a549 cells


Summary: An immortalized cell line derived from human ADENOCARCINOMA, ALVEOLAR basal epithelial cells isolated from the lungs of a male patient in 1972. The cell line is positive for KERATIN, can synthesize LECITHIN, and contains high levels of POLYUNSATURATED FATTY ACIDS in its PLASMA MEMBRANE. It is used as a model for PULMONARY ALVEOLI function and virus infections, as a TRANSFECTION host, and for PRECLINICAL DRUG EVALUATION.

Top Publications

  1. Nguyen B, Yoshimura K, Kumazawa S, Tawata S, Maruta H. Frondoside A from sea cucumber and nymphaeols from Okinawa propolis: Natural anti-cancer agents that selectively inhibit PAK1 in vitro. Drug Discov Ther. 2017;11:110-114 pubmed publisher
    ..To the best of our knowledge, FRA is the first marine compound that selectively inhibits PAK1. Likewise, these nymphaeols are the first propolis ingredients that selectively inhibit PAK1. ..
  2. Lee H, Her N, Kang D, Jung S, Shin J, Lee M, et al. Radiation-inducible miR-770-5p sensitizes tumors to radiation through direct targeting of PDZ-binding kinase. Cell Death Dis. 2017;8:e2693 pubmed publisher
    ..When miR-770-5p was overexpressed, relative cell number was reduced due to increased apoptosis in MCF7 and A549 cells. Transcriptomic and bioinformatic analyses revealed that PDZ-binding kinase (PBK) might be a possible target of ..
  3. Wang L, Liu X, Ren Y, Zhang J, Chen J, Zhou W, et al. Cisplatin-enriching cancer stem cells confer multidrug resistance in non-small cell lung cancer via enhancing TRIB1/HDAC activity. Cell Death Dis. 2017;8:e2746 pubmed publisher
    ..Our findings illustrate a novel perspective in the evolution of chemotherapy resistance and provide a promising approach for the treatment of patients with NSCLC. ..
  4. Chen H, Lin M, Chen C, Shu J. The expression of fibronectin is significantly suppressed in macrophages to exert a protective effect against Staphylococcus aureus infection. BMC Microbiol. 2017;17:92 pubmed publisher
    ..This suppression may play a protective role in macrophages against S. aureus infection. This study provides the first demonstration that Fn is suppressed in macrophages by S. aureus infection. ..
  5. Tabaja N, Yuan Z, Oswald F, Kovall R. Structure-function analysis of RBP-J-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes. J Biol Chem. 2017;292:10549-10563 pubmed publisher
    ..Taken together, these results provide molecular insights into the mechanism of RITA-mediated regulation of Notch signaling, contributing to our understanding of how CSL functions as a transcriptional repressor of Notch target genes. ..
  6. Caino M, Seo J, Wang Y, Rivadeneira D, Gabrilovich D, Kim E, et al. Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer. J Clin Invest. 2017;127:3755-3769 pubmed publisher
    ..Therefore, SNPH is a stress-regulated mitochondrial switch of the cell proliferation-motility balance in cancer, and its pathway may represent a therapeutic target. ..
  7. Karki S, Yildirim Ayan E, Eisenmann K, Ayan H. Miniature Dielectric Barrier Discharge Nonthermal Plasma Induces Apoptosis in Lung Cancer Cells and Inhibits Cell Migration. Biomed Res Int. 2017;2017:8058307 pubmed publisher
    ..5%, 14.1%, and 6.3% of the cell population, respectively. Additionally, we observed reduced A549 cell migration in response to mDBD plasma treatment. Thus, mDBD plasma system can be a viable platform for localized lung cancer therapy. ..
  8. Li H, Courtois E, Sengupta D, Tan Y, Chen K, Goh J, et al. Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors. Nat Genet. 2017;49:708-718 pubmed publisher
    ..Overall, our results demonstrate that unbiased single-cell RNA-seq profiling of tumor and matched normal samples provides a unique opportunity to characterize aberrant cell states within a tumor. ..
  9. Sugiyama Y, Asai K, Yamada K, Kureya Y, Ijiri N, Watanabe T, et al. Decreased levels of irisin, a skeletal muscle cell-derived myokine, are related to emphysema associated with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2017;12:765-772 pubmed publisher
    ..05). Decreased serum irisin levels are related to emphysema in patients with COPD and involved in epithelial apoptosis, resulting in emphysema. Irisin could be a novel treatment for emphysema in patients with COPD. ..

More Information

Publications112 found, 100 shown here

  1. Wu J, He Z, Yang X, Li K, Wang D, Sun F. RCCD1 depletion attenuates TGF-β-induced EMT and cell migration by stabilizing cytoskeletal microtubules in NSCLC cells. Cancer Lett. 2017;400:18-29 pubmed publisher
    ..Collectively, these findings support RCCD1 as a novel regulator of TGF-β-induced EMT in NSCLC. ..
  2. Yang F, Gu Y, Zhao Z, Huang J, Jiang W, Cheng S. NHERF1 Suppresses Lung Cancer Cell Migration by Regulation of Epithelial-Mesenchymal Transition. Anticancer Res. 2017;37:4405-4414 pubmed
    ..The expression of NHERF1 significantly decreased in the TGF-?1-induced A549 cells. Overexpression of NHERF1 significantly inhibited the migratory ability of cells and reversed the TGF-?1-induced ..
