hct116 cells

Summary

Summary: Human COLORECTAL CARCINOMA cell line.

Top Publications

  1. Li R, Deng Z, Hu N, Liang X, Liu B, Luo J, et al. Biphasic effects of TGF?1 on BMP9-induced osteogenic differentiation of mesenchymal stem cells. BMB Rep. 2012;45:509-14 pubmed
    ..Our findings strongly suggest that TGF?1 may exert a biphasic effect on BMP9-induced osteogenic differentiation of mesenchymal stem cells...
  2. Basile V, Belluti S, Ferrari E, Gozzoli C, Ganassi S, Quaglino D, et al. bis-Dehydroxy-Curcumin triggers mitochondrial-associated cell death in human colon cancer cells through ER-stress induced autophagy. PLoS ONE. 2013;8:e53664 pubmed publisher
    ..Our findings describe the mechanism through which bDHC promotes tumor selective inhibition of proliferation, providing unequivocal evidence of the role of autophagy in contrasting the proliferation of colon cancer cells. ..
  3. Zhang S, Han Z, Jing Y, Tao S, Li T, Wang H, et al. CD133(+)CXCR4(+) colon cancer cells exhibit metastatic potential and predict poor prognosis of patients. BMC Med. 2012;10:85 pubmed publisher
    ..Growing evidence suggests that a subset of cells exists among cancer stem cells. This distinct subpopulation is thought to contribute to liver metastasis; however, it has not been fully explored in CRC yet...
  4. Roy S, Levi E, Majumdar A, Sarkar F. Expression of miR-34 is lost in colon cancer which can be re-expressed by a novel agent CDF. J Hematol Oncol. 2012;5:58 pubmed publisher
    ..Numerous cellular events, including deregulated expression of microRNAs (miRNAs), specifically the family of miR-34 consisting of miR-34a, b and c, is known to regulate the processes of growth and metastasis...
  5. Ehteda A, Galettis P, Chu S, Pillai K, Morris D. Complexation of albendazole with hydroxypropyl-?-cyclodextrin significantly improves its pharmacokinetic profile, cell cytotoxicity and antitumor efficacy in nude mice. Anticancer Res. 2012;32:3659-66 pubmed
    ..Therefore, the aim of this study was to formulate ABZ with acetic acid/2-hydroxypropyl-?-cyclodextrin (HP?CD) with the view of improving its aqueous solubility and therefore, its antitumor efficacy...
  6. Chen X, Müller G, Quaas M, Fischer M, Han N, Stutchbury B, et al. The forkhead transcription factor FOXM1 controls cell cycle-dependent gene expression through an atypical chromatin binding mechanism. Mol Cell Biol. 2013;33:227-36 pubmed publisher
    ..Thus, we have uncovered a novel and unexpected mode of chromatin binding of a FOX transcription factor that allows it to specifically control cell cycle-dependent gene expression...
  7. Kaliszczak M, Trousil S, Aberg O, Perumal M, Nguyen Q, Aboagye E. A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth. Br J Cancer. 2013;108:342-50 pubmed publisher
    ..This study investigates whether a histone deacetylase subtype 6 (HDAC6) inhibitor could be used in the treatment of solid tumours...
  8. Schachter M, Merrick K, Larochelle S, Hirschi A, Zhang C, Shokat K, et al. A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression. Mol Cell. 2013;50:250-60 pubmed publisher
    ..Therefore, mitogen signaling drives a CDK-activation cascade during G1 progression, and CAK might be rate-limiting for R point passage...
  9. Colangelo T, Fucci A, Votino C, Sabatino L, Pancione M, Laudanna C, et al. MicroRNA-130b promotes tumor development and is associated with poor prognosis in colorectal cancer. Neoplasia. 2013;15:1086-99 pubmed
    ..Detection of onco-miR-130b and its association with PPAR? may be useful as a prognostic biomarker. Its targeting in vivo should be evaluated as a novel effective therapeutic tool against CRC...

More Information

Publications103 found, 100 shown here

  1. Feng Y, Dai X, Li X, Wang H, Liu J, Zhang J, et al. EGF signalling pathway regulates colon cancer stem cell proliferation and apoptosis. Cell Prolif. 2012;45:413-9 pubmed publisher
    ..This study assesses whether EGF, bFGF and IGF signalling pathways are essential for colon CSC proliferation and self-renewal...
  2. Huang H, Huang H, Lee H, Tsai A, Peng C, Lai M, et al. Anticancer activity of MPT0E028, a novel potent histone deacetylase inhibitor, in human colorectal cancer HCT116 cells in vitro and in vivo. PLoS ONE. 2012;7:e43645 pubmed publisher
    ..in both solid and hematological tumor cell lines at micromolar concentrations, and was especially potent in HCT116 cells. MPT0E028 had a stronger apoptotic activity and inhibited HDACs activity more potently than SAHA, the first ..
