kb cells


Summary: This line KB is now known to be a subline of the ubiquitous KERATIN-forming tumor cell line HeLa. It was originally thought to be derived from an epidermal carcinoma of the mouth, but was subsequently found, based on isoenzyme analysis, HeLa marker chromosomes, and DNA fingerprinting, to have been established via contamination by HELA CELLS. The cells are positive for keratin by immunoperoxidase staining. KB cells have been reported to contain human papillomavirus18 (HPV-18) sequences.

Top Publications

  1. Shi X, Wang S, Lee I, Shen M, Baker J. Comparison of the internalization of targeted dendrimers and dendrimer-entrapped gold nanoparticles into cancer cells. Biopolymers. 2009;91:936-42 pubmed publisher
    ..This study underlines the fact that metal or inorganic NPs entrapped within dendrimers interact with cells in a similar way to that of dendrimers lacking host NPs...
  2. Xiang G, Wu J, Lu Y, Liu Z, Lee R. Synthesis and evaluation of a novel ligand for folate-mediated targeting liposomes. Int J Pharm. 2008;356:29-36 pubmed publisher
    ..The liposomes were taken up selectively by KB cells, which overexpress FR-alpha...
  3. Chen Y, Lin G, Chuang Y, Chia W, Hueng D, Lin C, et al. Triptolide circumvents drug-resistant effect and enhances 5-fluorouracil antitumor effect on KB cells. Anticancer Drugs. 2010;21:502-13 pubmed publisher
    ..In this study, we show that triptolide possesses an anticancer effect on drug-sensitive parental KB cells and multidrug-resistant KB-7D and KB-tax cells that overexpress multidrug resistance protein and MDR, ..
  4. Sun L, Zhao Y, Yuan H, Li X, Cheng A, Lou H. Solamargine, a steroidal alkaloid glycoside, induces oncosis in human K562 leukemia and squamous cell carcinoma KB cells. Cancer Chemother Pharmacol. 2011;67:813-21 pubmed publisher
    ..The aim of this study was to demonstrate that solamargine (SM) mediates its cytotoxicity via oncosis...
  5. Jiang G, Ren B, Xu L, Song S, Zhu C, Ye F. Survivin may enhance DNA double-strand break repair capability by up-regulating Ku70 in human KB cells. Anticancer Res. 2009;29:223-8 pubmed
    ..This study was conducted to investigate whether survivin plays a role in the DNA repair process in the KB human squamous cell carcinoma cell line...
  6. Tiwari A, Sodani K, Wang S, Kuang Y, Ashby C, Chen X, et al. Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters. Biochem Pharmacol. 2009;78:153-61 pubmed publisher
    ..Also, these findings may be useful in clinical practice for cancer combination therapy with nilotinib...
  7. Chen Y, Lin G, Chia W, Lin C, Chuang Y, Sytwu H. Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivo. Oral Oncol. 2009;45:562-8 pubmed publisher
    ..that TPL induces prominent growth inhibition and apoptosis in two oral cancer cell lines, SCC25 and OEC-M1 and in KB cells. Our results indicate that TPL induces a dose-dependent apoptosis of these cells at nanomolar concentration...
  8. Cha J, Moon S, Kim H, Cha I, Lee K. Essential oil of Artemisia capillaris induces apoptosis in KB cells via mitochondrial stress and caspase activation mediated by MAPK-stimulated signaling pathway. J Food Sci. 2009;74:T75-81 pubmed publisher
    ..The essential oil induced cell death of KB cells through apoptosis, as evidenced by the increased cell population in the sub-G1 phase, the appearance of condensed ..
  9. Wang J, Tai L, Tzang C, Fong W, Guan X, Yang M. 1p31, 7q21 and 18q21 chromosomal aberrations and candidate genes in acquired vinblastine resistance of human cervical carcinoma KB cells. Oncol Rep. 2008;19:1155-64 pubmed
    ..This study also demonstrates that the combination of CGH and cDNA microarray is a very useful tool to detect drug resistant targets in cancer treatment...

More Information


  1. Zhan X, Feng X, Kong Y, Chen Y, Tan W. JNK signaling maintains the mesenchymal properties of multi-drug resistant human epidermoid carcinoma KB cells through snail and twist1. BMC Cancer. 2013;13:180 pubmed publisher
  2. Cha J, Jeong M, Kim H, Lee J, Lee K. MAPK activation is necessary to the apoptotic death of KB cells induced by the essential oil isolated from Artemisia iwayomogi. J Ethnopharmacol. 2009;123:308-14 pubmed publisher
    ..Previously, the purified essential oil was isolated from Artemisia iwayomogi, herein named AIEO, and found to contain the active components responsible for the chemopreventive potential of the herb...
  3. Ding Y, He L, Cao K, Lu Y, Gu L, Fu L. [Apoptosis of human carcinoma of mouth floor KB cells and multidrug resistant KBv200 cells induced by azide methyl anthraquinone derivative]. Yao Xue Xue Bao. 2005;40:22-6 pubmed
    To determine the effects of azide methyl anthraquinone derivative (AMAD) on growth inhibition and inducing apoptosis of multidrug resistant (MDR) KBv200 cells and parental drug-sensitive KB cells.
