tumor cell line

Summary

Summary: A cell line derived from cultured tumor cells.

Webpages

  1. franklin g. berger
    www.biol.sc.edu/faculty/berger.html
  2. nereus pharmaceuticals - novel drug discovery - screening
    www.nereuspharm.com/screening.shtml
  3. faculty profile
    lifesciences.umaryland.edu/faculty/default.asp?ID=193
  4. rugers las - working safely with animals
    las.rutgers.edu/working.htm
  5. faculty research summary: prof. bruce s. babiarz
    cbn.rutgers.edu/faculty/faculty.php?f=babiarz
  6. ricinus
    lib.bioinfo.pl/meid:55870
  7. ming zhang, phd
    www.feinberg.northwestern.edu/igp/facindex/ZhangM.html
  8. henry h. q. heng, ph.d
    cmmg.biosci.wayne.edu/Faculty/heng/heng.htm
  9. roswell park cancer institute - dolnick, bruce, phd - comprehensive cancer center
    www.roswellpark.org/document.asp?lid=3386&print=true
  10. environmental health perspectives 105, supplement 4, june 1997: article by kurelec
    www.ehponline.org/members/1997/Suppl-4/kurelec-full.html

Research Grants

  1. MELK as Functional Marker for Mammary Tumors
    Alexey V Terskikh; Fiscal Year: 2008
  2. BENEFICIAL EFFECTS OF GINKGO BILOBA IN CANCER
    Vassilios Papadopoulos; Fiscal Year: 2002
  3. Molecular Targeting and Imaging of Pituitary Adenomas
    Nelson M Oyesiku; Fiscal Year: 2008
  4. The Role of Spermidine/Spermine N1-Acetyltransferase on
    Deborah A Carper; Fiscal Year: 2006
  5. Molecular Targeting and Imaging of Pituitary Adenomas
    Nelson M Oyesiku; Fiscal Year: 2007
  6. Molecular Mechanisms of Phenolic Agent-induced Apoptosis
    Ah-Ng Kong; Fiscal Year: 2006
  7. TELOMERIC REPEATS AND THE RESPONSE TO IONIZING RADIATION
    John P Murnane; Fiscal Year: 2004
  8. CLA as a Mediator of Human Prostate Tumor Metastasis
    Charles J Dimitroff; Fiscal Year: 2005
  9. Neural Control of Large Intestinal Mucosa
    Helen J Cooke; Fiscal Year: 2005
  10. Gene Therapy for Prostate Cancer
    Selvarangan Ponnazhagan; Fiscal Year: 2007

Publications

  1. A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model
    Hui Guan
    Division of Pediatrics and Departments of Cancer Biology and Surgical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 11:2662-9
  2. Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line
    Hector Biliran
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Clin Cancer Res 11:6075-86
  3. Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways
    Sudhakar Chintharlapalli
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843, USA
    J Biol Chem 280:24903-14
  4. Suppression of colorectal tumor growth by regulated survivin targeting
    Binghua Li
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
    J Mol Med 84:1077-86
  5. Possible involvement of RUNX3 silencing in the peritoneal metastases of gastric cancers
    Chouhei Sakakura
    Surgery and Regenerative Medicine, Kyoto Prefectural University of Medicine, Japan
    Clin Cancer Res 11:6479-88
  6. Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth
    Peiwen Fei
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cancer Cell 6:597-609
  7. Stable suppression of tumorigenicity by Pin1-targeted RNA interference in prostate cancer
    Akihide Ryo
    Department of Pathology, Yokohama City University School of Medicine, Yokohama, Japan
    Clin Cancer Res 11:7523-31
  8. Ovarian carcinomas: CCN genes are aberrantly expressed and CCN1 promotes proliferation of these cells
    Sigal Gery
    Division of Hematology Oncology, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Clin Cancer Res 11:7243-54
  9. Knockdown of RAB25 expression by RNAi inhibits growth of human epithelial ovarian cancer cells in vitro and in vivo
    Yang Fan
    Department of Obstetrics and Gynecology, Xijing Hospital Fourth Military Medical University, Xi an, China
    Pathology 38:561-7
  10. Synergistic effects of acyclic retinoid and OSI-461 on growth inhibition and gene expression in human hepatoma cells
    Masahito Shimizu
    Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Clin Cancer Res 10:6710-21

Scientific Experts

Detail Information

Webpages23

  1. franklin g. berger
    www.biol.sc.edu/faculty/berger.html
  2. nereus pharmaceuticals - novel drug discovery - screening
    www.nereuspharm.com/screening.shtml
  3. faculty profile
    lifesciences.umaryland.edu/faculty/default.asp?ID=193
  4. rugers las - working safely with animals
    las.rutgers.edu/working.htm
  5. faculty research summary: prof. bruce s. babiarz
    cbn.rutgers.edu/faculty/faculty.php?f=babiarz
  6. ricinus
    lib.bioinfo.pl/meid:55870
  7. ming zhang, phd
    www.feinberg.northwestern.edu/igp/facindex/ZhangM.html
  8. henry h. q. heng, ph.d
    cmmg.biosci.wayne.edu/Faculty/heng/heng.htm
  9. roswell park cancer institute - dolnick, bruce, phd - comprehensive cancer center
    www.roswellpark.org/document.asp?lid=3386&print=true
  10. environmental health perspectives 105, supplement 4, june 1997: article by kurelec
    www.ehponline.org/members/1997/Suppl-4/kurelec-full.html
  11. dtp - human tumor cell line screen
    dtp.nci.nih.gov/docs/cancer/cancer_data.html
  12. supporting johns hopkins research
    pathology.jhu.edu/pancreas/support.php
  13. linking gene expression patterns to therapeutic groups in breast cancer
    mbcf.dfci.harvard.edu/labs/pardee/expression_patterns.html
  14. medline publication: effects of methylselenocysteine on pkc activity, cdk2 phosphorylation and gadd gene expression in synchronized mouse mammary epithelial tumor cells
    www.fred.psu.edu/ds/retrieve/fred/medlinepub/10656618
  15. indolequinones
    lib.bioinfo.pl/meid:185368
  16. prostate cancer and diseases of the prostate - center for prostate disease research
    www.cpdr.org/about/gene_expression.html
  17. pasteurella pneumotropica causa la regresion de tumores humanos trasplantados en ratones inmunodeficientes
    www.infodoctor.org/cgi-bin/abstracts.pl?uid=16871912
  18. medline publication: correlation between human cell growth response to interleukin 1 and receptor binding
    www.fred.psu.edu/ds/retrieve/fred/medlinepub/2970890
  19. adrenomedullin expression in human tumor cell line...[j biol chem. 1996] - pubmed result
    www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMe ...
  20. cell line, tumor
    matusevicius.lib.bioinfo.pl/meid:1106

