transformed cell line

Summary

Summary: Eukaryotic cell line obtained in a quiescent or stationary phase which undergoes conversion to a state of unregulated growth in culture, resembling an in vitro tumor. It occurs spontaneously or through interaction with viruses, oncogenes, radiation, or drugs/chemicals.

Top Publications

  1. Wyatt H, Tsang A, Lobb D, Beattie T. Human telomerase reverse transcriptase (hTERT) Q169 is essential for telomerase function in vitro and in vivo. PLoS ONE. 2009;4:e7176 pubmed publisher
    ..A conserved glutamine residue in the TERT N-terminus is important for anchor site interactions in lower eukaryotes. The significance of this residue in higher eukaryotes, however, has not been investigated...
  2. JIMENEZ R, Lee J, Francesconi M, Castellani G, Neretti N, Sanders J, et al. Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR). PLoS ONE. 2010;5:e9084 pubmed publisher
    ..However, regulation of gene expression through mTOR is c-Myc-independent and cannot be attributed to the involvement of specific transcription factors regulated by the rapamycin-sensitive mTOR Complex 1. ..
  3. Schmid E, Roos H, Sauter W, Rickinger A, Jaehnert I, Eckardt Schupp F. Chromosome analysis of the differential radiosensitivity of an Epstein-Barr virus (EBV)-transformed B cell line and B and T lymphocytes from the same blood donor. Int J Radiat Biol. 2010;86:47-55 pubmed publisher
    ..53-1.46 for the EBV-transformed cell line, from 0.76-0.80 for resting B lymphocytes and from 2.36-2...
  4. Kikkawa Y, Takaki S, Matsuda Y, Okabe K, Taniguchi M, Oomachi K, et al. The influence of Tribenoside on expression and deposition of epidermal laminins in HaCaT cells. Biol Pharm Bull. 2010;33:307-10 pubmed
    ..These results suggest that tribenoside interacts with epidermal cells and regulates the expression and localization of laminins to help reconstruct BMs in wound healing of hemorrhoids. ..
  5. Chen L, Pernazza D, Scott L, Lawrence H, Ren Y, Luo Y, et al. Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112. Biochem Pharmacol. 2010;80:801-10 pubmed publisher
    ..Thus, the SPI-112 methyl ester analog was able to inhibit cellular Shp2 PTP activity. ..
  6. Jiang Y, Zheng W, Teegarden D. 1?, 25-Dihydroxyvitamin D regulates hypoxia-inducible factor-1? in untransformed and Harvey-ras transfected breast epithelial cells. Cancer Lett. 2010;298:159-66 pubmed publisher
    ..These results support that 1,25(OH)(2)D regulates HIF-1? protein level via transcriptional regulation in MCF10A cells in contrast to through proteosomal degradation with the presence of H-ras oncogene in MCF10A cells. ..
  7. Wang J, Van Damme P, Cruchaga C, Gitcho M, Vidal J, Seijo Martinez M, et al. Pathogenic cysteine mutations affect progranulin function and production of mature granulins. J Neurochem. 2010;112:1305-15 pubmed publisher
    ..Our data suggest that these mutations affect the function of full-length PGRN as well as elastase cleavage of PGRN into GRNs, leading to neurodegeneration. ..
  8. Zijno A, Porcedda P, Saini F, Allione A, Garofalo B, Marcon F, et al. Unsuitability of lymphoblastoid cell lines as surrogate of cryopreserved isolated lymphocytes for the analysis of DNA double-strand break repair activity. Mutat Res. 2010;684:98-105 pubmed publisher
    ..These results indicate that LCL may be unsuitable for investigating genotype-phenotype correlations with phenotypic DNA repair assays, especially when low impact functional genetic variants are involved. ..
  9. Zhao C, Hu H, Meng L, Li Q, Lin A. Immortalization of bovine mammary epithelial cells alone by human telomerase reverse transcriptase. Cell Biol Int. 2010;34:579-86 pubmed publisher
    ..Interestingly, two immortal cell lines showed a significant distinction in proliferation rate, implying that other mechanisms might be involved in proliferation control. ..