  4. Anuchapreeda S, Leechanachai P, Smith M, Ambudkar S, Limtrakul P. Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells. Biochem Pharmacol. 2002;64:573-82 pubmed
    ..In summary, this study describes the duel modulation of MDR1 expression and Pgp function by the phytochemical curcumin, which may be an attractive new agent for the chemosensitization of cancer cells...
  5. Mongelli E, Pomilio A, Sánchez J, Guerra F, Massanet G. ent-Kaur-16-en-19-oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum. Phytother Res. 2002;16:387-8 pubmed
    ..This compound was potent against the brine shrimp (LC(50) = 4.8 microg/mL) and KB cells (IC(50) = 1.6 microg/mL).
  6. Majoros I, Myc A, Thomas T, Mehta C, Baker J. PAMAM dendrimer-based multifunctional conjugate for cancer therapy: synthesis, characterization, and functionality. Biomacromolecules. 2006;7:572-9 pubmed
    ..We present here the synthesis, characterization, and functionality of these dendrimer conjugates...
  7. Strozyk E, Poppelmann B, Schwarz T, Kulms D. Differential effects of NF-kappaB on apoptosis induced by DNA-damaging agents: the type of DNA damage determines the final outcome. Oncogene. 2006;25:6239-51 pubmed
    ..This may have implications for the role of NF-kappaB in carcinogenesis and for the application of NF-kappaB inhibitors in anticancer therapy...
  8. Chauvin C, de Oliveira F, Ronot X, Mousseau M, Leverve X, Fontaine E. Rotenone inhibits the mitochondrial permeability transition-induced cell death in U937 and KB cells. J Biol Chem. 2001;276:41394-8 pubmed
    ..chain complex I have been reported, we have investigated the effects of rotenone on PTP regulation in U937 and KB cells. We show that rotenone was more potent than cyclosporin A at inhibiting Ca(2+)-induced PTP opening in digitonin-..
  9. Eick S, Reissmann A, Rodel J, Schmidt K, Pfister W. Porphyromonas gingivalis survives within KB cells and modulates inflammatory response. Oral Microbiol Immunol. 2006;21:231-7 pubmed
    ..The purpose of the study was to investigate the intracellular survival of Porphyromonas gingivalis as a possible mechanism for maintaining periodontitis...
  10. Zhou B, Mi S, Mo X, Shih J, Tsai J, Hu E, et al. Time and sequence dependence of hydroxyurea in combination with gemcitabine in human KB cells. Anticancer Res. 2002;22:1369-77 pubmed
    ..Exposure of human oropharyngeal carcinoma KB cells to HU followed by the addition of Gem at various times significantly enhanced cytotoxicity when compared to ..
  11. Frausin F, Cocchietto M, Bergamo A, Scarcia V, Furlani A, Sava G. Tumour cell uptake of the metastasis inhibitor ruthenium complex NAMI-A and its in vitro effects on KB cells. Cancer Chemother Pharmacol. 2002;50:405-11 pubmed
    The uptake of NAMI-A (imidazolium trans-imidazoledimethylsulphoxidetetrachlororuthenate) by KB cells in vitro was compared with the effects of this compound on the cell cycle phase distribution of the cells.
  12. Shen Y, Wang S, Pan Y, Lo K, Chakraborty R, Chien C, et al. New taxane diterpenoids from the leaves and twigs of Taxus sumatrana. J Nat Prod. 2002;65:1848-52 pubmed
    ..Taxuspine F and compound 5 possessed moderate activity against Hepa cells only, while 3, 6, 7, and 10-deacetylbaccatin III showed only marginal activity against Hepa cells...
  13. Fu L, He L, Liang Y, Chen L, Xiong H, Yang X, et al. Experimental chemotherapy against xenografts derived from multidrug resistant KBv200 cells and parental drug-sensitive KB cells in nude mice by annonaceous acetogenin 89-2. Yao Xue Xue Bao. 2003;38:565-70 pubmed
    Annonaceous acetogenin 89-2 was obtained from atemoya plant. To investigate the effect of 89-2 on experimental chemotherapy against xenografts derived from multidrug resistant KBv200 cells and parental drug-sensitive KB cells.
  14. Fu L, Liang Y, Deng L, Ding Y, Chen L, Ye Y, et al. Characterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistance. Cancer Chemother Pharmacol. 2004;53:349-56 pubmed
    ..625 micromol/l produced a 7.6-fold reversal of MDR, but showed no effect on the sensitivity of drug-sensitive KB cells in vitro. In the KBv200 cell xenograft model in nude mice, neither Tet nor VCR inhibited tumor growth...