Research Grants62

  1. MELK as Functional Marker for Mammary Tumors
    Alexey V Terskikh; Fiscal Year: 2008
    ..MELK expression marks PyMT tumors in vivo and that knocking down MELK expression inhibits growth of a mammary tumor cell line in vitro...
  2. BENEFICIAL EFFECTS OF GINKGO BILOBA IN CANCER
    Vassilios Papadopoulos; Fiscal Year: 2002
    ..Ginkgo biloba leaves (EGB 761) inhibited PBR expression and cell proliferation in the aggressive human breast tumor cell line MDA-23 1, but not in a non-aggressive cell line...
  3. Molecular Targeting and Imaging of Pituitary Adenomas
    Nelson M Oyesiku; Fiscal Year: 2008
    ..In Aim 1, we will test the hypothesis (i) by cell culture of a pituitary tumor cell line, aT3-1, which is a model of human NF tumors...
  4. The Role of Spermidine/Spermine N1-Acetyltransferase on
    Deborah A Carper; Fiscal Year: 2006
    ..Previous work with a human tumor cell line has shown that IPENSpm and BENSpm behave similarly by reducing polyamine amounts through an increase in SSAT ..
  5. Molecular Targeting and Imaging of Pituitary Adenomas
    Nelson M Oyesiku; Fiscal Year: 2007
    ..In Aim 1, we will test the hypothesis (i) by cell culture of a pituitary tumor cell line, aT3-1, which is a model of human NF tumors...
  6. Molecular Mechanisms of Phenolic Agent-induced Apoptosis
    Ah-Ng Kong; Fiscal Year: 2006
    ..whether the activation of the MAPK (ERK, JNK, and p38) pathway by EGCG and other tea polyphenols in two human tumor cell line models (cervical squamous carcinoma HeLa, and colon HT29) is involved in apoptosis...
  7. TELOMERIC REPEATS AND THE RESPONSE TO IONIZING RADIATION
    John P Murnane; Fiscal Year: 2004
    ..The analysis of spontaneous HSV- tk mutants in the EJ-30 tumor cell line have demonstrated that telomere loss can result in either terminal deletions involving chromosome healing or ..
  8. CLA as a Mediator of Human Prostate Tumor Metastasis
    Charles J Dimitroff; Fiscal Year: 2005
    ..We have obtained preliminary evidence showing that a human prostate tumor cell line derived from bone metastases expresses the leukocyte E-selectin ligand, cutaneous lymphocyte-associated ..
  9. Neural Control of Large Intestinal Mucosa
    Helen J Cooke; Fiscal Year: 2005
    ..pig, human or nucleotide- receptor deficient mice n response to mechanical stimulation or in a carcinoid tumor cell line, BON...
  10. Gene Therapy for Prostate Cancer
    Selvarangan Ponnazhagan; Fiscal Year: 2007
    ..angiostatin, endostatin and sFlt-1 have shown protection against the growth of a human epithelial ovarian tumor cell line in athymic mice indicating the efficacy of AAV-mediated anti-angiogenic gene therapy...
  11. CORE--CHEMOTHERAPY
    William R Waud; Fiscal Year: 2004
    ..evaluations will be conducted using one of the three leading prodrugs and varying proportions of a parental tumor cell line and the corresponding Lentivirus transduced line (e.g., 10%, 1%, 0.1%, and 0.01% transduced line)...
  12. INSTABILITY OF MICROSATELLITES IN MAMMALIAN CELLS
    ROSANN FARBER; Fiscal Year: 2004
    ..results in elevation of mutation rates in the fibroblasts; these rates will be compared with those in a tumor cell line with a mutation in the same gene...
  13. Development and standardization of retrovirus detection
    Arifa S Khan; Fiscal Year: 2002
    ..In fact, in one human tumor cell line, there was no replication of any of the Rh or Pt isoaltes...
  14. Animal Model for Local Inflammation-Induced Breast Cancer
    Harikrishna Nakshatri; Fiscal Year: 2007
    ..Our studies have shown that mammary tumor cell line derived from transgenic mice expressing her2/neu oncogene have markedly increased NF-?B activation and ..
  15. Animal Model for Local Inflammation-Induced Breast Cancer
    Harikrishna Nakshatri; Fiscal Year: 2008
    ..Our studies have shown that mammary tumor cell line derived from transgenic mice expressing her2/neu oncogene have markedly increased NF-?B activation and ..
  16. VALIDATION OF A HUMAN CD34+ STEM CELL TOXICITY BIOASSAY
    Leslie Recio; Fiscal Year: 2008
    ..critical genes that regulate cellular responses to stressors, the results of environmental agents tested in tumor cell line-based assays may have limited relevance to human health and disease, and there is a need for a human primary ..
  17. Bone-Homing Molecules on Human Prostate Tumor Cells
    Charles J Dimitroff; Fiscal Year: 2004
    ..We have preliminary evidence showing that a human bone-metastatic prostate tumor cell line expresses a known leukocyte E-selectin ligand, but there is no definitive evidence on its function on these ..
  18. Validation of Galectin-3 as a Target in Cancer Therapy
    Fu-Tong Liu; Fiscal Year: 2003
    ..We have demonstrated galectin-3's involvement in promoting proliferation of a leukemic tumor cell line under suboptimal growth conditions, and in inhibition of apoptosis...
  19. Biobehavioral-Cytokine Interactions in Ovarian Cancer
    Susan K Lutgendorf; Fiscal Year: 2007
    ..we have observed that stress hormones, such as norepinephrine, induce production of VEGF from an ovarian tumor cell line and that these tumor cells also express beta-adrenergic receptors...
  20. Labeling of Octreotide with Positron Emitters
    Carolyn J Anderson; Fiscal Year: 2006
    ..in SSTR2 analogs (TETA- vs CB-TE2A-Y3-TATE) correlates to different nuclear localization in a SSTr2-positive tumor cell line (Aim 1). These data will be correlated to cell killing data in the same cell line (Aim 2)...
  21. Regulation by kruppel like factor in the colon
    CHI-CHUAN C TSENG; Fiscal Year: 2005