  3. Prakasam G, Singh R, Iqbal M, Saini S, Tiku A, Bamezai R. Pyruvate kinase M knockdown-induced signaling via AMP-activated protein kinase promotes mitochondrial biogenesis, autophagy, and cancer cell survival. J Biol Chem. 2017;292:15561-15576 pubmed publisher
    ..The stable knockdown of PK isoforms in A549 cells significantly reduced the cellular ATP level, whereas in H1299 cells the level of ATP was unaltered...
  4. Yu W, Peng W, Jiang H, Sha H, Li J. LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non-small cell lung cancer cells. Tumour Biol. 2017;39:1010428317721440 pubmed publisher
    ..Collectively, our findings reveal an oncogenic role for HOXA11-AS in non-small cell lung cancer tumorigenesis...
  5. Jin H, Yang L, Jeong K. Flightless-I homolog regulates glucocorticoid receptor-mediated transcription via direct interaction of the leucine-rich repeat domain. Mol Biol Rep. 2017;44:243-250 pubmed publisher
    ..Chromatin immunoprecipitation assay were carried out with FLII-depleted A549 cells to determine the role of FLII at GR binding sites...
  6. Qiu W, Wu J, Choi J, Hirai H, Nishida H, Kawagishi H. Cytotoxic compounds against cancer cells from Bombyx mori inoculated with Cordyceps militaris. Biosci Biotechnol Biochem. 2017;81:1224-1226 pubmed publisher
    ..In the bioassay examining cytotoxicity against cancer cells, both compounds showed toxicity against A549, PANC-1, and MCF-7 cancer cells. ..
  7. Mali P, Shirsat P, Khomane N, Nayak L, Nanubolu J, Meshram H. 1,3-Dipolar Cycloaddition Reactions for the Synthesis of Novel Oxindole Derivatives and Their Cytotoxic Properties. ACS Comb Sci. 2017;19:633-639 pubmed publisher
    ..Most of the compounds showed moderate to potent cytotoxic activity against the tested cell lines. ..
  8. Petpiroon N, Sritularak B, Chanvorachote P. Phoyunnanin E inhibits migration of non-small cell lung cancer cells via suppression of epithelial-to-mesenchymal transition and integrin ?v and integrin ?3. BMC Complement Altern Med. 2017;17:553 pubmed publisher
    ..and proliferative effects of phoyunnanin E on human non-small cell lung cancer-derived H460, H292, and A549 cells and human keratinocyte HaCaT cells were investigated by MTT assay...
  9. Nihira N, Ogura K, Shimizu K, North B, Zhang J, Gao D, et al. Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function. Sci Signal. 2017;10: pubmed publisher
    ..Therefore, this study indicates that dynamic acetylation is a molecular switch in the regulation of MDM2 substrate specificity, revealing further insight into the posttranslational regulation of the MDM2/p53 cell survival axis. ..
  10. Gu Y, Albuquerque C, Braas D, Zhang W, Villa G, Bi J, et al. mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT. Mol Cell. 2017;67:128-138.e7 pubmed publisher
    ..These results identify an unanticipated mechanism regulating amino acid metabolism in cancer, enabling tumor cells to adapt to changing environmental conditions. ..
  11. Lee W, Chen P, Wu W, Wu H, Lan C, Huang Y, et al. Panobinostat sensitizes KRAS-mutant non-small-cell lung cancer to gefitinib by targeting TAZ. Int J Cancer. 2017;141:1921-1931 pubmed publisher
    ..Our findings identify that targeting TAZ-mediated compensatory mechanism is a novel therapeutic approach to overcome gefitinib resistance in KRAS-mutant/EGFR-wild-type NSCLC. ..
  12. Álvarez Fraga L, Rumbo Feal S, Perez A, Gómez M, Gayoso C, Vallejo J, et al. Global assessment of small RNAs reveals a non-coding transcript involved in biofilm formation and attachment in Acinetobacter baumannii ATCC 17978. PLoS ONE. 2017;12:e0182084 pubmed publisher
    ..The present work serves as a basis for future studies examining the complex regulatory network that regulate biofilm biogenesis and attachment to eukaryotic cells in A. baumannii ATCC 17978. ..
  13. Wang F, Chen J, Dai W, He Z, Zhai D, Chen W. Pharmacokinetic studies and anticancer activity of curcumin-loaded nanostructured lipid carriers. Acta Pharm. 2017;67:357-371 pubmed publisher
    ..In addition, the anticancer activity of Cur-NLC against human lung adenocarcinoma A549 cells was verified by a cellular uptake study, and a cytotoxicity and apoptosis assay...
  14. Kathayat R, Cao Y, Elvira P, Sandoz P, Zaballa M, Springer M, et al. Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes. Nat Commun. 2018;9:334 pubmed publisher
    ..Altogether, this work reveals that mitochondrial S-palmitoylation is actively regulated by "eraser" enzymes that respond to alterations in mitochondrial lipid homeostasis. ..
  15. Koo T, Yoon A, Cho H, Bae S, Yun C, Kim J. Selective disruption of an oncogenic mutant allele by CRISPR/Cas9 induces efficient tumor regression. Nucleic Acids Res. 2017;45:7897-7908 pubmed publisher
  16. He B, Yang D, Qin M, Zhang Y, He B, Dai W, et al. Increased cellular uptake of peptide-modified PEGylated gold nanoparticles. Biochem Biophys Res Commun. 2017;494:339-345 pubmed publisher
    ..Other energy independent endocytosis pathways were also identified. Our work revealed a new strategy to modify gold nanoparticles with CPP and illustrated the cellular uptake pathway of CPP-modified gold nanoparticles...
