ht29 cells


Summary: Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells such as the GOBLET CELLS.

Top Publications

  1. Samant R, Clarke P, Workman P. E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cells. Proc Natl Acad Sci U S A. 2014;111:6834-9 pubmed publisher
    ..Our results reveal the importance of CUL5 in multiple aspects of the cellular response to HSP90 inhibition. ..
  2. Lopez P, Gonzalez Rodriguez I, Sanchez B, Ruas Madiedo P, Suarez A, Margolles A, et al. Interaction of Bifidobacterium bifidum LMG13195 with HT29 cells influences regulatory-T-cell-associated chemokine receptor expression. Appl Environ Microbiol. 2012;78:2850-7 pubmed publisher
    ..The transcriptome profile of HT29 cells cultured in the presence of B...
  3. Tsukahara T, Haniu H. Peroxisome proliferator-activated receptor gamma overexpression suppresses proliferation of human colon cancer cells. Biochem Biophys Res Commun. 2012;424:524-9 pubmed publisher
    ..We observed a correlation between the level of PPAR? expression and the cells' sensitivity for proliferation...
  4. Jouan Lanhouet S, Arshad M, Piquet Pellorce C, Martin Chouly C, Le Moigne Müller G, Van Herreweghe F, et al. TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation. Cell Death Differ. 2012;19:2003-14 pubmed publisher
  5. Yeh T, Wang S, Dai C, Duh C. Briacavatolides A-C, new briaranes from the Taiwanese octocoral Briareum excavatum. Mar Drugs. 2012;10:1019-26 pubmed publisher
    ..The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 1-5 and their cytotoxicity against selected cancer cell lines were evaluated...
  6. Park H, Kim I, Kim J, Nam T. Induction of apoptosis by laminarin, regulating the insulin-like growth factor-IR signaling pathways in HT-29 human colon cells. Int J Mol Med. 2012;30:734-8 pubmed publisher
    ..These results are important for understanding the roles of IGF-IR in colon cancer cell tumorigenesis, and suggest that laminarin shows activity against human colon cancer...
  7. Pitino I, Randazzo C, Cross K, Parker M, Bisignano C, Wickham M, et al. Survival of Lactobacillus rhamnosus strains inoculated in cheese matrix during simulated human digestion. Food Microbiol. 2012;31:57-63 pubmed publisher
    ..The ability to attach to the cheese matrix during digestion was confirmed by scanning electron microscopy, also indicating production of extracellular polysaccharides as a response to acid stress...
  8. Esposito D, Aru F, Lattanzio R, Morgano A, Abbondanza M, Malekzadeh R, et al. The insulin receptor substrate 1 (IRS1) in intestinal epithelial differentiation and in colorectal cancer. PLoS ONE. 2012;7:e36190 pubmed publisher
    ..colonic epithelium, primary CRCs with paired liver metastases and in vitro polarizing Caco2 and HT29 cells. IRS1 mRNA and protein resulted higher, relative to paired mucosa, in adenomas of familial adenomatous polyposis ..
  9. Christensen J, El Gebali S, Natoli M, Sengstag T, Delorenzi M, Bentz S, et al. Defining new criteria for selection of cell-based intestinal models using publicly available databases. BMC Genomics. 2012;13:274 pubmed publisher
    ..The objective of this study was, therefore, to establish objective criteria for choosing relevant cell lines to assess their appropriateness as tumor models as well as for drug absorption studies...

More Information

Publications101 found, 100 shown here

  1. Hu X, Song L, Huang L, Zheng Q, Yu R. Antitumor effect of a polypeptide fraction from Arca subcrenata in vitro and in vivo. Mar Drugs. 2012;10:2782-94 pubmed
    ..4% and 46.4% for H-22, and 34.0%, 45.8% and 60.1% for S-180 tumor-bearing mice. The results demonstrated that P2 might be a potential antitumor agent with high efficiency in dose-dependent and time-dependent manners and low toxicity...