    ..is reduced in colon cancer tissue and that constitutive expression of an antisense GKLF DNA in a colon tumor cell line results in cell hyperproliferation...
  22. Novel TNF Chimeric Vector for Treatment of Pancreatic Cancer
    Tony R Reid; Fiscal Year: 2008
    ..To do this, each tumor cell line will be characterized with respect to expression of TNF on the cell surface by flow cytometry, release of TNF ..
  23. A Novel HTS Cell-Based Assay For Cyclic GMP
    Gary A Piazza; Fiscal Year: 2007
    ..The specific aims of this proposal are to: 1) generate a stable transfected colon tumor cell line that expresses the cGMP biosensor, 2) develop an image-based assay to measure cGMP levels in transfected cell ..
  24. Novel Recombinant Immunoglobulin Forms for Cancer Therap
    Jeffrey Schlom; Fiscal Year: 2005
    ..The HuCOL-1SDR showed similar binding reactivity to the CEA expressed on the surface of a tumor cell line as the HuCOL-1...
  25. Novel TNF Chimeric Vector for Treatment of Pancreatic Cancer
    Tony R Reid; Fiscal Year: 2007
    ..To do this, each tumor cell line will be characterized with respect to expression of TNF on the cell surface by flow cytometry, release of TNF ..
  26. MELANOMA ANTIGENS INDENTIFIED FROM GMCSF VACCINATION
    FRANK S HODI; Fiscal Year: 2002
    ..from initial screening with autologous sera of a cDNA expression library constructed from a patient's tumor cell line. The first revealed a novel product with structural similarities to MUC-1, a member of a family of ..
  27. Molecular Beacon Aptamer for Diagnostic Cancer Imaging
    Weihong Tan; Fiscal Year: 2002
    ..The new imaging and sensing techniques will then be applied for tumor cell line and tissue sample study...
  28. DNA vaccines for metastatic breast cancer at old age
    Claudia Gravekamp; Fiscal Year: 2008
    ..The model is based on the injection of a syngeneic mouse mammary tumor cell line into immune competent mice, which then give rise to metastatic breast cancer without immunological rejection...
  29. Analysis of Loss of Function of MAD2 in Mammals
    Loren S Michel; Fiscal Year: 2006
    ..techniques to inactivate one MAD2 allele and induce aneuploidy in an otherwise chromosomally stable human tumor cell line. The metastatic behavior of these cells and their sensitivity to clinically relevant spindle inhibitors will ..
  30. DNA vaccines for metastatic breast cancer at old age
    Claudia Gravekamp; Fiscal Year: 2005
    ..The model is based on the injection of a syngeneic mouse mammary tumor cell line into immune competent mice, which then give rise to metastatic breast cancer without immunological rejection...
  31. DNA vaccines for metastatic breast cancer at old age
    Claudia Gravekamp; Fiscal Year: 2007
    ..The model is based on the injection of a syngeneic mouse mammary tumor cell line into immune competent mice, which then give rise to metastatic breast cancer without immunological rejection...
  32. Nonmuscle Myosin II-C and its Isoform
    Robert S Adelstein; Fiscal Year: 2006
    ..leads to a delay in cytokinesis, resulting in a decrease in cell proliferation in the A549 human lung tumor cell line. For in vivo study of nonmuscle myosin II-C1 function, we generated hypomorphic knockout mice using ..
  33. HDAC6-Selective Inhibitors for Pancreatic Cancer Treatment
    Werner Tueckmantel; Fiscal Year: 2008
    ..survival in vitro; and (3) to determine the in vivo efficacy of the 5 best HDACIs on established pancreatic tumor cell line xenografts with co-administration of gemcitabine...
  34. GM - CSF - producing tumor cell line as a CML vaccine
    Catherine J Wu; Fiscal Year: 2006
    ..The goal of this proposal is to carry out an initial phase I trial using this potentially valuable reagent and thus provide a basis for the continuation and refinement of clinical trials using this reagent...
  35. Permeability of heteromeric heart gap junction channels
    Alonso P Moreno; Fiscal Year: 2007
    ..Our model will be a cultured tumor cell line whose membrane potential and growth depends upon direct communication through gap junctions...
  36. DDR1 controls tumor homing in breast to bone metastasis
    Wolfgang F Vogel; Fiscal Year: 2004
    ..aims to test these hypotheses are: 1) To re-express DDRla and -b in the highly metastatic human breast tumor cell line MDA-MB 231, which lacks endogenous expression of kinase-active DDR1...
  37. Activated EGF Receptor in Ovarian Cancer
    Laurie G Hudson; Fiscal Year: 2006
    ..Our preliminary findings indicate that stable introduction of EGFRvIII into an ovarian tumor cell line alters cellular phenotype with regard to loss of cell:cell contact, increased migration and causes a striking ..
  38. Transcriptional Regulation in hMLH1-Silenced Colon Cells
    W David Sedwick; Fiscal Year: 2007
    ..Detailed microarray analyses in our laboratory of a human colon tumor cell line in which the mismatch repair gene, hMLH1 is aberrantly silenced for expression have defined a set of genes on ..
  39. Phototoxicity Screening Assay in Reconstituted Skin
    GEORGE DEGEORGE; Fiscal Year: 2006
    ..are composed of primary human keratinocytes in a 3D culture system, a more relevant model than a mouse tumor cell line; and (3) test substances can be applied directly, avoiding the often problematic solubilization of ..
  40. Emerging Technologies Applied to the Discovery of Human Tumor Viruses
    Patrick S Moore; Fiscal Year: 2008
    ..To demonstrate the feasibility of this method, we performed pilot studies of DTS on a tumor cell line infected with latent KSHV virus. DTS rapidly and uniquely identified 5 KSHV transcripts de novo comprising 0...