  17. Tanoue K, Rosewell Shaw A, Watanabe N, Porter C, Rana B, Gottschalk S, et al. Armed Oncolytic Adenovirus-Expressing PD-L1 Mini-Body Enhances Antitumor Effects of Chimeric Antigen Receptor T Cells in Solid Tumors. Cancer Res. 2017;77:2040-2051 pubmed publisher
    ..i>Cancer Res; 77(8); 2040-51. ©2017 AACR. ..
  18. Bai Z, Gao M, Zhang H, Guan Q, Xu J, Li Y, et al. BZML, a novel colchicine binding site inhibitor, overcomes multidrug resistance in A549/Taxol cells by inhibiting P-gp function and inducing mitotic catastrophe. Cancer Lett. 2017;402:81-92 pubmed publisher
    ..cells to die by mitotic catastrophe (MC), a p53-independent apoptotic-like cell death, whereas induced A549 cells to die by apoptosis...
  19. Zhong L, Sun S, Shi J, Cao F, Han X, Chen Z. MicroRNA-125a-5p plays a role as a tumor suppressor in lung carcinoma cells by directly targeting STAT3. Tumour Biol. 2017;39:1010428317697579 pubmed publisher
    ..mechanism of mir-125a-5p in lung cancer cells, miR-125a-5p mimic or mir-125a-5p inhibitor was transfected into A549 cells. Mir-125a-5p displayed an obvious upregulation in A549 cells transfected with miR-125a-5p and an obvious ..
  20. Zhou J, Liu S, Chen Y, Fu Y, Silver A, Hill M, et al. Identification of two novel functional tRNA-derived fragments induced in response to respiratory syncytial virus infection. J Gen Virol. 2017;98:1600-1610 pubmed publisher
    ..Regulating the expression and/or activity of these tRFs may provide new insights into preventive and therapeutic strategies for RSV infection. The study also accumulated data for future development of a tRF targeting algorithm...
  21. Lu W, Hawley B, Skalka G, Baldock R, Smith E, Bader A, et al. Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair. Nat Commun. 2018;9:532 pubmed publisher
    ..Removal of the RNA component of these structures results in impaired repair. These results show how RNA can be a direct and critical mediator of DNA damage repair in human cells. ..
  22. Kalai Selvi S, Vinoth A, Varadharajan T, Weng C, Vijaya Padma V. Neferine augments therapeutic efficacy of cisplatin through ROS- mediated non-canonical autophagy in human lung adenocarcinoma (A549 cells). Food Chem Toxicol. 2017;103:28-40 pubmed publisher
  23. Zhou Y, Wang Y, Zhao Z, Wang Y, Zhang N, Zhang H, et al. 37LRP induces invasion in hypoxic lung adenocarcinoma cancer cells A549 through the JNK/ERK/c-Jun signaling cascade. Tumour Biol. 2017;39:1010428317701655 pubmed publisher
    ..Hypoxia-induced invasion of A549 cells was inhibited by the pharmacologic inhibitors of c-Jun N-terminal kinase (SP600125) and extracellular signal-..
  24. Jalili V, Matteucci M, Masseroli M, Ceri S. Explorative visual analytics on interval-based genomic data and their metadata. BMC Bioinformatics. 2017;18:536 pubmed publisher
    ..GeMSE is available at http://www.bioinformatics.deib.polimi.it/GeMSE/ , and its source code is available at https://github.com/Genometric/GeMSE under GPLv3 open-source license. ..
  25. Yang R, Li P, Zhang G, Lu C, Wang H, Zhao G. Long Non-Coding RNA XLOC_008466 Functions as an Oncogene in Human Non-Small Cell Lung Cancer by Targeting miR-874. Cell Physiol Biochem. 2017;42:126-136 pubmed publisher
    ..XLOC_008466 functions as an oncogene in NSCLC by regulating the miR-874-MMP2/XIAP axis, which indicates that XLOC_008466 may be a useful marker and potential therapeutic target in NSCLC. ..
  26. Zheng X, Xu W, Sun R, Yin H, Dong C, Zeng H. Synergism between thioredoxin reductase inhibitor ethaselen and sodium selenite in inhibiting proliferation and inducing death of human non-small cell lung cancer cells. Chem Biol Interact. 2017;275:74-85 pubmed publisher
    ..In short, BBSKE synergizes selenite in inhibiting proliferation and inducing death of NSCLC cells; BBSKE combined with selenite may be a treatment strategy for NSCLC. ..
  27. Wang M, Han J, Marcar L, Black J, Liu Q, Li X, et al. Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin-EGFR Pathway. Cancer Res. 2017;77:2018-2028 pubmed publisher
    ..Our results illuminate the basis for the radiation resistance of KRAS-mutated lung cancers, with possible implications for prognostic and therapeutic strategies. Cancer Res; 77(8); 2018-28. ©2017 AACR. ..
  28. Kaplan A, Akalın Çiftçi G, Kutlu H. The apoptotic and genomic studies on A549 cell line induced by silver nitrate. Tumour Biol. 2017;39:1010428317695033 pubmed publisher
    ..Silver nitrate showed inhibitory effects against A549 cells in a dose- and time-dependent manner for 24, 48, and 72?h and induced apoptosis...
  29. He L, Fan F, Hou X, Gao C, Meng L, Meng S, et al. Resveratrol suppresses pulmonary tumor metastasis by inhibiting platelet-mediated angiogenic responses. J Surg Res. 2017;217:113-122 pubmed publisher
    ..In addition, RSV attenuated the platelet secretion and angiogenic responses induced by A549 cells in vitro and suppressed A549 lung cancer metastasis and angiogenesis in nude mice...