  15. Thomas T, Majoros I, Kotlyar A, Kukowska Latallo J, Bielinska A, Myc A, et al. Targeting and inhibition of cell growth by an engineered dendritic nanodevice. J Med Chem. 2005;48:3729-35 pubmed
    ..This trifunctional dendrimer-drug conjugate bound to FA receptor-expressing KB cells in a dose-dependent and saturable manner...
  16. Singh S, Chhipa R, Vijayakumar M, Bhat M. DNA damaging drugs-induced down-regulation of Bcl-2 is essential for induction of apoptosis in high-risk HPV-positive HEp-2 and KB cells. Cancer Lett. 2006;236:213-21 pubmed
    ..targets, induce apoptosis in various cancer cells including human papillomavirus (HPV) positive HEp-2 and KB cells. The present work reports the involvement of Bcl-2 in response to the exposure of HEp-2 and KB cells to Carb or 5-..
  17. Wang X, Jia D, Liang Y, Yan S, Ding Y, Chen L, et al. Lgf-YL-9 induces apoptosis in human epidermoid carcinoma KB cells and multidrug resistant KBv200 cells via reactive oxygen species-independent mitochondrial pathway. Cancer Lett. 2007;249:256-70 pubmed
    ..the effect of Lgf-YL-9 on cytotoxicity and cell apoptosis in human epidermoid carcinoma drug-sensitive parental KB cells and multidrug resistant (MDR) KBv200 cells...
  18. Eick S, Rodel J, Einax J, Pfister W. Interaction of Porphyromonas gingivalis with KB cells: comparison of different clinical isolates. Oral Microbiol Immunol. 2002;17:201-8 pubmed
    ..of different Porphyromonas gingivalis strains (15 clinical isolates and ATCC 33277) to attach to and invade KB cells, in relation to other properties such as release of interleukin (IL)-6 and IL-8, cytotoxicity, proteolytic ..
  19. Aoki S, Chen Z, Higasiyama K, Setiawan A, Akiyama S, Kobayashi M. Reversing effect of agosterol A, a spongean sterol acetate, on multidrug resistance in human carcinoma cells. Jpn J Cancer Res. 2001;92:886-95 pubmed
    ..We conclude that agosterol A directly inhibited drug efflux through P-gp and/or MRP1...
  20. Kukowska Latallo J, Candido K, Cao Z, Nigavekar S, Majoros I, Thomas T, et al. Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer. Cancer Res. 2005;65:5317-24 pubmed
    ..Targeting methotrexate increased its antitumor activity and markedly decreased its toxicity, allowing therapeutic responses not possible with a free drug...
  21. Liu X, Zhou B, Xue L, Shih J, Tye K, Qi C, et al. The ribonucleotide reductase subunit M2B subcellular localization and functional importance for DNA replication in physiological growth of KB cells. Biochem Pharmacol. 2005;70:1288-97 pubmed
    ..A living cell sorting study that used KB cells in normal growth, further confirmed that M2B increased to maximum levels at the G(1)/S-phase transition, and ..
  22. Zhang J, Tao L, Liang Y, Chen L, Mi Y, Zheng L, et al. Anthracenedione derivatives as anticancer agents isolated from secondary metabolites of the mangrove endophytic fungi. Mar Drugs. 2010;8:1469-81 pubmed publisher
    ..Furthermore, we demonstrate that the mechanism involved in the apoptosis induced by compound 6 is probably related to mitochondrial dysfunction. Additionally, the structure-activity relationships of these compounds are discussed...
  23. McCollum A, Teneyck C, Stensgard B, Morlan B, Ballman K, Jenkins R, et al. P-Glycoprotein-mediated resistance to Hsp90-directed therapy is eclipsed by the heat shock response. Cancer Res. 2008;68:7419-27 pubmed publisher
    ..Taken together, our results indicate that targeting of Hsp27 and Hsp70 should be exploited to increase the clinical efficacy of Hsp90-directed therapy. ..
  24. Matsuda K, Nakagawa S, Nakano T, Asaumi J, Jagetia G, Kawasaki S. Effects of KNK437 on heat-induced methylation of histone H3 in human oral squamous cell carcinoma cells. Int J Hyperthermia. 2006;22:729-35 pubmed
    ..Heating of HSC4 cells at 45 degrees C for 20 min and KB cells for 3 min gradually increased H3-Lys4 and H3-Lys9 methylation...
  25. Phifer S, Lee D, Seo E, Kim N, Graf T, Kroll D, et al. Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis. J Nat Prod. 2007;70:954-61 pubmed
    ..2 mg kg-1 per injection when administered intraperitoneally...
  26. Bisson Boutelliez C, Massin F, Dumas D, Miller N, Lozniewski A. Desulfovibrio spp. survive within KB cells and modulate inflammatory responses. Mol Oral Microbiol. 2010;25:226-35 pubmed publisher
    ..Desulfovibrio strains were co-cultured with KB cells and counts of intracellular bacteria evaluated up to 3 days after infection...