  41. Emerging Technologies Applied to the Discovery of Human Tumor Viruses
    Patrick S Moore; Fiscal Year: 2007
    ..To demonstrate the feasibility of this method, we performed pilot studies of DTS on a tumor cell line infected with latent KSHV virus. DTS rapidly and uniquely identified 5 KSHV transcripts de novo comprising 0...
  42. REGULATION OF THE DIFFERENTIATION OF MOUSE KERATIOCYTES
    W J Pledger; Fiscal Year: 2002
    ..Primary cells have a functional cyclin degradation system whereas the tumor cell line does not. Thus, the role of cyclin degradation and cyclin/cdk activity in growth control will be evaluated...
  43. Development a combined prophylactic and therapeutic cerv
    SAMIR KHLEIF; Fiscal Year: 2006
    ..We have established a tumor cell line expressing a E2 protein...
  44. CITED1 nuclear localization and its role in Wilms' tumor pathogenesis
    HAROLD NEWTON LOVVORN; Fiscal Year: 2008
    ..cell lines that misexpress either a predominantly cytosolic or nuclear fraction of CITED1 in the human Wilms' tumor cell line, WIT49, and will assess the effects of these manipulations on Wilms' tumor biology. In his second aim, Dr...
  45. Bcl-2 selective inhibitors: development and application to cancer treatment
    Chengguo Xing; Fiscal Year: 2008
    ..Second, a Bcl-2 inhibitor identified by Wang et al (YC 137) selectively induces apoptosis in a tumor cell line that overexpresses Bcl-2 protein and shows less toxicity to normal cells...
  46. Bcl-2 selective inhibitors: development and application to cancer treatment
    Chengguo Xing; Fiscal Year: 2007
    ..Second, a Bcl-2 inhibitor identified by Wang et al (YC 137) selectively induces apoptosis in a tumor cell line that overexpresses Bcl-2 protein and shows less toxicity to normal cells...
  47. Bcl-2 selective inhibitors: development and application to cancer treatment
    Chengguo Xing; Fiscal Year: 2006
    ..Second, a Bcl-2 inhibitor identified by Wang et al (YC 137) selectively induces apoptosis in a tumor cell line that overexpresses Bcl-2 protein and shows less toxicity to normal cells...
  48. Role of Fibroblast-Derived MT1-MMP in Oral Cancer
    Eben L Rosenthal; Fiscal Year: 2006
    ..test this hypothesis we propose to assess the potential of fibroblasts to promote in vitro and in vivo OCSCC tumor cell line invasion during co-culture with 1) MT1-MMP deficient and wild-type murine fibroblasts, or 2) MT1-MMP vector ..
  49. Molecular Targeting of Bcl-xL Pathway in Cancer
    Subrata Haldar; Fiscal Year: 2008
    ..of a phosphorylation null (Ser 62 Ala) mutant Bcl-xL enhanced the growth of an established prostate tumor cell line in vitro by reducing the apoptotic threshold...
  50. Molecular Targeting of Bcl-xL Pathway in Cancer
    Subrata Haldar; Fiscal Year: 2007
    ..of a phosphorylation null (Ser 62 Ala) mutant Bcl-xL enhanced the growth of an established prostate tumor cell line in vitro by reducing the apoptotic threshold...
  51. Novel Immunoadhesin Molecule for Cancer Therapy
    James W Larrick; Fiscal Year: 2007
    ..Moreover, Met-Fc inhibits growth of a glioma tumor cell line in a mouse xenograft model...
  52. Total Synthesis of Anticancer Angents Methyl Tortuoate A and B
    Jeffrey B Sperry; Fiscal Year: 2007
    ..potent in vitro cytotoxicity against the human nasopharyngeal carcinoma CNE-2 cell line and the murine P-388 tumor cell line. The ability to design and modify a proposed synthesis to access these potential drugs and numerous analogs ..
  53. Total Synthesis of Anticancer Angents Methyl Tortuoate A and B
    Jeffrey B Sperry; Fiscal Year: 2008
    ..potent in vitro cytotoxicity against the human nasopharyngeal carcinoma CNE-2 cell line and the murine P-388 tumor cell line. The ability to design and modify a proposed synthesis to access these potential drugs and numerous analogs ..
  54. TRANSCRIPTIONAL TARGETS OF THE WT1 TUMOR SUPPRESSOR
    PATRICIA E STANHOPE-BAKER; Fiscal Year: 2002
    ..Manipulation of WT1 in a Wilms tumor cell line and gene expression profiling will be used to identify physiologically relevant transcriptional targets of ..
  55. INDUCIBLE GENES IN ANGIOGENESIS AND TUMOR GROWTH
    Lester F Lau; Fiscal Year: 2003
    ..Furthermore, expression of cyr61 in a tumor cell line that does not normally express it enhances the size and vascularization of tumors that develop from these ..
  56. LEF/TCF Function in Adult Stem Cell Fate and Tumorigenesis
    Stephen R Lyle; Fiscal Year: 2007
    ..2) Determine the cellular and molecular properties of a new sebaceous tumor cell line showing deficient LEF-1 signaling...
  57. Exploiting novel uses of gene-modified drug-resistant hematopoietic cells
    H Trent Spencer; Fiscal Year: 2008
    ..and in vivo expansion of HSC-derived immunocompetent cells, where 100% of mice inoculated with a sarcoma tumor cell line achieve long-term cure...
  58. LEF/TCF Function in Adult Stem Cell Fate and Tumorigenesis
    Stephen R Lyle; Fiscal Year: 2008
    ..2) Determine the cellular and molecular properties of a new sebaceous tumor cell line showing deficient LEF-1 signaling...
  59. Regulation of Cellular Senescence by MEG3 RNA
    Yunli Zhou; Fiscal Year: 2007
    ..A Tet-on expression system will be used to establish stable clones in a human tumor cell line with regulatable MEG3 expression...
  60. Regulation Of Mutant P53
    Dan L Longo; Fiscal Year: 2004
    ..The mutant p53 from RL and wild type p53 will be transfected separately in a human colon tumor cell line, HCT 116, which has p53 null background...