  30. Jakovljević K, Matić I, Stanojkovic T, Krivokuca A, Marković V, Joksović M, et al. Synthesis, antioxidant and antiproliferative activities of 1,3,4-thiadiazoles derived from phenolic acids. Bioorg Med Chem Lett. 2017;27:3709-3715 pubmed publisher
    ..3'h with 4-chlorophenyl moiety was found to be the most effective in inhibition of survival of lung carcinoma A549 cells. All examined thiadiazoles except 3a and 3'a exerted higher cytotoxic activities on A549 and HL-60 cancer cells ..
  31. Momtazi A, Askari Khorasgani O, Abdollahi E, Sadeghi Aliabadi H, Mortazaeinezhad F, Sahebkar A. Phytochemical Analysis and Cytotoxicity Evaluation of Kelussia odoratissima Mozaff. J Acupunct Meridian Stud. 2017;10:180-186 pubmed publisher
    ..odoratissima leaf extract against human cancer cell lines. This activity of K. odoratissima may find application in combination with traditional herbal medicines to develop a new anticancer pharmacopuncture therapy. ..
  32. Van den Driessche F, Vanhoutte B, Brackman G, Crabbé A, Rigole P, Vercruysse J, et al. Evaluation of combination therapy for Burkholderia cenocepacia lung infection in different in vitro and in vivo models. PLoS ONE. 2017;12:e0172723 pubmed publisher
    ..This stresses the importance of validating hits resulting from in vitro studies in physiologically relevant model systems. ..
  33. Chao W, Deng J, Li P, Liang Y, Huang G. 3,4-Dihydroxybenzalactone Suppresses Human Non-Small Cell Lung Carcinoma Cells Metastasis via Suppression of Epithelial to Mesenchymal Transition, ROS-Mediated PI3K/AKT/MAPK/MMP and NFκB Signaling Pathways. Molecules. 2017;22: pubmed publisher
    ..In this study, we used highly metastatic A549 cells to investigate efficacy of DBL inhibition of cancer metastasis and possible mechanisms...
  34. Lee J, Kim Y, Im C, Kim S, Kim S, Min S, et al. Grape Seed Proanthocyanidin Inhibits Mucin Synthesis and Viral Replication by Suppression of AP-1 and NF-?B via p38 MAPKs/JNK Signaling Pathways in Respiratory Syncytial Virus-Infected A549 Cells. J Agric Food Chem. 2017;65:4472-4483 pubmed publisher
    ..Concomitantly, GSP inhibited the replication of RSV within A549 cells. Taken together, all our results suggest that GSP could be a potent therapeutic agent to suppress excessive ..
  35. Wenta T, Glaza P, Jarząb M, Zarzecka U, Zurawa Janicka D, Lesner A, et al. The role of the LB structural loop and its interactions with the PDZ domain of the human HtrA3 protease. Biochim Biophys Acta Proteins Proteom. 2017;1865:1141-1151 pubmed publisher
    ..Furthermore, a monomeric form of the ?N-HtrA3L is proteolytically inactive. In conclusion, our results suggest that the expanded LB loop promotes the ?N-HtrA3L activity by stabilizing the protease native trimeric structure. ..
  36. Chen S, Huang Y, Liu Z, Yu W, Zhang H, Li K, et al. Sulphur dioxide suppresses inflammatory response by sulphenylating NF-?B p65 at Cys38 in a rat model of acute lung injury. Clin Sci (Lond). 2017;131:2655-2670 pubmed publisher
    ..Hence, down-regulation of SO2/AAT is involved in pulmonary inflammation during ALI. Furthermore, SO2 suppressed inflammation by sulphenylating NF-?B p65 at Cys38. ..
  37. Rajan D, Chinnadurai R, O Keefe E, Boyoglu Barnum S, Todd S, Hartert T, et al. Protective role of Indoleamine 2,3 dioxygenase in Respiratory Syncytial Virus associated immune response in airway epithelial cells. Virology. 2017;512:144-150 pubmed publisher
    ..and is upregulated with RSV infection, we studied it in vivo during infection of BALB/c mice and in vitro in A549 cells. RSV infection upregulated IDO transcripts in vivo and in vitro...
  38. Lin M, Bi H, Yan Y, Huang W, Zhang G, Zhang G, et al. Parthenolide suppresses non-small cell lung cancer GLC-82 cells growth via B-Raf/MAPK/Erk pathway. Oncotarget. 2017;8:23436-23447 pubmed publisher
    ..All above provide an insight to understand the action of parthenolide as a potential B-Raf inhibitor in treatment of NSCLC. ..
  39. Treiber T, Treiber N, Plessmann U, Harlander S, Daiß J, Eichner N, et al. A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. Mol Cell. 2017;66:270-284.e13 pubmed publisher
    ..We provide an extended database of RBPs that interact with pre-miRNAs in extracts of different cell types, highlighting a widespread layer of co- and posttranscriptional regulation of miRNA biogenesis. ..
  40. El Hussein A, Hamblin M. ROS generation and DNA damage with photo-inactivation mediated by silver nanoparticles in lung cancer cell line. IET Nanobiotechnol. 2017;11:173-178 pubmed publisher
    ..The results showed the occurrence of DNA damage in lung cancer cells (A549) through the generation of ROS shown by mitochondrial membrane potential changes. ..
    ..In conclusion, cucurbitacin A inhibits cancer growth in A-549 NSCLC cells by inducing apoptosis, targeting m-TOR/PI3K/Akt signalling pathway and G2/M cell cycle. ..