  2. Aso K, Goi T, Nakazawa T, Kimura Y, Hirono Y, Katayama K, et al. The expression of integrins is decreased in colon cancer cells treated with polysaccharide K. Int J Oncol. 2013;42:1175-80 pubmed publisher
    ..Suppression of integrin expression on the cell surface and reduced adhesion to vascular endothelial cells were observed as a novel mechanism of action of PSK on colon cancer cells...
  3. Park J, Yi J, Jin Y, Lee Y, Lee J, Lee Y, et al. Sialylation of epidermal growth factor receptor regulates receptor activity and chemosensitivity to gefitinib in colon cancer cells. Biochem Pharmacol. 2012;83:849-57 pubmed publisher
    ..In contrast, overexpression of ST6Gal I decreased the cytotoxic effect of gefitinib. These results suggest that sialylation of the EGFR affects EGF-mediated cell growth and induces chemoresistance to gefitinib in colon cancer cells...
  4. Wei B, Han X, Qi C, Zhang S, Zheng Z, Huang Y, et al. Coaction of spheroid-derived stem-like cells and endothelial progenitor cells promotes development of colon cancer. PLoS ONE. 2012;7:e39069 pubmed publisher
    ..Our findings indicate that spheroid cells possess the characteristics of cancer stem cells, and the coaction of CSCs and EPCs may play an important role in the development of colon cancer...
  5. Pu J, Bai D, Yang X, Lu X, Xu L, Lu J. Adrenaline promotes cell proliferation and increases chemoresistance in colon cancer HT29 cells through induction of miR-155. Biochem Biophys Res Commun. 2012;428:210-5 pubmed publisher
    ..we reported that adrenaline increased the cell proliferation and decreased the cisplatin induced apoptosis in HT29 cells. Further study found that adrenaline increased miR-155 expression in an NF?B dependent manner...
  6. Riganti C, Rolando B, Kopecka J, Campia I, Chegaev K, Lazzarato L, et al. Mitochondrial-targeting nitrooxy-doxorubicin: a new approach to overcome drug resistance. Mol Pharm. 2013;10:161-74 pubmed publisher
    ..We suggest that NitDOX may represent the prototype of a new class of multifunctional anthracyclines, which have cellular targets different from conventional anthracyclines and greater efficacy against drug-resistant tumors...
  7. Chen L, Song L, Li T, Zhu J, Xu J, Zheng Q, et al. A new antiproliferative and antioxidant peptide isolated from Arca subcrenata. Mar Drugs. 2013;11:1800-14 pubmed publisher
    ..8, 10.1 and 10.5 ?g/mL. The scavenging percentage of H3 at 8 mg/mL to 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radicals were 56.8% and 47.5%, respectively...
  8. Rosenthal R, Gunzel D, Finger C, Krug S, Richter J, Schulzke J, et al. The effect of chitosan on transcellular and paracellular mechanisms in the intestinal epithelial barrier. Biomaterials. 2012;33:2791-800 pubmed publisher
    ..These results suggest that the rapid and reversible absorption-enhancing chitosan effect is due to changes in intracellular pH caused by the activation of a chloride-bicarbonate exchanger resulting in the opening of the TJ...
  9. Calon A, Espinet E, Palomo Ponce S, Tauriello D, Iglesias M, Céspedes M, et al. Dependency of colorectal cancer on a TGF-?-driven program in stromal cells for metastasis initiation. Cancer Cell. 2012;22:571-84 pubmed publisher
    ..This crosstalk confers a survival advantage to metastatic cells. The dependency on the TGF-? stromal program for metastasis initiation could be exploited to improve the diagnosis and treatment of CRC...
  10. Pokrovsky V, Treshalina H, Lukasheva E, Sedakova L, Medentzev A, Arinbasarova A, et al. Enzymatic properties and anticancer activity of L-lysine ?-oxidase from Trichoderma cf. aureoviride Rifai BKMF-4268D. Anticancer Drugs. 2013;24:846-51 pubmed publisher
    ..This study presents promising data on the possible application of LO in clinical oncology for patients with colorectal cancer. ..