  27. Hu C, Yang D, Wang Z, Huang P, Wang X, Chen D, et al. Bio-mimetically synthesized Ag@BSA microspheres as a novel electrochemical biosensing interface for sensitive detection of tumor cells. Biosens Bioelectron. 2013;41:656-62 pubmed publisher
    ..a novel cytosensor, comprised of bio-mimetically synthesized Ag@BSA composite microspheres, for the detection of KB cells (a model system) is described...
  28. Wu Y, Ho Y, Mao Y, Wang X, Yu B, Leong K, et al. Uptake and intracellular fate of multifunctional nanoparticles: a comparison between lipoplexes and polyplexes via quantum dot mediated Förster resonance energy transfer. Mol Pharm. 2011;8:1662-8 pubmed publisher
    ..to their unlabeled counterparts as evidenced by their comparable antisense activities against protein R2 in KB cells. Flow cytometry and confocal microscopy revealed similar pattern of uptake for these two types of nanoparticles, ..
  29. Zhou Y, Xu X, Sun Y, Wang H, Sun H, You Q. Synthesis, cytotoxicity and topoisomerase II inhibitory activity of lomefloxacin derivatives. Bioorg Med Chem Lett. 2013;23:2974-8 pubmed publisher
    ..Of the compounds prepared compounds 9d and 9g exhibited strong inhibition against topoisomerase II at 100?M. In addition, docking studies were performed to predict the inhibition mode. ..
  30. Wang F, Liang Y, Wu X, Su X, Fu L. ABCG2-overexpressing S1-M1-80 cell xenografts in nude mice keep original biochemistry and cell biological properties. Chin J Cancer. 2012;31:150-8 pubmed publisher
    ..These results suggest that S1-M1-80 cell xenografts in nude mice retain their original cytological characteristics at 9 weeks. Thus, this model could serve as a good system for further investigation of ABCG2-mediated MDR...
  31. Liu X, Zhou B, Mi S, Xue L, Shih J, Lee J, et al. An increase of cytochrome C oxidase mediated disruption of gemcitabine incorporation into DNA in a resistant KB clone. Biochem Pharmacol. 2007;73:1927-38 pubmed
    ..In summary, an increase of CCOX activity and free ATP level may reduce the transport, metabolism and DNA incorporation of Gem, resulting in Gem resistance. ..
  32. Zhu M, He W, Gao E, Lin L, Zhang Y, Dai L, et al. Synthesis, characterization, and cytotoxicity in vitro of the complex [Mn (Hptc) (phen) (OH)] n. Life Sci. 2012;90:519-24 pubmed publisher
    ..In vitro apoptosis assay of the complexes were examined on HeLa and KB cells, exhibited cytotoxic specificity and a significant cancer cell inhibitory rate...
  33. Shen Y, Chen S, Zhuang S, Wang C. Contribution of tomato phenolics to suppression of COX-2 expression in KB cells. J Food Sci. 2008;73:C1-10 pubmed publisher
    ..extracts on the regulation of 12-o-teradecanoylphorbol-13-acetate (TPA)-induced inflammatory responses in KB cells. HPLC showed that tomato phenolic profiles were similar between small and big tomatoes either by fresh or heated ..
  34. Lee D, Kessel E, Edinger D, He D, Klein P, Voith von Voithenberg L, et al. Dual antitumoral potency of EG5 siRNA nanoplexes armed with cytotoxic bifunctional glutamyl-methotrexate targeting ligand. Biomaterials. 2016;77:98-110 pubmed publisher
    ..These polyplexes access KB cells by binding to the folate receptor in a MTX-dependent manner and induce efficient gene silencing activity in ..
  35. Kim J, Jung H, Lim W, Kim S, Ko Y, Karna S, et al. Down-regulation of heat-shock protein 27-induced resistance to photodynamic therapy in oral cancer cells. J Oral Pathol Med. 2013;42:9-16 pubmed publisher
    ..b>KB cells transfected with HSP27 siRNA were exposed to hematoporphyrin (HP) followed by irradiation at 635 nm at an energy ..
  36. He Z, Yu Y, Zhang Y, Yan Y, Zheng Y, He J, et al. Gene delivery with active targeting to ovarian cancer cells mediated by folate receptor alpha. J Biomed Nanotechnol. 2013;9:833-44 pubmed
    ..All the data indicated that F-PEG-CLPs would be a promising gene vector targeting for ovarian cancer therapy. ..
  37. Wu J, Yu Z, Fong W, Shi Y. Chemotherapeutic activities of Carthami Flos and its reversal effect on multidrug resistance in cancer cells. Afr J Tradit Complement Altern Med. 2013;10:36-40 pubmed
    ..These results indicate that CF could be a potential alternative adjuvant antitumour herbal medicine representing a promising approach to the treatment of some malignant and MDR cancers in the future. ..
  38. Tip Pyang S, Limpipatwattana Y, Khumkratok S, Siripong P, Sichaem J. A new cytotoxic 1-azaanthraquinone from the stems of Goniothalamus laoticus. Fitoterapia. 2010;81:894-6 pubmed publisher
    ..Compound 1 showed the highest cytotoxicity against KB and HeLa cells with IC(50) values of 0.68 and 0.50 ?g/ml, respectively. ..