  42. Lv T, Yu T, Fang Y, Zhang S, Jiang M, Zhang H, et al. Role of generation on folic acid-modified poly(amidoamine) dendrimers for targeted delivery of baicalin to cancer cells. Mater Sci Eng C Mater Biol Appl. 2017;75:182-190 pubmed publisher
    ..demonstrated increased drug uptake level in folate receptor (FR)-positive Hela cancer cells than FR-negative A549 cells, and the cellular uptake efficiency of PAMAM-FA is closely related with the generation of PAMAM...
  43. Hay Koren A, Bialik S, Levin Salomon V, Kimchi A. Changes in cIAP2, survivin and BimEL expression characterize the switch from autophagy to apoptosis in prolonged starvation. J Intern Med. 2017;281:458-470 pubmed publisher
    ..The decrease in the anti-apoptotic IAPs and the increase in the pro-apoptotic BimEL may thus constitute a molecular switch from autophagy to apoptosis during prolonged starvation. ..
  44. Jin S, Tian S, Luo M, Xie W, Liu T, Duan T, et al. Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells. Mol Cell. 2017;68:308-322.e4 pubmed publisher
  45. Zheng Q, Li Z, Zhou S, Zhang Q, Zhou L, Fu X, et al. Heparin-binding Hemagglutinin of Mycobacterium tuberculosis Is an Inhibitor of Autophagy. Front Cell Infect Microbiol. 2017;7:33 pubmed publisher
    ..In particular, the autophagy of A549 cells was determined based on microtubule-associated protein 1 light chain 3 alpha (LC3) activity...
  46. Liu H, Zhang L, Sun J, Chen W, Li S, Wang Q, et al. Endoplasmic Reticulum Protein SCAP Inhibits Dengue Virus NS2B3 Protease by Suppressing Its K27-Linked Polyubiquitylation. J Virol. 2017;91: pubmed publisher
    ..Both of these functions protect STING from being cleaved by the NS2B3 protease and thus contribute to host antiviral response. ..
  47. Lee Y, Choi Y, Lee J, Shim D, Park W, Seo S. TP53 alteration determines the combinational cytotoxic effect of doxorubicin and an antioxidant NAC. Tumour Biol. 2017;39:1010428317700159 pubmed publisher
    ..In conclusion, TP53 genetic alteration is a critical factor that determines the use of antioxidant supplements during doxorubicin treatment. ..
  48. Sivanand S, Rhoades S, Jiang Q, Lee J, Benci J, Zhang J, et al. Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination. Mol Cell. 2017;67:252-265.e6 pubmed publisher
    ..Upon PARP inhibition, ACLY silencing promotes genomic instability and cell death. Thus, the spatial and temporal control of acetyl-CoA production by ACLY participates in the mechanism of DNA repair pathway choice. ..
  49. Zago M, Sheridan J, Traboulsi H, Hecht E, Zhang Y, Guerrina N, et al. Low levels of the AhR in chronic obstructive pulmonary disease (COPD)-derived lung cells increases COX-2 protein by altering mRNA stability. PLoS ONE. 2017;12:e0180881 pubmed publisher
    ..Therefore, we conclude that the AhR controls COX-2 protein via mRNA stability by a mechanism independent of miR-146a. Low levels of the AhR may therefore contribute to the heightened inflammation common in COPD patients. ..
  50. Szewczuk M, Boguszewska K, Zebrowska M, Balcerczak E, Stasiak M, Swiatkowska M, et al. Virus-directed enzyme prodrug therapy and the assessment of the cytotoxic impact of some benzimidazole derivatives. Tumour Biol. 2017;39:1010428317713675 pubmed publisher
    ..the pro-apoptotic properties of all tested compounds in normoxia and hypoxia, especially according to virused A549 cells where the time of exposition was reduced from 48 to 4?h...
  51. Monchusi B, Ntwasa M. Methyl pyruvate protects a normal lung fibroblast cell line from irinotecan-induced cell death: Potential use as adjunctive to chemotherapy. PLoS ONE. 2017;12:e0182789 pubmed publisher
    ..We conclude that methyl pyruvate may preferentially kill cancer cells and protect normal cells during chemotherapy. ..
  52. Che D, Zhang S, Jing Z, Shang L, Jin S, Liu F, et al. Macrophages induce EMT to promote invasion of lung cancer cells through the IL-6-mediated COX-2/PGE2/?-catenin signalling pathway. Mol Immunol. 2017;90:197-210 pubmed publisher
  53. Glasner A, Oiknine Djian E, Weisblum Y, Diab M, Panet A, Wolf D, et al. Zika Virus Escapes NK Cell Detection by Upregulating Major Histocompatibility Complex Class I Molecules. J Virol. 2017;91: pubmed publisher
    ..Countering MHC class I upregulation and boosting NK cell activity may be employed as prophylactic measures to combat Zika virus infection. ..
  54. Yao D, Cui H, Zhou S, Guo L. Morin inhibited lung cancer cells viability, growth, and migration by suppressing miR-135b and inducing its target CCNG2. Tumour Biol. 2017;39:1010428317712443 pubmed publisher
    ..We found that morin-treated A549 cells showed statistically decreased cell viability, colony formation, and migration rate when comparing with the ..
  55. Shen M, Xu Z, Jiang K, Xu W, Chen Y, Xu Z. Long noncoding nature brain-derived neurotrophic factor antisense is associated with poor prognosis and functional regulation in non-small cell lung caner. Tumour Biol. 2017;39:1010428317695948 pubmed publisher
    ..Overexpressing brain-derived neurotrophic factor antisense may also have a therapeutic potential in inhibiting non-small cell lung cancer tumor growth. ..