Publications62

  1. A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model
    Hui Guan
    Division of Pediatrics and Departments of Cancer Biology and Surgical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 11:2662-9
    ..These data suggest that targeting VEGF165 may provide a therapeutic option for Ewing's sarcoma...
  2. Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line
    Hector Biliran
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Clin Cancer Res 11:6075-86
    ..RNA (siRNA)--mediated knockdown of cyclin D1 were done in the newly established Ela-myc pancreatic tumor cell line. Cisplatin sensitivity of control, overexpressing, and siRNA-transfected cells was determined by the 3-(4,5-..
  3. Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways
    Sudhakar Chintharlapalli
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843, USA
    J Biol Chem 280:24903-14
    ....
  4. Suppression of colorectal tumor growth by regulated survivin targeting
    Binghua Li
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
    J Mol Med 84:1077-86
    ..Synergized with the chemotherapeutic drug cisplatin, regulated surDN expression completely suppressed tumor growth. These results indicated that this modified RU486-regulated system could be useful in cancer-targeting therapy...
  5. Possible involvement of RUNX3 silencing in the peritoneal metastases of gastric cancers
    Chouhei Sakakura
    Surgery and Regenerative Medicine, Kyoto Prefectural University of Medicine, Japan
    Clin Cancer Res 11:6479-88
    ..Identification of such genes could suggest new therapeutic modalities and therapeutic targets...
  6. Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth
    Peiwen Fei
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cancer Cell 6:597-609
    ..Thus, Bnip3L, capable of attenuating tumorigenicity, mediates p53-dependent apoptosis under hypoxia, which provides a novel understanding of p53 in tumor suppression...
  7. Stable suppression of tumorigenicity by Pin1-targeted RNA interference in prostate cancer
    Akihide Ryo
    Department of Pathology, Yokohama City University School of Medicine, Yokohama, Japan
    Clin Cancer Res 11:7523-31
    ..Hence, Pin1 may serve as a promising therapeutic target, particularly for recurrent prostate tumors...
  8. Ovarian carcinomas: CCN genes are aberrantly expressed and CCN1 promotes proliferation of these cells
    Sigal Gery
    Division of Hematology Oncology, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Clin Cancer Res 11:7243-54
    ..Furthermore, our results suggest that CCN1 may play a role in ovarian carcinogenesis by stimulating survival and antiapoptotic signaling pathways...
  9. Knockdown of RAB25 expression by RNAi inhibits growth of human epithelial ovarian cancer cells in vitro and in vivo
    Yang Fan
    Department of Obstetrics and Gynecology, Xijing Hospital Fourth Military Medical University, Xi an, China
    Pathology 38:561-7
    ....
  10. Synergistic effects of acyclic retinoid and OSI-461 on growth inhibition and gene expression in human hepatoma cells
    Masahito Shimizu
    Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Clin Cancer Res 10:6710-21
    ..Our results suggest that the combination of acyclic retinoid plus OSI-461 might be an effective regimen for the chemoprevention and chemotherapy of human hepatoma and possibly other malignancies...
  11. Enhanced growth suppression of Philadephia1 leukemia cells by targeting bcr3/abl2 and VEGF through antisense strategy
    X L Cong
    State Key Laboratory of Experimental Hematology, National Research Center for Stem Cell Engineering and Technology, Tianjin, China
    Leukemia 19:1517-24
    ..These results demonstrate that targeting both bcr3/abl2 and VEGF can result in an additive tumor-suppressive action and may represent an excellent strategy to augment the efficacy of chemotherapy in CML...
  12. Doxorubicin modulates telomerase activity in Ewing's sarcoma in vitro and in vivo
    Claudia Lanvers Kaminsky
    University Children s Hospital, Department of Pediatric Hematology and Oncology, Albert Schweitzer Str 33, 48129 Muenster, Germany
    Oncol Rep 14:751-8
    ..No correlation was observed between TA, proliferation, apoptosis and necrosis. The results suggest doxorubicin induces down-regulation of hTERT gene expression that at least in part modulates TA in these tumours...
  13. Inhibition of phosphatidylinositol 3-kinase sensitizes ovarian cancer cells to carboplatin and allows adjunct chemotherapy treatment
    Suzanne D Westfall
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4231, USA
    Mol Cancer Ther 4:1764-71
    ..g., LY294002) as an adjunct platinum-based drug therapy for treatment of ovarian cancer...
  14. S100P promotes pancreatic cancer growth, survival, and invasion
    Thiruvengadam Arumugam
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 11:5356-64
    ..Thus, interference with S100P may provide a novel approach for treatment of pancreatic cancer...
  15. Suppression of RAD21 gene expression decreases cell growth and enhances cytotoxicity of etoposide and bleomycin in human breast cancer cells
    Josephine M Atienza
    Sequenom, Inc, 3595 John Hopkins Court, San Diego, CA 92121, USA
    Mol Cancer Ther 4:361-8
    ..Based on these findings, we conclude that RAD21 is a novel target for developing cancer therapeutics that can potentially enhance the antitumor activity of chemotherapeutic agents acting via induction of DNA damage...
  16. A novel antisense oligonucleotide inhibiting several antiapoptotic Bcl-2 family members induces apoptosis and enhances chemosensitivity in androgen-independent human prostate cancer PC3 cells
    Kazuki Yamanaka
    The Prostate Centre, Vancouver General Hospital, British Columbia, Canada
    Mol Cancer Ther 4:1689-98
    ....
  17. Enhanced proliferative potential of hematopoietic cells expressing degradation-resistant c-Myb mutants
    Francesca Corradini
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 280:30254-62