  11. Aldhous M, Soo K, Stark L, Ulanicka A, Easterbrook J, Dunlop M, et al. Cigarette smoke extract (CSE) delays NOD2 expression and affects NOD2/RIPK2 interactions in intestinal epithelial cells. PLoS ONE. 2011;6:e24715 pubmed publisher
    ..In SW480 and HT29 cells the TNFα-induced NOD2 expression at 4 hours was reduced by CSE (p = 0...
  12. Boal F, Puhar A, Xuereb J, Kunduzova O, Sansonetti P, Payrastre B, et al. PI5P Triggers ICAM-1 Degradation in Shigella Infected Cells, Thus Dampening Immune Cell Recruitment. Cell Rep. 2016;14:750-759 pubmed publisher
    ..In conclusion, we describe here an immune evasion mechanism used by the pathogen Shigella to divert the host cell trafficking machinery in order to reduce immune cell recruitment. ..
  13. Pitek A, Wen A, Shukla S, Steinmetz N. The Protein Corona of Plant Virus Nanoparticles Influences their Dispersion Properties, Cellular Interactions, and In Vivo Fates. Small. 2016;12:1758-69 pubmed publisher
    ..Our results provide insight into the in vivo properties of VNPs and suggest that the protein corona effect should be considered during the development of efficacious, targeted VNP formulations. ..
  14. Liao C, Song E, Chang T, Lin W, Liu H, Chen L, et al. Evaluation of cellular retinoic acid binding protein 2 gene expression through the retinoic acid pathway by co-incubation of Blastocystis ST-1 with HT29 cells in vitro. Parasitol Res. 2016;115:1965-75 pubmed publisher
    ..Together, our data indicate that CRABP2, RARα, and PCNA expressions are involved in RA signaling regulatory networks that affect the growth, proliferation, and inflammation of HT-29 cells. ..
  15. DeBerardinis A, Lemieux S, Hadden M. Analogues of the Inhoffen-Lythgoe diol with anti-proliferative activity. Bioorg Med Chem Lett. 2013;23:5367-70 pubmed publisher
    ..Thus, the cellular mechanism(s) that govern the anti-proliferative activity for this class of truncated vitamin D-based structures appears to be different from classical mechanisms previously identified for these scaffolds. ..
  16. Li P, Wang G, Yang Z, Duan W, Peng Z, Kong L, et al. Development of drug-loaded chitosan-vanillin nanoparticles and its cytotoxicity against HT-29 cells. Drug Deliv. 2016;23:30-5 pubmed publisher
    ..The results indicate that the chitosan nanoparticles crosslinked with vanillin are a promising vehicle for the delivery of anticancer drugs. ..
  17. Smn Mydin R, Sreekantan S, Hazan R, Farid Wajidi M, Mat I. Cellular Homeostasis and Antioxidant Response in Epithelial HT29 Cells on Titania Nanotube Arrays Surface. Oxid Med Cell Longev. 2017;2017:3708048 pubmed publisher
    ..Present toxicogenomic approach focused on epithelial HT29 cells with TNA surface...
  18. Li Y, Xu J, Ju H, Xiao Y, Chen H, Lv J, et al. A network-based, integrative approach to identify genes with aberrant co-methylation in colorectal cancer. Mol Biosyst. 2014;10:180-90 pubmed publisher
    ..These results show that the network-centric method could identify novel disease biomarkers and model how oncogenic lesions mediate epigenetic changes, providing important insights into tumorigenesis. ..
  19. Radhakrishnan V, Kojs P, Young G, Ramalingam R, Jagadish B, Mash E, et al. pTyr421 cortactin is overexpressed in colon cancer and is dephosphorylated by curcumin: involvement of non-receptor type 1 protein tyrosine phosphatase (PTPN1). PLoS ONE. 2014;9:e85796 pubmed publisher
  20. Holscher H, Davis S, Tappenden K. Human milk oligosaccharides influence maturation of human intestinal Caco-2Bbe and HT-29 cell lines. J Nutr. 2014;144:586-91 pubmed publisher
    ..However, effects on differentiation, digestive function, and epithelial barrier function differed between the HMOs tested. These results suggest differential roles for specific HMOs in maturation of the gastrointestinal tract. ..