  56. Khan A, Katanic D, Thakar J. Meta-analysis of cell- specific transcriptomic data using fuzzy c-means clustering discovers versatile viral responsive genes. BMC Bioinformatics. 2017;18:295 pubmed publisher
    ..com/Thakar-Lab/FIGS ) to facilitate use of of pipeline. Future extension of FIGS across different immune cell-types will improve mechanistic investigation followed by high-throughput omics studies. ..
  57. Yu R, Han L, Ni X, Wang M, Xue P, Zhang L, et al. Kruppel-like factor 4 inhibits non-small cell lung cancer cell growth and aggressiveness by stimulating transforming growth factor-?1-meidated ERK/JNK/NF-?B signaling pathways. Tumour Biol. 2017;39:1010428317705574 pubmed publisher
    ..Findings identify Kruppel-like factor 4 can be regarded as a possible new molecular agent for designing novel therapeutic protein drug for lung cancer treatment to control non-small cell lung cancer growth. ..
  58. Mi Y, He M, Liu B. [MiR-133b Affect the Proliferation and Drug Sensitivity in A549 Lung Cancer Stem Cells by Targeting PKM2]. Zhongguo Fei Ai Za Zhi. 2017;20:376-381 pubmed publisher
    ..Using immune magnetic separation method to select the CD133+/CD34+ lung cancer stem cells from A549 cells, and using flow cytometry to detect the purity...
  59. Shiba I, Kouzaki R, Yamada H, Endo Y, Takino T, Sato H, et al. Design and Synthesis of Novel Anti-metastatic Hypoxic Cytotoxin TX-2137 Targeting AKT Kinase. Anticancer Res. 2017;37:3877-3883 pubmed
    ..In addition, TX-2137 exhibited hypoxia-selective cytotoxicity towards A549 cells and inhibited liver metastasis of B16-F10 cells in a xenograft chick embryo model in the same way as doxorubicin...
  60. Maknitikul S, Luplertlop N, Grau G, Ampawong S. Dysregulation of pulmonary endothelial protein C receptor and thrombomodulin in severe falciparum malaria-associated ARDS relevant to hemozoin. PLoS ONE. 2017;12:e0181674 pubmed publisher
    ..The dysregulation of EPCR and TM in the lung, especially in those with increased levels of hemozoin, may play an important role in the pathogenesis of malaria-associated ARDS through an apoptotic pathway. ..
  61. Yang L, Wen Y, Lv G, Lin Y, Tang J, Lu J, et al. ?-Lipoic acid inhibits human lung cancer cell proliferation through Grb2-mediated EGFR downregulation. Biochem Biophys Res Commun. 2017;494:325-331 pubmed publisher
    ..Recently, ? -LA has been reported to inhibit the growth of various cancer cells, but the precise signaling pathways that mediate the effects of ? -LA on non-small cell lung cancer (NSCLC) development remain unclear...
  62. Nagaraja S, Krishnamoorthy V, Raviraj R, Paramasivam A, Nagarajan D. Effect of Trichostatin A on radiation induced epithelial-mesenchymal transition in A549 cells. Biochem Biophys Res Commun. 2017;493:1534-1541 pubmed publisher
  63. Cai Y, Ruan J, Yao X, Zhao L, Wang B. MicroRNA-187 modulates epithelial-mesenchymal transition by targeting PTRF in non-small cell lung cancer. Oncol Rep. 2017;37:2787-2794 pubmed publisher
    ..Collectively, our data highlight the pivotal role of miR-187 in the progression of NSCLC, indicating this factor as a potential candidate in molecular cancer therapy. ..
  64. Kim J, Jeong H, Jung D, Yoon H, Kim S, Kim H, et al. Synthesis and biological evaluation of fluoro-substituted 3,4-dihydroquinazoline derivatives for cytotoxic and analgesic effects. Bioorg Med Chem. 2017;25:4656-4664 pubmed publisher
    ..In addition, compound 8g (KCP10067F) was found to partially protect from inflammatory pain via a blockade of Cav3.2 channels. ..
  65. Fujiwara K, Kobayashi T, Fujimoto H, Nakahara H, D Alessandro Gabazza C, Hinneh J, et al. Inhibition of Cell Apoptosis and Amelioration of Pulmonary Fibrosis by Thrombomodulin. Am J Pathol. 2017;187:2312-2322 pubmed publisher
  66. Huang C, Kolokoltsova O, Mateer E, Koma T, Paessler S. Highly Pathogenic New World Arenavirus Infection Activates the Pattern Recognition Receptor Protein Kinase R without Attenuating Virus Replication in Human Cells. J Virol. 2017;91: pubmed publisher
  67. Luo H, Li Z, Ge H, Mei D, Zhao L, Jiang L, et al. HMGA2 upregulation mediates Cd-induced migration and invasion in A549 cells and in lung tissues of mice. Chem Biol Interact. 2017;277:1-7 pubmed publisher
    ..In conclusion, upregulation of HMGA2 plays an important role in Cd-enhanced migration and invasion. Suppressing HMGA2 expression might have potential values in prevention of Cd-resulted toxicities. ..
  68. Wang T, Liu Y, Zou J, Cheng Z. Interleukin-17 induces human alveolar epithelial to mesenchymal cell transition via the TGF-?1 mediated Smad2/3 and ERK1/2 activation. PLoS ONE. 2017;12:e0183972 pubmed publisher
    ..The results indicated that IL-17 can induce A549 cells to undergo morphological changes and phenotypic markers changes, such as down-regulated E-cad expression and up-..