  3. Quaas M, Müller G, Engeland K. p53 can repress transcription of cell cycle genes through a p21(WAF1/CIP1)-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements. Cell Cycle. 2012;11:4661-72 pubmed publisher
    ..In the case of promoters that do not hold CDE or E2F elements, binding of DREAM and MMB solely relies on a CHR site. Thus, p53 can repress target genes indirectly through CHR elements...
  4. Zhang M, Liu Y, Feng H, Bian X, Zhao W, Yang Z, et al. CD133 affects the invasive ability of HCT116 cells by regulating TIMP-2. Am J Pathol. 2013;182:565-76 pubmed publisher
    ..CD133(high) and CD133(low) HCT116 cells were isolated, and the proliferation and invasive ability of these two subpopulations were tested...
  5. Du G, Zhang Z, Wen X, Yu C, Calway T, Yuan C, et al. Epigallocatechin Gallate (EGCG) is the most effective cancer chemopreventive polyphenol in green tea. Nutrients. 2012;4:1679-91 pubmed publisher
    ..The gallic acid group significantly enhanced catechin's anticancer potential. This property could be utilized in future semi-synthesis of flavonoid derivatives to develop novel anticancer agents...
  6. Havermann S, Rohrig R, Chovolou Y, Humpf H, Watjen W. Molecular effects of baicalein in Hct116 cells and Caenorhabditis elegans : activation of the Nrf2 signaling pathway and prolongation of lifespan. J Agric Food Chem. 2013;61:2158-64 pubmed publisher
    ..of Nrf2, increases ARE-dependent luciferase activity, and enhances the expression of heme oxygenase-1 in Hct116 cells. Additionally, accumulation of the Nrf2 homologue SKN-1 in nuclei of intestinal cells of C...
  7. Prosser G, Copp J, Mowday A, Guise C, Syddall S, Williams E, et al. Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A. Biochem Pharmacol. 2013;85:1091-103 pubmed publisher
    ..Nonetheless, our oxidoreductase library and optimised screens provide valuable tools to identify preferred nitroreductase-prodrug combinations to advance to preclinical evaluation...
  8. Aso K, Goi T, Nakazawa T, Kimura Y, Hirono Y, Katayama K, et al. The expression of integrins is decreased in colon cancer cells treated with polysaccharide K. Int J Oncol. 2013;42:1175-80 pubmed publisher
    ..Suppression of integrin expression on the cell surface and reduced adhesion to vascular endothelial cells were observed as a novel mechanism of action of PSK on colon cancer cells...
  9. Meng X, Wu J, Pan C, Wang H, Ying X, Zhou Y, et al. Genetic and epigenetic down-regulation of microRNA-212 promotes colorectal tumor metastasis via dysregulation of MnSOD. Gastroenterology. 2013;145:426-36.e1-6 pubmed publisher
    ..miR-212 is transcribed from a stable intron of a non-protein coding gene, and is reportedly down-regulated in different tumor types. We investigated the role of miR-212 in colorectal carcinogenesis and progression...
  10. Kolossov V, Beaudoin J, Ponnuraj N, DiLiberto S, Hanafin W, Kenis P, et al. Thiol-based antioxidants elicit mitochondrial oxidation via respiratory complex III. Am J Physiol Cell Physiol. 2015;309:C81-91 pubmed
    ..Our findings provide new evidence of a functional link between exogenous thiol-containing antioxidants and mitochondrial respiration. ..
  11. Ju T, Gao D, Fang Z. Targeting colorectal cancer cells by a novel sphingosine kinase 1 inhibitor PF-543. Biochem Biophys Res Commun. 2016;470:728-734 pubmed publisher
    ..Collectively, our results demonstrate that PF-543 exerts potent anti-CRC activity in vitro and in vivo. Mitochondrial programmed necrosis pathway is likely the key mechanism responsible for PF-543's actions in CRC cells. ..
  12. Yousef A, El Masry O, Abdel Mohsen M. Impact of Cellular Genetic Make-up on Colorectal Cancer Cell Lines Response to Ellagic Acid: Implications of Small Interfering RNA. Asian Pac J Cancer Prev. 2016;17:743-8 pubmed
    ..EA had a multi-disciplinary pro-apoptotic anti-proliferative approach, having inhibited Akt phosphorylation, induced cell cycle arrest and showed an anti-proliferative potential in HCT-116 cells (expressing mutant K-Ras). ..