  39. Intaraudom C, Bunbamrung N, Dramae A, Boonyuen N, Kongsaeree P, Srichomthong K, et al. Terphenyl derivatives and drimane - Phathalide/isoindolinones from Hypoxylon fendleri BCC32408. Phytochemistry. 2017;139:8-17 pubmed publisher
    ..Cytotoxicity against both cancerous (KB, MCF-7, NCI-H187) and non-cancerous (Vero) cells of these compounds were also evaluated. ..
  40. Müller C, Schubiger P, Schibli R. Isostructural folate conjugates radiolabeled with the matched pair 99mTc/188Re: a potential strategy for diagnosis and therapy of folate receptor-positive tumors. Nucl Med Biol. 2007;34:595-601 pubmed
    ..Cell binding experiments were performed with FR-positive human KB cells. Biodistribution was assessed in female nude mice, bearing KB tumor xenografts...
  41. Khrizman A, Slack R, Remsing R, Little S, Yardley V, Moyna G. Synthesis and in vitro protozoocidal evaluation of novel diazabicyclic tropolone derivatives. Arch Pharm (Weinheim). 2007;340:569-76 pubmed
  42. Kashiwada Y, Sekiya M, Yamazaki K, Ikeshiro Y, Fujioka T, Yamagishi T, et al. Triterpenoids from the floral spikes of Betula platyphylla var. japonica and their reversing activity against multidrug-resistant cancer cells. J Nat Prod. 2007;70:623-7 pubmed
    ..Compound 10 reversed the cytotoxicity of colchicine against KB-C2 cells at 8.1 microM and showed comparable potency to 5 microM verapamil. ..
  43. Czabanka M, Korherr C, Brinkmann U, Vajkoczy P. Influence of TBK-1 on tumor angiogenesis and microvascular inflammation. Front Biosci. 2008;13:7243-9 pubmed
    ..The TBK-1 pathway might be an important cross-link between angiogenesis and inflammation representing a possible target for anti-tumor therapy. ..
  44. Gan C, Etoh T, Hayashi M, Komiyama K, Kam T. Leucoridines A-D, cytotoxic Strychnos-Strychnos bisindole alkaloids from Leuconotis. J Nat Prod. 2010;73:1107-11 pubmed publisher
    ..Alkaloids 1-4 showed moderate cytotoxicity against drug-sensitive and vincristine-resistant human KB cells.
  45. Dosio F, Arpicco S, Stella B, Brusa P, Cattel L. Folate-mediated targeting of albumin conjugates of paclitaxel obtained through a heterogeneous phase system. Int J Pharm. 2009;382:117-23 pubmed publisher
    ..Binding and in vitro cytotoxicity studies on human nasopharyngeal epidermal carcinoma KB and colorectal carcinoma HT-29 cells (as negative control) demonstrated increased selectivity and anti-tumoral activity. ..
  46. Lu X, Zhu W, Xie Y, Li X, Gao Y, Li F, et al. Near-IR core-substituted naphthalenediimide fluorescent chemosensors for zinc ions: ligand effects on PET and ICT channels. Chemistry. 2010;16:8355-64 pubmed publisher
    ..Also both PND and PNT were successfully used to image intracellular Zn(2+) ions in the living KB cells.
  47. Müller C, Bunka M, Reber J, Fischer C, Zhernosekov K, Türler A, et al. Promises of cyclotron-produced 44Sc as a diagnostic match for trivalent ?--emitters: in vitro and in vivo study of a 44Sc-DOTA-folate conjugate. J Nucl Med. 2013;54:2168-74 pubmed publisher
    ..Thus, (44)Sc is a valid alternative to (68)Ga for imaging and dosimetry before (177)Lu-radionuclide tumor therapy. ..
  48. Jiang S, Chen X, Ding Y, Chen Z, Zhu L, Feng H, et al. [Epigallocatechin-3-gallate induces G1 phase cell cycle arrest in KB cells]. Nan Fang Yi Ke Da Xue Xue Bao. 2009;29:1381-3 pubmed
    ..the effects of epigallocatechin-3-gallate (EGCG) on the proliferation of human oral epithelial cancer cell line KB cells and the molecular mechanisms. KB cells were treated with various concentrations of EGCG for 24 or 48 h...
  49. Yan Y, Li W, Huang Y, Liao W. The COX-2 inhibitor Celecoxib enhances the sensitivity of KB/VCR oral cancer cell lines to Vincristine by down-regulating P-glycoprotein expression and function. Prostaglandins Other Lipid Mediat. 2012;97:29-35 pubmed publisher
    ..01). The underlying mechanism of these phenomena is likely correlated with the down-regulation of the expression and function of P-gp due to Celecoxib, thereby increasing the amount of VCR accumulated in KB/VCR cells. ..