  21. Lee K, Zhong X, Gu S, Kruel A, Dorner M, Perry K, et al. Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex. Science. 2014;344:1405-10 pubmed publisher
    ..Together, these studies establish the molecular mechanism of how HAs contribute to the oral toxicity of BoNT/A...
  22. Cheraghi O, Dehghan G, Mahdavi M, Rahbarghazi R, Rezabakhsh A, Charoudeh H, et al. Potent anti-angiogenic and cytotoxic effect of conferone on human colorectal adenocarcinoma HT-29 cells. Phytomedicine. 2016;23:398-405 pubmed publisher
    ..In addition to anti-angiogenic properties of conferone, a profound decrease in migration capability of HT-29 cells was also evident. ..
  23. Krug S. Contribution of the tricellular tight junction to paracellular permeability in leaky and tight epithelia. Ann N Y Acad Sci. 2017;1397:219-230 pubmed publisher
    ..In conclusion, in leaky epithelia the bicellular TJ accounts for nearly the entire paracellular ion conductance, whereas in tight epithelia the low bicellular TJ conductance has large impact on the tTJ. ..
  24. Maya S, Sarmento B, Lakshmanan V, Menon D, Jayakumar R. Actively targeted cetuximab conjugated gamma-poly(glutamic acid)-docetaxel nanomedicines for epidermal growth factor receptor over expressing colon cancer cells. J Biomed Nanotechnol. 2014;10:1416-28 pubmed
    ..In short, CET-DTXL-gamma-PGA nanoparticles enhance the tumor selective therapeutic efficacy for colon cancer. ..
  25. Dai S, Xiao K, Zhang L, Han Q. New neo-clerodane diterpenoids from Scutellaria strigillosa with cytotoxic activities. J Asian Nat Prod Res. 2016;18:456-61 pubmed publisher
    ..In vitro, two new compounds exhibited cytotoxic activities against four tumor cell lines (HONE-1, P-388, MCF7, and HT29), and gave IC50 values in the range of 3.4-8.9???. ..
  26. Kadayat T, Banskota S, Gurung P, Bist G, Thapa Magar T, Shrestha A, et al. Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. Eur J Med Chem. 2017;137:575-597 pubmed publisher
  27. Xiao Y, Ramiscal J, Kowanetz K, Del Nagro C, Malek S, Evangelista M, et al. Identification of preferred chemotherapeutics for combining with a CHK1 inhibitor. Mol Cancer Ther. 2013;12:2285-95 pubmed publisher
    ..In conclusion, our results show that selection of an appropriate agent to combine with a CHK1 inhibitor needs to be carefully evaluated in the context of the genetic background and tumor type in which it will be used. ..
  28. Oda S, Fukami T, Yokoi T, Nakajima M. Epigenetic regulation of the tissue-specific expression of human UDP-glucuronosyltransferase (UGT) 1A10. Biochem Pharmacol. 2014;87:660-7 pubmed publisher
    ..Thus, epigenetic regulation is one of the mechanisms that determine the tissue-specific expression of UGT1A10. ..
  29. Akram I, Georges R, Hielscher T, Adwan H, Berger M. The chemokines CCR1 and CCRL2 have a role in colorectal cancer liver metastasis. Tumour Biol. 2016;37:2461-71 pubmed publisher
    ..In summary, the data point to an important role of CCR1 and CCRL2 under conditions of organ colonization and both chemokine receptors qualify as targets of treatment during early colorectal cancer liver metastasis. ..
  30. Patten D, Hussein E, Davies S, Humphreys P, Collett A. Commensal-derived OMVs elicit a mild proinflammatory response in intestinal epithelial cells. Microbiology. 2017;163:702-711 pubmed publisher
    ..We also demonstrate a unique interaction between commensal-derived OMVs and host cells. ..