    ..Thus, enhanced stability of c-Myb by activation of PI-3K-dependent pathway(s) might contribute to the higher proliferative potential of BCR/ABL-expressing and, perhaps, other leukemic cells...
  18. Vitamins K1 and K2 potentiate hyperthermia by down-regulating Hsp72 expression in vitro and in vivo
    Shuji Shimohara
    Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan
    Int J Oncol 27:1527-33
    ..The findings here that VK1 and VK2 inhibit heat-shock-induced Hsp72 suggest their possible use as an adjuvant for hyperthermia in cancer therapy...
  19. STAT1 and Nmi are downstream targets of Ets-1 transcription factor in MCF-7 human breast cancer cell
    Hae Hyun Jung
    Biomedical Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon dong Kangnam gu, Seoul 135 710, Korea
    FEBS Lett 579:3941-6
    ..Taken together, our results indicate that STAT1 and Nmi are downstream targets of Ets-1 in MCF-7 human breast cancer cells...
  20. Vesnarinone inhibits angiogenesis and tumorigenicity of human oral squamous cell carcinoma cells by suppressing the expression of vascular endothelial growth factor and interleukin-8
    Koji Harada
    Second Department of Oral and Maxillofacial Surgery, University of Tokushima, School of Dentistry, Tokushima 770 8504, Japan
    Int J Oncol 27:1489-97
    ..These findings suggest that vesnarinone can suppress the angiogenesis and growth of oral squamous cell carcinoma cells by inhibiting the expression of VEGF and IL-8 involved in blockade of NF-kappaB activity...
  21. Inhibition of cyclooxygenase-1 and -2 expression by targeting the endothelin a receptor in human ovarian carcinoma cells
    Francesca Spinella
    Laboratories of Molecular Pathology and Ultrastructure and Immunology, Regina Elena Cancer Institute, Rome, Italy
    Clin Cancer Res 10:4670-9
    ..Pharmacological blockade of the ET(A)R is an attractive strategy to control COX-2 induction, which has been associated with ovarian carcinoma progression and chemoresistance...
  22. Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model
    Sue Ellen Touma
    Department of Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Clin Cancer Res 11:3558-66
    ..These results indicate that ATRA and histone deacetylase inhibitor therapies should be explored for the treatment of advanced RCC...
  23. Potential of endogenous estrogen receptor beta to influence the selective ER modulator ERbeta complex
    Bin Chen
    Robert H. Lurie Comprehensive Cancer Center, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Int J Oncol 27:327-35
    ..We conclude that endogenous ERbeta may not play a dominant role in the modulation of the tamoxifen ERalpha complex, or in the development of tamoxifen-stimulated resistant tumor growth...
  24. Suppression of distant pulmonary metastasis of MDA-MB 435 human breast carcinoma established in mammary fat pads of nude mice by retroviral-mediated TIMP-2 gene transfer
    Young-Kwan Lee
    Laboratory of Retroviruses and Gene Therapy, Indang Institute of Molecular Biology, Inje University, Seoul 100-032, Korea
    J Gene Med 7:145-57
    ....
  25. Targeting matrilysin and its impact on tumor growth in vivo: the potential implications in breast cancer therapy
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    Clin Cancer Res 11:6012-9
    ..Elimination of matrilysin is associated with low invasiveness and slow tumor growth. Taken together, the study suggests that targeting matrilysin may have important therapeutic implications...
  26. Epigenetic silencing of novel tumor suppressors in malignant melanoma
    Viswanathan Muthusamy
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Cancer Res 66:11187-93
    ..Reexpression of either of two of the silenced genes, HOXB13 and SYK, resulted in reduced colony formation in vitro and diminished tumor formation in vivo, indicating that these genes function as tumor suppressors in melanoma...
  27. Cyclin D1 and pancreatic carcinoma: a proliferative agonist and chemotherapeutic antagonist
    J Alan Diehl
    Department of Cancer Biology, The Leonard and Madlyn Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6160, USA
    Clin Cancer Res 11:5665-7
  28. FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells
    Tsuyoshi Imai
    Department of Pediatrics, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
    Oncogene 22:9231-42
    ..These findings suggest that FR901228 is a highly promising antitumor agent against osteosarcoma, inducing apoptosis by the activation of the Fas/FasL system...
  29. Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): superiority over single-agent receptor targeting
    Pablo Matar
    Laboratory of Oncology Research, Medical Oncology Service, Vall d'Hebron University Hospital, Barcelona, Spain
    Clin Cancer Res 10:6487-501
    ..CONCLUSIONS: Our findings suggest both shared and complementary mechanisms of action with gefitinib and cetuximab and support combined EGFR targeting as a clinically exploitable strategy...
  30. Antitumor activity of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib (ZD1839, Iressa) in non-small cell lung cancer cell lines correlates with gene copy number and EGFR mutations but not EGFR protein levels
    Barbara A Helfrich
    Tobacco Related Malignancy Program, University of Colorado Cancer Center, Aurora, CO 80010, USA
    Clin Cancer Res 12:7117-25
    ..Several of these have subsequently been shown to identify NSCLC patients likely to benefit from gefitinib therapy...
  31. Histone deacetylase inhibitor FK228 activates tumor suppressor Prdx1 with apoptosis induction in esophageal cancer cells
    Isamu Hoshino
    Department of Frontier Surgery M9, Graduate School of Medicine, Chiba University, Japan
    Clin Cancer Res 11:7945-52
    ....
  32. Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines
    Sakura Sakajiri
    Division of Hematology/Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Exp Hematol 33:53-61
    ..In nude mice, SAHA significantly inhibited growth of a mantle cell lymphoma without major toxic side effects. In summary, HDACIs are promising therapeutic agents for human lymphoid cancers...