  13. Bertin M, Wahome P, Zimba P, He H, Moeller P. Trichophycin A, a Cytotoxic Linear Polyketide Isolated from a Trichodesmium thiebautii Bloom. Mar Drugs. 2017;15: pubmed publisher
    ..These cytotoxicity observations suggest that toxicity may be related to the polyol character of these polyketide compounds. ..
  14. Tamhane T, Lllukkumbura R, Lu S, Maelandsmo G, Haugen M, Brix K. Nuclear cathepsin L activity is required for cell cycle progression of colorectal carcinoma cells. Biochimie. 2016;122:208-18 pubmed publisher
    ..Cathepsin L was represented as the full-length protein in the nuclei of HCT116 cells from which stefin B, a potent cathepsin L inhibitor, was absent...
  15. Englinger B, Mair M, Miklos W, Pirker C, Mohr T, van Schoonhoven S, et al. Loss of CUL4A expression is underlying cisplatin hypersensitivity in colorectal carcinoma cells with acquired trabectedin resistance. Br J Cancer. 2017;116:489-500 pubmed publisher
    ..In vivo xenograft experiments were conducted. Selection of HCT116 cells for trabectedin resistance resulted in p53-independent hypersensitivity of the selected subline against ..
  16. Lee K, Cho S, Choi Y, Choi Y, Lee G, Jeon C, et al. Herbal prescription, Danggui-Sayuk-Ga-Osuyu-Senggang-Tang, inhibits TNF-?-induced epithelial-mesenchymal transition in HCT116 colorectal cancer cells. Int J Mol Med. 2018;41:373-380 pubmed publisher
    ..A non?toxic dose of DSGOST (50 µg/ml) on HCT116 cells was determined by MTT assay. Furthermore, DSGOST prevented the TNF???induced invasive phenotype in HCT116 cells...
  17. LaBonia G, Ludwig K, Mousseau C, Hummon A. iTRAQ Quantitative Proteomic Profiling and MALDI-MSI of Colon Cancer Spheroids Treated with Combination Chemotherapies in a 3D Printed Fluidic Device. Anal Chem. 2017;: pubmed publisher
    ..This system is a high-throughput and cost effective approach to examine novel drugs and drug combinations prior to animal testing...
  18. Lee S, Kopp F, Chang T, Sataluri A, Chen B, Sivakumar S, et al. Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins. Cell. 2016;164:69-80 pubmed publisher
  19. Kim K, Kwon S, Yun J, Jeong H, Kim H, Lee E, et al. STAT3 activation in endothelial cells is important for tumor metastasis via increased cell adhesion molecule expression. Oncogene. 2017;36:5445-5459 pubmed publisher
    ..Collectively, our findings demonstrate that STAT3 activation in ECs promotes tumor metastasis through the induction of cell adhesion molecules, demonstrating a role for ECs in response to tumor cells during tumor metastasis. ..
  20. Shen L, Chou H, Kato M. TIF1? is phosphorylated at serine 473 in colorectal tumor cells through p38 mitogen-activated protein kinase as an oxidative defense mechanism. Biochem Biophys Res Commun. 2017;492:310-315 pubmed publisher
    ..Taken together, this suggests that it is primarily peroxide-induced p38 MAPK that mediates Ser473 phosphorylation and activation of TIF1? to enable more efficient DNA repair to assist in tumor cell survival against exogenous ROS. ..
  21. Colangelo T, Polcaro G, Ziccardi P, Pucci B, Muccillo L, Galgani M, et al. Proteomic screening identifies calreticulin as a miR-27a direct target repressing MHC class I cell surface exposure in colorectal cancer. Cell Death Dis. 2016;7:e2120 pubmed publisher
    ..These results may pave the way for better diagnosis, patient stratification and novel therapeutic approaches. ..
  22. Park Y, Lee S, Kim S, Liu Y, Lee M, Shin J, et al. MicroRNA-9 suppresses cell migration and invasion through downregulation of TM4SF1 in colorectal cancer. Int J Oncol. 2016;48:2135-43 pubmed publisher
    ..whereas, overexpression of anti-miR-9 and siRNA-TM4SF1 inversely regulated the TM4SF1 mRNA and protein level in HCT116 cells. Furthermore, miR-9 suppressed not only TM4SF1 expression but also MMP-2, MMP-9 and VEGF expression...
  23. Zhao H, Ning S, Nolley R, Scicinski J, Oronsky B, Knox S, et al. The immunomodulatory anticancer agent, RRx-001, induces an interferon response through epigenetic induction of viral mimicry. Clin Epigenetics. 2017;9:4 pubmed publisher
    ..The striking safety profile of RRx-001 in comparison to other more toxic epigenetic and immunomodulatory agents such as azacitidine makes it a leading candidate for such clinical applications. ..