More Information

Publications119 found, 100 shown here

  1. Ewe D, Tachibana M, Kikutani S, Gruber A, Río Bártulos C, Konert G, et al. The intracellular distribution of inorganic carbon fixing enzymes does not support the presence of a C4 pathway in the diatom Phaeodactylum tricornutum. Photosynth Res. 2018;137:263-280 pubmed publisher
    ..to operate a C4 pathway, silencing of the pyruvate orthophosphate dikinase (PPDK) in a genetically transformed cell line does not lead to reduced photosynthetic carbon fixation...
  2. Delaroche D, Cantrelle F, Subra F, van Heijenoort C, Guittet E, Jiao C, et al. Cell-penetrating peptides with intracellular actin-remodeling activity in malignant fibroblasts. J Biol Chem. 2010;285:7712-21 pubmed publisher
    ..Therefore, cell-penetrating peptides might interact with intracellular protein partners, such as actin. In addition, the fact that they could reverse the tumoral phenotype is of interest for therapeutic purposes. ..
  3. Hail N, Chen P, Bushman L. Teriflunomide (leflunomide) promotes cytostatic, antioxidant, and apoptotic effects in transformed prostate epithelial cells: evidence supporting a role for teriflunomide in prostate cancer chemoprevention. Neoplasia. 2010;12:464-75 pubmed
    ..These mechanistic findings advocate a role for TFN and mitochondrial bioenergetics in prostate cancer chemoprevention. ..
  4. Liao Y, Anttonen A, Liukkonen E, Gaily E, Maljevic S, Schubert S, et al. SCN2A mutation associated with neonatal epilepsy, late-onset episodic ataxia, myoclonus, and pain. Neurology. 2010;75:1454-8 pubmed publisher
    ..Mutations in SCN2A, encoding the brain sodium channel Na(V)1.2, have previously been reported to be associated with benign familial neonatal infantile seizures, febrile seizures plus, and intractable epilepsy of infancy...
  5. Hsuchou H, Kastin A, Tu H, Joan Abbott N, Couraud P, Pan W. Role of astrocytic leptin receptor subtypes on leptin permeation across hCMEC/D3 human brain endothelial cells. J Neurochem. 2010;115:1288-98 pubmed publisher
  6. Tan K, Baur R, Charon S, Goeldner M, Sigel E. Relative positioning of diazepam in the benzodiazepine-binding-pocket of GABA receptors. J Neurochem. 2009;111:1264-73 pubmed publisher
    ..Based on these observations we propose a relative positioning of diazepam within the benzodiazepine-binding site of alpha(1)beta(2)gamma(2) receptors. ..
  7. Siu M, Wong E, Chan H, Kong D, Woo N, Tam K, et al. Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion. Int J Cancer. 2010;127:21-31 pubmed publisher
    ..Our findings suggest that Pak1, p-Pak1 and p-Pak2 play important roles in ovarian carcinogenesis. Pak1 and p-Pak1 may be potential prognostic markers and therapeutic molecular targets in ovarian cancer. ..
  8. Bhattacharya A, Sankar S, Panicker M. Differences in the C-terminus contribute to variations in trafficking between rat and human 5-HT(2A) receptor isoforms: identification of a primate-specific tripeptide ASK motif that confers GRK-2 and beta arrestin-2 interactions. J Neurochem. 2010;112:723-32 pubmed publisher
  9. Reddy P, Lungu G, Kuang X, Stoica G, Wong P. Neuroprotective effects of the drug GVT (monosodium luminol) are mediated by the stabilization of Nrf2 in astrocytes. Neurochem Int. 2010;56:780-8 pubmed publisher
    ..This suggests that the neuroprotective effects of GVT may be mediated by the stabilization of the Nrf2 protein, allowing continuous upregulation of Nrf2 levels in the astrocytes. ..
  10. Srikanth B, Vaidya M, Kalraiya R. O-GlcNAcylation determines the solubility, filament organization, and stability of keratins 8 and 18. J Biol Chem. 2010;285:34062-71 pubmed publisher
    ..These results strongly indicate the involvement of O-GlcNAc on K8/18 in regulating their solubility and stability, which may have a bearing on the functions of these keratins. ..