  69. Zhang M, Gao C, Yang Y, Li G, Dong J, Ai Y, et al. MiR-424 Promotes Non-Small Cell Lung Cancer Progression and Metastasis through Regulating the Tumor Suppressor Gene TNFAIP1. Cell Physiol Biochem. 2017;42:211-221 pubmed publisher
    ..Moreover, TNFAIP1 silencing and miR-424 modified A549 cells were subcutaneous injected into node BALB/c mice to confirm the regulation of miR-424 on TNFAIP1 in regulating ..
  70. Nguyen H, Ito T, Kurimoto S, Ogawa M, Win N, Hung V, et al. New merosesquiterpenes from a Vietnamese marine sponge of Spongia sp. and their biological activities. Bioorg Med Chem Lett. 2017;27:3043-3047 pubmed publisher
    ..subtilis and anti-S. aureus sesquiterpene phenol 9 lacked cytotoxic activities against three human cancer cell lines (A549, lung cancer; MCF7, breast cancer; HeLa, cervix cancer) and a human normal cell line (WI-38 fibroblast). ..
  71. Gong Y, Lan H, Yu Z, Wang M, Wang S, Chen Y, et al. Blockage of glycolysis by targeting PFKFB3 alleviates sepsis-related acute lung injury via suppressing inflammation and apoptosis of alveolar epithelial cells. Biochem Biophys Res Commun. 2017;491:522-529 pubmed publisher
    ..Moreover, LPS specifically induces apoptotic insults to A549 cell through lactate-mediated enhancement of ROS. ..
  72. Wang R, Chen H, Yang F, Deng Y, Ao H, Xie X, et al. Iridoids from the roots of Valeriana jatamansi Jones. Phytochemistry. 2017;141:156-161 pubmed publisher
    ..Some also showed moderate neuroprotective effects against CoCl2-induced neuronal cell death in PC12 cells. ..
  73. Pancewicz Wojtkiewicz J, Bernatowicz P. The Effect of Afatinib Treatment in Non-small Cell Lung Cancer Cells. Anticancer Res. 2017;37:3543-3546 pubmed
    ..Advanced analysis, might be helpful in understanding the mechanisms of relations between tyrosine kinase inhibition of EGFR and HSPA5 in lung cancer cells. ..
  74. Chen M, Lei X, Shi C, Huang M, Li X, Wu B, et al. Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents. J Clin Invest. 2017;127:3689-3701 pubmed publisher
    ..This study demonstrates that targeting tumor pericytes with an FAP?-activated VDA prodrug represents a potential vascular disruption strategy in overcoming tumor resistance to VDA treatments. ..
  75. Xiao Y, Tian C, Huang T, Han B, Wang M, Ma H, et al. 8-Cetylberberine inhibits growth of lung cancer in vitro and in vivo. Life Sci. 2018;192:259-269 pubmed publisher
    ..In animal studies, BALB/c nude mice were subcutaneously injected with A549 cells in the armpit and administrated with different dose of HBBR and BBR...
  76. He M, Li K, Yu C, Lv B, Zhao N, Deng J, et al. In vitro study of FUZ as a novel potential therapeutic target in non-small-cell lung cancer. Life Sci. 2018;197:91-100 pubmed publisher
    ..Overall, our results in vitro show that FUZ is responsible for NSCLC progression and metastasis, suggesting that FUZ can be a potential therapeutic target for NSCLC. ..
  77. Xu S, Yao H, Pei L, Hu M, Li D, Qiu Y, et al. Design, synthesis, and biological evaluation of NAD(P)H: Quinone oxidoreductase (NQO1)-targeted oridonin prodrugs possessing indolequinone moiety for hypoxia-selective activation. Eur J Med Chem. 2017;132:310-321 pubmed publisher
    ..Thus, this suggests that some of the target compounds activated by NQO1 are novel prodrug candidates potential for selective anticancer therapy. ..
  78. Zhao Z, Cheng S, Zabkiewicz C, Chen J, Zhang L, Ye L, et al. Reduced Expression of RanBPM Is Associated with Poorer Survival from Lung Cancer and Increased Proliferation and Invasion of Lung Cancer Cells In Vitro. Anticancer Res. 2017;37:4389-4397 pubmed
    ..Increased expression of RanBPM associates with postponed disease progression and better prognosis. RanBPM plays an inhibitory role in regulating proliferation and invasion of lung cancer cells. ..
  79. Shankaraiah N, Nekkanti S, Brahma U, Praveen Kumar N, Deshpande N, Prasanna D, et al. Synthesis of different heterocycles-linked chalcone conjugates as cytotoxic agents and tubulin polymerization inhibitors. Bioorg Med Chem. 2017;25:4805-4816 pubmed publisher
    ..In addition, molecular docking studies of the most active compounds 4a and 4b into the colchicine site of the tubulin, revealed the possible mode of interaction by these new conjugates. ..
  80. Wei Y, Kim T, Peng D, Duan D, Gibbons D, Yamauchi M, et al. Fibroblast-specific inhibition of TGF-?1 signaling attenuates lung and tumor fibrosis. J Clin Invest. 2017;127:3675-3688 pubmed publisher
    ..These findings elucidate a therapeutic approach to attenuate fibrosis and the disease-promoting effects of tissue stiffness by specifically targeting T?RI kinase in LOXL2-expressing cells. ..