  50. Cheng H, Chien H, Liao C, Yang Y, Huang S. Carotenoids suppress proliferating cell nuclear antigen and cyclin D1 expression in oral carcinogenic models. J Nutr Biochem. 2007;18:667-75 pubmed
    ..In the in vitro cell experiment, KB cells were cultured, and the inhibitory effect of carotenoids (beta-carotene, lycopene and lutein) on cell ..
  51. Etemad Moghadam S, Fouladdel S, Azizi E, Alaeddini M. In vitro study on the effect of doxorubicin on the proliferation markers MCM3 and Ki-67. J BUON. 2013;18:1062-8 pubmed
    ..b>KB cells were treated with doxorubicin and its effect on apoptosis, mRNA levels and protein expression of MCM3 and Ki-67 ..
  52. Leamon C, Reddy J, Vetzel M, Dorton R, Westrick E, Parker N, et al. Folate targeting enables durable and specific antitumor responses from a therapeutically null tubulysin B analogue. Cancer Res. 2008;68:9839-44 pubmed publisher
    ..Collectively, these results show that this potent antiproliferative tubulysin compound can be specifically delivered to FR-positive tumors to provide substantial therapeutic benefit using well-tolerable dosing regimens. ..
  53. Gourdain S, Dairou J, Denhez C, Bui L, Rodrigues Lima F, Janel N, et al. Development of DANDYs, new 3,5-diaryl-7-azaindoles demonstrating potent DYRK1A kinase inhibitory activity. J Med Chem. 2013;56:9569-85 pubmed publisher
    ..None of the active compounds were cytotoxic to KB cells at 10(-6) M...
  54. Johari Ahar M, Barar J, Alizadeh A, Davaran S, Omidi Y, Rashidi M. Methotrexate-conjugated quantum dots: synthesis, characterisation and cytotoxicity in drug resistant cancer cells. J Drug Target. 2016;24:120-33 pubmed publisher
    ..l-cysteine capped CdSe QDs (MTX-QD nanoconjugates) and evaluated their internalisation and cytotoxicity in the KB cells with/without resistancy to MTX...
  55. Pathirana R, O Brien Simpson N, Visvanathan K, Hamilton J, Reynolds E. Flow cytometric analysis of adherence of Porphyromonas gingivalis to oral epithelial cells. Infect Immun. 2007;75:2484-92 pubmed
    ..was a logarithmic relationship between the bacterial cell ratio (BCR), that is the number of bacterial cells to KB cells, and the percentage of KB cells with W50 cells attached...
  56. Yu Y, Kim E, Park D, Shim G, Lee S, Kim Y, et al. Cationic solid lipid nanoparticles for co-delivery of paclitaxel and siRNA. Eur J Pharm Biopharm. 2012;80:268-73 pubmed publisher
    ..The use of cSLN increased the cellular uptake of fluorescent dsRNA in human epithelial carcinoma KB cells, with PcSLN complexed to fluorescence-labeled dsRNA promoting the greatest uptake...
  57. Lim W, Kim O, Jung J, Ko Y, Ha J, Oh H, et al. Dichloromethane fraction from Gardenia jasminoides: DNA topoisomerase 1 inhibition and oral cancer cell death induction. Pharm Biol. 2010;48:1354-60 pubmed publisher
  58. Thomas T, Huang B, Choi S, Silpe J, Kotlyar A, Desai A, et al. Polyvalent dendrimer-methotrexate as a folate receptor-targeted cancer therapeutic. Mol Pharm. 2012;9:2669-2676 pubmed publisher
    ..The conjugate inhibits dihydrofolate reductase, and induces cytotoxicity in FR-expressing KB cells through FR-specific cellular internalization...
  59. Mautner V. Growth and purification of enteric adenovirus type 40. Methods Mol Med. 2007;130:145-56 pubmed
    ..Methods to propagate Ad40 in complementing cell lines and to evaluate infectivity and particle number are presented in this chapter...
  60. Toyota M, Ikeda R, Kenmoku H, Asakawa Y. Activity-guided isolation of cytotoxic bis-bibenzyl constituents from Dumortiera hirsuta. J Oleo Sci. 2013;62:105-8 pubmed
    ..the ether extract of Dumortiera hirsute (Japanese liverwort), using cytotoxicity testing with cultured HL 60 and KB cells, resulted in the isolation of a new cytotoxic bis-bibenzyl compound, along with the two known bis-bibenzyls: ..
  61. Chu W, Wang Y, Liu S, Yang X, Wang S, Li S, et al. Synthesis, cytotoxicity and DNA-binding properties of Pd(II), Cu(II) and Zn(II) complexes with 4'-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2,2':6',2?-terpyridine. Bioorg Med Chem Lett. 2013;23:5187-91 pubmed publisher
    ..The results reveal that all the complexes display high cytotoxicity against all the tested cancer cell lines, and complex 3 is selective for G-quadruplex over duplex DNA. ..