  11. Fei X, Wang A, Wang D, Meng X, Ma J, Hong L, et al. Establishment of malignantly transformed dendritic cell line SU3-ihDCTC induced by Glioma stem cells and study on its sensitivity to resveratrol. BMC Immunol. 2018;19:7 pubmed publisher
    ..This paper is designed to investigate the sensitivity of malignantly transformed cell line (ihDCTC) induced by glioma stem cells (GSCs) in TME to chemotherapeutic drugs...
  12. Gadau S, Lepore G, Zedda M, Mura A, Farina V. Different nitrosative-induced microtubular modifications and testosterone neuroprotective effects on high-D-glucose-exposed neuroblastoma and glioma cells. Neuro Endocrinol Lett. 2009;30:515-24 pubmed
  13. Micklethwaite K, Savoldo B, Hanley P, Leen A, Demmler Harrison G, Cooper L, et al. Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation. Blood. 2010;115:2695-703 pubmed publisher
    ..This approach may prove beneficial for patients with high-risk B-ALL who have recently received an HSC or CB transplant and are at risk of infection and relapse. ..
  14. Kanamori A, Catrinescu M, Kanamori N, Mears K, Beaubien R, Levin L. Superoxide is an associated signal for apoptosis in axonal injury. Brain. 2010;133:2612-25 pubmed publisher
    ..Early detection of axonal injury with superoxide could serve as a predictive biomarker for patients with optic neuropathy. ..
  15. Cederholm J, Absalom N, Sugiharto S, Griffith R, Schofield P, Lewis T. Conformational changes in extracellular loop 2 associated with signal transduction in the glycine receptor. J Neurochem. 2010;115:1245-55 pubmed publisher
    ..These results demonstrate that loop 2 does undergo a conformational change as part of the mechanism that couples ligand binding to channel opening. ..
  16. Johnson K, Ovsyannikova I, Mason C, Bergen H, Poland G. Discovery of naturally processed and HLA-presented class I peptides from vaccinia virus infection using mass spectrometry for vaccine development. Vaccine. 2009;28:38-47 pubmed publisher
    ..Thus, direct identification of naturally processed and presented HLA peptides gives important information not provided by current computational methods for identifying potential vaccinia epitopes. ..
  17. Sealey D, Zheng L, Taboski M, Cruickshank J, Ikura M, Harrington L. The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization. Nucleic Acids Res. 2010;38:2019-35 pubmed publisher
  18. Vernengo L, Chourbagi O, Panuncio A, Lilienbaum A, Batonnet Pichon S, Bruston F, et al. Desmin myopathy with severe cardiomyopathy in a Uruguayan family due to a codon deletion in a new location within the desmin 1A rod domain. Neuromuscul Disord. 2010;20:178-87 pubmed publisher
    ..This is the first time that a mutation affecting this domain in the desmin molecule is described in a desminopathy. ..
  19. Soltoff S, Hedden L. Isoproterenol and cAMP block ERK phosphorylation and enhance [Ca2+]i increases and oxygen consumption by muscarinic receptor stimulation in rat parotid and submandibular acinar cells. J Biol Chem. 2010;285:13337-48 pubmed publisher
  20. Vollmer T, Hinse D, Kleesiek K, Dreier J. Interactions between endocarditis-derived Streptococcus gallolyticus subsp. gallolyticus isolates and human endothelial cells. BMC Microbiol. 2010;10:78 pubmed publisher
    ..gallolyticus subsp. gallolyticus adhesion and invasion of human endothelial cells, revealing important initial information of strain variability, behaviour and characteristics of this as yet barely analyzed pathogen. ..
  21. Wondergem R, Graves B, Ozment Skelton T, Li C, Williams D. Lipopolysaccharides directly decrease Ca2+ oscillations and the hyperpolarization-activated nonselective cation current If in immortalized HL-1 cardiomyocytes. Am J Physiol Cell Physiol. 2010;299:C665-71 pubmed publisher
    ..We conclude that LPS inhibits activation of I(f), enhances its deactivation, and impairs regulation of [Ca2+]i in HL-1 cardiomyocytes via TLR-4 and other mechanisms. ..
