neuroendocrine cells


Summary: Specialized NEURONS that produce hormones, such as NEUROPEPTIDES or BIOGENIC AMINES. They generally are in the NERVOUS SYSTEM, such as HYPOTHALAMUS, but can be found in other organs or systems. These neurons contain dense neurosecretory granules and PROPROTEIN CONVERTASES allowing the rapidly release of NEUROHORMONES into the blood circulation upon stimulation.

Top Publications

  1. Mucio Ramírez S, Sánchez Islas E, Sánchez Jaramillo E, Currás Collazo M, Juárez González V, Álvarez González M, et al. Perinatal exposure to organohalogen pollutants decreases vasopressin content and its mRNA expression in magnocellular neuroendocrine cells activated by osmotic stress in adult rats. Toxicol Appl Pharmacol. 2017;329:173-189 pubmed publisher
    ..cFOS mRNA expression was evaluated in order to determine neuroendocrine cells activation due to osmotic stimulation...
  2. Minnerly J, Zhang J, Parker T, Kaul T, Jia K. The cell non-autonomous function of ATG-18 is essential for neuroendocrine regulation of Caenorhabditis elegans lifespan. PLoS Genet. 2017;13:e1006764 pubmed publisher
    ..elegans lifespan through the transcription factor DAF-16/FOXO in response to reduced IGF signaling. ..
  3. Emery A, Xu W, Eiden M, Eiden L. Guanine nucleotide exchange factor Epac2-dependent activation of the GTP-binding protein Rap2A mediates cAMP-dependent growth arrest in neuroendocrine cells. J Biol Chem. 2017;292:12220-12231 pubmed publisher
  4. Aristizabal Prada E, Orth M, Nölting S, Spöttl G, Maurer J, Auernhammer C. The MTH1 inhibitor TH588 demonstrates anti-tumoral effects alone and in combination with everolimus, 5-FU and gamma-irradiation in neuroendocrine tumor cells. PLoS ONE. 2017;12:e0178375 pubmed publisher
    ..Collectively our data not only provide insights into how TH588 exactly kills cancer cells but also depict novel perspectives for combinatorial treatment approaches encompassing TH588. ..
  5. Shi G, Somlo D, Kim G, Prescianotto Baschong C, Sun S, Beuret N, et al. ER-associated degradation is required for vasopressin prohormone processing and systemic water homeostasis. J Clin Invest. 2017;127:3897-3912 pubmed publisher
    ..This study highlights a pathway linking ERAD to prohormone conformational maturation in neuroendocrine cells, expanding the role of ERAD in providing a conducive ER environment for nascent proteins to reach proper ..
  6. Travis W. Lung tumours with neuroendocrine differentiation. Eur J Cancer. 2009;45 Suppl 1:251-66 pubmed publisher
  7. Maina P, Shao P, Jia X, Liu Q, Umesalma S, Marin M, et al. Histone demethylase PHF8 regulates hypoxia signaling through HIF1? and H3K4me3. Biochim Biophys Acta Gene Regul Mech. 2017;1860:1002-1012 pubmed publisher
    ..Therefore, targeting PHF8 can potentially be a novel therapeutic strategy in cancer therapy. ..
  8. Zhang X, Jiang S, Mitok K, Li L, Attie A, Martin T. BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells. J Cell Biol. 2017;216:2151-2166 pubmed publisher
    ..Several C2 domain-containing proteins are known to regulate Ca2+-dependent DCV exocytosis in neuroendocrine cells. In this study, we identified others by screening all (∼139) human C2 domain-containing proteins by ..
  9. Sauer R, Griff S, Blau A, Franke A, Mairinger T, Grah C. Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia diagnosed by transbronchial lung cryobiopsy: a case report. J Med Case Rep. 2017;11:95 pubmed publisher
    ..This report and current literature indicate that transbronchial lung cryobiopsy can be used as a safe and practicable tool to obtain high quality biopsies of lung parenchyma in order to diagnose micronodular lesions of the lung. ..

More Information


  1. Fukami K, Sekiguchi F, Kawabata A. Hydrogen Sulfide and T-Type Ca2+ Channels in Pain Processing, Neuronal Differentiation and Neuroendocrine Secretion. Pharmacology. 2017;99:196-203 pubmed publisher
    ..Key Messages: The H2S/Cav3.2 pathway may serve as therapeutic targets for treatment of intractable pain, neuronal injury, androgen-independent prostate cancer, cardiovascular diseases, etc. ..
  2. Li Z, Chen C, Wang J, Hsia E, Li W, Squires J, et al. Neuroendocrine differentiation of prostate cancer. Asian J Androl. 2013;15:328-32 pubmed publisher
  3. Sinha S, Fu Y, Grimont A, Ketcham M, Lafaro K, Saglimbeni J, et al. PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk. Cancer Res. 2017;77:1868-1879 pubmed publisher
    ..Nerve-responsive neuroendocrine cells exerted trophic influences and potentiated global PanIN organoid growth...
  4. Megha -, Hasan G. IP3R-mediated Ca2+ release regulates protein metabolism in Drosophila neuroendocrine cells: implications for development under nutrient stress. Development. 2017;144:1484-1489 pubmed publisher
    ..Thus cell-specific regulation of protein synthesis by IP3R in NE cells influences protein metabolism. We propose that this regulation helps developing animals survive in poor nutritional conditions. ..
  5. Barrios J, Patel K, Aven L, Achey R, Minns M, Lee Y, et al. Early life allergen-induced mucus overproduction requires augmented neural stimulation of pulmonary neuroendocrine cell secretion. FASEB J. 2017;31:4117-4128 pubmed publisher
    Pulmonary neuroendocrine cells (PNECs) are the only innervated airway epithelial cells. To what extent neural innervation regulates PNEC secretion and function is unknown...
  6. Friedman J, Mantzoros C. 20 years of leptin: from the discovery of the leptin gene to leptin in our therapeutic armamentarium. Metabolism. 2015;64:1-4 pubmed publisher
  7. Rohde K, Bering T, Furukawa T, Rath M. A modulatory role of the Rax homeobox gene in mature pineal gland function: Investigating the photoneuroendocrine circadian system of a Rax conditional knockout mouse. J Neurochem. 2017;143:100-111 pubmed publisher
    ..Our data suggest that Rax controls pineal gene expression and via Aanat may modulate melatonin synthesis. ..
  8. Fruh M, De Ruysscher D, Popat S, Crino L, Peters S, Felip E. Small-cell lung cancer (SCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2013;24 Suppl 6:vi99-105 pubmed publisher