  31. Sui H, Zhao J, Zhou L, Wen H, Deng W, Li C, et al. Tanshinone IIA inhibits β-catenin/VEGF-mediated angiogenesis by targeting TGF-β1 in normoxic and HIF-1α in hypoxic microenvironments in human colorectal cancer. Cancer Lett. 2017;403:86-97 pubmed publisher
    ..Our research provides a new anti-angiogenesis strategy and strengthens support for the use of Tan IIA as an angiogenesis inhibitor. ..
  32. Do Y, Sul J, Jang K, Kang N, Kim Y, Kim Y, et al. A novel RIPK1 inhibitor that prevents retinal degeneration in a rat glaucoma model. Exp Cell Res. 2017;359:30-38 pubmed publisher
    ..Conversely, Nec-1 and Cpd27 protected RGCs from TNF-stimulated death, while RIC failed to inhibit the death of RGCs. This implies that RIPK1 activates alternative pathways depending on the context of the ischemic insults. ..
  33. Sun L, Zhi Z, Chen L, Zhou Q, Li X, Gan W, et al. SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p. Cancer Lett. 2017;409:104-115 pubmed publisher
    ..In conclusion, our study demonstrated a functional role of the SIRT1/miR-15b-5p/ACOX1 axis in CRC metastasis and suggested a potential target for metastatic CRC therapy. ..
  34. Li H, Dai S, Zhen T, Shi H, Zhang F, Yang Y, et al. Clinical and biological significance of miR-378a-3p and miR-378a-5p in colorectal cancer. Eur J Cancer. 2014;50:1207-21 pubmed publisher
    ..In conclusion, miR-378a-3p and miR-378a-5p expression might play an important role as tumour suppressor gene in the initial stage of carcinogenesis of CRC. ..
  35. He X, Kong X, Yan J, Yan J, Zhang Y, Wu Q, et al. CP-31398 prevents the growth of p53-mutated colorectal cancer cells in vitro and in vivo. Tumour Biol. 2015;36:1437-44 pubmed publisher
    ..CP-31398 would be developed as a therapeutic candidate for p53-mutated CRC due to the restoration of mutant p53 tumor suppressor functions. ..
  36. Cherkezyan L, Zhang D, Subramanian H, Taflove A, Backman V. Reconstruction of explicit structural properties at the nanoscale via spectroscopic microscopy. J Biomed Opt. 2016;21:25007 pubmed publisher
  37. Lambert G, Baldwin M. Evidence for dual receptor-binding sites in Clostridium difficile toxin A. FEBS Lett. 2016;590:4550-4563 pubmed publisher
    ..An internal deletion of RBD2 from TcdA holotoxin ablated toxicity in HT29 cells. These data are consistent with the recently proposed dual receptor model of cellular entry.
  38. Terzuoli E, Giachetti A, Ziche M, Donnini S. Hydroxytyrosol, a product from olive oil, reduces colon cancer growth by enhancing epidermal growth factor receptor degradation. Mol Nutr Food Res. 2016;60:519-29 pubmed publisher
    ..Cbl activation induces, in turn, EGFR ubiquitination. Our results reveal a new mechanism for HT's antitumour effects that may be important for colon tumour prevention and treatment. ..
  39. Beale G, Haagensen E, Thomas H, Wang L, Revill C, Payne S, et al. Combined PI3K and CDK2 inhibition induces cell death and enhances in vivo antitumour activity in colorectal cancer. Br J Cancer. 2016;115:682-90 pubmed publisher
    ..GDC-0941; pan-PI3K inhibitor) resulted in synergistic growth inhibition, and enhanced cytotoxicity in HT29 cells in vitro and HT29 tumour growth inhibition in vivo...
  40. Oh B, Lee S, Cho H, Park Y, Kim J, Yoon S, et al. Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutathione reductase activity in colorectal cancer. Cell Death Dis. 2017;8:e2682 pubmed publisher
    ..These results suggest that high CST1 expression may be involved in autophagic induction and protects from AF-induced cell death by inhibition of ROS generation through the regulation of GR activity. ..