  33. Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model
    Yuki Ishii
    Division of Hematology/Oncology, Department of Medicine, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA
    J Natl Cancer Inst 98:1238-47
    ..In addition, bortezomib can amplify the proapoptotic function of cyclin D1, raising the possibility that cyclin D1 levels may be a marker for predicting the response to this novel drug...
  34. [Effects of small interfering RNA specific for Her-2 gene on biological behavior of ovarian carcinoma cell]
    Ying Zhou
    Anhui Province Key Laboratory of Molecular Medicine, Hefei 230001, China
    Zhonghua Fu Chan Ke Za Zhi 41:830-3
    ..05), and the growth of the corresponding implanted tumor slowed down significantly (P < 0.01). CONCLUSION: siRNA can inhibit the expression of Her-2 gene effectively, which restrains the biological behavior of ovarian carcinoma cell...
  35. Apoptotic action of 17beta-estradiol in raloxifene-resistant MCF-7 cells in vitro and in vivo
    Hong Liu
    Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Natl Cancer Inst 95:1586-97
    ....
  36. Expression of constitutively active Akt-3 in MCF-7 breast cancer cells reverses the estrogen and tamoxifen responsivity of these cells in vivo
    Jesika Faridi
    Department of Molecular Pharmacology, Stanford University, 269 West Campus Drive, Stanford, California 94305-5174, USA
    Clin Cancer Res 9:2933-9
    ..Finally, these tumors are resistant to ICI 182,780. These findings suggest that the amount of active Akt present in breast cancers may be important in the relative efficacy of different treatments...
  37. Interferon receptor expression regulates the antiproliferative effects of interferons on cancer cells and solid tumors
    T Charis Wagner
    Department of Immunology, Berlex Bioscience Inc, Richmond, CA 94804, USA
    Int J Cancer 111:32-42
    ....
  38. Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis
    Charles E Ducker
    Apogee Biotechnology Corporation, Hershey, PA, USA
    Mol Cancer Res 3:463-76
    ..Overall, the data indicate that NMT1 and NMT2 have only partially overlapping functions and that NMT1 is critical for tumor cell proliferation...
  39. RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo
    Sai MuraliKrishna Pulukuri
    Department of Biomedical and Therapeutic Sciences Program of Cancer Biology, University of Illinois College of Medicine, Peoria, Illinois 61656, USA
    J Biol Chem 280:36529-40
    ..Thus, RNA interference-directed targeting of uPA and uPAR is a convenient and novel tool for studying the biological role of the uPA-uPAR system and raises the potential of its application for prostate cancer therapy...
  40. Small-molecule antagonists of p53-MDM2 binding: research tools and potential therapeutics
    Lyubomir T Vassilev
    Roche Research Center, Hoffman La Roche Inc, Nutley, New Jersey 07110, USA
    Cell Cycle 3:419-21
    ..Their potent activity against osteosarcoma xenografts suggests that MDM2 antagonists may have clinical utility in the treatment of tumors with wild-type p53...
  41. The effects of taurolidine, a novel antineoplastic agent, on human malignant mesothelioma
    Linda Nici
    Department of Medicine, Rhode Island Hospital and Brown University, Providence, Rhode Island 02908, USA
    Clin Cancer Res 10:7655-61
    ..CONCLUSIONS: Taurolidine has significant antineoplastic activity against MM in vitro and in vivo, in part, due to tumor cell apoptosis. These findings warrant further study for potential clinical usefulness...
  42. Anti-cancer and pro-apoptotic effects of an herbal medicine and Saccharomyces cerevisiae product (CKBM) on human hepatocellular carcinoma HepG2 cells in vitro and in vivo
    J Y W Chan
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, Hong Kong
    Immunopharmacol Immunotoxicol 26:597-609
    ....
  43. HIF-1alpha attenuates tumor growth in spite of augmented vascularization in an A549 adenocarcinoma mouse model
    Rajkumar Savai
    Department of Internal Medicine II, Medical School of the Justus-Liebig-University, D-35392 Giessen, Germany
    Int J Oncol 27:393-400
    ..We conclude that in lung A549 cells, overexpression of HIF-1alpha negatively affects tumor growth due to decreased proliferation and increased apoptosis, despite augmented angiogenesis...
  44. Induction of apoptosis in human ovarian epithelial cancer cells by antisurvivin oligonucleotides
    Xiangyi Ma
    Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical School, Huazhong University of Science and Technology, P.R. China
    Oncol Rep 14:275-9
    ..We concluded that down-regulation of survivin by a targeted antisense oligonucleotide appears to be an effective gene therapy approach in the treatment of ovarian cancer...
  45. Effect of bortezomib on human neuroblastoma cell growth, apoptosis, and angiogenesis
    Chiara Brignole
    Laboratory of Oncology, G. Gaslini Children's Hospital, Largo G. Gaslini 5, 16147 Genoa, Italy
    J Natl Cancer Inst 98:1142-57
    ..6 days, P<.001). CONCLUSIONS: Bortezomib is an effective inhibitor of neuroblastoma cell growth and angiogenesis. These findings provide the rationale for further clinical investigation of bortezomib in pediatric neuroblastoma...
  46. Activated checkpoint kinase 2 provides a survival signal for tumor cells
    Jagadish C Ghosh
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cancer Res 66:11576-9
    ..Therefore, activated Chk2 circumvents its own tumor-suppressive functions by promoting tumor cell survival. Inhibiting Chk2 in combination with DNA-damaging agents may provide a rational approach for treating resistant tumors...
  47. Promotion of cell differentiation, and suppression of cell growth and cyclooxygenase-2 expression by differentiation-inducing agents in human oral squamous carcinoma SCC25 cells
    Junko Kuroda
    Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine, Hyogo 663 8501, Japan
    Int J Oncol 26:361-7
    ....