  22. Clements D, Markwick L, Puri N, Johnson S. Role of the CXCR4/CXCL12 axis in lymphangioleiomyomatosis and angiomyolipoma. J Immunol. 2010;185:1812-21 pubmed publisher
    ..The mTOR inhibitor rapamycin, but not AMD3100, inhibited growth of AML tumor xenografts. We conclude that the CXCL12/CXCR4 axis promotes, but is not absolutely required for, AML/LAM cell growth and survival. ..
  23. Yang C, Sudderth J, Dang T, Bachoo R, Bachoo R, McDonald J, et al. Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling. Cancer Res. 2009;69:7986-93 pubmed publisher
  24. Cheung P, Deng W, Man C, Tse W, Srivastava G, Law S, et al. Genetic alterations in a telomerase-immortalized human esophageal epithelial cell line: implications for carcinogenesis. Cancer Lett. 2010;293:41-51 pubmed publisher
    ..Our data also revealed a novel positive regulation of p16(INK4a) on cyclin D1. These findings probably represent early crucial events and mechanisms in esophageal carcinogenesis. ..
  25. Betser Cohen G, Mizrahi S, Elboim M, Alsheich Bartok O, Mandelboim O. The association of MHC class I proteins with the 2B4 receptor inhibits self-killing of human NK cells. J Immunol. 2010;184:2761-8 pubmed publisher
  26. Wu Y, Starzinski Powitz A, Guo S. Constitutive and tumor necrosis factor-alpha-stimulated activation of nuclear factor-kappaB in immortalized endometriotic cells and their suppression by trichostatin A. Gynecol Obstet Invest. 2010;70:23-33 pubmed publisher
    ..NF-kappaB activation may play a critical role in the pathogenesis in endometriosis. Targeting NF-kappaB with histone deacetylase inhibitors or other compounds might hold promise as novel therapeutics for endometriosis. ..
  27. Bae J, Rezaie A. Thrombin upregulates the angiopoietin-Tie2 Axis: endothelial protein C receptor occupancy prevents the thrombin mobilization of angiopoietin 2 and P-selectin from Weibel-Palade bodies. J Thromb Haemost. 2010;8:1107-15 pubmed publisher
    ..The antagonist of this pathway, Ang2, is stored in Weibel-Palade bodies within endothelial cells...
  28. Hensley K, Christov A, Kamat S, Zhang X, Jackson K, Snow S, et al. Proteomic identification of binding partners for the brain metabolite lanthionine ketimine (LK) and documentation of LK effects on microglia and motoneuron cell cultures. J Neurosci. 2010;30:2979-88 pubmed publisher
    ..The results are discussed with reference to possible biochemical origins, paracrine functions, neurological significance, and pharmacological potential of lanthionyl compounds. ..
  29. Prylutska S, Grynyuk I, Palyvoda K, Matyshevska O. Photoinduced cytotoxic effect of fullerenes C60 on transformed T-lymphocytes. Exp Oncol. 2010;32:29-32 pubmed
    ..The present study suggests that pristine fullerenes C(60) have the potential to be an effective photosensitizer and exhibit cytotoxic effect on transformed T-cells in vitro . ..
  30. Ismail N, Pravda E, Li D, Shih S, Dallabrida S. Angiopoietin-1 reduces H(2)O(2)-induced increases in reactive oxygen species and oxidative damage to skin cells. J Invest Dermatol. 2010;130:1307-17 pubmed publisher
    ..Our findings show that ang1 blocks free radical damage to skin cells and may be clinically useful to prevent and/or reduce photoaging and skin cancer. ..
  31. Chen X, Thibeault S. Biocompatibility of a synthetic extracellular matrix on immortalized vocal fold fibroblasts in 3-D culture. Acta Biomater. 2010;6:2940-8 pubmed publisher
    ..This investigation demonstrates that Carbylan GSX may serve as a natural biomaterial for tissue-engineering of human vocal folds. ..