  41. Czerwonka A, Kawka K, Cykier K, Lemieszek M, Rzeski W. Evaluation of anticancer activity of water and juice extracts of young Hordeum vulgare in human cancer cell lines HT-29 and A549. Ann Agric Environ Med. 2017;24:345-349 pubmed publisher;b>Conclusions.</b> The obtained results indicate a cancer chemopreventive potential of young barley as a safe dietary agent in colon carcinoma. ..
  42. Monjaret F, Fernandes M, Duchemin Pelletier E, Argento A, Degot S, Young J. Fully Automated One-Step Production of Functional 3D Tumor Spheroids for High-Content Screening. J Lab Autom. 2016;21:268-80 pubmed publisher
    ..Higher quality data and a more efficient HCS work chain should encourage integration of micropatterned spheroid models within fundamental research and drug discovery applications. ..
  43. Mandal H, Jariwala R, Bagchi T. Isolation and characterization of lactobacilli from human faeces and indigenous fermented foods for their potential application as probiotics. Can J Microbiol. 2016;62:349-59 pubmed publisher
    ..5) and to different bile salt concentrations in comparison with LGG, and hence, they could be considered as potential probiotic candidates. ..
  44. Wieczorek K, Wiktorska M, Sacewicz Hofman I, Boncela J, Lewinski A, Kowalska M, et al. Filamin A upregulation correlates with Snail-induced epithelial to mesenchymal transition (EMT) and cell adhesion but its inhibition increases the migration of colon adenocarcinoma HT29 cells. Exp Cell Res. 2017;359:163-170 pubmed publisher
    ..FLNA upregulation, which correlates with cell metastatic properties, maybe an additional target for combination therapy in colorectal carcinoma tumor progression. ..
  45. Bozhenko V, Shramova E, Shishkin A, Ivanov A, Khokhlova E, Lebedin Y, et al. Characteristics of new monomolecular chimeric T-cell receptors to carcinoembryonic antigen. Bull Exp Biol Med. 2013;156:165-71 pubmed
    ..Human peripheral blood lymphocytes transfected with the above constructs demonstrated high cytotoxic activity against HCT116 cells expressing carcinoembryonic antigen. ..
  46. Wang H, Nie L, Wu L, Liu Q, Guo X. NR2F2 inhibits Smad7 expression and promotes TGF-?-dependent epithelial-mesenchymal transition of CRC via transactivation of miR-21. Biochem Biophys Res Commun. 2017;485:181-188 pubmed publisher
    ..Thus, NR2F2 could promote TGF-?-induced EMT and inhibit Smad7 expression via transactivation of miR-21, and NR2F2 may be a new common therapeutic target for CRC. ..
  47. Wang Z, Guo L, Wang Y, Zhou H, Wang S, Chen D, et al. Inhibition of HSP90α protects cultured neurons from oxygen-glucose deprivation induced necroptosis by decreasing RIP3 expression. J Cell Physiol. 2018;233:4864-4884 pubmed publisher
    ..studies have shown that HSP90α is involved in receptor interacting protein 3 (RIP3)-mediated necroptosis in HT29 cells. It is known that oxygen and glucose deprivation (OGD) can induce necroptosis, which is regulated by RIP3 in ..
  48. Przybyła T, Sakowicz Burkiewicz M, Maciejewska I, Bielarczyk H, Pawełczyk T. Suppression of ID1 expression in colon cancer cells increases sensitivity to 5-fluorouracil. Acta Biochim Pol. 2017;64:315-322 pubmed publisher
    ..In conclusion, ID1 expression impacts the sensitivity of colon cancer cells to 5-FU and may be considered as a potential predictive marker in CRC treatment. ..
  49. Zhang P, Lai Z, Chen H, Zhang M, Wang A, Jia T, et al. Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice. J Exp Clin Cancer Res. 2017;36:190 pubmed publisher
    ..observation were used to identify the cytotoxicity of different combinations of curcumin and 5-Fu in HCT116 and HT29 cells. Cell immunofluorescence assay, Flow cytometry and Western blot were employed to detect changes of autophagy and ..