  81. Liao H, Pan C, Chou P, Chen Y, Wu T, Sheu M, et al. Toxicological effects of NCKU-21, a phenanthrene derivative, on cell growth and migration of A549 and CL1-5 human lung adenocarcinoma cells. PLoS ONE. 2017;12:e0185021 pubmed publisher
    ..However, repression of PI3K-AKT activation by NCKU-21 was found in CL1-5 cells but not in A549 cells. In addition, increases in phosphatidylserine externalization and caspase-3 activity also confirmed the ..
  82. Azad T, Janse van Rensburg H, Lightbody E, Neveu B, Champagne A, Ghaffari A, et al. A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis. Nat Commun. 2018;9:1061 pubmed publisher
    ..Thus, our work offers a biosensor tool for the study of the Hippo pathway and suggests a role for Hippo signaling in regulating blood vessel formation in physiological and pathological settings. ..
  83. Hiraku Y, Nishikawa Y, Ma N, Afroz T, Mizobuchi K, Ishiyama R, et al. Nitrative DNA damage induced by carbon-black nanoparticles in macrophages and lung epithelial cells. Mutat Res. 2017;818:7-16 pubmed publisher
    ..Both types of CB induced 8-nitroG formation, mainly in the nucleus of RAW 264.7 and A549 cells, and CB95 tended to induce more 8-nitroG formation than did CB56...
  84. Che B, Luo Q, Zhai B, Fan G, Liu Z, Cheng K, et al. Cytotoxicity and genotoxicity of nanosilver in stable GADD45? promoter-driven luciferase reporter HepG2 and A549 cells. Environ Toxicol. 2017;32:2203-2211 pubmed publisher
    ..And furthermore, the GADD45? promoter-driven luciferase reporter cells, especially the HepG2-luciferase cells, could provide a new and valuable tool for predicting nanomaterials genotoxicity in humans. ..
  85. Pu M, Li C, Qi X, Chen J, Wang Y, Gao L, et al. MiR-1254 suppresses HO-1 expression through seed region-dependent silencing and non-seed interaction with TFAP2A transcript to attenuate NSCLC growth. PLoS Genet. 2017;13:e1006896 pubmed publisher
    ..Overall, these findings identify the dual inhibition of HO-1 by miR-1254 as a novel functional mechanism of miRNA, which results in a more effective inhibition of oncogenic mRNA, and leads to a tumor suppressive effect. ..
  86. Reddy V, Lerner E. Activation of mas-related G-protein-coupled receptors by the house dust mite cysteine protease Der p1 provides a new mechanism linking allergy and inflammation. J Biol Chem. 2017;292:17399-17406 pubmed publisher
    ..Der p1 also induced the release of IL-6 from heterologous cells expressing MRGPRX1. In summary, activation of Mrgprs by the allergen Der p1 may contribute to inflammation. ..
  87. Yoo H, Kim J, Jo E, Cho C, Lee S, Kang H, et al. Modified Panax ginseng extract regulates autophagy by AMPK signaling in A549 human lung cancer cells. Oncol Rep. 2017;37:3287-3296 pubmed publisher
    ..the mechanisms underlying the effects of MRGX, we performed a microarray analysis of gene expression in the A549 cells. Molecular mechanisms that were associated with the anticancer activity of MRGX were studied, with a special ..
  88. Zhang R, Song L, Jiang B, Wang L, Wu N, Guo S, et al. Design of antitumor agents containing carbohydrate based on GLUT1, and evaluation of antiproliferative activity. Bioorg Med Chem Lett. 2017;27:2488-2492 pubmed publisher
    ..Moreover, compound 9 blocked A549 cells at the G0/G1 phase...
  89. Marostica L, de Barros A, Oliveira J, Salgado B, Cassali G, Leite E, et al. Antitumor effectiveness of a combined therapy with a new cucurbitacin B derivative and paclitaxel on a human lung cancer xenograft model. Toxicol Appl Pharmacol. 2017;329:272-281 pubmed publisher
    ..B, showed potential in vitro synergistic antiproliferative effects combined with paclitaxel (PTX) in A549 cells. In sequence, the purpose of this study was to evaluate the in vivo antitumor efficacy of this combined therapy ..
  90. Li H, Wu H, Zhang H, Li Y, Li S, Hou Q, et al. Identification of curcumin-inhibited extracellular matrix receptors in non-small cell lung cancer A549 cells by RNA sequencing. Tumour Biol. 2017;39:1010428317705334 pubmed publisher
    ..We found that lots of genes and signaling pathways were significantly altered after curcumin treatment in A549 cells. With bioinformatics approaches (gene ontology, Kyoto Encyclopedia of Genes and Genomes, and STRING), we found ..
  91. Shen F, Wang Z, Wu S, Ren S, Man R, Wang B, et al. Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX. Bioorg Med Chem Lett. 2017;27:3653-3660 pubmed publisher
    ..35±0.24?M for 5-LOX). Further investigation confirmed that 11g could induce human non-small cell lung cancer A549 cells apoptosis and arrest the cell cycle at G2 phase in a dose-dependent manner...
  92. Lin P, Wu T, Wu D, Wang L, Chen C, Lee H. An increase in BAG-1 by PD-L1 confers resistance to tyrosine kinase inhibitor in non-small cell lung cancer via persistent activation of ERK signalling. Eur J Cancer. 2017;85:95-105 pubmed publisher
    ..We therefore suggest a combination of an ERK inhibitor with a TKI as a potential strategy for conquering PD-L1-mediated tumour invasion and TKI resistance in NSCLC patients whose tumours harbour high PD-L1/high BAG-1 expression. ..