  24. Li J, Teng Y, Liu S, Wang Z, Chen Y, Zhang Y, et al. Cinnamaldehyde affects the biological behavior of human colorectal cancer cells and induces apoptosis via inhibition of the PI3K/Akt signaling pathway. Oncol Rep. 2016;35:1501-10 pubmed publisher
    ..The mechanisms of action involve the regulation of expression of genes involved in apoptosis, invasion and adhesion via inhibition of the PI3K/Akt signaling pathway. ..
  25. Wang H, Wang Y, Du Q, Lu P, Fan H, Lu J, et al. Inflammasome-independent NLRP3 is required for epithelial-mesenchymal transition in colon cancer cells. Exp Cell Res. 2016;342:184-92 pubmed publisher
    ..In summary, our results showed that the NLRP3 expression, not the inflammasome activation, was required for EMT in colorectal cancer cells. ..
  26. Ma J, Li J, Tian Y. Synthesis and bioactivity evaluation of 2,3-diaryl acrylonitrile derivatives as potential anticancer agents. Bioorg Med Chem Lett. 2017;27:81-85 pubmed publisher
    ..In particular, compounds 4d and 4p were found to be the most potent against HeLa (4.20?M) and HCT116 cells (0...
  27. Liu S, Liu B. Overexpression of Nitrogen Permease Regulator Like-2 (NPRL2) Enhances Sensitivity to Irinotecan (CPT-11) in Colon Cancer Cells by Activating the DNA Damage Checkpoint Pathway. Med Sci Monit. 2018;24:1424-1433 pubmed
    ..RESULTS A CCK8 assay revealed that the overexpression of NPRL2 improved the sensitivity of CPT-11 in HCT116 cells (P<0.05)...
  28. Ben Salem I, Prola A, Boussabbeh M, Guilbert A, Bacha H, Lemaire C, et al. Activation of ER stress and apoptosis by α- and β-zearalenol in HCT116 cells, protective role of Quercetin. Neurotoxicology. 2016;53:334-342 pubmed publisher
    ..We investigated the possible underlying mechanism in α-ZOL and β-ZOL-induced toxicity in HCT116 cells. We showed that cell treatment with α-ZOL/β-ZOL generated endoplasmic reticulum (ER) stress and activated ..
  29. Yousef B, Hassan H, Guerram M, Hamdi A, Wang B, Zhang L, et al. Pristimerin inhibits proliferation, migration and invasion, and induces apoptosis in HCT-116 colorectal cancer cells. Biomed Pharmacother. 2016;79:112-9 pubmed publisher
    ..Collectively, pristimerin exerted both in vitro and in vivo cytotoxic and anti-metastatic effects on HCT-116 cells, suggesting that pristimerin has potential as a new anticancer drug for treatment of colon cancer. ..
  30. Lai M, Chang C, Sun H. Hypoxia Induces Autophagy through Translational Up-Regulation of Lysosomal Proteins in Human Colon Cancer Cells. PLoS ONE. 2016;11:e0153627 pubmed publisher
    ..that hypoxia inhibits translation through activation of PERK and inactivation of mTOR in human colon cancer HCT116 cells. Prolonged hypoxia (1% O2, 16 h) dramatically inhibits general translation in HCT116 cells, yet selected mRNAs ..
  31. Ai G, Dachineni R, Kumar D, Alfonso L, Marimuthu S, Bhat G. Aspirin inhibits glucose?6?phosphate dehydrogenase activity in HCT 116 cells through acetylation: Identification of aspirin-acetylated sites. Mol Med Rep. 2016;14:1726-32 pubmed publisher
  32. Ben Salem I, Boussabbeh M, Kantaoui H, Bacha H, Abid Essefi S. Crocin, the main active saffron constituent, mitigates dichlorvos-induced oxidative stress and apoptosis in HCT-116 cells. Biomed Pharmacother. 2016;82:65-71 pubmed publisher
    ..effects, against the cytotoxicity and the apoptosis produced by exposure to Dichlorvos (DDVP) in HCT116 cells were investigated in this work...
  33. Eshelman M, Shah M, Raup Konsavage W, Rennoll S, Yochum G. TCF7L1 recruits CtBP and HDAC1 to repress DICKKOPF4 gene expression in human colorectal cancer cells. Biochem Biophys Res Commun. 2017;487:716-722 pubmed publisher
    ..These findings uncover a critical role for TCF7L1 in repressing DKK4 gene expression to promote the oncogenic potential of CRCs. ..
  34. Chen T, Zheng F, Tao J, Tan S, Zeng L, Peng X, et al. Insulin-Like Growth Factor-1 Contributes to Mucosal Repair by β-Arrestin2-Mediated Extracellular Signal-Related Kinase Signaling in Experimental Colitis. Am J Pathol. 2015;185:2441-53 pubmed publisher
    ..Furthermore, β-arrestin2 was overexpressed or altered in HCT116 cells by transfection before IGF-1 treatment in vitro...