  62. Wongsa N, Kanokmedhakul S, Kanokmedhakul K, Kongsaeree P, Prabpai S, Pyne S. Parviflorals A-F, trinorcadalenes and bis-trinorcadalenes from the roots of Decaschistia parviflora. Phytochemistry. 2013;95:368-74 pubmed publisher
    ..30-192.13 ?M. In addition, several of these compounds possessed cytotoxicity towards the cancer cell lines, KB, MCF7 and NCI-H187 with IC50 values in the range of 2.20-90.09 ?M...
  63. Xiao B, Guo J. [The anti-proliferation and anti-migration dual effects of aloe-emodin on KB cells and its mechanism]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2009;44:50-2 pubmed
    To investigate the anti-proliferation and anti-migration dual effects of aloe-emodin on KB cells and its mechanisms.
  64. Sun X, Ponte J, Yoder N, Laleau R, Coccia J, Lanieri L, et al. Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates. Bioconjug Chem. 2017;28:1371-1381 pubmed publisher
    ..These results support the use of DAR 3-4 for maytansinoid ADCs but suggest that the exploration of lower or higher DAR may be warranted depending on the biology of the target antigen...
  65. Piao X, Zou Y, Wu J, Li C, Yi T. Multiresponsive switchable diarylethene and its application in bioimaging. Org Lett. 2009;11:3818-21 pubmed publisher
    ..More importantly, having low toxicity, it can enter live cells as a fluorescent probe and can also serve as a detector for the biological process of metal ion transmembrane transport...
  66. Wang Q, Ge H, Zhang J, Wu J, Song Y, Zhang Y, et al. Cochliones A-D, four new tetrahydrochromanone derivatives from endophytic Cochliobolus sp. J Asian Nat Prod Res. 2010;12:485-91 pubmed publisher
    ..99 and 4.59 microg/ml, respectively...
  67. Ohtsu N, Takaoka K, Segawa E, Hashitani S, Noguchi K, Kishimoto H, et al. Antitumor effects of inhibitors of nitric oxide synthase or cyclooxygenase-2 on human KB carcinoma cells overexpressing COX-2. Oncol Rep. 2010;24:31-6 pubmed
    ..These results suggest that L-NAME and celecoxib significantly inhibit the proliferation of murine squamous cell carcinoma in vivo. L-NAME as well as celecoxib might thus be useful for the design and development of new antitumor drugs...
  68. Mai H, Nguyen T, Pham V, Litaudon M, Guéritte F, Tran D, et al. Cytotoxic prenylated isoflavone and bipterocarpan from Millettia pachyloba. Planta Med. 2010;76:1739-42 pubmed publisher
    ..Absolute configuration of 2 was proposed based on that of the known compound (-)-pisatine (8). Compounds 1 and 2 exhibited cytotoxicity against KB cells with IC(50) values of 2.0 and 17.6?µM, respectively.
  69. Su Y, Wei X, Peng F, Zhong Y, Lu Y, Su S, et al. Gold nanoparticles-decorated silicon nanowires as highly efficient near-infrared hyperthermia agents for cancer cells destruction. Nano Lett. 2012;12:1845-50 pubmed publisher
    ..In particular, three different cancer cells treated with AuNPs@SiNWs were completely destructed within 3 min of NIR irradiation, demonstrating the exciting potential of AuNPs@SiNWs for NIR hyperthermia agents...
  70. Clipet F, Tricot S, Alno N, Massot M, Solhi H, Cathelineau G, et al. In vitro effects of Choukroun's platelet-rich fibrin conditioned medium on 3 different cell lines implicated in dental implantology. Implant Dent. 2012;21:51-6 pubmed publisher
    ..We used 3 different cell lines implicated in dental implantology: osteoblast, keratinocyte, and fibroblast...
  71. Yanti -, Lee M, Kim D, Hwang J. Inhibitory effect of panduratin A on c-Jun N-terminal kinase and activator protein-1 signaling involved in Porphyromonas gingivalis supernatant-stimulated matrix metalloproteinase-9 expression in human oral epidermoid cells. Biol Pharm Bull. 2009;32:1770-5 pubmed
    ..caused the decreased levels of MMP-9 secretion, protein, and gene expression in human oral epidermoid KB cells exposed to P. gingivalis supernatant...
  72. Lin C, Lu W, Wang C, Chan Y, Chen M. Capsaicin induces cell cycle arrest and apoptosis in human KB cancer cells. BMC Complement Altern Med. 2013;13:46 pubmed publisher
    ..The anti-proliferative effects of capsaicin on human KB cancer cells are still unknown. Therefore, we examined the viability, cell cycle progression, and factors associated with apoptosis in KB cells treated with capsaicin.
  73. Zhou M, Zhang X, Yang Y, Liu Z, Tian B, Jie J, et al. Carrier-free functionalized multidrug nanorods for synergistic cancer therapy. Biomaterials. 2013;34:8960-7 pubmed publisher
    ..The MDNCs can also gain imaging capabilities by encapsulated with an organic dye, which render the multidrug nanorod an all-in-one processing system for cancer diagnosis and treatment. ..