  50. Béres N, Szabó D, Kocsis D, Szucs D, Kiss Z, Müller K, et al. Role of Altered Expression of miR-146a, miR-155, and miR-122 in Pediatric Patients with Inflammatory Bowel Disease. Inflamm Bowel Dis. 2016;22:327-35 pubmed publisher
    ..Our data suggest the TNF-?-related involvement of these miRs in the pathogenesis of IBD. ..
  51. Zhong S, Ji D, Li Y, Lin T, Lv Z, Chen H. Activation of P27kip1-cyclin D1/E-CDK2 pathway by polysaccharide from Phellinus linteus leads to S-phase arrest in HT-29 cells. Chem Biol Interact. 2013;206:222-9 pubmed publisher
    ..These results suggested that the activation of P27kip1-cyclin D1/E-CDK2 pathway is involved in P1-induced S-phase cell cycle arrest in HT-29 cells...
  52. Ding B, Frisina R, Zhu X, Sakai Y, Sokolowski B, Walton J. Direct control of Na(+)-K(+)-2Cl(-)-cotransport protein (NKCC1) expression with aldosterone. Am J Physiol Cell Physiol. 2014;306:C66-75 pubmed publisher
    ..Having a procedure for controlling NKCC1 protein expression opens the doors for therapeutic interventions for diseases involving the mis-regulation or depletion of NKCC1 proteins, for example during aging. ..
  53. Chopra A, Anderson A, Giardina C. Novel piperazine-based compounds inhibit microtubule dynamics and sensitize colon cancer cells to tumor necrosis factor-induced apoptosis. J Biol Chem. 2014;289:2978-91 pubmed publisher
    ..These compounds should help illuminate the role of microtubules in regulating apoptotic ligand sensitivity and may ultimately be useful for developing agents that augment the anti-cancer activities of the immune response. ..
  54. Xue Y, Zhang H, Wang H, Hu J, Du M, Zhu M. Host inflammatory response inhibits Escherichia coli O157:H7 adhesion to gut epithelium through augmentation of mucin expression. Infect Immun. 2014;82:1921-30 pubmed publisher
    ..coli O157:H7 adherence to HT-29 cells. These data suggest that the inflammatory cytokine response acts to protect host epithelial cells against E. coli O157:H7 colonization, at least in part, by promoting mucin production. ..
  55. Monian P, Jiang X. The Cellular Apoptosis Susceptibility Protein (CAS) Promotes Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis and Cell Proliferation. J Biol Chem. 2016;291:2379-88 pubmed publisher
    ..These findings suggest that CAS plays contrasting roles in proliferation and apoptosis and that overexpression of CAS in tumors could serve as a potential biomarker to guide therapeutic choices. ..
  56. Cheng S, Wang S, Ou Y, Duh C. Mollisolactones A and B, novel dinormonoterpenes from the soft coral Sinularia mollis. Bioorg Med Chem Lett. 2016;26:879-881 pubmed publisher
  57. Wiemann J, Heller L, Csuk R. Targeting cancer cells with oleanolic and ursolic acid derived hydroxamates. Bioorg Med Chem Lett. 2016;26:907-909 pubmed publisher
    ..3 μM), A2780 (ovarian carcinoma, EC50=3.4 μM) and HT29 (colon adenocarcinoma, EC50=5.6 μM) while being significantly less cytotoxic for fibroblasts (EC50=20.4 μM). ..
  58. Wang M, Zhou A, An T, Kong L, Yu C, Liu J, et al. N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells. J Exp Clin Cancer Res. 2016;35:41 pubmed publisher
    ..Our findings suggest that NHPI may be developed as a promising candidate for cancer therapeutics by targeting mTOR signaling pathway and as such warrants further exploration. ..
  59. Jung H, Jun S, Lee M, Kim H, Wang X, Ji H, et al. PAF and EZH2 induce Wnt/?-catenin signaling hyperactivation. Mol Cell. 2013;52:193-205 pubmed publisher
    ..Our studies reveal an unexpected role of PAF in regulating Wnt signaling and propose a regulatory mechanism of Wnt signaling during tumorigenesis. ..