  35. Mazzoccoli G, Colangelo T, Panza A, Rubino R, De Cata A, Tiberio C, et al. Deregulated expression of cryptochrome genes in human colorectal cancer. Mol Cancer. 2016;15:6 pubmed publisher
    ..as an additional layer of regulation: higher CRY1 and CRY2 protein levels coincided with a wild type p53 as in HCT116 cells and this condition only marginally affected the apoptotic and cell proliferation characteristics of the cells ..
  36. Yan J, Zhang F, Huang Q. FTIR Microspectroscopy Probes Particle-Radiation Effect on HCT116 cells (p53+/+, p53-/-). Radiat Res. 2017;: pubmed publisher
    ..After alpha-particle irradiation of HCT116 cells (p53+/+, p53-/-), cell cycle arrest, DNA damage and lipid peroxidation in the cancer ..
  37. Stein U, Jurchott K, Walther W, Bergmann S, Schlag P, Royer H. Hyperthermia-induced nuclear translocation of transcription factor YB-1 leads to enhanced expression of multidrug resistance-related ABC transporters. J Biol Chem. 2001;276:28562-9 pubmed
    ..However, a combination of hyperthermia and drug treatment effectively reduced cell survival of the HCT15 and HCT116 cells. These results demonstrate that activation of MDR1 and MRP1 gene expression and increased efflux pump activity ..
  38. Park S, Lee S, Cho H, Kim T, Kim J, Kim J, et al. Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer. Oncotarget. 2016;7:9501-12 pubmed publisher
    ..These results suggest that DPEP1 promotes cancer metastasis by regulating E-cadherin plasticity and that it might be a potential therapeutic target for preventing the progression of colon cancer. ..
  39. Shin S, Ahn S, Koh D, Lim Y. p53-dependent and -independent mechanisms are involved in (E)-1-(2-hydroxyphenyl)-3-(2-methoxynaphthalen-1-yl)prop-2-en-1-one (HMP)-induced apoptosis in HCT116 colon cancer cells. Biochem Biophys Res Commun. 2016;479:913-919 pubmed publisher
    ..These results suggest that HMP triggers caspase-mediated apoptosis through two distinct mechanisms involving p53-dependent and p53-independent, Egr-1-dependent pathways. ..
  40. Xiao Y, Yang X, Miao Y, He X, Wang M, Sha W. Inhibition of cell proliferation and tumor growth of colorectal cancer by inhibitors of Wnt and Notch signaling pathways. Oncol Lett. 2016;12:3695-3700 pubmed
    ..Our results may pave the way for using inhibitors of Wnt and Notch signaling pathways together to treat colorectal cancer. ..
  41. Hichri F, Znati M, Bouajila J, Ben Jannet H. New cytotoxic sesquiterpene lactones from Achillea cretica L. growing in Tunisia. J Asian Nat Prod Res. 2017;:1-8 pubmed publisher
    ..It has been found that achicretin 2 exhibited more potent inhibitory activity with IC50 = values of 14.0 ± 1.0 and 16.0 ± 2.0 ?M against OVCAR-3 and HCT-116 cells, respectively...
  42. Chen Y, Jiang T, Shi L, He K. hcrcn81 promotes cell proliferation through Wnt signaling pathway in colorectal cancer. Med Oncol. 2016;33:3 pubmed publisher
    ..LoVo(+hcrcn81) and SMMC-7721(+hcrcn81) cells were tested, of which hcrcn81 was knockdown in LS174T, HCT116 cells and hcrcn81 was overexpressed in LoVo, SMMC-7721 cells...
  43. Xu J, Zhou L, Ji L, Chen F, Fortmann K, Zhang K, et al. The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis. Nat Commun. 2016;7:10761 pubmed publisher
    ..In sum, this study identifies REGγ-mediated control of IκBɛ as a molecular mechanism that contributes to NFκB activation and promotes bowel inflammation and associated tumour formation in response to chronic injury. ..
  44. Chopra A, Bond M, Bleiler M, Yeagley M, Wright D, Giardina C. Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301. PLoS ONE. 2016;11:e0153818 pubmed publisher
    ..Together with a reversible arrest state, AK301 is a potent promoter of a mitosis-to-apoptosis transition that can target cancer cells with mitotic defects. ..
  45. Zhang J, Wang J, Xu J, Lu Y, Jiang J, Wang L, et al. Curcumin targets the TFEB-lysosome pathway for induction of autophagy. Oncotarget. 2016;7:75659-75671 pubmed publisher
    ..In this study, we first found that Curcumin treatment enhances autophagic flux in both human colon cancer HCT116 cells and mouse embryonic fibroblasts (MEFs)...