  32. Takeuchi H, Takahashi M, Norose Y, Takeshita T, Fukunaga Y, Takahashi H. Transformation of breast milk macrophages by HTLV-I: implications for HTLV-I transmission via breastfeeding. Biomed Res. 2010;31:53-61 pubmed
    ..These findings suggested that BrMMpsi might be an appropriate HTLV-I reservoir involved in MTCT transmission via breastfeeding. ..
  33. Zhou H, Dehn D, Kepa J, Siegel D, Scott D, Tan W, et al. NAD(P)H:quinone oxidoreductase 1-compromised human bone marrow endothelial cells exhibit decreased adhesion molecule expression and CD34+ hematopoietic cell adhesion. J Pharmacol Exp Ther. 2010;334:260-8 pubmed publisher
  34. Sheaffer A, Lee M, Qi H, Chaniewski S, Zheng X, Farr G, et al. A Small Molecule Inhibitor Selectively Induces Apoptosis in Cells Transformed by High Risk Human Papilloma Viruses. PLoS ONE. 2016;11:e0155909 pubmed publisher
    ..performed to identify compounds that prevented proliferation of the human Papilloma virus type 16 (HPV-16) transformed cell line Ca Ski. A series of quinoxaline compounds exemplified by Compound 1 was identified...
  35. Maglione V, Marchi P, Di Pardo A, Lingrell S, Horkey M, Tidmarsh E, et al. Impaired ganglioside metabolism in Huntington's disease and neuroprotective role of GM1. J Neurosci. 2010;30:4072-80 pubmed publisher
    ..Our data identify GM1 as a potential treatment for HD. ..
  36. Besgen P, Trommler P, Vollmer S, Prinz J. Ezrin, maspin, peroxiredoxin 2, and heat shock protein 27: potential targets of a streptococcal-induced autoimmune response in psoriasis. J Immunol. 2010;184:5392-402 pubmed publisher
    ..Additionally, ezrin and hsp27 might constitute antigenic links between psoriasis and inflammatory bowel disease, uveitis, or arteriosclerosis, which are clinically associated. ..
  37. Fritz V, Benfodda Z, Rodier G, Henriquet C, Iborra F, Avances C, et al. Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice. Mol Cancer Ther. 2010;9:1740-54 pubmed publisher
    ..Together, our data support for the first time the concept of targeting the lipogenic enzyme SCD1 as a new promising therapeutic approach to block oncogenesis and prostate cancer progression. ..
  38. Larmann J, Frenzel T, Hahnenkamp A, Herzog C, Lorenz A, Steinbicker A, et al. In vivo fluorescence-mediated tomography for quantification of urokinase receptor-dependent leukocyte trafficking in inflammation. Anesthesiology. 2010;113:610-8 pubmed publisher
    ..Targeting u-PAR for modulation of leukocyte recruitment is a promising therapeutic strategy to ameliorate leukocyte induced tissue damage. ..
  39. Taylor J, Cheuk A, Tsang P, Chung J, Song Y, Desai K, et al. Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models. J Clin Invest. 2009;119:3395-407 pubmed publisher
    ..These findings support the potential therapeutic targeting of FGFR4 in RMS. ..
  40. Tochikura T, Motokawa K, Naito Y, Kozutsumi Y, Tanabe Tochikura A, Hohdatsu T. Differential CXCR4 expression and function in subpopulations of the feline lymphoma cell line 3201 susceptible to feline immunodeficiency virus. J Feline Med Surg. 2010;12:269-77 pubmed publisher
    ..Determining the mechanism(s) within 3201-S cells that restrict FIV could result in therapeutic strategies against FIV infection. ..
  41. Lee H, Zhang H, Schulz V, Tuck D, Forget B. Downstream targets of HOXB4 in a cell line model of primitive hematopoietic progenitor cells. Blood. 2010;116:720-30 pubmed publisher
  42. Sinha S, Gupta S, Malhotra S, Krishna N, Meru A, Babu V, et al. AE9C90CB: a novel, bladder-selective muscarinic receptor antagonist for the treatment of overactive bladder. Br J Pharmacol. 2010;160:1119-27 pubmed publisher
    ..Therefore, AE9C90CB may be a promising compound for the treatment of overactive bladder with reduced potential to cause dry mouth than currently available antimuscarinic drugs. ..