  60. Zhang W, He J, Du Y, Gao X, Liu Y, Liu Q, et al. Upregulation of nemo-like kinase is an independent prognostic factor in colorectal cancer. World J Gastroenterol. 2015;21:8836-47 pubmed publisher
    ..NLK overexpression is an independent prognostic factor in colorectal cancer and knockdown of NLK expression inhibits colorectal cancer progression and metastasis. ..
  61. Moon H, Kim S, Ku J. Correlation between the promoter methylation status of ATP-binding cassette sub-family G member 2 and drug sensitivity in colorectal cancer cell lines. Oncol Rep. 2016;35:298-306 pubmed publisher
    ..Our data suggest that the ABCG2 expression level regulated by methylation is related to anticancer drug sensitivity. Based on these results, it can be applied to predict the anticancer drug response. ..
  62. Lemes L, de Andrade Ramos G, de Oliveira A, da Silva F, de Castro Couto G, da Silva Boni M, et al. Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease. Eur J Med Chem. 2016;108:687-700 pubmed publisher
    ..Collectively, the data suggest that the approach to obtain potential anti-Alzheimer drugs from CNSL is worth of further pursuit and development. ..
  63. Kang M, Kim M, Kim W, Um J, Shin Y, Song J, et al. Lanatoside C suppressed colorectal cancer cell growth by inducing mitochondrial dysfunction and increased radiation sensitivity by impairing DNA damage repair. Oncotarget. 2016;7:6074-87 pubmed publisher
    ..Thus, lanatoside C could be a potential molecule for anti-cancer drugs and radiosensitizing agents. ..
  64. Khalife R, Hodroj M, Fakhoury R, Rizk S. Thymoquinone from Nigella sativa Seeds Promotes the Antitumor Activity of Noncytotoxic Doses of Topotecan in Human Colorectal Cancer Cells in Vitro. Planta Med. 2016;82:312-21 pubmed publisher
    ..In conclusion, thymoquinone increased the effectiveness of the chemotherapeutic reagent topotecan by inhibiting proliferation and lowering toxicity through p53- and Bax/Bcl2-independent mechanisms. ..
  65. Chen L, Zhu Z, Gao W, Jiang Q, Yu J, Fu C. Systemic analysis of different colorectal cancer cell lines and TCGA datasets identified IGF-1R/EGFR-PPAR-CASPASE axis as important indicator for radiotherapy sensitivity. Gene. 2017;627:484-490 pubmed publisher
    ..As a result, the apoptosis rate of EGF and NVP-ADW742 treated HT29 cells was significantly higher than that of those wild type ones, which indicated that high EGFR and low IGF-1R ..
  66. Jin H, Chen L, Wang S, Chao D. Portulaca oleracea extract can inhibit nodule formation of colon cancer stem cells by regulating gene expression of the Notch signal transduction pathway. Tumour Biol. 2017;39:1010428317708699 pubmed publisher
    ..The tumor volume of the HT29 cells was two times larger than that of HT29 cancer stem cells. Treatment with P...
  67. Nakata K, Sugi Y, Narabayashi H, Kobayakawa T, Nakanishi Y, Tsuda M, et al. Commensal microbiota-induced microRNA modulates intestinal epithelial permeability through the small GTPase ARF4. J Biol Chem. 2017;292:15426-15433 pubmed publisher
  68. Ding L, Tang F, Huang W, Jin Q, Shen H, Wei P. Design, synthesis, and biological evaluation of novel 3-pyrrolo[b]cyclohexylene-2-dihydroindolinone derivatives as potent receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2013;23:5630-3 pubmed publisher
    ..Additionally, some compounds also showed favorable antiproliferative activities against a panel of cancer cell lines (BXPC-3, T24, BGC, HEPG2 and HT29). ..
  69. Jaganathan S, Supriyanto E, Mandal M. Events associated with apoptotic effect of p-Coumaric acid in HCT-15 colon cancer cells. World J Gastroenterol. 2013;19:7726-34 pubmed publisher
    ..To investigate the events associated with the apoptotic effect of p-Coumaric acid, one of the phenolic components of honey, in human colorectal carcinoma (HCT-15) cells...
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