in endothelial cells. Blood. 2014;123:3697-705 pubmed publisher
    ..We generated Lman1 conditional knockout mice to characterize the FVIII secretion profiles of endothelial cells and hepatocytes...
  55. Kitagawa M, Hojo M, Imayoshi I, Goto M, Ando M, Ohtsuka T, et al. Hes1 and Hes5 regulate vascular remodeling and arterial specification of endothelial cells in brain vascular development. Mech Dev. 2013;130:458-66 pubmed publisher
    ..In addition, arterial identity of endothelial cells was partially lost in the brain of these mutant mice...
  56. Li H, Zheng Y. Effects of mycophenolic Acid on the proliferation and endothelin-1 and interleukin-6 secretion of rat pulmonary microvascular endothelial cells. Cell Physiol Biochem. 2013;32:1354-61 pubmed publisher
    To investigate the effect of mycophenolic acid (MPA) on the proliferation of rat pulmonary microvascular endothelial cells (PMVECs) and on the secretion of endothelin-1 (ET-1) and interleukin-6 (IL-6) by these cells.
  57. Thom V, Wendel M, Deussen A. Regulation of ecto-5´-nucleotidase by docosahexaenoic acid in human endothelial cells. Cell Physiol Biochem. 2013;32:355-66 pubmed publisher
    ..This study assessed DHA effects on extracellular adenine purines...
  58. Bergmann S, Schoenen H, Hammerschmidt S. The interaction between bacterial enolase and plasminogen promotes adherence of Streptococcus pneumoniae to epithelial and endothelial cells. Int J Med Microbiol. 2013;303:452-62 pubmed publisher
    ..of human alveolar type II pneumocytes (A549), nasopharyngeal epithelium (Detroit 562) and brain-derived endothelial cells (HBMEC)...
  59. Orlova V, Drabsch Y, Freund C, Petrus Reurer S, van den Hil F, Muenthaisong S, et al. Functionality of endothelial cells and pericytes from human pluripotent stem cells demonstrated in cultured vascular plexus and zebrafish xenografts. Arterioscler Thromb Vasc Biol. 2014;34:177-86 pubmed publisher
    b>Endothelial cells (ECs), pericytes, and vascular smooth muscle cells (vSMCs) are essential for vascular development, and their dysfunction causes multiple cardiovascular diseases...
  60. Weidemann A, Breyer J, Rehm M, Eckardt K, Daniel C, Cicha I, et al. HIF-1? activation results in actin cytoskeleton reorganization and modulation of Rac-1 signaling in endothelial cells. Cell Commun Signal. 2013;11:80 pubmed publisher
    ..Whereas effects of HIF-stabilization on transcriptional responses have been thoroughly investigated in endothelial cells, the molecular details of cytoskeletal changes elicited by PHD-inhibition remain largely unknown...
  61. Li W, Xu H, Hu Y, He P, Ni Z, Xu H, et al. Edaravone protected human brain microvascular endothelial cells from methylglyoxal-induced injury by inhibiting AGEs/RAGE/oxidative stress. PLoS ONE. 2013;8:e76025 pubmed publisher
    ..Using cultured human brain microvascular endothelial cells (HBMEC), protective effects of edaravone on MGO and MGO enhancing oxygen-glucose deprivation (OGD) induced ..
  62. Yan L, Kang M, Qin Z, Zhang W, Li Y, Ou H. An intronic miRNA regulates expression of the human endothelial nitric oxide synthase gene and proliferation of endothelial cells by a mechanism related to the transcription factor SP-1. PLoS ONE. 2013;8:e70658 pubmed publisher
    ..This study was to investigate the molecular mechanisms underlying the 27nt-miRNA-mediated regulation of expression of the endothelial nitric oxide synthase (eNOS) gene...