  43. Teskac K, Kristl J. The evidence for solid lipid nanoparticles mediated cell uptake of resveratrol. Int J Pharm. 2010;390:61-9 pubmed publisher
    ..The cytostatic effect of SLN-RSV was much more expressed than that of RSV in solution. Delivery of RSV by SLN contributes to effectiveness of RSV on decreasing cell proliferation, with potential benefits for prevention of skin cancer. ..
  44. Khanna S, Parinandi N, Kotha S, Roy S, Rink C, Bibus D, et al. Nanomolar vitamin E alpha-tocotrienol inhibits glutamate-induced activation of phospholipase A2 and causes neuroprotection. J Neurochem. 2010;112:1249-60 pubmed publisher
    ..This work presents first evidence recognizing glutamate-induced changes in cPLA(2) as a novel mechanism responsible for neuroprotection observed in response to nanomolar concentrations of TCT. ..
  45. Provenzano C, Pascucci B, Lupari E, Civitareale D. Large scale analysis of transcription factor TTF-1/NKX2.1 target genes in GnRH secreting cell line GT1-7. Mol Cell Endocrinol. 2010;323:215-23 pubmed publisher
    ..1 at the promoter level. To further support the role of TTF-1 in GnRH neurons, we show that Sparc is involved in the regulation of the GnRH secretion in GT1-7 cells. ..
  46. Rosenberg S, Yang J, Kammula U, Hughes M, Restifo N, Schwarz S, et al. Different adjuvanticity of incomplete freund's adjuvant derived from beef or vegetable components in melanoma patients immunized with a peptide vaccine. J Immunother. 2010;33:626-9 pubmed publisher
    ..A survey of ongoing clinical trials listed in ClinicalTrials.gov revealed 36 trials currently accruing patients that are using the olive-derived Montanide ISA 51 IFA. ..
  47. McIntosh P, Laskey P, Sullivan K, Davy C, Wang Q, Jackson D, et al. E1--E4-mediated keratin phosphorylation and ubiquitylation: a mechanism for keratin depletion in HPV16-infected epithelium. J Cell Sci. 2010;123:2810-22 pubmed publisher
  48. Hsu C, Chan D, Wolozin B. LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins. Neurodegener Dis. 2010;7:68-75 pubmed publisher
    ..These results are consistent with a putative role of LRRK2 in regulating the stress kinase cascade. ..
  49. Chakrabarti L, Zahra R, Jackson S, Kazemi Esfarjani P, Sopher B, Mason A, et al. Mitochondrial dysfunction in NnaD mutant flies and Purkinje cell degeneration mice reveals a role for Nna proteins in neuronal bioenergetics. Neuron. 2010;66:835-47 pubmed publisher
    ..Our studies indicate that Nna1 loss of function results in altered bioenergetics and mitochondrial dysfunction. ..
  50. Hsu C, Chan D, Greggio E, Saha S, Guillily M, Ferree A, et al. MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2. J Neurochem. 2010;112:1593-604 pubmed publisher
    ..These results were confirmed by deletion of sek-1 in C. elegans. These data demonstrate that MKKs and LRRK2 function in similar biological pathways, and support a role for LRRK2 in modulating the cellular stress response. ..
  51. Tobar N, Villar V, Santibanez J. ROS-NFkappaB mediates TGF-beta1-induced expression of urokinase-type plasminogen activator, matrix metalloproteinase-9 and cell invasion. Mol Cell Biochem. 2010;340:195-202 pubmed publisher
    ..Thus, ROS-NFkappaB acts as the crucial signal in TGF-beta1-induced uPA and MMP-9 expression thereby mediating the enhancement of cellular malignity by TGF-beta1...
  52. Fecker L, Stockfleth E, Braun F, Rodust P, Schwarz C, Köhler A, et al. Enhanced death ligand-induced apoptosis in cutaneous SCC cells by treatment with diclofenac/hyaluronic acid correlates with downregulation of c-FLIP. J Invest Dermatol. 2010;130:2098-109 pubmed publisher
    ..Thus, induction of apoptosis appears to be highly characteristic of the mode of action of diclofenac/HA, and the therapeutic effect may be related to sensitization of neoplastic keratinocytes for death ligand-induced apoptosis...