  46. Shaker S, Marzouk M. Utilization of Cyanoacetohydrazide and Oxadiazolyl Acetonitrile in the Synthesis of Some New Cytotoxic Heterocyclic Compounds. Molecules. 2016;21:155 pubmed publisher
    ..Also they were tested as antioxidants. Almost all of the tested compounds showed satisfactory activity. ..
  47. Zhdanov A, Aviello G, Knaus U, Papkovsky D. Cellular ROS imaging with hydro-Cy3 dye is strongly influenced by mitochondrial membrane potential. Biochim Biophys Acta Gen Subj. 2017;1861:198-204 pubmed publisher
    ..intensity and localisation of a commercial hydro-Cy3 probe in respiring and non-respiring colon carcinoma HCT116 cells. We found that the oxidised (fluorescent) form of hydro-Cy3 is highly homologous to the common ??m-sensitive ..
  48. Muralidharan V, Alagumuthu M, Iyer S. Iodine catalyzed three component synthesis of 1-((2-hydroxy naphthalen-1-yl)(phenyl)(methyl))pyrrolidin-2-one derivatives: Rationale as potent PI3K inhibitors and anticancer agents. Bioorg Med Chem Lett. 2017;27:2510-2514 pubmed publisher
    ..22nM and 107.39nM). The SAR studies demonstrated that the most potent compounds are 4c and 4f and can be developed into precise PI3K inhibitors with the capability to treat various cancers. ..
  49. Kang S, Kim W, Jeong S, Lee Y, Nam J, Lee S, et al. Oxidized 5-aminosalicylic acid activates Nrf2-HO-1 pathway by covalently binding to Keap1: Implication in anti-inflammatory actions of 5-aminosalicylic acid. Free Radic Biol Med. 2017;108:715-724 pubmed publisher
    ..Human colon carcinoma HCT116 cells were treated with HOCl-reacted 5-ASA. Oxidized 5-ASA activated Nrf2 while 5-ASA itself was not effective...
  50. Kowalczyk K, Błauz A, Ciszewski W, Wieczorek A, Rychlik B, Plazuk D. Colchicine metallocenyl bioconjugates showing high antiproliferative activities against cancer cell lines. Dalton Trans. 2017;46:17041-17052 pubmed publisher
    ..and Rc5 are 6-7 times more cytotoxic toward HepG2 cells, while Fc4 and Fc5 are two times more cytotoxic toward HCT116 cells as colchicine...
  51. Valley M, Karassina N, Aoyama N, Carlson C, Cali J, Vidugiriene J. A bioluminescent assay for measuring glucose uptake. Anal Biochem. 2016;505:43-50 pubmed publisher
    ..Significant assay signals of 2-fold or more have also been measured with human induced pluripotent stem cell (iPSC)-derived cardiomyocytes and skeletal myoblasts. ..
  52. Ma M, Bai J, Ling Y, Chang W, Xie G, Li R, et al. Monoacylglycerol lipase inhibitor JZL184 regulates apoptosis and migration of colorectal cancer cells. Mol Med Rep. 2016;13:2850-6 pubmed publisher
    ..Therefore, in colorectal cancer, MAGL may be considered a potential therapeutic target and JZL184 may be a possible therapeutic agent...
  53. Piaru S, Mahmud R, Abdul Majid A, Ismail S, Man C. Chemical composition, antioxidant and cytotoxicity activities of the essential oils of Myristica fragrans and Morinda citrifolia. J Sci Food Agric. 2012;92:593-7 pubmed
    ..In this study the chemical composition, antioxidant activities and cytotoxic effect of the essential oils of Myristica fragrans (nutmeg) and Morinda citrifolia (mengkudu) were determined...
  54. Li H, Zhang H, Chen Y, Liu X, Qian J. MiR-423-3p enhances cell growth through inhibition of p21Cip1/Waf1 in colorectal cancer. Cell Physiol Biochem. 2015;37:1044-54 pubmed publisher
    ..Importantly, all these data were validated in the tumorigenesis assay in vivo. In conclusion, our findings demonstrated a critical impact of miR-423-3p on CRC growth. ..
  55. Wright D, Marchal C, Hoang K, Ankney J, Nguyen S, Rushing A, et al. Human T-cell leukemia virus type-1-encoded protein HBZ represses p53 function by inhibiting the acetyltransferase activity of p300/CBP and HBO1. Oncotarget. 2016;7:1687-706 pubmed publisher
    ..This mechanism may explain how p53 activity is restricted in ATL cells that do not express Tax due to modifications of the HTLV-1 provirus, which accounts for a majority of patient samples. ..