  48. Blockage of NF-kappaB induces serine 15 phosphorylation of mutant p53 by JNK kinase in prostate cancer cells
    Luiz F Zerbini
    New England Baptist Bone and Joint Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Cycle 4:1247-53
    ..Together, these results highlight the importance of Ser15 phosphorylation in regulating the oncogenic function of mutant p53 and apoptosis induction in the context of the NF-kappaB/IkappaB signaling pathway...
  49. Inhibition of platelet-derived growth factor receptor signaling restricts the growth of human breast cancer in the bone of nude mice
    Dina Chelouche Lev
    Department of Cancer Biology, University of Texas M.D. Anderson Cancer Center, University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas, USA
    Clin Cancer Res 11:306-14
    ..Interfering with PDGFR signaling may be an approach to control the progressive growth of breast cancer cells and thus reduce bone lysis...
  50. The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim
    Malti Nikrad
    Hollings Cancer Center, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA
    Mol Cancer Ther 4:443-9
    ..These results implicate BH3-only proteins, in particular both Bik and Bim, as important mediators of the antitumor action of bortezomib and establish their role in its enhancement of TRAIL-induced apoptosis...
  51. Up-regulation of insulin-like growth factor binding protein-3 by apigenin leads to growth inhibition and apoptosis of 22Rv1 xenograft in athymic nude mice
    Sanjeev Shukla
    Department of Urology, Case Western Reserve University, Cleveland, Ohio, USA
    FASEB J 19:2042-4
    ..This study presents the first evidence that the in vitro and in vivo growth inhibitory effects of apigenin involve modulation of IGF-axis signaling in prostate cancer...
  52. Diallyl trisulfide suppresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of beta-tubulin
    Takashi Hosono
    Department of Applied Life Sciences, Nihon University Graduate School of Bioresource Sciences, Kanagawa 252-8510, Japan
    J Biol Chem 280:41487-93
    ..1 Da. The potent antitumor activity of DATS was also demonstrated in nude mice bearing HCT-15 xenografts. This is the first paper describing intracellular target molecules directly modified by garlic components...
  53. RWJ-241947 (MCC-555), a unique peroxisome proliferator-activated receptor-gamma ligand with antitumor activity against human prostate cancer in vitro and in beige/nude/ X-linked immunodeficient mice and enhancement of apoptosis in myeloma cells induced by
    Takashi Kumagai
    Departments of Medicine and Pathology, Center of Health of Science, University of California at Los Angeles School of Medicine, Los Angeles, California 90048, USA
    Clin Cancer Res 10:1508-20
    ..Small, well-defined clinical studies using RWJ-241947 are in order for these cancers...
  54. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases
    Frank Winkler
    E.L. Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Cancer Cell 6:553-63
    ..During the normalization window, but not before or after it, VEGFR2 blockade increases pericyte coverage of brain tumor vessels via upregulation of Ang1 and degrades their pathologically thick basement membrane via MMP activation...
  55. Specific COX-2 inhibitor, meloxicam, suppresses proliferation and induces apoptosis in human HepG2 hepatocellular carcinoma cells
    Jie Li
    Hepatosurgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Gastroenterol Hepatol 21:1814-20
    ....
  56. Antiproliferative activity of angiotensin II receptor blocker through cross-talk between stromal and epithelial prostate cancer cells
    Hiroji Uemura
    Department of Urology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Mol Cancer Ther 4:1699-709
    ..Because prostate stromal cells are thought to be involved in the initiation and development of prostate cancer, the present data suggest the possibility that ARBs are a novel therapeutic class of agents for prostate cancer...
  57. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity
    Jiazhi Sun
    Department of Interdisciplinary Oncology, Drug Discovery and Molecular Oncology Programs, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Drive, MRC DRDIS, Tampa, FL 33612 9497, USA
    Oncogene 24:3236-45
    ..These studies further validate STAT3 as a drug discovery target and provide evidence that pharmacological agents that can selectively reduce the P-STAT3 levels in human cancer cells result in tumor apoptosis and growth inhibition...
  58. Alpha1-antitrypsin inhibits angiogenesis and tumor growth
    Hanhua Huang
    Department of Urology and Robert H. Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA
    Int J Cancer 112:1042-8
    ..Comparative analysis of the human tumors and normal tissues of origin showed correlation between reduced local alpha(1)-antitrypsin expression and more aggressive tumor growth...
  59. Ferritin contributes to melanoma progression by modulating cell growth and sensitivity to oxidative stress
    Alfonso Baldi
    Laboratory C, Department for the Development of Therapeutic Programs, Center for Experimental Research, Regina Elena Cancer Institute, Rome, Italy
    Clin Cancer Res 11:3175-83
    ..The potential significance of these findings deserves to be validated in a clinical setting...
  60. Combined targeting of epidermal growth factor receptor and MDM2 by gefitinib and antisense MDM2 cooperatively inhibit hormone-independent prostate cancer
    Roberto Bianco
    Dipartimento di Endocrinologia e Oncologia Molecolare e Clinica, Università di Napoli Federico II, Naples, Italy
    Clin Cancer Res 10:4858-64
    ....
  61. Antineoplastic effects of rosiglitazone and PPARgamma transactivation in neuroblastoma cells
    I Cellai
    Endocrine Unit, Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders DENOThe, University of Florence, Florence, Italy
    Br J Cancer 95:879-88
    ..This finding indicates that PPARgamma activity may be useful to select those patients, for whom PPARgamma agonists may have a beneficial therapeutic effect...