  53. Lechner M, Kratochwill K, Lichtenauer A, Rehulka P, Mayer B, Aufricht C, et al. A proteomic view on the role of glucose in peritoneal dialysis. J Proteome Res. 2010;9:2472-9 pubmed publisher
    ..This finding supports the hypothesis that cellular response to full-PDF stress is not primarily induced by the high glucose concentration, even when focusing on proteins belonging to the glucose associated pathways...
  54. Maciejowski J, George K, Terret M, Zhang C, Shokat K, Jallepalli P. Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. J Cell Biol. 2010;190:89-100 pubmed publisher
  55. Kong K, Kim H, Song K, Woo Y, Choi W, Park H, et al. Capsaicin impairs proliferation of neural progenitor cells and hippocampal neurogenesis in young mice. J Toxicol Environ Health A. 2010;73:1490-501 pubmed publisher
    ..Interestingly, capsaicin decreased ERK activation in the hippocampus, suggesting that reduced ERK signaling may be involved in the capsaicin-mediated regulation of hippocampal neurogenesis...
  56. Liu L, Xu H, Jiang H, Wang J, Song N, Xie J. Ghrelin prevents 1-methyl-4-phenylpyridinium ion-induced cytotoxicity through antioxidation and NF-kappaB modulation in MES23.5 cells. Exp Neurol. 2010;222:25-9 pubmed publisher
    ..These results suggest that the protective effects of ghrelin on MPP(+)-induced cytotoxicity may be ascribed to its antioxidative properties, and the modulation of nuclear factor-kappaB...
  57. Ross D, Zhou H. Relationships between metabolic and non-metabolic susceptibility factors in benzene toxicity. Chem Biol Interact. 2010;184:222-8 pubmed publisher
    ..These examples illustrate how the metabolic susceptibility factor NQO1 may influence non-metabolic susceptibility pathways for benzene toxicity...
  58. Calay D, Vind Kezunovic D, Frankart A, Lambert S, Poumay Y, Gniadecki R. Inhibition of Akt signaling by exclusion from lipid rafts in normal and transformed epidermal keratinocytes. J Invest Dermatol. 2010;130:1136-45 pubmed publisher
    ..Thus, the integrity of lipid rafts is required for the activity of Akt and cell survival and may serve as a potential pharmacological target in the treatment of epidermal cancers...
  59. Kim K, Jung D, Jang D, Kim Y, Kim J, Kim H, et al. Puerarin suppresses AGEs-induced inflammation in mouse mesangial cells: a possible pathway through the induction of heme oxygenase-1 expression. Toxicol Appl Pharmacol. 2010;244:106-13 pubmed publisher
    ..Taken together, our results demonstrate that puerarin-induced expression of HO-1 is mediated by the PKC delta-Nrf-2-HO-1 pathway and inhibits N-carboxymethyllysine (CML)-induced inflammation in mouse mesangial cells...
  60. Soto Reyes E, Recillas Targa F. Epigenetic regulation of the human p53 gene promoter by the CTCF transcription factor in transformed cell lines. Oncogene. 2010;29:2217-27 pubmed publisher
    ..We propose that CTCF is a strategic component responsible for the maintenance and segregation of epigenetic traits...
  61. Jiang S, Benson C, Zaharia L, Abrams S, Hou S. Abscisic acid does not evoke calcium influx in murine primary microglia and immortalised murine microglial BV-2 and N9 cells. Biochem Biophys Res Commun. 2010;401:435-9 pubmed publisher
    ..The broad conclusion that ABA evokes [Ca(2+)]i in microglia requires more evidence and further careful examination...
  62. Xu J, Zhang X, Pelayo R, Monestier M, Ammollo C, Semeraro F, et al. Extracellular histones are major mediators of death in sepsis. Nat Med. 2009;15:1318-21 pubmed publisher
    ..We conclude that extracellular histones are potential molecular targets for therapeutics for sepsis and other inflammatory diseases...