  56. Bersani C, Huss M, Giacomello S, Xu L, Bianchi J, Eriksson S, et al. Genome-wide identification of Wig-1 mRNA targets by RIP-Seq analysis. Oncotarget. 2016;7:1895-911 pubmed publisher
    ..Since Wig-1 is a transcriptional target of the tumor suppressor p53, these results have implications for our understanding of p53-dependent stress responses and tumor suppression...
  57. Jensen N, Agama K, Roy A, Smith D, Pfister T, Rømer M, et al. Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations. J Exp Clin Cancer Res. 2016;35:56 pubmed publisher
    ..Importantly, two yet unreported TOP1 mutations were identified, and it was underlined that cross-resistance to the new indenoisoquinoline drugs depends on the specific underlying molecular mechanism of resistance to SN-38. ..
  58. Naraginti S, Li Y. Preliminary investigation of catalytic, antioxidant, anticancer and bactericidal activity of green synthesized silver and gold nanoparticles using Actinidia deliciosa. J Photochem Photobiol B. 2017;170:225-234 pubmed publisher
    ..The AgNPs treated HCT116 cells showed 78% viability at highest concentration (350?g/mL), while AuNPs showed 71% viability at highest ..
  59. Nicolaides N, Skyrla E, Vlachakis D, Psarra A, Moutsatsou P, Sertedaki A, et al. Functional characterization of the hGRαT556I causing Chrousos syndrome. Eur J Clin Invest. 2016;46:42-9 pubmed publisher
    ..The hGRαT556I causes Chrousos syndrome by impairing multiple steps of the glucocorticoid signal transduction pathway. ..
  60. Zhao Q, Xu X, Xie Z, Liu X, You Q, Guo Q, et al. Design, synthesis and biological evaluation of 3-substituted indenoisoquinoline derivatives as topoisomerase I inhibitors. Bioorg Med Chem Lett. 2016;26:1068-1072 pubmed publisher
    ..The most potent compounds 9a and 10a demonstrated more cytotoxicity than HCPT and TPT and was comparable to CPT in inhibitory activities on Top I in our biological assay. ..
  61. Zhao L, Zheng W, Wang G, Kang X, Qin L, Ji J, et al. Epigenetic silencing of miR-181b contributes to tumorigenicity in colorectal cancer by targeting RASSF1A. Int J Oncol. 2016;48:1977-84 pubmed publisher
  62. Lv H, Zhang Z, Wang Y, Li C, Gong W, Wang X. MicroRNA-92a Promotes Colorectal Cancer Cell Growth and Migration by Inhibiting KLF4. Oncol Res. 2016;23:283-290 pubmed
    ..This could be an alternative therapeutic target for CRC. ..
  63. Ding L, Sun R, Zhang X. Rap2b siRNA significantly enhances the anticancer therapeutic efficacy of adriamycin in a gold nanoshell-based drug/gene co-delivery system. Oncotarget. 2017;8:21200-21211 pubmed publisher
    Rap2b is a novel p53 target we have identified recently. Knockdown of Rap2b sensitizes HCT116 cells to adriamycin-induced apoptosis, indicating that Rap2b promotes adriamycin resistance in cancer cells...
  64. Abouzid K, Al Ansary G, El Naggar A. Eco-friendly synthesis of novel cyanopyridine derivatives and their anticancer and PIM-1 kinase inhibitory activities. Eur J Med Chem. 2017;134:357-365 pubmed publisher
    ..Finally, a molecular docking study was conducted to reveal the probable interaction with the Pim-1 kinase active site. ..
  65. Gao D, Wang Y, Xie W, Yang T, Jiang Y, Guo Y, et al. Metabolomics study on the antitumor effect of marine natural compound flexibilide in HCT-116 colon cancer cell line. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1014:17-23 pubmed publisher
    ..The UPLC/Q-TOF MS based metabolomics approach provides new insights into the mechanistic studies of flexibilide on tumor cells, which benefit its further improvement and application. ..
  66. Buj R, Mallona I, Díez Villanueva A, Barrera V, Mauricio D, Puig Domingo M, et al. Quantification of unmethylated Alu (QUAlu): a tool to assess global hypomethylation in routine clinical samples. Oncotarget. 2016;7:10536-46 pubmed publisher
    ..In conclusion, QUAlu is a simple and robust method to determine Alu hypomethylation in human biospecimens and may be easily implemented in research and clinical settings...
  67. Choi H, Ryu H, Son A, Seo B, Hwang S, Song J, et al. The novel anthraquinone derivative IMP1338 induces death of human cancer cells by p53-independent S and G2/M cell cycle arrest. Biomed Pharmacother. 2016;79:308-14 pubmed publisher
    ..These results provide a basis for future investigations assessing the promising anticancer properties of IMP1338. ..