  74. Franqueville L, Henning P, Magnusson M, Vigne E, Schoehn G, Blair Zajdel M, et al. Protein crystals in Adenovirus type 5-infected cells: requirements for intranuclear crystallogenesis, structural and functional analysis. PLoS ONE. 2008;3:e2894 pubmed publisher
    ..Thus, we propose that TB5 staining of Ad-infected 293 cells can be used as a prognostic assay for the viability and productivity of fiber-modified Ad5 vectors...
  75. Cui Z, Cui Y, Luo G, Yang S, Ling X, Lou Y, et al. Kallikrein-related peptidase 4 contributes to the tumor metastasis of oral squamous cell carcinoma. Biosci Biotechnol Biochem. 2017;81:1768-1777 pubmed publisher
    ..Treatment with a PI3 K/AKT activator reversed the migration-inhibitory effect of KLK4 shRNA. Our study suggests that KLK4 may contribute to the metastasis of OSCC through the PI3 K/AKT signaling pathway. ..
  76. Lim K, Hiraku O, Komiyama K, Kam T. Jerantinines A-G, cytotoxic Aspidosperma alkaloids from Tabernaemontana corymbosa. J Nat Prod. 2008;71:1591-4 pubmed publisher
    ..The structures were established using NMR and MS analysis. Five of the alkaloids isolated and two derivatives (1-5, 8, 9) displayed pronounced in vitro cytotoxicity against human KB cells (IC50 < 1 microg/mL).
  77. León Rivera I, Mirón López G, Molina Salinas G, Herrera Ruiz M, Estrada Soto S, del Carmen Gutiérrez M, et al. Tyrianthinic acids from Ipomoea tyrianthina and their antimycobacterial activity, cytotoxicity, and effects on the central nervous system. J Nat Prod. 2008;71:1686-91 pubmed publisher
  78. Hong K, Kim J, Hong J, Yoon H, Lee J, Hong S, et al. Inhibition of Akt activity induces the mesenchymal-to-epithelial reverting transition with restoring E-cadherin expression in KB and KOSCC-25B oral squamous cell carcinoma cells. J Exp Clin Cancer Res. 2009;28:28 pubmed publisher
    ..We also investigate whether inhibition of Akt activity would affect the E-cadherin repressors and signaling molecules like NF-kappaB, ERK, and p38...
  79. Zhu Y, Cen J, Zhang Y, Feng Y, Yang Y, Li Y, et al. The multidrug resistant modulator HZ08 reverses multidrug resistance via P-glycoprotein inhibition and apoptosis sensitization in human epidermoid carcinoma cell line KBV200. Arzneimittelforschung. 2012;62:236-42 pubmed publisher
    ..Therefore, the outstanding reversal effect of HZ08 occurs not only through suppressing the P-glycoprotein function but also through activating the intrinsic apoptosis pathway...
  80. Alaeddini M, Fouladdel S, Etemad Moghadam S, Etemad Moghaddam S, Azizi E. Expression of fascin protein and mRNA in the KB carcinoma cell line following treatment with doxorubicin. J Cancer Res Ther. 2011;7:427-32 pubmed publisher
    ..Fascin is an actin-bundling protein that has been shown to be overexpressed in various carcinomas, but the effect of doxorubicin on its protein and mRNA has not been investigated...
  81. Tanaka A, Arai Y, Kim S, Ham J, Usuki T. Synthesis and biological evaluation of bilobol and adipostatin A. J Asian Nat Prod Res. 2011;13:290-6 pubmed publisher
    ..The structure-activity relationship study of synthetic products was described by means of cytotoxic assay against human KB carcinoma cell lines...
  82. Riviere K, Huang Z, Jerger K, Macaraeg N, Szoka F. Antitumor effect of folate-targeted liposomal doxorubicin in KB tumor-bearing mice after intravenous administration. J Drug Target. 2011;19:14-24 pubmed publisher
  83. Lee D, Park G, Oh K, Oh N, Kwag D, Youn Y, et al. Multifunctional poly (lactide-co-glycolide) nanoparticles for luminescence/magnetic resonance imaging and photodynamic therapy. Int J Pharm. 2012;434:257-63 pubmed publisher
    ..Overall, PLGA nanoparticles resulted in a significant tumor volume regression for the light-illuminated KB tumor in vivo and enhanced the contrast at the tumor region, compared to that of Feridex(®) (commercial contrast agent)...
  84. Gabant M, Schmitz Afonso I, Gallard J, Menou J, Laurent D, Debitus C, et al. Sulfated steroids: ptilosteroids A-C and ptilosaponosides A and B from the Solomon Islands marine sponge Ptilocaulis spiculifer. J Nat Prod. 2009;72:760-3 pubmed publisher
    ..The structures were determined by spectroscopic methods. Biological tests of these compounds showed that they are not cytotoxic against KB cells.
  85. Guardia P, Di Corato R, Lartigue L, Wilhelm C, Espinosa A, Garcia Hernandez M, et al. Water-soluble iron oxide nanocubes with high values of specific absorption rate for cancer cell hyperthermia treatment. ACS Nano. 2012;6:3080-91 pubmed publisher