  63. Nakahara F, Sakata Yanagimoto M, Komeno Y, Kato N, Uchida T, Haraguchi K, et al. Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia. Blood. 2010;115:2872-81 pubmed publisher
    ..These results suggest that Hes1 is a key molecule in blast crisis transition in CML...
  64. Li S, Gallup M, Chen Y, McNamara N. Molecular mechanism of proinflammatory cytokine-mediated squamous metaplasia in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2010;51:2466-75 pubmed publisher
    ..Here the molecular mechanisms controlling SPRR1B gene expression in response to IL-1beta and IFN-gamma are elucidated...
  65. Singh R, Wang Y, Schattenberg J, Xiang Y, Czaja M. Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation. Am J Physiol Gastrointest Liver Physiol. 2009;297:G907-17 pubmed
  66. Wu Y, Wu W, Wong W, Ward E, Thrasher A, Goldblatt D, et al. Human gamma delta T cells: a lymphoid lineage cell capable of professional phagocytosis. J Immunol. 2009;183:5622-9 pubmed publisher
  67. Pacheu Grau D, Gómez Durán A, López Pérez M, Montoya J, Ruiz Pesini E. Mitochondrial pharmacogenomics: barcode for antibiotic therapy. Drug Discov Today. 2010;15:33-9 pubmed publisher
    ..Systems are available to analyze the interaction between antibiotics and mitochondrial DNA genetic variants, thus making a pharmacogenomic approach to antibiotic therapy possible...
  68. Hirabayashi Y, Oka Y, Ikeda T, Fujii H, Ishii T, Sasaki T, et al. The endoplasmic reticulum stress-inducible protein, Herp, is a potential triggering antigen for anti-DNA response. J Immunol. 2010;184:3276-83 pubmed publisher
    ..Thus, Herp represents a candidate autoantigen for anti-DNA Abs. This study may help explain how common environmental factors induce the production of anti-DNA Abs and contribute the development of SLE...
  69. Hour T, Lai Y, Kuan C, Chou C, Wang J, Tu H, et al. Transcriptional up-regulation of SOD1 by CEBPD: a potential target for cisplatin resistant human urothelial carcinoma cells. Biochem Pharmacol. 2010;80:325-34 pubmed publisher
    ..Furthermore, our data suggest that SOD inhibitors, which are already used as anti-angiogenic agents, may be suitable for combinatorial chemotherapy to prevent or treat cisplatin resistance in bladder and possibly other cancers. ..
  70. Noutsopoulos D, Markopoulos G, Vartholomatos G, Kolettas E, Kolaitis N, Tzavaras T. VL30 retrotransposition signals activation of a caspase-independent and p53-dependent death pathway associated with mitochondrial and lysosomal damage. Cell Res. 2010;20:553-62 pubmed publisher
  71. Laihia J, Kallio J, Taimen P, Kujari H, Kahari V, Leino L. Protodynamic intracellular acidification by cis-urocanic acid promotes apoptosis of melanoma cells in vitro and in vivo. J Invest Dermatol. 2010;130:2431-9 pubmed publisher
    ..These results identify cis-UCA as an anticancer agent inhibiting melanoma growth by immediate intracellular acidification followed by apoptotic cell death in vivo...
  72. Gómez Posada J, Etxeberria A, Roura Ferrer M, Areso P, Masin M, Murrell Lagnado R, et al. A pore residue of the KCNQ3 potassium M-channel subunit controls surface expression. J Neurosci. 2010;30:9316-23 pubmed publisher
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    ..9 and K(m2) = 307 microM). Collectively, the data show that hepatic uptake of EE2-Sul can be mediated by three transporters (OATP1B1, OATP2B1, and NTCP), whereas biliary excretion of EE2-Sul into bile likely involves BCRP...
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    ..The personalized IFNs could have a longer circulation time, fewer side effects but higher efficacy. We anticipate that the system can provide an improved form of IFN for medical uses...
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    ..These findings indicate that SBMA pathogenesis is mediated by misappropriation of native protein function, a mechanism that may apply broadly to polyglutamine diseases...
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