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    ..was submitted to bioassay-guided fractionation, leading to isolation of the bioactive piericidins A and C, glucopiericidin, and three known diketopiperazines, cyclo(l-Phe-trans-4-OH-l-Pro), cyclo(l-Phe-l-Pro), and cyclo(l-Trp-l-Pro). ..
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    ..Collectively, our findings established a functional role for thrombin and its targets PAR-1 and fibrinogen in the pathogenesis of colonic adenocarcinoma, supporting tumor growth as well as local invasion and metastasis. ..
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    ..These miRNAs have the potential for use in colon cancer therapy as they are related to p53, pro- or anti-inflammatory cyto- or chemokines after the radiation and SN38 treatment. ..
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    ..The present study suggests that the ternary complexes stabilized with hyaluronic acid-green tea catechin conjugates can be widely utilized for CD44-targeted delivery of nucleic acid-based therapeutics. ..
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    ..The p.Q1853E variant of ALPK2, which had been accumulating in the Japanese population, induced a metastatic phenotype by disrupting ALPK2 function. ..
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    ..These results suggest a potential mechanism to target mutant KRAS signalling through ECT2 in cancers that are reliant on activating KRAS mutations and remain refractory to current treatments. ..
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    ..Taken together, our results suggest that the BMP-2 induced STAT3-mediated induction of colon cancer cell metastasis requires an EMT and/or changes in CSC markers. ..
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    ..Tyr118 phosphorylation even without involvement of FAK, so that specific inhibition of ERK or KRS in parental HCT116 cells blocked cell-cell adhesion and cell-substrate properties for focal adhesion formation and signaling activity...
  82. Huun J, Gansmo L, Mannsåker B, Iversen G, Øvrebø J, Lønning P, et al. Impact of the MDM2 splice-variants MDM2-A, MDM2-B and MDM2-C on cytotoxic stress response in breast cancer cells. BMC Cell Biol. 2017;18:17 pubmed publisher
    ..Although MDM2-B induced slight changes in the cell cycle profile, overall, we found the impact of the three MDM2 splice variants on potential cellular endpoints upon doxorubicin treatment to be limited. ..
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  84. Long Z, Bai Z, Song J, Zheng Z, Li J, Zhang J, et al. miR-141 Inhibits Proliferation and Migration of Colorectal Cancer SW480 Cells. Anticancer Res. 2017;37:4345-4352 pubmed
    ..in SW480 cells was not affected by miR-141. Our results suggest that miR-141 functions as a tumor suppressor through ZEB2 and HGFR in CRC cells. ..
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    ..These results suggest a novel regulatory mechanism for mTOR gene expression that integrates the global protein synthesis changes induced by translational inhibitory conditions. ..
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    ..The wavy-HB chip may serve as a promising platform for CTC capture and cancer diagnosis. ..
  87. Shang D, Ma Q, Wei R. Cytotoxic phenylpropanoid glycosides from Cirsium japonicum. J Asian Nat Prod Res. 2016;18:1122-1130 pubmed
    ..35-11.32 ?M. The known compounds 4-12 were obtained from this plant for the first time...
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    ..Sustained calcium supplementation was able to enhance the potency of 5-FU targeting the primary CRC. ..
  89. Shi W, Yan D, Zhao C, Xiao M, Wang Y, Ma H, et al. Inhibition of IL-6/STAT3 signaling in human cancer cells using Evista. Biochem Biophys Res Commun. 2017;491:159-165 pubmed publisher
    ..These results suggest that it may be possible for Evista to emerge as a chemoprevention agent for breast cancer and other cancers such as colon cancer or multiple myeoloma by targeting IL-6/STAT3 signaling. ..
  90. McNulty S, Sullivan L, Sullivan B. Human Centromeres Produce Chromosome-Specific and Array-Specific Alpha Satellite Transcripts that Are Complexed with CENP-A and CENP-C. Dev Cell. 2017;42:226-240.e6 pubmed publisher
    ..This work shows that each human alpha satellite array produces a unique set of non-coding transcripts, and RNAs present at active centromeres are necessary for kinetochore assembly and cell-cycle progression. ..
  91. Ding W, Tong Y, Zhang X, Pan M, Chen S. Study of Arsenic Sulfide in Solid Tumor Cells Reveals Regulation of Nuclear Factors of Activated T-cells by PML and p53. Sci Rep. 2016;6:19793 pubmed publisher
    ..that AS and cyclosporine A (CsA) exerted synergistic inhibitory effect on cell growth and c-Myc expression in HCT116 cells. AS inhibited the expression of PML, c-Myc, NFATc1, NFATc3, and NFATc4, while stimulating the expression of p53 ..
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    ..In summary, it is expected that HA-UMCS will offer a new method for targeted co-delivery of drugs to tumors overexpressing CD44 receptors. ..